{"id":238863,"date":"2022-05-16T09:00:00","date_gmt":"2022-05-16T08:00:00","guid":{"rendered":"https:\/\/eu.intelligentlabs.org\/uzivanie-probiotik-s-antibiotikami\/"},"modified":"2022-05-16T09:00:00","modified_gmt":"2022-05-16T08:00:00","slug":"uzivanie-probiotik-s-antibiotikami","status":"publish","type":"post","link":"https:\/\/eu.intelligentlabs.org\/sk-sk\/uzivanie-probiotik-s-antibiotikami\/","title":{"rendered":"U\u017e\u00edvanie probiot\u00edk s antibiotikami \u2013 bezpe\u010dn\u00e1 kombin\u00e1cia?"},"content":{"rendered":"\r\n

Ak u\u017e\u00edvate antibiotik\u00e1 a rozm\u00fd\u0161\u013eate, \u010di je bezpe\u010dn\u00e9 ich u\u017e\u00edva\u0165 spolu s probiotikami, ste na spr\u00e1vnom mieste. V tomto \u010dl\u00e1nku si povieme viac nielen o t\u00e9me u\u017e\u00edvanie probiot\u00edk s antibiotikami, ale o tom, kedy ich u\u017e\u00edva\u0165 a o mo\u017en\u00fdch ved\u013eaj\u0161\u00edch \u00fa\u010dinkoch ich u\u017e\u00edvania v rovnakom obdob\u00ed.<\/p>\r\n\r\n\r\n\r\n

Probiotick\u00e9 v\u00fd\u017eivov\u00e9 doplnky<\/a> s\u00fa \u010doraz popul\u00e1rnej\u0161ie a ich s\u00fabe\u017en\u00e9 u\u017e\u00edvanie s antibiotikami je \u010dastou praxou. Zdravotn\u00edcki odborn\u00edci spopularizovali pojem zdrav\u00e1 \u010drevn\u00e1 fl\u00f3ra a s\u00fa \u010doraz n\u00e1chylnej\u0161\u00ed predpisova\u0165 probiotik\u00e1 spolo\u010dne s antibiotikami.<\/p>\r\n\r\n\r\n\r\n

Na druhej strane s\u00fa aj pacienti dobre informovan\u00ed o pozit\u00edvnych aspektoch probiot\u00edk. Vedia, \u017ee antibiotik\u00e1 by mohli po\u0161kodi\u0165 dobr\u00e9 bakt\u00e9rie v ich \u010drev\u00e1ch a chc\u00fa preto adekv\u00e1tnu ochranu. Celkovo sa antibiotick\u00e1 lie\u010dba a s\u00fabe\u017en\u00e9 u\u017e\u00edvanie probiot\u00edk stali rutinou mnoh\u00fdch lek\u00e1rov.<\/p>\r\n\r\n\r\n\r\n

Pre\u010do je u\u017e\u00edvanie antibiot\u00edk nevyhnutn\u00e9<\/strong><\/h2>\r\n\r\n\r\n\r\n

Antibiotik\u00e1 s\u00fa lieky, schopn\u00e9 zachr\u00e1ni\u0165 \u013eudsk\u00e9 \u017eivoty. Medic\u00edna pred a po ich objaven\u00ed sa zmenila doslovne zo d\u0148a na de\u0148. Mili\u00f3ny \u013eud\u00ed sa vyhli smrti len v\u010faka antibiotik\u00e1m. Paradoxne, doslovn\u00fd v\u00fdznam slova antibiotikum je \u201eproti \u017eivotu\u201c. N\u00e1zov je kombin\u00e1ciou latinsk\u00e9ho slova \u201eanti\u201c, \u010do znamen\u00e1 proti, a gr\u00e9ckeho slova \u201ebios\u201c, \u010do znamen\u00e1 \u017eivot (1<\/a>).<\/p>\r\n\r\n\r\n\r\n

Antibiotik\u00e1 ni\u010dia bakt\u00e9rie, \u010do od\u00f4vod\u0148uje ich n\u00e1zov z mikrobiologick\u00e9ho h\u013eadiska. Vhodn\u00e9 antibiotik\u00e1 m\u00f4\u017eu p\u00f4sobivo zlep\u0161i\u0165 sympt\u00f3my a zefekt\u00edvni\u0165 lie\u010dbu u v\u00e1\u017ene chor\u00fdch jedincov s nebezpe\u010dn\u00fdmi infekciami. Ni\u010d nie je dokonal\u00e9 a to plat\u00ed aj pre antibiotik\u00e1. Okrem ni\u010denia patog\u00e9nnych bakt\u00e9ri\u00ed by mohli negat\u00edvne ovplyvni\u0165 aj na\u0161u \u010drevn\u00fa fl\u00f3ru.<\/p>\r\n\r\n\r\n\r\n

