![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-02.jpg\")
<\/figure>\n\n\n\nPojem \u201efol\u00e1t\u201c (kyselina listov\u00e1) ozna\u010duje skupinu v\u00fd\u017eivn\u00fdch l\u00e1tok nach\u00e1dzaj\u00facich sa v potravin\u00e1ch, najm\u00e4 zelenej listovej zelenine, fazuli a vajciach. Jedn\u00e1 sa o prirodzene sa vyskytuj\u00face a vo vode rozpustn\u00e9 formy vitam\u00ednu B9. (1) \u013dudia be\u017ene pou\u017e\u00edvaj\u00fa slovo \u201efol\u00e1t\u201c, ako keby op\u00edsali jednu \u017eivinu. \u201eFol\u00e1ty\u201c v\u00e1m mo\u017eno bude znie\u0165 vtipne, preto\u017ee tento tvar mno\u017en\u00e9ho \u010d\u00edsla je menej \u010dast\u00fd. Medzi potraviny s vysok\u00fdm obsahom kyseliny listovej patr\u00ed kel, brokolica, citrusov\u00e9 plody, \u0161parg\u013ea, ban\u00e1ny, fazu\u013ea a pe\u010de\u0148. (1) Fazu\u013ea a pe\u010de\u0148 poskytuj\u00fa ove\u013ea prirodzenej\u0161iu formu kyseliny listovej ako in\u00e9 potraviny z vy\u0161\u0161ie uveden\u00e9ho zoznamu. <\/p>\n\n\n\n
Ak m\u00e1 \u010dlovek vysok\u00fa potrebu fol\u00e1tov alebo m\u00e1 nedostatok aj po ich konzum\u00e1cii, je ve\u013emi pravdepodobn\u00e9, \u017ee pr\u00e1ve strava nie je najlep\u0161\u00edm sp\u00f4sobom, ako telu dopria\u0165 fol\u00e1t. Existuj\u00fa choroby a genetick\u00e9 faktory, ktor\u00e9 m\u00f4\u017eu zabr\u00e1ni\u0165 niektor\u00fdm jedincom v metabolizovan\u00ed fol\u00e1tu v potravin\u00e1ch. Prin\u00e1\u0161ame v\u00e1m viac inform\u00e1ci\u00ed.<\/p>\n\n\n\n
\n\n\n\n
\u010co je kyselina listov\u00e1?<\/strong><\/h2>\n\n\n\nKyselina listov\u00e1 je syntetick\u00e1 a vo vode rozpustn\u00e1 forma vitam\u00ednu B9. Produkuje sa aj synteticky na pokrytie potrieb organizmu.. Mnoho druhov chleba, pe\u010diva a obiln\u00edn obsahuje pr\u00e1ve kyselinu listov\u00fa. <\/p>\n\n\n\n![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/what-is-5-mthf-methylfolate-a-comprehensive-jargon-free-guide-02.jpg\")
<\/figure>\n\n\n\nV roku 1998 USA nariadili, aby sa do konkr\u00e9tnych obiln\u00edn prid\u00e1vala aj kyselina listov\u00e1, aby sa zabezpe\u010dil dostato\u010dn\u00fd pr\u00edjem B9 pre cel\u00fa popul\u00e1ciu.. Od roku 2017 nariadilo 86 kraj\u00edn legislat\u00edvnym z\u00e1konom, \u017ee p\u0161eni\u010dn\u00e1 m\u00faka mus\u00ed obsahova\u0165 ur\u010dit\u00e9 minim\u00e1lne mno\u017estvo kyseliny listovej. (2) (3) 16 kraj\u00edn z celkov\u00e9ho po\u010dtu 86 vydalo to ist\u00e9 nariadenie aj pre kukuri\u010dn\u00fa m\u00faku. \u0160es\u0165 kraj\u00edn tie\u017e pridalo na zoznam navy\u0161e aj ry\u017eov\u00fa m\u00faku.<\/p>\n\n\n\n
\n\n\n\n\u010co je 5-MTHF?<\/strong><\/h2>\n\n\n\n5-metyltetrahydrofol\u00e1t alebo 5-MTHF je pr\u00edrodn\u00e1 forma vitam\u00ednu B9, ktor\u00fa je na\u0161e telo pripraven\u00e9 absorbova\u0165 a pou\u017ei\u0165 na v\u00fd\u017eivov\u00e9 \u00fa\u010dely. Z tohto d\u00f4vodu je to dnes ve\u013emi popul\u00e1rna forma fol\u00e1tu, najm\u00e4 u \u013eud\u00ed, ktor\u00ed maj\u00fa probl\u00e9my s metaboliz\u00e1ciou in\u00fdch foriem B9 z potrav\u00edn a doplnkov. 5-MTHF m\u00f4\u017eete pozna\u0165 aj pod in\u00fdmi n\u00e1zvam<\/strong>i:<\/p>\n\n\n\n- L-5-MTHF<\/li>
- L-metylfol\u00e1t<\/li>
- L-metylfol\u00e1t v\u00e1penat\u00fd (iba ak je viazan\u00fd na v\u00e1penat\u00fa so\u013e)<\/li>
- Metylfol\u00e1t<\/li>
- Kyselina levomefolov\u00e1<\/li><\/ul>\n\n\n\n
U niektor\u00fdch vy\u0161\u0161ie uveden\u00fdch n\u00e1zvov si v\u0161imnite \u201eL\u201c. Toto p\u00edsmeno nazna\u010duje, \u017ee ve\u013ek\u00e1 v\u00e4\u010d\u0161ina \u013eud\u00ed ho dok\u00e1\u017ee absorbova\u0165. \u201c6 (S)\u201c namiesto \u201eL\u201c takisto ozna\u010duje tento pr\u00edpad. Ak je \u201eL\u201c nahraden\u00e9 \u201e6 (R)\u201c, potom v\u00e1m oto zlo\u017eenie pravdepodobne ve\u013emi nepom\u00f4\u017ee.<\/p>\n\n\n\n
\n\n\n\nKtor\u00e9 formy fol\u00e1tu dok\u00e1\u017ee na\u0161e telo najlep\u0161ie absorbova\u0165 a zu\u017eitkova\u0165? <\/strong><\/h2>\n\n\n\n![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/o-que-e-5-mthf-o-melhor-guia-sobre-folato-e-metilfolato-04-4-300x300.jpg\")
<\/figure><\/div>\n\n\n\n\u0160t\u00fadia publikovan\u00e1 v British Journal of Pharmacology porovn\u00e1vala absorpciu 6 (S) -5-MTHF v tele s kyselinou listovou. Subjekty boli zdrav\u00e9 \u017eeny, ktor\u00e9 mali probl\u00e9my so vstreb\u00e1van\u00edm fol\u00e1tu a kyseliny listovej zo stravy, preto\u017ee ich g\u00e9ny potrebn\u00e9 na spracovanie t\u00fdchto \u017eiv\u00edn boli chybn\u00e9. 6 (S) -5-MTHF reagoval ove\u013ea lep\u0161ie v z\u00edskavan\u00ed pou\u017eite\u013en\u00e9ho vitam\u00ednu B9 do krvnej plazmy, kde sa za\u010d\u00edna tento magick\u00fd proces. <\/p>\n\n\n\n
V tejto \u0161t\u00fadii vedci pou\u017eili 6 (S) -5-MTHF, ktor\u00fd sa viazal na v\u00e1penat\u00fa so\u013e. \u00c1no, predmetom v\u00fdskumu bola kyselina listov\u00e1, pokia\u013e ide o absorpciu … ALE … \u010eal\u0161ia \u0161t\u00fadia porovn\u00e1vala l\u00e1tky na b\u00e1ze v\u00e1pnika s inou formou 6 (S) -5-MTHF viazanou na glukozam\u00edn namiesto v\u00e1pniku u potkanov. Vedci tie\u017e porovnali obe formy s kyselinou listovou. \u0160t\u00fadia uk\u00e1zala 1,8-kr\u00e1t vy\u0161\u0161iu maxim\u00e1lnu hladinu v plazme ako 5-MTHF viazan\u00e9ho na v\u00e1penat\u00fa so\u013e a 3,1-kr\u00e1t vy\u0161\u0161iu hladinu ako u kyseliny listovej. (5) Preto Intelligent Labs pou\u017e\u00edva 6 (S) -5-MTHF naviazan\u00fd na glukozam\u00edn bez obsahu m\u00e4kk\u00fd\u0161ov. V na\u0161ich doplnkoch pou\u017e\u00edvame patentovan\u00fd vzorec s n\u00e1zvom Quatrefolic Acid\u00ae a pon\u00fakame dve verzie: 1mg 5-MTHF<\/a> and 5mg 5-MTHF<\/a><\/p>\n\n\n\n5-MTHF existuje aj pod in\u00fdmi n\u00e1zvami<\/strong><\/h2>\n\n\n\nMetafolin\u00ae<\/strong> – doplnok 5-MTHF vyu\u017e\u00edvaj\u00faci L-metylfol\u00e1t v\u00e1penat\u00fd. Je k dispoz\u00edcii iba prostredn\u00edctvom predajcov s licenciou udelenou jej autormi. Deplin\u00ae<\/strong> – T\u00e1to 5-MTHF formula, ktor\u00e1 je dostupn\u00e1 na lek\u00e1rsky predpis, bola vyvinut\u00e1 tak, aby uspokojila nutri\u010dn\u00e9 potreby pacientov s depresiou a zv\u00fd\u0161ila aktivitu antidepres\u00edv. Quatrefolic Acid\u00ae<\/strong> – op\u00e4\u0165 sme pri zl\u00fa\u010denine, ktor\u00fa pou\u017e\u00edvame aj my v Intelligent Labs. Je medzin\u00e1rodne patentovan\u00e1 spolo\u010dnos\u0165ou Gnosis a je to vedecky najvyspelej\u0161ia formula 5-MTHF na trhu. Tento 5-MTHF je lep\u0161ie absorbovan\u00fd v na\u0161om organizme, preto\u017ee je viazan\u00fd na glukozam\u00edn bez obsahu m\u00e4kk\u00fd\u0161ov namiesto v\u00e1pnika. Spolo\u010dnos\u0165 Intelligent Labs m\u00e1 k dispoz\u00edcii dva doplnky s obsahom 5-MTHF v dvoch r\u00f4znych d\u00e1vkach.<\/p>\n\n\n\n
\n\n\n\nAk\u00e9 zdravotn\u00e9 benefity pre n\u00e1\u0161 organizmus m\u00e1 fol\u00e1t a 5-MTHF?<\/strong><\/h2>\n\n\n\nJe potrebn\u00fd pre z\u00e1kladn\u00e9 telesn\u00e9 funkcie<\/strong><\/h3>\n\n\n\nB9 je potrebn\u00fd najm\u00e4 pri t\u00fdchto \u010dinnostiach:<\/strong> (6)(7)(8)<\/p>\n\n\n\n- Energia zo sacharidov<\/li>
- DNA & RNA<\/li>
- \u010cerven\u00e9 a biele krvinky<\/li>
- Melaton\u00edn, chemick\u00e1 l\u00e1tka, ktor\u00e1 reguluje sp\u00e1nok<\/li>
- D\u00f4le\u017eit\u00e9 neurotransmitery ako norepinefr\u00edn, seroton\u00edn a dopam\u00edn<\/li>
- Nervov\u00fd syst\u00e9m<\/li><\/ul>\n\n\n\n
![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-04.jpg\")
<\/figure>\n\n\n\nZabra\u0148uje vzniku vroden\u00fdch ch\u00fdb plodu po\u010das tehotenstva<\/strong><\/h3>\n\n\n\nPoskytovatelia zdravotnej starostlivosti \u010dasto odpor\u00fa\u010daj\u00fa, aby si tehotn\u00e9 \u017eeny dop\u013a\u0148ali fol\u00e1t u\u017e po\u010das tehotenstva, aby sa zabr\u00e1nilo vroden\u00fdm chyb\u00e1m, ako s\u00fa poruchy neur\u00e1lnej trubice. D\u00f4vod je jednoduch\u00fd – \u00fa\u010dinok nedostatku fol\u00e1tov na v\u00fdvoj die\u0165a\u0165a bol sk\u00faman\u00fd pomerne extenz\u00edvne. (9) Na v\u00fdvoj nervov\u00e9ho syst\u00e9mu po\u010das tehotenstva je potrebn\u00fd dostatok fol\u00e1tu, ie to k\u013e\u00fa\u010dov\u00e1 f\u00e1za u\u017e od samotn\u00e9ho za\u010diatku tehotenstva. \u017deny si zvy\u010dajne neuvedomuj\u00fa, \u017ee s\u00fa tehotn\u00e9, \u010dastokr\u00e1t na to pr\u00eddu a\u017e po nieko\u013ek\u00fdch t\u00fd\u017ed\u0148och. Aj ke\u010f sa st\u00e1le sna\u017e\u00edte otehotnie\u0165, je dobr\u00e9 sa uisti\u0165, \u017ee hladina va\u0161ej kyseliny listovej v organizme m\u00e1 adekv\u00e1tne spr\u00e1vnu \u00farove\u0148. (6)<\/p>\n\n\n\n
P\u00e1ni, nie\u010do aj pre v\u00e1s!<\/strong><\/h3>\n\n\n\nMu\u017ei, ktor\u00ed sa sna\u017eia po\u010da\u0165 die\u0165a, by sa tie\u017e mali ubezpe\u010di\u0165, \u017ee netrpia nedostatkom fol\u00e1tu. \u0160t\u00fadia z roku 2013 zistila, \u017ee mu\u017ei, ktor\u00ed nemaj\u00fa po\u010das obdobia, kedy sa pok\u00fa\u0161ali splodi\u0165 die\u0165a, zdrav\u00e9 hladiny tohto vitam\u00ednu, mohli prispie\u0165 k zna\u010dn\u00e9mu zv\u00fd\u0161eniu pravdepodobnosti vzniku deform\u00e1ci\u00ed. (10) \u017den\u00e1m sa dokona odpor\u00fa\u010da, aby za\u010dali s u\u017e\u00edvan\u00edm v\u00fd\u017eivov\u00fdch doplnkov u\u017e nieko\u013eko mesiacov pred po\u010dat\u00edm, aby sa zv\u00fd\u0161ila \u0161anca na po\u010datie a donosenie zdrav\u00e9ho die\u0165a\u0165a. (11)<\/p>\n\n\n\n
Mo\u017en\u00e9 zn\u00ed\u017eenie rizika vzniku depresie a \/ alebo lep\u0161\u00ed \u00fa\u010dinok antidepres\u00edv<\/strong><\/h3>\n\n\n\nDeplin\u00ae, liekov\u00e1 forma 5-MTHF, bola patentovan\u00e1 \u0161peci\u00e1lne na lie\u010dbu depresie a zvy\u0161ovanie \u00fa\u010dinku u\u017e\u00edvania antidepres\u00edv u pacientov s depresiou. Sp\u00f4sob, ak\u00fdm 5-MTHF pom\u00e1ha pri depresi\u00e1ch, nie je zn\u00e1my, ale \u0161t\u00fadie ukazuj\u00fa, \u017ee v\u00fd\u017eivov\u00e9 doplnky s jeho obsahom m\u00f4\u017eu by\u0165 u\u017eito\u010dn\u00e9. \u0160t\u00fadie zameran\u00e9 na depresiu zvy\u010dajne pou\u017e\u00edvaj\u00fa ve\u013emi vysok\u00e9 d\u00e1vky v porovnan\u00ed s be\u017en\u00fdm pou\u017eit\u00edm u\u017e\u00edvate\u013eov. <\/p>\n\n\n\n
V \u0161t\u00fadii z roku 2013, ktor\u00e1 zah\u0155\u0148ala viac ako 500 pacientov lie\u010den\u00fdch na depresiu, automatick\u00e9 telefonick\u00e9 prieskumy nazna\u010dili lep\u0161iu priemern\u00fa kvalitu \u017eivota a vy\u0161\u0161iu spokojnos\u0165 s liekmi na depresiu u\u017e po troch mesiacoch u\u017e\u00edvania. Zlep\u0161ila sa aj spokojnos\u0165 so vz\u0165ahmi s pr\u00edbuzn\u00fdmi, priate\u013emi, spolupracovn\u00edkmi, partnermi a nezn\u00e1mymi \u013eu\u010fmi. Celkov\u00e9 rozdiely po 95 d\u0148och boli naozaj signifikantn\u00e9. Subjekty pou\u017e\u00edvali super \u00fa\u010dinn\u00fa formu predp\u00edsan\u00e9ho 5-MTHF. Ka\u017ed\u00e1 d\u00e1vka bola bu\u010f 7,5 mg alebo 15 mg. Po\u010diato\u010dn\u00e1 d\u00e1vka pre be\u017en\u00fdch pou\u017e\u00edvate\u013eov 5-MTHF bez depresie je zvy\u010dajne 1 mg alebo e\u0161te ni\u017e\u0161ia. (12) <\/p>\n\n\n\n
Jedn\u00fdm z d\u00f4vodov t\u00fdchto v\u00fdhod u pacientov s depresiou m\u00f4\u017ee by\u0165 fakt, \u017ee fol\u00e1t je nevyhnutnou s\u00fa\u010das\u0165ou v\u00fdroby hlavn\u00fdch neurotransmiterov, ako je seroton\u00edn, dopam\u00edn a norepinefr\u00edn, a m\u00f4\u017ee ich pom\u00e1ha\u0165 aj regulova\u0165. (13) 5-MTHF m\u00f4\u017ee dobre fungova\u0165 aj pri niektor\u00fdch pr\u00edznakoch bipol\u00e1rnej poruchy. \u0160es\u0165t\u00fd\u017ed\u0148ov\u00e1 \u0161t\u00fadia s 10 \u00fa\u010dastn\u00edkmi s ve\u013ekou mierou depresie a bipol\u00e1rnou poruchou preuk\u00e1zala s\u013eubn\u00e9 v\u00fdsledky: (14)<\/strong> \u201eVedci zistili, \u017ee u pacientov s bipol\u00e1rnou poruchou u\u017e\u00edvaj\u00facich L-metylfol\u00e1t sa preuk\u00e1zalo zlep\u0161enie sympt\u00f3mov depresie, be\u017en\u00e9ho fungovania, sebapozn\u00e1vania a zn\u00ed\u017eenie samovra\u017eedn\u00fdch my\u0161lienok.\u201c<\/em> UPOZORNENIE: Ak trp\u00edte depresiou, v\u017edy sa pora\u010fte so svoj\u00edm lek\u00e1rom sk\u00f4r, ako za\u010dnete pou\u017e\u00edva\u0165 ak\u00fako\u013evek formu doplnku kyseliny listovej, a to aj v n\u00edzkych d\u00e1vkach.<\/p>\n\n\n\nRedukcia homocyste\u00ednu, z\u00e1palovej l\u00e1tky<\/strong><\/h3>\n\n\n\nHomocyste\u00edn je zl\u00fa\u010denina v \u013eudskom tele, ktor\u00e1 zvy\u0161uje z\u00e1pal. Mnoho chor\u00f4b m\u00e1 p\u00f4vod pr\u00e1ve v z\u00e1pale. Vysok\u00e9 hladiny homocyste\u00ednu m\u00f4\u017eu zvy\u0161ova\u0165 riziko<\/strong>: (18)<\/p>\n\n\n\n- Krvn\u00fdch zrazen\u00edn<\/li>
- M\u0155tvice<\/li>
- Alzheimer\u2019s Alzheimerovej choroby<\/li>
- Srdcov\u00e9ho infarktu<\/li>
- Ischemickej choroby srdca<\/li>
- Osteopor\u00f3zy<\/li>
- Ateroskler\u00f3zy<\/li><\/ul>\n\n\n\n