Z\u00e1va\u017en\u00e9 bakteri\u00e1lne infekcie s\u00fa jasn\u00fdm d\u00f4vodom na predpisovanie antibiot\u00edk. Napriek tomu sa tieto \u017eivot zachra\u0148uj\u00face lieky pou\u017e\u00edvaj\u00fa ove\u013ea viac, ako je potrebn\u00e9. Napr\u00edklad, hoci je v\u00e4\u010d\u0161ina infekci\u00ed horn\u00fdch d\u00fdchac\u00edch ciest (URTI) v\u00edrusov\u00e9ho p\u00f4vodu, mnoh\u00e9 z nich s\u00fa lie\u010den\u00e9 antibiotikami.<\/p>\r\n\r\n\r\n\r\n

\"u\u017e\u00edvanie<\/figure>\r\n\r\n\r\n\r\n

Strach z mo\u017en\u00fdch bakteri\u00e1lnych komplik\u00e1ci\u00ed motivuje lek\u00e1ra, aby prem\u00fd\u0161\u013eal o lie\u010dbe antibiotikami, ale najm\u00e4 v pr\u00edpadoch, ke\u010f sympt\u00f3my mierne nazna\u010duj\u00fa mo\u017en\u00fa bakteri\u00e1lnu infekciu. O\u010dak\u00e1vania pacientov, \u017ee u\u017e od za\u010diatku prejavu sympt\u00f3mov z\u00edskaj\u00fa siln\u00fd a r\u00fdchlo p\u00f4sobiaci liek, predstavuj\u00fa pre lek\u00e1rov ve\u013ek\u00fd tlak.<\/p>\r\n\r\n\r\n\r\n

Na glob\u00e1lnej \u00farovni \u010del\u00edme nadmern\u00e9mu predpisovaniu antibiot\u00edk. D\u00f4sledkom nadmern\u00e9ho pou\u017e\u00edvania antibiot\u00edk v celosvetovom meradle je antibiotick\u00e1 rezistencia. Na individu\u00e1lnej \u00farovni sa zvy\u0161uje mo\u017enos\u0165 ved\u013eaj\u0161\u00edch \u00fa\u010dinkov antibiot\u00edk najm\u00e4 s ich \u010dast\u00fdm u\u017e\u00edvan\u00edm.<\/p>\r\n\r\n\r\n\r\n

Pre\u010do s\u00fa probiotik\u00e1 d\u00f4le\u017eit\u00e9?<\/strong><\/h2>\r\n\r\n\r\n\r\n

N\u00e1zov probiotikum znamen\u00e1 \u201epre \u017eivot\u201c, \u010do je opak v porovnan\u00ed s v\u00fdznamom slova antibiotikum. Probiotik\u00e1, zn\u00e1me aj ako \u201edobr\u00e9 bakt\u00e9rie\u201c, s\u00fa \u017eiv\u00e9 mikroorganizmy. Ke\u010f s\u00fa tieto \u017eiv\u00e9 kult\u00fary prij\u00edman\u00e9 prostredn\u00edctvom potravy alebo doplnkov, prospievaj\u00fa v\u00e1\u0161mu zdraviu (2<\/a>).<\/p>\r\n\r\n\r\n\r\n

Antibiotik\u00e1 m\u00f4\u017eu ovplyvni\u0165 rovnov\u00e1hu \u010drevnej fl\u00f3ry s mo\u017enos\u0165ou z\u00e1va\u017en\u00fdch ved\u013eaj\u0161\u00edch \u00fa\u010dinkov. N\u00e1\u0161 gastrointestin\u00e1lny trakt je hostite\u013eom viac ako 500 r\u00f4znych druhov bakt\u00e9ri\u00ed (2<\/a>). Tieto \u201edobr\u00e9\u201c bakt\u00e9rie z probiot\u00edk vytv\u00e1raj\u00fa v \u010drev\u00e1ch m\u00e9dium, ktor\u00e9 br\u00e1ni postupu patog\u00e9nnych alebo \u201ezl\u00fdch\u201c mikroorganizmov. Ak na\u0161e prospe\u0161n\u00e9 mikr\u00f3by nie s\u00fa v rovnov\u00e1he, budujeme si z\u00e1klad pre zdravotn\u00e9 probl\u00e9my.<\/p>\r\n\r\n\r\n\r\n

Probiotik\u00e1 sa pou\u017e\u00edvaj\u00fa na prevenciu dysbalancie \u010drevnej fl\u00f3ry alebo na lie\u010dbu zmenen\u00e9ho zlo\u017eenia \u010drevn\u00fdch mikr\u00f3bov. Medzi naj\u010dastej\u0161ie pou\u017e\u00edvan\u00e9 probiotik\u00e1 patria druhy Lactobacillus<\/em> a Bifidobacterium<\/em>. Probiotik\u00e1 nie s\u00fa ako in\u00e9 doplnky v\u00fd\u017eivy \u2013 s\u00fa to \u017eiv\u00e9 mikroorganizmy. Ke\u010f je n\u00e1\u0161 komplexn\u00fd \u010drevn\u00fd mikrobiologick\u00fd svet ohrozen\u00fd alebo ovplyvnen\u00fd, probiotik\u00e1 s\u00fa tu na to, aby v\u00e1m pomohli.<\/p>\r\n\r\n\r\n\r\n

Pozrite si na\u0161e 50 mili\u00e1rd CFU, 10 kme\u0148ov\u00fdch probiot\u00edk a prebiot\u00edk s obsahom vl\u00e1kniny Sunfiber a FOS<\/a>. Ka\u017ed\u00e9 balenie v\u00e1m vydr\u017e\u00ed asi 2 mesiace u\u017e\u00edvania, tak\u017ee z\u00edskate dostatok podpory pre zdravie v\u00e1\u0161ho tr\u00e1viaceho traktu.<\/p>\r\n\r\n\r\n\r\n

\"probiotik\u00e1<\/figure>\r\n\r\n\r\n\r\n

Pre\u010do je u\u017e\u00edvanie probiot\u00edk s antibiotikami tak\u00e9 d\u00f4le\u017eit\u00e9?<\/strong><\/h2>\r\n\r\n\r\n\r\n

Pomenovanie probiot\u00edk a antibiot\u00edk d\u00e1va zmysel len vtedy, ke\u010f sa zamysl\u00edme nad ich vplyvom na \u010drevn\u00fa fl\u00f3ru. A\u017e potom by sa \u017eivot zachra\u0148uj\u00face lieky, ak\u00fdmi s\u00fa antibiotik\u00e1, mohli sp\u00e1ja\u0165 so zni\u010den\u00edm ur\u010ditej formy \u017eivota. Naozaj by mohli po\u0161kodi\u0165 \u201edobr\u00e9 bakt\u00e9rie\u201c v na\u0161ich \u010drev\u00e1ch s n\u00e1sledn\u00fdm mno\u017een\u00edm patog\u00e9nnych bakt\u00e9ri\u00ed.<\/p>\r\n\r\n\r\n\r\n

Dve be\u017en\u00e9 choroby, ktor\u00e9 m\u00f4\u017eu vznikn\u00fa\u0165 v d\u00f4sledku antibiotickej lie\u010dby, s\u00fa hna\u010dka, spojen\u00e1 s antibiotikami a infekcia Clostridium difficile (3<\/a>). Ob\u010das sa m\u00f4\u017eu vyskytn\u00fa\u0165 aj \u017eivot ohrozuj\u00face infekcie. Zmena homeost\u00e1zy v r\u00e1mci \u010drevnej fl\u00f3ry potenci\u00e1lne s\u00favis\u00ed s mnoh\u00fdmi chorobami a tieto s\u00favislosti s\u00fa predmetom intenz\u00edvneho v\u00fdskumu.<\/p>\r\n\r\n\r\n\r\n

Probiotik\u00e1 pom\u00e1haj\u00fa predch\u00e1dza\u0165 hna\u010dke, spojenej s antibiotikami<\/strong><\/h3>\r\n\r\n\r\n\r\n

Probiotik\u00e1 s\u00fa mnoh\u00fdmi medic\u00ednskymi odborn\u00edkmi pova\u017eovan\u00e9 za doplnky, schopn\u00e9 predch\u00e1dza\u0165 alebo lie\u010di\u0165 ved\u013eaj\u0161ie \u00fa\u010dinky antibiot\u00edk na \u00farovni \u010drevnej fl\u00f3ry. Existuje mno\u017estvo vedeck\u00fdch \u0161t\u00fadi\u00ed, ktor\u00e9 podporuj\u00fa u\u017e\u00edvanie probiot\u00edk po\u010das u\u017e\u00edvania antibiot\u00edk. Probiotik\u00e1 maj\u00fa pozit\u00edvnu \u00falohu v prevencii hna\u010dky spojenej s antibiotikami u dospelej aj detskej popul\u00e1cie (4<\/a>).<\/p>\r\n\r\n\r\n\r\n

Okrem toho r\u00f4zne probiotick\u00e9 formul\u00e1cie vykazuj\u00fa priazniv\u00e9 \u00fa\u010dinky a prevent\u00edvne v\u00fdsledky sa zachov\u00e1vaj\u00fa aj pri r\u00f4znych antibiotick\u00fdch re\u017eimoch. Taktie\u017e probiotik\u00e1 sa \u00faspe\u0161ne pou\u017e\u00edvaj\u00fa v r\u00f4znych indik\u00e1ci\u00e1ch na lie\u010dbu antibiotikami (4<\/a>).<\/p>\r\n\r\n\r\n\r\n

V pediatrickej popul\u00e1cii sa antibiotik\u00e1 predpisuj\u00fa pomerne \u010dasto a preto je hna\u010dka, spojen\u00e1 s antibiotikami u det\u00ed, \u010dast\u00fdm probl\u00e9mom. Dokonca aj tie najpr\u00edsnej\u0161ie systematick\u00e9 preh\u013eady uzn\u00e1vaj\u00fa schopnos\u0165 antibiot\u00edk zmeni\u0165 mikrobi\u00e1lnu rovnov\u00e1hu v na\u0161om gastrointestin\u00e1lnom trakte (5<\/a>).<\/p>\r\n\r\n\r\n\r\n