Vysok\u00e9 hladiny tejto zl\u00fa\u010deniny s\u00favisia s n\u00edzkou hladinou vitam\u00ednov B6, B9 a B12. T\u00e1to kombin\u00e1cia je siln\u00fdm prediktorom kognit\u00edvneho poklesu u mu\u017eov a pravdepodobne aj u \u017eien. (15) Zdrav\u00e9 hladiny v\u0161etk\u00fdch troch konkr\u00e9tnych vitam\u00ednov skupiny B s\u00fa d\u00f4le\u017eit\u00e9 pre udr\u017eanie homocyste\u00ednu pod kontrolou. 5-MTHF m\u00f4\u017ee zabr\u00e1ni\u0165 ur\u010dit\u00e9mu kognit\u00edvnemu poklesu, ale je ur\u010dite vhodn\u00e9 a odpor\u00fa\u010dan\u00e9, ak si budete udr\u017eiava\u0165 adekv\u00e1tne hladiny aj \u010fal\u0161\u00edch dvoch. (15) (16) (17) Medzi \u010fal\u0161ie pr\u00ed\u010diny vysokej hladiny homocyste\u00ednu patria: probl\u00e9my s hypotyre\u00f3zou, choroby obli\u010diek a psori\u00e1za. <\/p>\n\n\n\n
Neobvi\u0148ujte automaticky za tieto diagn\u00f3zy nedostatok vitam\u00ednu B. (18) Ako ste u\u017e \u010d\u00edtali vy\u0161\u0161ie, z\u00e1kony v desiatkach kraj\u00edn zn\u00ed\u017eili obsah homocyste\u00ednu nariaden\u00edm, aby boli m\u00faky obohaten\u00e9 kyselinou listovou. 24-t\u00fd\u017ed\u0148ov\u00e1 randomizovan\u00e1 placebo \u0161t\u00fadia preuk\u00e1zala, \u017ee 5-MTHF je pri zni\u017eovan\u00ed hlad\u00edn homocyste\u00ednu u zdrav\u00fdch \u013eud\u00ed ove\u013ea efekt\u00edvnej\u0161\u00ed ako kyselina listov\u00e1. (19)<\/p>\n\n\n\n
Mo\u017en\u00e9 zn\u00ed\u017eenie rizika m\u0155tvice a srdcov\u00e9ho infarktu<\/strong><\/h3>\n\n\n\n5-MTHF by mohol zlep\u0161i\u0165 zdravie srdca a krvn\u00e9ho obehu zn\u00ed\u017een\u00edm hladiny homocyste\u00ednu a \u010fal\u0161\u00edmi mechanizmami. Je to v\u0161ak komplikovan\u00e9. Riziko srdcov\u00e9ho infarktu alebo cievnej mozgovej pr\u00edhody by sa mohlo zn\u00ed\u017ei\u0165 iba vtedy, ak m\u00e1te nedostatok fol\u00e1tu. <\/p>\n\n\n\n![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-06-1024x512.jpg\")
<\/figure>\n\n\n\nPrin\u00e1\u0161ame zhrnutie k\u013e\u00fa\u010dov\u00fdch faktov, ktor\u00e9 s\u00fa zauj\u00edmav\u00e9 minim\u00e1lne tak, ako dobr\u00e1 detekt\u00edvka … \u0160t\u00fadia z roku 2015 zistila, \u017ee mu\u017ei, ktor\u00ed si dop\u013a\u0148ali kyselinu listov\u00fa a u\u017e\u00edvali enalapril, liek zni\u017euj\u00faci krvn\u00fd tlak, mali zn\u00ed\u017een\u00e9 riziko mozgovej pr\u00edhody po\u010das nasleduj\u00facich 4,5 rokov. V\u00fdsledky boli v\u00fdznamn\u00e9 pre skupinu s u\u017e\u00edvan\u00edm kyseliny listovej a enalaprilu v porovnan\u00ed so skupinou, ktor\u00e1 u\u017e\u00edvala iba enalapril. Zd\u00e1 sa, \u017ee aj star\u00e9 \u0161t\u00fadie zo 70. rokov ukazuj\u00fa zn\u00ed\u017een\u00e9 riziko m\u0155tvice a srdcov\u00e9ho infarktu v d\u00f4sledku zv\u00fd\u0161en\u00e9ho u\u017e\u00edvania fol\u00e1tov. (20) <\/p>\n\n\n\n
Na druhej strane niektor\u00e9 \u0161t\u00fadie z USA, zalo\u017een\u00e9 na placebe, nepreuk\u00e1zali zn\u00ed\u017eenie rizika m\u0155tvice alebo srdcov\u00e9ho infarktu. To by mohlo znamena\u0165, \u017ee fol\u00e1t vykazuje tento efekt\u00edvny \u00fa\u010dinok iba vtedy, ke\u010f ho maj\u00fa pacienti nedostatok. <\/p>\n\n\n\n
Pripome\u0148me, \u017ee USA za\u010dali posil\u0148ova\u0165 jeho obsah v obilnin\u00e1ch v roku 1998, \u010do by mohlo vysvetli\u0165 niektor\u00e9 v\u00fdsledky zo 70. rokov. \u013dudia mali vtedy jednoducho ni\u017e\u0161iu hladinu fol\u00e1tov. (20) \u010c\u00edna neposil\u0148uje obilniny obsahom fol\u00e1tov, \u010do znamen\u00e1, \u017ee aj ich popul\u00e1cia m\u00f4\u017ee trpie\u0165 jeho nedostatkom. Niektor\u00e9 zo star\u00fdch americk\u00fdch \u0161t\u00fadi\u00ed sledovali \u013eud\u00ed, ktor\u00ed mali v minulosti mozgov\u00fa pr\u00edhodu a infarkt. Ako reakciu na tieto udalosti mohli t\u00edto pacienti zn\u00ed\u017ei\u0165 riziko u\u017e\u00edvan\u00edm in\u00fdch liekov a potrav\u00edn, ako bola napr\u00edklad aj kyselina listov\u00e1. (20)<\/p>\n\n\n\n
\n\n\n\nAko zisti\u0165, \u010di trp\u00edte nedostatkom kyseliny listovej?<\/strong><\/h2>\n\n\n\nNiektor\u00e9 pr\u00edznaky signalizuj\u00fa, \u017ee nedostatok fol\u00e1tu sp\u00f4sobuje an\u00e9miu (nedostatok \u010derven\u00fdch krviniek) Chronick\u00e9 spomalenie organizmu a \u00fanava: <\/strong>(21)<\/p>\n\n\n\n- Neschopnos\u0165 sa poriadne nad\u00fdchnu\u0165<\/li>
- V\u00fdbu\u0161nos\u0165, mrzutos\u0165 a podr\u00e1\u017edenos\u0165<\/li>
- Poko\u017eka vyzer\u00e1 mimoriadne bledo<\/li>
- \u010eal\u0161ie pr\u00edznaky nedostatku kysl\u00edka v krvi, napr\u00edklad probl\u00e9my s pam\u00e4\u0165ou<\/li><\/ul>\n\n\n\n
\u010eal\u0161ie pr\u00edznaky nedostatku fol\u00e1tu<\/strong>: (22)<\/p>\n\n\n\n- Pred\u010dasn\u00e9 \u0161edivenie vlasov<\/li>
- Opuchnut\u00fd jazyk<\/li>
- Rany alebo vredy v \u00fastach<\/li>
- Die\u0165a m\u00e1 vroden\u00e9 chyby a deform\u00e1cie a vy ste jedn\u00fdm z rodi\u010dov<\/li>
- Hna\u010dka<\/li>
- Probl\u00e9my s rastom<\/li><\/ul>\n\n\n\n
Samodiagnostika nedostatku fol\u00e1tu je zlo\u017eit\u00e1. Je to \u010diasto\u010dne preto, \u017ee pr\u00edznaky nedostatku fol\u00e1tu a in\u00fdch vitam\u00ednov skupiny B sa navz\u00e1jom prekr\u00fdvaj\u00fa. V\u00e1\u0161 lek\u00e1r pravdepodobne vykon\u00e1 testy na vyl\u00fa\u010denie pr\u00ed\u010din a in\u00fdch pr\u00edznakov.<\/p>\n\n\n\n
\n\n\n\n\u010co sp\u00f4sobuje nedostatok fol\u00e1tu a kyseliny listovej?<\/strong><\/h2>\n\n\n\nStrava bez potrav\u00edn, ktor\u00e9 maj\u00fa vysok\u00fd obsah fol\u00e1tov<\/strong><\/h3>\n\n\n\nAk nejed\u00e1vate dostatok fazule, vajec, zelenej zeleniny a in\u00fdch potrav\u00edn alebo v\u00fd\u017eivov\u00fdch doplnkov bohat\u00fdch na fol\u00e1ty, pravdepodobne budete ma\u0165 nedostatok fol\u00e1tu v tele.<\/p>\n\n\n\n![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-07.jpg\")
<\/figure>\n\n\n\n\u010co br\u00e1ni vstreb\u00e1vaniu fol\u00e1tov zo stravy a v\u00fd\u017eivov\u00fdch doplnkov<\/strong><\/h3>\n\n\n\nZl\u00e9 vstreb\u00e1vanie kyseliny listovej a fol\u00e1tov zo stravy m\u00f4\u017ee sp\u00f4sobi\u0165 ve\u013ea faktorov, vr\u00e1tane: <\/strong>(21)<\/p>\n\n\n\n- Ochorenie ako Crohnova choroba, celiakia, niektor\u00e9 druhy rakoviny a poruchy obli\u010diek<\/li>
- Poruchy g\u00e9nu MTHFR, ktor\u00e9 s\u00fa be\u017en\u00e9<\/li>
- Interakcie s liekmi, ktor\u00e9 interferuj\u00fa s fol\u00e1tom<\/li>
- Nadmern\u00e9 u\u017e\u00edvanie alkoholu alebo antac\u00edd<\/li>
- Mut\u00e1cia g\u00e9nov zodpovedn\u00fdch za metaboliz\u00e1ciu fol\u00e1tu<\/li><\/ul>\n\n\n\n