Deti v\u0161etk\u00fdch vekov\u00fdch kateg\u00f3ri\u00ed m\u00f4\u017eu tie\u017e profitova\u0165 z probiot\u00edk. Pozrite si n\u00e1\u0161 doplnok v\u00fd\u017eivy Detsk\u00e9 probiotik\u00e1 a prebiotik\u00e1 bez cukru<\/a>. Ka\u017ed\u00e1 kapsula obsahuje 6 mili\u00e1rd CFU a bude fungova\u0165 24 hod\u00edn denne, aby chr\u00e1nila bru\u0161ko v\u00e1\u0161ho die\u0165a\u0165a.<\/p>\r\n\r\n\r\n\r\n

Probiotik\u00e1 pom\u00e1haj\u00fa obnovi\u0165 rovnov\u00e1hu \u010drevnej fl\u00f3ry<\/strong><\/h3>\r\n\r\n\r\n\r\n

Probiotik\u00e1 s\u00fa tie\u017e uzn\u00e1van\u00e9 ako doplnky, schopn\u00e9 obnovi\u0165 \u010drevn\u00fa fl\u00f3ru. Kmene, naj\u010dastej\u0161ie pou\u017e\u00edvan\u00e9 v probiotik\u00e1ch, konkr\u00e9tne Lactobacillus<\/em> a Bifidobacterium<\/em>, s\u00fa \u00fa\u010dinn\u00e9 pri prevencii hna\u010dky, spojenej s antibiotikami v d\u00f4sledku amoxicil\u00ednu a kyseliny klavulanovej, \u010dasto pou\u017e\u00edvan\u00e9ho antibiotika\u00a0 (6<\/a>).<\/p>\r\n\r\n\r\n\r\n

Obzvl\u00e1\u0161\u0165 desiv\u00fdm d\u00f4sledkom nadmern\u00e9ho u\u017e\u00edvania antibiot\u00edk je infekcia Clostridium difficile<\/a>. Tento typ infekcie m\u00f4\u017ee by\u0165 \u017eivot ohrozuj\u00faci, najm\u00e4 ak je sp\u00f4soben\u00fd multirezistentn\u00fdmi kme\u0148mi tohto mikroorganizmu. Naru\u0161enie \u010drevnej fl\u00f3ry antibiotikami m\u00f4\u017ee vies\u0165 k zn\u00ed\u017eeniu odolnosti vo\u010di nebezpe\u010dn\u00fdm mikr\u00f3bom, ako je Clostridium difficile\u00a0 (7<\/a>).<\/p>\r\n\r\n\r\n\r\n

Na z\u00e1klade systematick\u00e9ho preh\u013eadu a metaanal\u00fdzy 31 randomizovan\u00fdch kontrolovan\u00fdch \u0161t\u00fadi\u00ed, zah\u0155\u0148aj\u00facich 8 672 pacientov, existuj\u00fa d\u00f4kazy, ktor\u00e9 nazna\u010duj\u00fa schopnos\u0165 probiot\u00edk predch\u00e1dza\u0165 hna\u010dke spojenej s Clostridium difficile (7<\/a>). Hna\u010dka, spojen\u00e1 s Clostridium difficile,predstavuje najz\u00e1va\u017enej\u0161iu formu hna\u010dky, spojenej s antibiotikami a je spojen\u00e1 s v\u00fdznamnou morbiditou a mortalitou (8<\/a>).<\/p>\r\n\r\n\r\n\r\n

\"probiotik\u00e1<\/figure>\r\n\r\n\r\n\r\n

Probiotik\u00e1 pom\u00e1haj\u00fa zlep\u0161i\u0165 v\u00fdsledky antibiot\u00edk<\/strong><\/h3>\r\n\r\n\r\n\r\n

V niektor\u00fdch indik\u00e1ci\u00e1ch probiotik\u00e1 zlep\u0161uj\u00fa v\u00fdsledky antibiot\u00edk. Pri pou\u017eit\u00ed s \u200b\u200bantibiotikami – pri lie\u010dbe recidivuj\u00facej bakteri\u00e1lnej vagin\u00f3zy a aer\u00f3bnej vaginit\u00eddy – predl\u017euj\u00fa peror\u00e1lne probiotik\u00e1 dobu remisie (9<\/a>).<\/p>\r\n\r\n\r\n\r\n

Pozn\u00e1mka: Ak trp\u00edte na tieto \u017eensk\u00e9 probl\u00e9my, n\u00e1\u0161 doplnok <\/em>Probiotik\u00e1 a prebiotik\u00e1 pre \u017eeny<\/em><\/a> je \u0161peci\u00e1lne navrhnut\u00fd tak, aby v\u00e1m pomohol. Ka\u017ed\u00e1 kapsula obsahuje 5 mili\u00e1rd CFU, Crantiva brusnicov\u00fd d\u017e\u00fas v pr\u00e1\u0161ku a D-man\u00f3zu.<\/em><\/p>\r\n\r\n\r\n\r\n

Pri lie\u010dbe infekcie Helicobacter pylori – jeden z terapeutick\u00fdch re\u017eimov zah\u0155\u0148a pou\u017eitie inhib\u00edtora prot\u00f3novej pumpy, bizmutu a dvoch antibiot\u00edk po\u010das 14 dn\u00ed. Ke\u010f sa k tejto \u0161tvorn\u00e1sobnej terapii prid\u00e1 probiotikum, kone\u010dn\u00e9 v\u00fdsledky s\u00fa viac ne\u017e uspokojiv\u00e9\u00a0 (10<\/a>). T\u00e1to terapia dok\u00e1zala dobr\u00e9 v\u00fdsledky naprie\u010d r\u00f4znymi profilmi antibiotickej rezistencie Helicobacter pylori.<\/p>\r\n\r\n\r\n\r\n

Paraleln\u00e1 konzum\u00e1cia probiotick\u00fdch doplnkov a antibiot\u00edk u pediatrickej popul\u00e1cie s recidivuj\u00facimi infekciami mo\u010dov\u00fdch ciest preuk\u00e1zala vy\u0161\u0161iu \u00fa\u010dinnos\u0165 v porovnan\u00ed s pr\u00edpadmi u\u017e\u00edvania samotn\u00fdch antibiot\u00edk (11<\/a>).<\/p>\r\n\r\n\r\n\r\n

Najlep\u0161ie na\u010dasovanie pre u\u017e\u00edvanie probiot\u00edk s antibiotikami<\/strong><\/h2>\r\n\r\n\r\n\r\n

Existuj\u00fa r\u00f4zne formy probiotick\u00fdch doplnkov. Napr\u00edklad existuj\u00fa probiotik\u00e1 vo forme kaps\u00fal alebo tabliet. N\u00e1poje s obsahom probiotick\u00fdch kult\u00far, ako je jogurt a kef\u00edr, s\u00fa zn\u00e1me po celom svete. Tieto prospe\u0161n\u00e9 mikroorganizmy musia odol\u00e1va\u0165 kysl\u00e9mu prostrediu \u017eal\u00fadka, aby sa dostali do \u010driev, kde uplat\u0148uj\u00fa svoj terapeutick\u00fd potenci\u00e1l.<\/p>\r\n\r\n\r\n\r\n

V z\u00e1vislosti od probiotickej formy by sa tieto doplnky mali u\u017e\u00edva\u0165 nala\u010dno alebo s jedlom<\/a>. Je ve\u013emi d\u00f4le\u017eit\u00e9 pre\u010d\u00edta\u0165 si pokyny pre pacientov, preto\u017ee neexistuje jedin\u00e9 spr\u00e1vne pravidlo. Ako pr\u00edklad m\u00f4\u017eu sl\u00fa\u017ei\u0165 probiotick\u00e9 doplnky bez enterosolventn\u00e9ho obalu. Mali by sa u\u017e\u00edva\u0165 tesne pred jedlom alebo s jedlom, obsahuj\u00facim niektor\u00e9 tuky (12<\/a>).<\/p>\r\n\r\n\r\n\r\n

To ist\u00e9 plat\u00ed aj pre antibiotik\u00e1. Tie\u017e existuj\u00fa v r\u00f4znych form\u00e1ch a musia by\u0165 schopn\u00e9 dosta\u0165 sa do \u010driev. Niektor\u00e9 z nich sa u\u017e\u00edvaj\u00fa nala\u010dno, in\u00e9 s jedlom. Op\u00e4\u0165 plat\u00ed, \u017ee pokyny v\u00fdrobcu pre pacientov s\u00fa ve\u013emi d\u00f4le\u017eit\u00e9 a generalizovanie nie je mo\u017en\u00e9.<\/p>\r\n\r\n\r\n\r\n

Na druhej strane znie logicky, \u017ee s\u00fa\u010dasn\u00e9 u\u017e\u00edvanie probiot\u00edk a antibiot\u00edk nie je dobr\u00fd n\u00e1pad. Jednoducho preto, \u017ee existuje mo\u017enos\u0165, \u017ee antibiotik\u00e1 zni\u010dia probiotick\u00e9 kmene, ke\u010f sa dostan\u00fa do vz\u00e1jomn\u00e9ho kontaktu v \u010drev\u00e1ch. Probiotik\u00e1, obsahuj\u00face dobr\u00e9 bakt\u00e9rie, by mali by\u0165 oddelen\u00e9 od antibiot\u00edk aspo\u0148 dve hodiny (2<\/a>).<\/p>\r\n\r\n\r\n\r\n

Tie\u017e, ak u\u017e\u00edvate doplnky s obsahom Saccharomyces bulardii<\/em>, je d\u00f4le\u017eit\u00e9 vedie\u0165, \u017ee s\u00fa to kvasinky, a teda prirodzene odoln\u00e9 vo\u010di antibakteri\u00e1lnym antibiotik\u00e1m (13<\/a>). Tento druh probiot\u00edk m\u00f4\u017ee by\u0165 citliv\u00fd na antimykotik\u00e1.<\/p>\r\n\r\n\r\n\r\n