Kyselina listov\u00e1 a pr\u00edrodn\u00fd fol\u00e1t v potravin\u00e1ch musia prejs\u0165 mnoh\u00fdmi chemick\u00fdmi reakciami, k\u00fdm sa z nich stane 5-MTHF, jedin\u00e1 u\u017eito\u010dn\u00e1 forma. V\u00e4\u010d\u0161ina z n\u00e1s metabolizuje fol\u00e1t a kyselinu listov\u00fa a efekt\u00edvne ich transformuje na 5-MTHF. Existuje g\u00e9n, ktor\u00fd riadi tento proces. Vol\u00e1 sa MTHFR a ka\u017ed\u00fd m\u00e1me jeho dve k\u00f3pie. Mnoh\u00ed z n\u00e1s v\u0161ak maj\u00fa vari\u00e1cie jednej alebo oboch t\u00fdchto g\u00e9nov\u00fdch k\u00f3pi\u00ed, ktor\u00e9 neumo\u017e\u0148uj\u00fa transform\u00e1cie na 5-MTHF. Ak je jedna k\u00f3pia g\u00e9nu nedostato\u010dn\u00e1 pre absorpciu fol\u00e1tu, \u00fa\u010dinnos\u0165 spracovania m\u00f4\u017ee by\u0165 ve\u013emi ovplyvnen\u00e1. Ak s\u00fa obe k\u00f3pie zl\u00e9, nebudete metabolizova\u0165 takmer \u017eiadne mno\u017estvo fol\u00e1tu alebo kyseliny listovej. (23) <\/p>\n\n\n\n
Ako zist\u00edte, \u017ee m\u00e1te jednu alebo dve zl\u00e9 mut\u00e1cie g\u00e9nu MTHFR? Budete musie\u0165 podst\u00fapi\u0165 test DNA a necha\u0165 ho posla\u0165 do medic\u00ednskeho laborat\u00f3ria. Laborat\u00f3ri\u00e1 na tento \u00fa\u010del n\u00e1jdete vo va\u0161om okol\u00ed aj online. Najsk\u00f4r si d\u00f4kladne pre\u0161tudujte, \u010do laborat\u00f3rium pon\u00faka alebo nechajte lek\u00e1ra vybra\u0165 laborat\u00f3rium za v\u00e1s. S\u00favislos\u0165 medzi obezitou a nedostato\u010dnou hladinou fol\u00e1tov je ve\u013emi siln\u00e1, ale zd\u00e1 sa, \u017ee nikto nepri\u0161iel na to, pre\u010do. <\/p>\n\n\n\n
Obezita<\/strong><\/p>\n\n\n\nV preh\u013eade \u0161t\u00fadi\u00ed publikovan\u00fdch v rokoch 2005 a\u017e 2015 sa sk\u00famali hladiny fol\u00e1tov u ob\u00e9znych \u017eien v \u201eplodnom veku\u201c so zvl\u00e1\u0161tnym d\u00f4razom na tehotn\u00e9 \u017eeny. Cie\u013eom vedcov bolo presk\u00fama\u0165 mo\u017en\u00e9 pr\u00ed\u010diny vysok\u00e9ho percenta deficitu fol\u00e1tu u t\u00fdchto \u017eien. Spomenuli by sme britsk\u00fa \u0161t\u00fadiu, ktor\u00e1 vyl\u00fa\u010dila faktory ako vitam\u00ednov\u00e9 doplnky, strava a vek. Pouk\u00e1zali by sme tie\u017e na nieko\u013eko \u010fal\u0161\u00edch \u0161t\u00fadi\u00ed, ktor\u00e9 vyl\u00fa\u010dili stravu ako pr\u00ed\u010dinu. Jedin\u00e9, \u010do bolo mo\u017en\u00e9 urobi\u0165, bolo odporu\u010di\u0165 viac \u0161t\u00fadi\u00ed o tejto skuto\u010dnosti plus tipy, ako v nich pokra\u010dova\u0165. (24) Dedukujeme: Samotn\u00e1 obezita alebo konkr\u00e9tne pr\u00ed\u010diny obezity by mohli zn\u00ed\u017ei\u0165 hladinu kyseliny listovej na nezdrav\u00fa \u00farove\u0148. Korel\u00e1cia je siln\u00e1 a v\u0161etky ot\u00e1zky sa t\u00fdkaj\u00fa toho, \u010do k \u010domu vedie. <\/p>\n\n\n\n
\u010eal\u0161ia \u0161t\u00fadia zaznamenala siln\u00fa korel\u00e1ciu medzi obezitou a nedostatkom fol\u00e1tov: V roku 2016 vedci presk\u00famali \u0161t\u00fadie so z\u00e1merom aktualizova\u0165 pokyny Americkej spolo\u010dnosti pre metabolick\u00fa a bariatrick\u00fa chirurgiu z roku 2008 t\u00fdkaj\u00face sa v\u00fd\u017eivy v bariatrickej chirurgii. Pokyny s\u00fa zalo\u017een\u00e9 na \u0161t\u00fadi\u00e1ch sk\u00famaj\u00facich hladinu \u017eiv\u00edn pred a po chirurgick\u00fdch z\u00e1krokoch na zn\u00ed\u017eenie hmotnosti. Nov\u00e9 odpor\u00fa\u010dania z roku 2016 odpor\u00fa\u010daj\u00fa skr\u00edning na nedostatok fol\u00e1tov pred t\u00fdmto typom oper\u00e1cie. D\u00f4vodom je fakt, \u017ee a\u017e 54% ob\u00e9znych pacientov m\u00e1 nedostatok fol\u00e1tov. (25) Vedci nemali v \u00famysle v tomto pr\u00edpade sk\u00fama\u0165 pr\u00ed\u010dinu a n\u00e1sledok. V\u0161\u00edmali si len s\u00favislos\u0165 a reagovali na \u0148u odpor\u00fa\u010dan\u00edm monitorovania a dopl\u0148ovania fol\u00e1tov pred chirurgick\u00fdm z\u00e1krokom.<\/p>\n\n\n\n
\n\n\n\nSp\u00f4sob, ako vyrie\u0161i\u0165 tento probl\u00e9m s g\u00e9nov\u00fdmi vari\u00e1ciami, je pou\u017ei\u0165 doplnok 5-MTHF, ktor\u00fd pre spr\u00e1vne pou\u017eitie v tele, nevy\u017eaduje s\u00e9riu chemick\u00fdch reakci\u00ed. In\u00fdmi slovami, 5-MTHF je u\u017e bioakt\u00edvny.<\/p>\n\n\n\n
<\/h3>\n\n\n\nNi\u010d\u00ed tepeln\u00e1 \u00faprava potrav\u00edn bohat\u00fdch na fol\u00e1ty, fol\u00e1ty samot<\/strong>n\u00e9<\/strong>?<\/strong><\/h2>\n\n\n\n![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-08.jpg\")
<\/figure>\n\n\n\nTo, \u010di varenie zn\u00ed\u017ei obsah fol\u00e1tov v potravin\u00e1ch, z\u00e1vis\u00ed od jedla, sp\u00f4sobu varenia a \u010dasu varenia. Be\u017en\u00e9 \u010dasy varu m\u00f4\u017eu zredukova\u0165 zhruba polovicu kyseliny listovej v \u0161pen\u00e1te a brokolici, ale varen\u00edm v pare sa obsah kyseliny listovej v\u00f4bec nezn\u00ed\u017ei. Zd\u00e1 sa, \u017ee ani varenie zemiakov a grilovanie m\u00e4sa nezni\u017euje hladinu fol\u00e1tu, aj ke\u010f ich var\u00edte dlh\u0161ie ako zvy\u010dajne. (26) Varen\u00edm cibule sa zn\u00ed\u017ei obsah kyseliny listovej o 35%, zatia\u013e \u010do pri pe\u010den\u00ed sa z nej eliminuje iba 15%. Ukazuje sa tie\u017e, \u017ee varen\u00fd hr\u00e1\u0161ok si zachov\u00e1va najviac fol\u00e1tu v porovnan\u00ed s in\u00fdmi met\u00f3dami varenia. Ak var\u00edte fazu\u013eu dve hodiny a potom ju bu\u010f upe\u010diete alebo vypra\u017e\u00edte, strat\u00ed a\u017e 50% obsahu. Jedna \u0161t\u00fadia odpor\u00fa\u010da namo\u010di\u0165 ju do slanej vody a potom ju prevari\u0165 v \u010derstvej vode, aby sa zachovalo \u010do najviac v\u00fd\u017eivn\u00fdch l\u00e1tok. (27)<\/p>\n\n\n\n
\n\n\n\nPotrebuj\u00fa tehotn\u00e9 \u017eeny alebo \u017eeny sna\u017eiace sa otehotnie\u0165 extra pr\u00edjem kyseliny listovej? <\/strong><\/h2>\n\n\n\nV lek\u00e1rskej komunite v\u0161eobecne prevl\u00e1da n\u00e1zor,, \u017ee udr\u017eiava\u0165 hladinu fol\u00e1tu na rovnakej \u00farovni je dobr\u00fd n\u00e1pad. S najv\u00e4\u010d\u0161ou pravdepodobnos\u0165ou tak predch\u00e1dzate niektor\u00fdm typom vroden\u00fdch ch\u00fdb a siln\u00e1 korel\u00e1cia to len potvrdzuje. Ako u\u017e bolo uveden\u00e9 vy\u0161\u0161ie, v tele potrebujete ve\u013ea bioakt\u00edvneho fol\u00e1tu od chv\u00edle, ke\u010f otehotniete, aby ste zaistili spr\u00e1vny v\u00fdvoj nervov\u00e9ho syst\u00e9mu die\u0165a\u0165a. To by mohlo znamena\u0165, \u017ee tento proces je vhodn\u00e9 za\u010da\u0165 u\u017e od momentu, kedy sa st\u00e1le sna\u017e\u00edte otehotnie\u0165. Suplement\u00e1cia 5-MTHF je najistej\u0161\u00ed sp\u00f4sob, ako zisti\u0165, \u017ee va\u0161e telo skuto\u010dne absorbuje dostatok fol\u00e1tu. Ak ste tehotn\u00e1, pora\u010fte sa so svoj\u00edm lek\u00e1rom. Neu\u017e\u00edvajte v\u00fd\u017eivov\u00e9 doplnky bez pokynov lek\u00e1ra, ktor\u00e9 prisp\u00f4sob\u00ed na mieru va\u0161im jedine\u010dn\u00fdm okolnostiam a na z\u00e1klade d\u00f4kladn\u00e9ho laborat\u00f3rneho testovania.<\/p>\n\n\n\n
\n\n\n\nJe mo\u017en\u00e9 ma\u0165 v tele nadbytok kyseliny listovej?<\/strong><\/h2>\n\n\n\nV lek\u00e1rskej vede ide o kontroverzn\u00fa t\u00e9mu. Niektor\u00ed vedci tvrdia, \u017ee vo va\u0161om tele m\u00f4\u017ee kolova\u0165 a\u017e pr\u00edli\u0161 ve\u013ea kyseliny listovej, \u010do m\u00f4\u017ee sp\u00f4sobi\u0165 zdravotn\u00e9 probl\u00e9my. (28) Kv\u00f4li kontroverzii a potrebe \u010fal\u0161\u00edch \u0161t\u00fadi\u00ed m\u00f4\u017eete n\u00e1js\u0165 r\u00f4zne vl\u00e1dne zdravotn\u00edcke agent\u00fary, ktor\u00e9 sa odmietaj\u00fa v t\u00fdchto diskusi\u00e1ch postavi\u0165 na kohoko\u013evek stranu a odpor\u00fa\u010daj\u00fa spotrebite\u013eom, aby rad\u0161ej ni\u010d neu\u017e\u00edvali.. Ni\u010d z toho sa v\u0161ak pravdepodobne net\u00fdka 5-MTHF alebo fol\u00e1tu zo stravy, ktor\u00fd sa prirodzene vytv\u00e1ra v potravin\u00e1ch. \u010co m\u00f4\u017ee sp\u00f4sobi\u0165 pr\u00edli\u0161 ve\u013ea kyseliny listovej?<\/p>\n\n\n\n
Mo\u017enos\u0165 maskovania pr\u00edznakov nedostatku vitam\u00ednu B12<\/strong><\/h3>\n\n\n\nPr\u00edli\u0161 ve\u013ea kyseliny listovej vo va\u0161om tele m\u00f4\u017ee zamaskova\u0165 pr\u00edznaky megaloblastickej an\u00e9mie sp\u00f4sobenej nedostatkom vitam\u00ednu B12. Nejde o konsenzus. Pre vedcov je to st\u00e1le z\u00e1hada. Ak je to pravda, potom si lek\u00e1r m\u00f4\u017ee \u013eahko zm\u00fdli\u0165 stanoven\u00fa diagn\u00f3zu. To m\u00f4\u017ee zhor\u0161i\u0165 ak\u00e9ko\u013evek probl\u00e9my spojen\u00e9 s krvou a po\u0161kodi\u0165 v\u00e1\u0161 mozog a nervov\u00fd syst\u00e9m. Po\u0161kodenie mozgu m\u00f4\u017ee sp\u00f4sobi\u0165 r\u00fdchly kognit\u00edvny pokles a zm\u00e4tok v tele. (29) Existuje zhoda v tom, \u017ee tento probl\u00e9m sa net\u00fdka 5-MTHF, na ktor\u00fd sa menia ostatn\u00e9 formy, ke\u010f s\u00fa spr\u00e1vne metabolizovan\u00e9. <\/p>\n\n\n\n
Konzum\u00e1cia pr\u00edli\u0161 ve\u013ea fazule, pomaran\u010dov alebo zelenej zeleniny s vysok\u00fdm obsahom kyseliny listovej tie\u017e nie je probl\u00e9mom, o ktor\u00fd sa zdravotn\u00edci zrejme ob\u00e1vaj\u00fa. (39) Nedostatok vitam\u00ednu B12 sa pova\u017euje za v\u00e4\u010d\u0161\u00ed probl\u00e9m pre vegetari\u00e1nov a star\u0161\u00edch dospel\u00fdch ako pre v\u00e4\u010d\u0161inu ostatn\u00fdch. Vegetari\u00e1nska strava nedod\u00e1va dostatok tohto vitam\u00ednu a star\u0161\u00ed dospel\u00ed ho dokonca \u0165a\u017eko absorbuj\u00fa. Obe skupiny m\u00f4\u017eu dop\u013a\u0148a\u0165 vitam\u00edn B12 sublingv\u00e1lne (pod jazyk). <\/p>\n\n\n\n
<\/h3>\n\n\n\n![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/was-ist-5-mthf-der-ultimative-guide-zu-folat-und-methylfolat-11.jpg\")
<\/figure>\n\n\n\nPoruchy sp\u00e1nku a zv\u00fd\u0161en\u00e1 n\u00e1ladovos\u0165<\/strong><\/h3>\n\n\n\nPr\u00edli\u0161 ve\u013ea kyseliny listovej, najm\u00e4 ak sa u\u017e\u00edva v doplnkoch v\u00fd\u017eivy, m\u00f4\u017ee sp\u00f4sobi\u0165 probl\u00e9my so sp\u00e1nkom a podr\u00e1\u017edenos\u0165. (30)<\/p>\n\n\n\n
Nevo\u013enos\u0165 a strata chuti do jedla<\/strong><\/h3>\n\n\n\nNiektor\u00ed \u013eudia m\u00f4\u017eu strati\u0165 chu\u0165 do jedla alebo ochorie\u0165, najm\u00e4 ak prij\u00edmaj\u00fa pr\u00edli\u0161 ve\u013ea kyseliny listovej z v\u00fd\u017eivov\u00fdch doplnkov alebo multivitam\u00ednov. (30)<\/p>\n\n\n\n
Rie\u0161enie<\/strong><\/h3>\n\n\n\nAk u\u017e\u00edvate v\u00fd\u017eivov\u00fd doplnok s obsahom fol\u00e1tu, uistite sa, \u017ee je v bioakt\u00edvnej forme: 5-MTHF. Pre\u010d\u00edtajte si etikety na va\u0161ich multivitam\u00ednoch. Obsahuj\u00fa pr\u00edli\u0161 ve\u013ea kyseliny listovej? V\u00e4\u010d\u0161ina dospel\u00fdch by mala prij\u00edma\u0165 asi 0,5 mg kyseliny listovej denne. Pre\u010d\u00edtajte si etikety aj na chlebe a obilnin\u00e1ch. Ak u\u017e\u00edvate doplnok 5-MTHF, potom sa sna\u017ete udr\u017eiava\u0165 kyselinu listov\u00fa v obohaten\u00fdch potravin\u00e1ch na minime a vyh\u00fdbajte sa multivitam\u00ednom obsahuj\u00facim kyselinu listov\u00fa. M\u00f4\u017ee, ale nemus\u00ed to by\u0165 probl\u00e9m, ktor\u00fd interferuje s 5-MTHF. <\/p>\n\n\n\n
\u00darad pre doplnky v\u00fd\u017eivy N\u00e1rodn\u00e9ho \u00fastavu zdravotn\u00edctva USA stanovil odpor\u00fa\u010dan\u00fa denn\u00fa horn\u00fa hranicu 1 mg pre kyselinu listov\u00fa, ktor\u00e1 poch\u00e1dza z obohaten\u00fdch obiln\u00edn a doplnkov. Nestanovili v\u0161ak limit pre fol\u00e1ty poch\u00e1dzaj\u00face zo zeleniny alebo z 5-MTHF. (29) Pod\u013ea Harvardsk\u00e9ho zdravotn\u00e9ho in\u0161tit\u00fatu sa kyselina listov\u00e1 z obiln\u00edn m\u00f4\u017ee v tele r\u00fdchlo hromadi\u0165 (31). Pozrite si \u00fadaje ni\u017e\u0161ie. Be\u017en\u00e9 potraviny obohaten\u00e9 o kyselinu listov\u00fa:<\/strong><\/p>\n\n\n\n- Miska \u0161peci\u00e1lnych K cere\u00e1li\u00ed: 0,394 mg<\/li>
- Porcia pracl\u00edkov: 0.172mg<\/li>
- 1 porcia varen\u00fdch \u0161pagiet: 0.166mg<\/li>
- 1 multivitam\u00edn: 0.4mg<\/li><\/ul>\n\n\n\n
Celkom<\/strong> = 1,132mg. Nie je \u0165a\u017ek\u00e9 prekona\u0165 t\u00fato horn\u00fa hranicu za jeden de\u0148, tak\u017ee si d\u00e1vajte pozor na konzum\u00e1ciu obiln\u00edn a vitam\u00ednov, najm\u00e4 ak hor\u0161ie metabolizujete kyselinu listov\u00fa. Tie\u017e sa presved\u010dte, \u017ee m\u00e1te dostatok vitam\u00ednu B12 a \u017ee ho va\u0161e telo naozaj aj zu\u017eitkuje. <\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-10.jpg\")
<\/figure>\n\n\n\nExistuj\u00fa v\u00fdhody u\u017e\u00edvania 5-MTHF v porovnan\u00ed s in\u00fdmi formami fol\u00e1tu?<\/strong><\/h2>\n\n\n\n5-MTHF pr svoju \u00fa\u010dinnos\u0165 nevy\u017eaduje, aby v tele prebiehali chemick\u00e9 reakcie<\/strong><\/h3>\n\n\n\nKyselina listov\u00e1, ktor\u00e1 je syntetick\u00e1, vy\u017eaduje viac chemick\u00fdch reakci\u00ed, k\u00fdm sa z nej stane bioakt\u00edvny 5-MTHF. Fol\u00e1t v strave, ktor\u00fd sa prirodzene vytv\u00e1ra v potravin\u00e1ch, tie\u017e vy\u017eaduje chemick\u00e9 reakcie predt\u00fdm, ako sa z neho stane 5-MTHF, ale menej ako kyselina listov\u00e1. In\u00fdmi slovami, po u\u017eit\u00ed 5-MTHF vo v\u00fd\u017eivovom doplnku m\u00e1 va\u0161e telo menej pr\u00e1ce. Nie s\u00fa potrebn\u00e9 \u017eiadne dodato\u010dn\u00e9 chemick\u00e9 reakcie.<\/p>\n\n\n\n