\"u\u017e\u00edvanie<\/figure>\r\n\r\n\r\n\r\n

Je mo\u017en\u00e9 u\u017e\u00edvanie probiot\u00edk s antibiotikami bez ved\u013eaj\u0161\u00edch \u00fa\u010dinkov?<\/strong><\/h2>\r\n\r\n\r\n\r\n

V\u0161etky lieky a v\u00fd\u017eivov\u00e9 doplnky m\u00f4\u017eu vies\u0165 k ne\u017eiaducim udalostiam. V\u00fdnimkou nie s\u00fa ani antibiotik\u00e1 a probiotik\u00e1. U\u017e\u00edvanie dvoch l\u00e1tok v rovnakom obdob\u00ed zvy\u0161uje mo\u017enos\u0165 ved\u013eaj\u0161\u00edch \u00fa\u010dinkov. Okrem hna\u010dky, s\u00favisiacej s antibiotikami a hna\u010dky, s\u00favisiacej s Clostridium difficile, m\u00f4\u017eu antibiotik\u00e1 vyvola\u0165 z\u00e1va\u017en\u00e9 alergick\u00e9 reakcie.<\/p>\r\n\r\n\r\n\r\n

Probiotik\u00e1m by sa mali vyhn\u00fa\u0165 pacienti, ktor\u00ed s\u00fa kriticky chor\u00ed na jednotk\u00e1ch intenz\u00edvnej starostlivosti, kriticky chor\u00e9 doj\u010dat\u00e1 a v\u0161etci jedinci, ktor\u00fdch imunitn\u00fd syst\u00e9m je v\u00e1\u017ene oslaben\u00fd (14<\/a>).<\/p>\r\n\r\n\r\n\r\n

Je \u0165a\u017ek\u00e9 n\u00e1js\u0165 v medic\u00ednskej literat\u00fare konkr\u00e9tne inform\u00e1cie o ved\u013eaj\u0161\u00edch \u00fa\u010dinkoch v pr\u00edpadoch, ke\u010f sa antibiotik\u00e1 a probiotik\u00e1 pou\u017e\u00edvaj\u00fa s\u00fa\u010dasne. Niektor\u00e9 \u0161t\u00fadie navy\u0161e preukazuj\u00fa zn\u00ed\u017eenie ved\u013eaj\u0161\u00edch \u00fa\u010dinkov, s\u00favisiacich s lie\u010dbou a zlep\u0161enie zdravia pacientov, ke\u010f sa k antibiotik\u00e1m prid\u00e1vaj\u00fa probiotik\u00e1 (10<\/a>).<\/p>\r\n\r\n\r\n\r\n

Probiotick\u00e1 bakt\u00e9ria Lactobacillus plantarum<\/em> je schopn\u00e1 predch\u00e1dza\u0165 niektor\u00fdm miernej\u0161\u00edm gastrointestin\u00e1lnym sympt\u00f3mom, spojen\u00fdm s u\u017e\u00edvan\u00edm antibiot\u00edk (15<\/a>). Suplement\u00e1cia probiotikami na eradik\u00e1ciu Helicobacter pylori m\u00f4\u017ee by\u0165 \u00fa\u010dinn\u00e1 pri zni\u017eovan\u00ed ne\u017eiaducich \u00fa\u010dinkov, s\u00favisiacich s lie\u010dbou (16<\/a>). Probiotick\u00e9 kvasinky Saccharomyces bulardii<\/em> s\u00fa tie\u017e schopn\u00e9 zn\u00ed\u017ei\u0165 v\u00fdskyt celkov\u00fdch ved\u013eaj\u0161\u00edch \u00fa\u010dinkov a ur\u010dit\u00fdch gastrointestin\u00e1lnych ne\u017eiaducich \u00fa\u010dinkov eradika\u010dnej terapie Helicobacter pylori (17<\/a>).<\/p>\r\n\r\n\r\n\r\n

Dlhodob\u00e9 u\u017e\u00edvanie probiot\u00edk s antibiotikami<\/strong><\/h2>\r\n\r\n\r\n\r\n

V niektor\u00fdch klinick\u00fdch situ\u00e1ci\u00e1ch sa antibiotik\u00e1 pou\u017e\u00edvaj\u00fa ove\u013ea dlh\u0161ie ako t\u00fd\u017ede\u0148 alebo dva. Dlh\u0161ie u\u017e\u00edvanie zvy\u0161uje pravdepodobnos\u0165 ved\u013eaj\u0161\u00edch \u00fa\u010dinkov, hoci s\u00fa probiotik\u00e1 v\u0161eobecne pova\u017eovan\u00e9 za bezpe\u010dn\u00e9 a dobre tolerovan\u00e9 doplnky v\u00fd\u017eivy (1<\/a>). Pri mnoh\u00fdch indik\u00e1ci\u00e1ch sa u\u017e\u00edvaj\u00fa dokonca a\u017e mesiace s vynikaj\u00facim bezpe\u010dnostn\u00fdm profilom.<\/p>\r\n\r\n\r\n\r\n