Interakcie s men\u0161\u00edm po\u010dtom liekov ako pri kyseline listovej<\/strong><\/h3>\n\n\n\nAby sa 5-MTHF stal bioakt\u00edvnym, nie je potrebn\u00e1 metabolick\u00e1 premena, je menej pravdepodobn\u00e9, \u017ee bude reagova\u0165 s liekmi a zn\u00ed\u017ei ich \u00fa\u010dinnos\u0165. (33) Psychiatri ho miluj\u00fa, preto\u017ee t\u00e1to forma fol\u00e1tu m\u00f4\u017ee prech\u00e1dza\u0165 priamo cez hematoencefalick\u00fa bari\u00e9ru a priamo do mozgu. Krvno-mozgov\u00e1 bari\u00e9ra zabra\u0148uje mnoh\u00fdm l\u00e1tkam prenikn\u00fa\u0165 do mozgu cez obehov\u00fd syst\u00e9m. 5-MTHF m\u00f4\u017ee prenika\u0165 priamo do nervov\u00e9ho syst\u00e9mu. (32) Je to zvy\u010dajne vinou metabolizmu, ktor\u00fd sp\u00f4sobuje, \u017ee kyselina listov\u00e1 interferuje s liekmi.<\/p>\n\n\n\n
Nezakr\u00fdva pr\u00edznaky nedostatku vitam\u00ednu B12<\/strong><\/h3>\n\n\n\nAj ke\u010f fol\u00e1t m\u00f4\u017ee zakr\u00fdva\u0165 po\u0161kodenie nervov\u00e9ho syst\u00e9mu sp\u00f4soben\u00e9 krvn\u00fdmi poruchami s\u00favisiacimi s nedostatkom B12, je dok\u00e1zan\u00e9, \u017ee 5-MTHF tento probl\u00e9m nesp\u00f4sobuje. (34)<\/p>\n\n\n\n
\n\n\n\nAk\u00e1 by mala by\u0165 prv\u00e1 d\u00e1vka tohto doplnku?<\/strong><\/h2>\n\n\n\nV\u00e4\u010d\u0161ina u\u017e\u00edvate\u013eov za\u010d\u00edna s 1 mg alebo e\u0161te menej 5-MTHF denne pri be\u017enom pou\u017e\u00edvan\u00ed. Niektor\u00e9 situ\u00e1cie m\u00f4\u017eu vy\u017eadova\u0165 5 mg alebo viac a v\u00e1\u0161 lek\u00e1r v\u00e1m v tomto pr\u00edpade dok\u00e1\u017ee poradi\u0165 asi najlep\u0161ie, ke\u010f\u017ee pozn\u00e1 v\u00e1\u0161 zdravotn\u00fd stav. Pam\u00e4tajte, \u017ee viac nemus\u00ed by\u0165 nevyhnutne lep\u0161ie, najm\u00e4 pokia\u013e ide o u\u017e\u00edvanie akejko\u013evek formy fol\u00e1tu.<\/p>\n\n\n\n
\n\n\n\nKto by NEMAL U\u017d\u00cdVA\u0164 5-MTHF?<\/strong><\/h2>\n\n\n\nAk ste alergick\u00fd na 5-MTHF, nemali by ste ho samozrejme \u010falej u\u017e\u00edva\u0165. Ak sa v\u00e1m objav\u00ed \u017eih\u013eavka, zvieranie na hrudn\u00edku alebo d\u00fdchavi\u010dnos\u0165, pova\u017eujte to za n\u00fadzov\u00e9 situ\u00e1cie a pohotovostn\u00e9 reakcie v\u00e1\u0161ho organizmu . Pred doplnen\u00edm 5-MTHF sa pora\u010fte so svoj\u00edm lek\u00e1rom, najm\u00e4 ak:<\/strong> (35)<\/p>\n\n\n\n- ste alergick\u00fd na kyselinu listov\u00fa obsiahnut\u00fa v obilnin\u00e1ch alebo multivitam\u00ednoch<\/li>
- v minulosti v\u00e1m bol diagnostikovan\u00fd nedostatok vitam\u00ednu B12<\/li>
- m\u00e1te bipol\u00e1rnu poruchu<\/li>
- ste tehotn\u00e1 alebo doj\u010d\u00edte alebo sa sna\u017e\u00edte otehotnie\u0165 (kv\u00f4li ur\u010deniu spr\u00e1vneho d\u00e1vkovania, ktor\u00e9 sa m\u00f4\u017ee l\u00ed\u0161i\u0165 od pr\u00edpadu k pr\u00edpadu)<\/li><\/ul>\n\n\n\n
\n\n\n\nBude 5-MTHF reagova\u0165 na lieky, ktor\u00e9 u\u017e\u00edvam?<\/strong><\/h2>\n\n\n\nPri 5-MTHF je menej pravdepodobn\u00e9, \u017ee bude interagova\u0165 s liekmi v porovnan\u00ed s kyselinou listovou (33), ale ur\u010dite neberte toto tvrdenie ako z\u00e1v\u00e4zn\u00fa inform\u00e1ciu. Ur\u010dite by ste sa mali porozpr\u00e1va\u0165 aj so svoj\u00edm lek\u00e1rom. Kyselina listov\u00e1 m\u00f4\u017ee zn\u00ed\u017ei\u0165 \u00fa\u010dinnos\u0165 v\u00e4\u010d\u0161iny liekov na z\u00e1chvaty, ako aj \u00fa\u010dinky pyrimetam\u00ednu (Daraprim), ktor\u00fdm sa lie\u010dia parazitick\u00e9 infekcie. Metotrex\u00e1t je liek, ktor\u00fd zni\u017euje aktivitu fol\u00e1tu v bunk\u00e1ch. (36) (37) Na druhej strane \u0161t\u00fadia interakci\u00ed kyseliny listovej s lamotrig\u00ednom odporu\u010dila suplement\u00e1ciu 5-MTHF ako alternat\u00edvny sp\u00f4sob prij\u00edmania kyseliny listovej pre pou\u017e\u00edvate\u013eov tohto lie\u010diva. Lie\u010divo sa pou\u017e\u00edva na prevenciu z\u00e1chvatov, vedcov v\u0161ak zauj\u00edmali najm\u00e4 poruchy n\u00e1lady, ako je bipol\u00e1rna depresia. Poznamenali, \u017ee 5-MTHF nemus\u00ed prech\u00e1dza\u0165 chemick\u00fdmi reakciami sk\u00f4r, ako ich mozog a in\u00e9 syst\u00e9my tela m\u00f4\u017eu re\u00e1lne pou\u017ei\u0165, tak\u017ee je menej pravdepodobn\u00e9, \u017ee bud\u00fa interferova\u0165 s lamotrig\u00ednom. (38)<\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-11.jpg\")
<\/figure>\n\n\n\nAko a kde m\u00e1m skladova\u0165 svoje v\u00fd\u017eivov\u00e9 doplnky s obsahom 5-MTHF?<\/strong><\/h2>\n\n\n\nJedna renomovan\u00e1 klinika v Clevelande odpor\u00fa\u010da na svojej webovej str\u00e1nke nasledovn\u00e9: \u201eSkladujte pri izbovej teplote od 15 do 30 stup\u0148ov C. Chr\u00e1\u0148te pred svetlom. Tento doplnok v\u00fd\u017eivy sa r\u00fdchlo rozklad\u00e1 a deaktivuje pri p\u00f4soben\u00ed tepla alebo svetla. Nepou\u017eit\u00fd liek po d\u00e1tume exspir\u00e1cie vyho\u010fte.\u201c (37) My v Intelligent Labs pou\u017e\u00edvame neprieh\u013eadn\u00e9 \u010dierne balenie, aby sme ochr\u00e1nili produkt pred p\u00f4soben\u00edm svetla. Skladujte v\u00fd\u017eivov\u00e9 doplnky tak, aby k nim nemali pr\u00edstup mal\u00e9 deti. 5-MTHF je relat\u00edvne bezpe\u010dn\u00fd a pred\u00e1vkovanie nie je smrte\u013en\u00e9. Be\u017enou praxou by pre ka\u017ed\u00e9ho z n\u00e1s malo by\u0165 heslo\u201elep\u0161ie sa spr\u00e1va\u0165 bezpe\u010dne ako nesk\u00f4r \u013eutova\u0165\u201c.<\/p>\n\n\n\n
\n\n\n\nO sprievodcovi<\/strong><\/h2>\n\n\n\nD\u00fafame, \u017ee tento \u010dl\u00e1nok je pre v\u00e1s u\u017eito\u010dn\u00fd. Z d\u00f4vodu neust\u00e1le sa vyv\u00edjaj\u00facej lek\u00e1rskej vedy nepredpokladajte, \u017ee sme v\u00e1m poskytli \u00faplne v\u0161etky inform\u00e1cie, ktor\u00e9 potrebujete vedie\u0165. Ak ste sa do\u010d\u00edtali a\u017e sem, vedzte, \u017ee aj vedci samotn\u00ed diskutuj\u00fa o niektor\u00fdch oblastiach spomenut\u00fdch v tomto \u010dl\u00e1nku. Pam\u00e4tajte tie\u017e, \u017ee tieto inform\u00e1cie nenahr\u00e1dzaj\u00fa rady v\u00e1\u0161ho lek\u00e1ra. Nem\u00f4\u017eeme tvrdi\u0165, \u017ee 5-MTHF je liekom alebo lie\u010dbou na ak\u00fako\u013evek chorobu. Tie\u017e nem\u00f4\u017eeme tvrdi\u0165, \u017ee n\u00e1\u0161 obsah \u010dl\u00e1nku v\u00e1m m\u00f4\u017ee pom\u00f4c\u0165 pri samodiagnostike. Iba v\u00e1\u0161 lek\u00e1r m\u00f4\u017ee poskytn\u00fa\u0165 spr\u00e1vnu diagn\u00f3zu a lie\u010dbu adekv\u00e1tnu v\u00e1\u0161mu zdravotn\u00e9mu stavu. <\/p>\n\n\n\n
\n\n\n\nVedecky potvrden\u00e9 zdroje<\/strong><\/h3>\n\n\n\n- Folic Acid. WebMD. https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1017\/folic-acid<\/a>.<\/li>
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- Cufasso J. Folate Deficiency. Healthline. https:\/\/www.healthline.com\/health\/folate-deficiency<\/a>.<\/li>
- Folic acid in diet. MedlinePlus. https:\/\/medlineplus.gov\/ency\/article\/002408.htm<\/a>.<\/li>
- MTHFR gene variant. Genetic and Rare Diseases Information Center. National Center for Advancing Translational Sciences. U.S. National Institutes of Health. https:\/\/rarediseases.info.nih.gov\/diseases\/10953\/mthfr-gene-mutation<\/a>.<\/li>
- Maffoni S, De Giuseppe R, Stanford FC, Cena H. Folate status in women of childbearing age with obesity: a review. Nutr Res Rev. 2017;30(2):265-71. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6232191<\/a><\/li>
- Parrott J, Frank L, Rabena R, Craggs-Dino L, Isom KA, Greiman L. American Society for Metabolic and Bariatric Surgery Integrated Health Nutritional Guidelines for the Surgical Weight Loss Patient 2016 Update: Micronutrients. Surgery for Obesity and Related Diseases. 2017;13(5):727-741. doi:10.1016\/j.soard.2016.12.018. Retrieved from https:\/\/asmbs.org\/app\/uploads\/2008\/09\/ASMBS-Nutritional-Guidelines-2016-Update.pdf<\/a><\/li>
- McKillop DJ, Pentieva K, Daly D, et al. The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet. Br J Nutr. 2002;88(6):681-8. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12493090<\/a><\/li>
- Fabbri ADT, Crosby GA. A review of the impact of preparation and cooking on the nutritional quality of vegetables and legumes. International Journal of Gastronomy and Food Science. 2016;3:2-11. doi:10.1016\/j.ijgfs.2015.11.001 Retrieved from https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1878450X15000207<\/a><\/li>
- Folic Acid. Office on Women\u2019s Health. U.S. Department of Health and Human Services. https:\/\/www.womenshealth.gov\/a-z-topics\/folic-acid<\/a>.<\/li>
- Folate. Office of Dietary Supplements. U.S. National Institutes of Health. https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/<\/a>.<\/li>
- Mayo Clinic Staff. Folate (Folic Acid). Mayo Clinic. https:\/\/www.mayoclinic.org\/drugs-supplements-folate\/art-20364625<\/a>.<\/li>
- Folic acid: Too much of a good thing? Harvard Heart Letter. Harvard Health Publishing. https:\/\/www.health.harvard.edu\/newsletter_article\/Folic_acid_Too_much_of_a_good_thing<\/a>.<\/li>
- Folate and Brain: Is 5-MTHF (methylfolate) better for the brain than folic acid?. MTHFR Support Australia. https:\/\/mthfrsupport.com.au\/2017\/04\/folate-and-brain\/<\/a>.<\/li>
- Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014;44(5):480-8. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24494987<\/a><\/li>
- Obeid R, Holzgreve W, Pietrzik K. Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects. J Perinat Med. 2013;41(5):469-83. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23482308<\/a><\/li>
- Multum C. L-Methylfolate. Drugs.com<\/a>. https:\/\/www.drugs.com\/mtm\/l-methylfolate.html<\/a><\/li>
- Vitamins and Supplements: Folic Acid. WebMD. https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1017\/folic-acid<\/a>.<\/li>
- Folic Acid, Vitamin B9 tablets. Cleveland Clinic Health Library. https:\/\/my.clevelandclinic.org\/health\/drugs\/18719-folic-acid-vitamin-b9-tablets<\/a>.<\/li>
- Mischoulon D, Zajecka J, Freeman MP, Fava M. Does folic acid interfere with lamotrigine? The Lancet Psychiatry. 2016;3(8):704-705. doi:10.1016\/s2215-0366(16)30167-5. Retrieved from https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(16)30167-5\/fulltext<\/a><\/li>
- Lamers Y, Prinz-Langenohl R, Moser R, Pietrzik K. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. Am J Clin Nutr. 2004;79(3):473-8. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14985224<\/a><\/li><\/ol>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
\u010co je 5-MTHF? Tento \u010dl\u00e1nok je zameran\u00fd na to, aby v\u00e1m poskytol v\u0161etky u\u017eito\u010dn\u00e9 a na d\u00f4kazoch zalo\u017een\u00e9 inform\u00e1cie o vitam\u00edne B9, fol\u00e1te, kyseline listovej, 5-MTHF a v\u00fd\u017eivov\u00fdch doplnkoch a potravin\u00e1ch, ktor\u00e9 udr\u017euj\u00fa va\u0161u hladinu vitam\u00ednu B9 na adekv\u00e1tnej \u00farovni. Dozviete sa o probl\u00e9moch, ktor\u00e9 m\u00f4\u017eu zn\u00ed\u017ei\u0165 hladinu B9 na nezdravo n\u00edzku hladinu – aj…<\/p>\n","protected":false},"author":2,"featured_media":161286,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[3174,3172,3173],"tags":[3175],"coauthors":[],"class_list":["post-238091","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-novinky","category-vyziva","category-zdravie","tag-5-mthf"],"taxonomy_info":{"category":[{"value":3174,"label":"Novinky"},{"value":3172,"label":"V\u00fd\u017eiva"},{"value":3173,"label":"Zdravie"}],"post_tag":[{"value":3175,"label":"5-MTHF"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-12-1024x512.jpg",1024,512,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/sk-sk\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":3174,"name":"Novinky","slug":"novinky","term_group":0,"term_taxonomy_id":3174,"taxonomy":"category","description":"","parent":0,"count":18,"filter":"raw","cat_ID":3174,"category_count":18,"category_description":"","cat_name":"Novinky","category_nicename":"novinky","category_parent":0},{"term_id":3172,"name":"V\u00fd\u017eiva","slug":"vyziva","term_group":0,"term_taxonomy_id":3172,"taxonomy":"category","description":"","parent":0,"count":46,"filter":"raw","cat_ID":3172,"category_count":46,"category_description":"","cat_name":"V\u00fd\u017eiva","category_nicename":"vyziva","category_parent":0},{"term_id":3173,"name":"Zdravie","slug":"zdravie","term_group":0,"term_taxonomy_id":3173,"taxonomy":"category","description":"","parent":0,"count":21,"filter":"raw","cat_ID":3173,"category_count":21,"category_description":"","cat_name":"Zdravie","category_nicename":"zdravie","category_parent":0}],"tag_info":[{"term_id":3175,"name":"5-MTHF","slug":"5-mthf","term_group":0,"term_taxonomy_id":3175,"taxonomy":"post_tag","description":"","parent":0,"count":2,"filter":"raw"}],"wpml":{"language":"sk-sk","is_original":true,"original_post_id":238091,"translations":{"sk-sk":{"id":238091,"language":"sk-sk","is_original":true}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/comments?post=238091"}],"version-history":[{"count":1,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091\/revisions"}],"predecessor-version":[{"id":238687,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091\/revisions\/238687"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/media\/161286"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/media?parent=238091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/categories?post=238091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/tags?post=238091"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/coauthors?post=238091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\n\n\n\nV roku 1998 USA nariadili, aby sa do konkr\u00e9tnych obiln\u00edn prid\u00e1vala aj kyselina listov\u00e1, aby sa zabezpe\u010dil dostato\u010dn\u00fd pr\u00edjem B9 pre cel\u00fa popul\u00e1ciu.. Od roku 2017 nariadilo 86 kraj\u00edn legislat\u00edvnym z\u00e1konom, \u017ee p\u0161eni\u010dn\u00e1 m\u00faka mus\u00ed obsahova\u0165 ur\u010dit\u00e9 minim\u00e1lne mno\u017estvo kyseliny listovej. (2) (3) 16 kraj\u00edn z celkov\u00e9ho po\u010dtu 86 vydalo to ist\u00e9 nariadenie aj pre kukuri\u010dn\u00fa m\u00faku. \u0160es\u0165 kraj\u00edn tie\u017e pridalo na zoznam navy\u0161e aj ry\u017eov\u00fa m\u00faku.<\/p>\n\n\n\n