Relevantn\u00fdm pr\u00edkladom paraleln\u00e9ho, dlhodob\u00e9ho u\u017e\u00edvania antibiot\u00edk a probiot\u00edk je v\u00fdskyt recidivuj\u00facich infekci\u00ed mo\u010dov\u00fdch ciest v detskej popul\u00e1cii. Niektor\u00e9 \u0161t\u00fadie zd\u00f4raz\u0148uj\u00fa bezpe\u010dnos\u0165 a \u00fa\u010dinnos\u0165 u\u017e\u00edvania probiot\u00edk s dlhodob\u00fdmi antibiotikami (11<\/a>). Nie je to prekvapen\u00edm, preto\u017ee mnoh\u00e9 vedeck\u00e9 \u010dl\u00e1nky odha\u013euj\u00fa, \u017ee probiotik\u00e1 \u00faspe\u0161ne obnovuj\u00fa \u010drevn\u00fa fl\u00f3ru, ke\u010f je jej rovnov\u00e1ha naru\u0161en\u00e1.<\/p>\r\n\r\n\r\n\r\n

Na z\u00e1ver<\/strong><\/h2>\r\n\r\n\r\n\r\n

Ako ste sa dozvedeli v tomto \u010dl\u00e1nku, je v\u0161eobecne prijate\u013en\u00e9 u\u017e\u00edvanie probiotik s antibiotikami. Majte v\u0161ak na pam\u00e4ti pravidlo 2 hod\u00edn, teda probiotik\u00e1 u\u017eite 2 hodiny po u\u017eit\u00ed antibiot\u00edk (alebo naopak). Aby ste dosiahli \u010do najlep\u0161ie v\u00fdsledky, nezabudnite si pre\u010d\u00edta\u0165 pokyny v\u00fdrobcu pre antibiotik\u00e1 aj prebiotik\u00e1.<\/p>\r\n\r\n\r\n\r\n

Zdroje

[vc_row el_id=\u201cZdroje\u201d][vc_column][vc_toggle title=Zdroje el_class=\u201cfaqs\u201d]<\/p>\r\n\r\n\r\n\r\n

(1) Brightman C. Antibiotics in general practice. Trends in Urology & Men\u2018s Health. 2014;Nov\/Dec:39-43.<\/p>\r\n\r\n\r\n\r\n

(2) Williams NT. Probiotics. Am J Health-Syst Pharm. 2010; 67:449-458.<\/p>\r\n\r\n\r\n\r\n

(3) Rehman A, Heinsen FA, Koenen ME, Venema K, Knecht H, Hellmig S, et al. Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine. BMC Microbiology. 2012;12(47)<\/p>\r\n\r\n\r\n\r\n

(4) Videlock EJ, Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2012;35(12):1355-1369.<\/p>\r\n\r\n\r\n\r\n

(5) Johnston BC, Goldenberg JZ, Vandvik PO, Sun X, Guyatt GH. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database of Systematic. 2011;11:CD004827.<\/p>\r\n\r\n\r\n\r\n

(6) Garc\u00eda Trallero O, Herrera Serrano L, Bibi\u00e1n Ingl\u00e9s M, Roche Vall\u00e9s D, Rodr\u00edguez AM. Effect of the administration of a probiotic with a combination of Lactobacillus and Bifidobacterium strains on antibiotic-associated diarrhea. Rev Esp Quimioter. 2019;32(3):268-272.<\/p>\r\n\r\n\r\n\r\n

(7) Goldenberg_JZ, Yap_C, Lytvyn_L, Lo_CKF, Beardsley_J, Mertz_D, Johnston_BC. Probiotics for the prevention of Clostridium di_icile-associated diarrhea in adults and children. Cochrane Database of Systematic Reviews 2017;12:CD006095.<\/p>\r\n\r\n\r\n\r\n

(8) Selinger CP, Bell A, Cairns A, Lockett M, Sebastian S, Haslam N. Probiotic VSL#3 prevents antibiotic-associated diarrhoea in a double-blind, randomized, placebo-controlled clinical trial. J Hosp Infect. 2013;84(2):159-165.<\/p>\r\n\r\n\r\n\r\n

(9) Heczko PB, Tomusiak A, Adamski P, Jakimiuk AJ, Stefa\u0144ski G, Miko\u0142ajczyk-Cicho\u0144ska A, et al. Supplementation of standard antibiotic therapy with oral probiotics for bacterial vaginosis and aerobic vaginitis: a randomised, double-blind, placebo-controlled trial. BMC Womens Health. 2015;15:115.<\/p>\r\n\r\n\r\n\r\n

(10) Poonyam P, Chotivitayatarakorn P, Vilaichone RK. High Effective of 14-Day High-Dose PPI- Bismuth-Containing Quadruple Therapy with Probiotics Supplement for Helicobacter Pylori Eradication: A Double Blinded-Randomized Placebo-Controlled Study. Asian Pac J Cancer Prev. 2019;20(9):2859-2864.<\/p>\r\n\r\n\r\n\r\n

(11) Mohseni MJ, Aryan Z, Emamzadeh-Fard S, Paydary K, Mofid V, Joudaki H, et al. Combination of Probiotics and Antibiotics in the Prevention of Recurrent Urinary Tract Infection in Children. Iran J Pediatr. 2013;23(4): 430\u2013438.<\/p>\r\n\r\n\r\n\r\n

(12) Tompkins TA, Mainville I, Arcand Y. The impact of meals on a probiotic during transit through a model of the human upper gastrointestinal tract. Benef Microbes. 2011;2(4):295-303.<\/p>\r\n\r\n\r\n\r\n

(13) Czerucka D, Piche T, Rampal P. Review article: yeast as probiotics \u2013Saccharomyces boulardii. Alimentary Pharmacology and Therapeutics. 2007;26(6):767-778.<\/p>\r\n\r\n\r\n\r\n

(14) Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M. A systematic review of the safety of probiotics. Expert Opin Drug Saf. 2014;13(2):227-239.<\/p>\r\n\r\n\r\n\r\n

(15) L\u00f6nnermark E, Friman V, Lappas G, Sandberg T, Berggren A, Adlerberth I. Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics. J Clin Gastroenterol. 2010;44(2):106-112.<\/p>\r\n\r\n\r\n\r\n

(16) Lv Z, Wang B, Zhou X, Wang F, Xie Y, Zheng H, et al. Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta\u2011analysis. Exp Ther Med. 2015;9(3):707-716.<\/p>\r\n\r\n\r\n\r\n

(17) Zhou BG, Chen LX, Li B, Wan LY, Ai YW. Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis. Helicobacter. 2019;24(5):e12651. [\/vc_toggle][\/vc_column][\/vc_row]<\/p>\r\n\r\n\r\n","protected":false},"excerpt":{"rendered":"

Ak u\u017e\u00edvate antibiotik\u00e1 a rozm\u00fd\u0161\u013eate, \u010di je bezpe\u010dn\u00e9 ich u\u017e\u00edva\u0165 spolu s probiotikami, ste na spr\u00e1vnom mieste. V tomto \u010dl\u00e1nku si povieme viac nielen o t\u00e9me u\u017e\u00edvanie probiot\u00edk s antibiotikami, ale o tom, kedy ich u\u017e\u00edva\u0165 a o mo\u017en\u00fdch ved\u013eaj\u0161\u00edch \u00fa\u010dinkoch ich u\u017e\u00edvania v rovnakom obdob\u00ed. Probiotick\u00e9 v\u00fd\u017eivov\u00e9 doplnky s\u00fa \u010doraz popul\u00e1rnej\u0161ie a ich s\u00fabe\u017en\u00e9…<\/p>\n","protected":false},"author":2,"featured_media":129467,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[3172],"tags":[],"coauthors":[],"class_list":["post-238863","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vyziva"],"taxonomy_info":{"category":[{"value":3172,"label":"V\u00fd\u017eiva"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2020\/06\/taking-probiotics-with-antibiotics-is-it-safe-to-do-so-01-1024x548.jpg",1024,548,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/sk-sk\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":3172,"name":"V\u00fd\u017eiva","slug":"vyziva","term_group":0,"term_taxonomy_id":3172,"taxonomy":"category","description":"","parent":0,"count":46,"filter":"raw","cat_ID":3172,"category_count":46,"category_description":"","cat_name":"V\u00fd\u017eiva","category_nicename":"vyziva","category_parent":0}],"tag_info":false,"wpml":{"language":"sk-sk","is_original":false,"original_post_id":131633,"translations":{"bg-bg":{"id":225794,"language":"bg-bg","is_original":false},"da-dk":{"id":222519,"language":"da-dk","is_original":false},"de-at":{"id":169262,"language":"de-at","is_original":false},"de-de":{"id":75372,"language":"de-de","is_original":false},"el-cy":{"id":229261,"language":"el-cy","is_original":false},"el-gr":{"id":228494,"language":"el-gr","is_original":false},"en-gb":{"id":131633,"language":"en-gb","is_original":true},"en-ie":{"id":166644,"language":"en-ie","is_original":false},"es-es":{"id":74935,"language":"es-es","is_original":false},"fi-fi":{"id":238671,"language":"fi-fi","is_original":false},"fr-fr":{"id":129466,"language":"fr-fr","is_original":false},"it-it":{"id":75137,"language":"it-it","is_original":false},"lt-lt":{"id":237081,"language":"lt-lt","is_original":false},"lv-lv":{"id":230626,"language":"lv-lv","is_original":false},"nl-be":{"id":217711,"language":"nl-be","is_original":false},"nl-nl":{"id":175635,"language":"nl-nl","is_original":false},"pt-pt":{"id":168918,"language":"pt-pt","is_original":false},"ro-ro":{"id":253661,"language":"ro-ro","is_original":false},"sk-sk":{"id":238863,"language":"sk-sk","is_original":false},"sl-si":{"id":239021,"language":"sl-si","is_original":false}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/comments?post=238863"}],"version-history":[{"count":0,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238863\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/media\/129467"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/media?parent=238863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/categories?post=238863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/tags?post=238863"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/coauthors?post=238863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}