\n\n\n\n
\u010co je 5-MTHF?<\/strong><\/h2>\n\n\n\n5-metyltetrahydrofol\u00e1t alebo 5-MTHF je pr\u00edrodn\u00e1 forma vitam\u00ednu B9, ktor\u00fa je na\u0161e telo pripraven\u00e9 absorbova\u0165 a pou\u017ei\u0165 na v\u00fd\u017eivov\u00e9 \u00fa\u010dely. Z tohto d\u00f4vodu je to dnes ve\u013emi popul\u00e1rna forma fol\u00e1tu, najm\u00e4 u \u013eud\u00ed, ktor\u00ed maj\u00fa probl\u00e9my s metaboliz\u00e1ciou in\u00fdch foriem B9 z potrav\u00edn a doplnkov. 5-MTHF m\u00f4\u017eete pozna\u0165 aj pod in\u00fdmi n\u00e1zvam<\/strong>i:<\/p>\n\n\n\n- L-5-MTHF<\/li>
- L-metylfol\u00e1t<\/li>
- L-metylfol\u00e1t v\u00e1penat\u00fd (iba ak je viazan\u00fd na v\u00e1penat\u00fa so\u013e)<\/li>
- Metylfol\u00e1t<\/li>
- Kyselina levomefolov\u00e1<\/li><\/ul>\n\n\n\n
U niektor\u00fdch vy\u0161\u0161ie uveden\u00fdch n\u00e1zvov si v\u0161imnite \u201eL\u201c. Toto p\u00edsmeno nazna\u010duje, \u017ee ve\u013ek\u00e1 v\u00e4\u010d\u0161ina \u013eud\u00ed ho dok\u00e1\u017ee absorbova\u0165. \u201c6 (S)\u201c namiesto \u201eL\u201c takisto ozna\u010duje tento pr\u00edpad. Ak je \u201eL\u201c nahraden\u00e9 \u201e6 (R)\u201c, potom v\u00e1m oto zlo\u017eenie pravdepodobne ve\u013emi nepom\u00f4\u017ee.<\/p>\n\n\n\n
\n\n\n\nKtor\u00e9 formy fol\u00e1tu dok\u00e1\u017ee na\u0161e telo najlep\u0161ie absorbova\u0165 a zu\u017eitkova\u0165? <\/strong><\/h2>\n\n\n\n<\/figure><\/div>\n\n\n\n\u0160t\u00fadia publikovan\u00e1 v British Journal of Pharmacology porovn\u00e1vala absorpciu 6 (S) -5-MTHF v tele s kyselinou listovou. Subjekty boli zdrav\u00e9 \u017eeny, ktor\u00e9 mali probl\u00e9my so vstreb\u00e1van\u00edm fol\u00e1tu a kyseliny listovej zo stravy, preto\u017ee ich g\u00e9ny potrebn\u00e9 na spracovanie t\u00fdchto \u017eiv\u00edn boli chybn\u00e9. 6 (S) -5-MTHF reagoval ove\u013ea lep\u0161ie v z\u00edskavan\u00ed pou\u017eite\u013en\u00e9ho vitam\u00ednu B9 do krvnej plazmy, kde sa za\u010d\u00edna tento magick\u00fd proces. <\/p>\n\n\n\n
V tejto \u0161t\u00fadii vedci pou\u017eili 6 (S) -5-MTHF, ktor\u00fd sa viazal na v\u00e1penat\u00fa so\u013e. \u00c1no, predmetom v\u00fdskumu bola kyselina listov\u00e1, pokia\u013e ide o absorpciu … ALE … \u010eal\u0161ia \u0161t\u00fadia porovn\u00e1vala l\u00e1tky na b\u00e1ze v\u00e1pnika s inou formou 6 (S) -5-MTHF viazanou na glukozam\u00edn namiesto v\u00e1pniku u potkanov. Vedci tie\u017e porovnali obe formy s kyselinou listovou. \u0160t\u00fadia uk\u00e1zala 1,8-kr\u00e1t vy\u0161\u0161iu maxim\u00e1lnu hladinu v plazme ako 5-MTHF viazan\u00e9ho na v\u00e1penat\u00fa so\u013e a 3,1-kr\u00e1t vy\u0161\u0161iu hladinu ako u kyseliny listovej. (5) Preto Intelligent Labs pou\u017e\u00edva 6 (S) -5-MTHF naviazan\u00fd na glukozam\u00edn bez obsahu m\u00e4kk\u00fd\u0161ov. V na\u0161ich doplnkoch pou\u017e\u00edvame patentovan\u00fd vzorec s n\u00e1zvom Quatrefolic Acid\u00ae a pon\u00fakame dve verzie: 1mg 5-MTHF<\/a> and 5mg 5-MTHF<\/a><\/p>\n\n\n\n5-MTHF existuje aj pod in\u00fdmi n\u00e1zvami<\/strong><\/h2>\n\n\n\nMetafolin\u00ae<\/strong> – doplnok 5-MTHF vyu\u017e\u00edvaj\u00faci L-metylfol\u00e1t v\u00e1penat\u00fd. Je k dispoz\u00edcii iba prostredn\u00edctvom predajcov s licenciou udelenou jej autormi. Deplin\u00ae<\/strong> – T\u00e1to 5-MTHF formula, ktor\u00e1 je dostupn\u00e1 na lek\u00e1rsky predpis, bola vyvinut\u00e1 tak, aby uspokojila nutri\u010dn\u00e9 potreby pacientov s depresiou a zv\u00fd\u0161ila aktivitu antidepres\u00edv. Quatrefolic Acid\u00ae<\/strong> – op\u00e4\u0165 sme pri zl\u00fa\u010denine, ktor\u00fa pou\u017e\u00edvame aj my v Intelligent Labs. Je medzin\u00e1rodne patentovan\u00e1 spolo\u010dnos\u0165ou Gnosis a je to vedecky najvyspelej\u0161ia formula 5-MTHF na trhu. Tento 5-MTHF je lep\u0161ie absorbovan\u00fd v na\u0161om organizme, preto\u017ee je viazan\u00fd na glukozam\u00edn bez obsahu m\u00e4kk\u00fd\u0161ov namiesto v\u00e1pnika. Spolo\u010dnos\u0165 Intelligent Labs m\u00e1 k dispoz\u00edcii dva doplnky s obsahom 5-MTHF v dvoch r\u00f4znych d\u00e1vkach.<\/p>\n\n\n\n
\n\n\n\nAk\u00e9 zdravotn\u00e9 benefity pre n\u00e1\u0161 organizmus m\u00e1 fol\u00e1t a 5-MTHF?<\/strong><\/h2>\n\n\n\nJe potrebn\u00fd pre z\u00e1kladn\u00e9 telesn\u00e9 funkcie<\/strong><\/h3>\n\n\n\nB9 je potrebn\u00fd najm\u00e4 pri t\u00fdchto \u010dinnostiach:<\/strong> (6)(7)(8)<\/p>\n\n\n\n- Energia zo sacharidov<\/li>
- DNA & RNA<\/li>
- \u010cerven\u00e9 a biele krvinky<\/li>
- Melaton\u00edn, chemick\u00e1 l\u00e1tka, ktor\u00e1 reguluje sp\u00e1nok<\/li>
- D\u00f4le\u017eit\u00e9 neurotransmitery ako norepinefr\u00edn, seroton\u00edn a dopam\u00edn<\/li>
- Nervov\u00fd syst\u00e9m<\/li><\/ul>\n\n\n\n
<\/figure>\n\n\n\nZabra\u0148uje vzniku vroden\u00fdch ch\u00fdb plodu po\u010das tehotenstva<\/strong><\/h3>\n\n\n\nPoskytovatelia zdravotnej starostlivosti \u010dasto odpor\u00fa\u010daj\u00fa, aby si tehotn\u00e9 \u017eeny dop\u013a\u0148ali fol\u00e1t u\u017e po\u010das tehotenstva, aby sa zabr\u00e1nilo vroden\u00fdm chyb\u00e1m, ako s\u00fa poruchy neur\u00e1lnej trubice. D\u00f4vod je jednoduch\u00fd – \u00fa\u010dinok nedostatku fol\u00e1tov na v\u00fdvoj die\u0165a\u0165a bol sk\u00faman\u00fd pomerne extenz\u00edvne. (9) Na v\u00fdvoj nervov\u00e9ho syst\u00e9mu po\u010das tehotenstva je potrebn\u00fd dostatok fol\u00e1tu, ie to k\u013e\u00fa\u010dov\u00e1 f\u00e1za u\u017e od samotn\u00e9ho za\u010diatku tehotenstva. \u017deny si zvy\u010dajne neuvedomuj\u00fa, \u017ee s\u00fa tehotn\u00e9, \u010dastokr\u00e1t na to pr\u00eddu a\u017e po nieko\u013ek\u00fdch t\u00fd\u017ed\u0148och. Aj ke\u010f sa st\u00e1le sna\u017e\u00edte otehotnie\u0165, je dobr\u00e9 sa uisti\u0165, \u017ee hladina va\u0161ej kyseliny listovej v organizme m\u00e1 adekv\u00e1tne spr\u00e1vnu \u00farove\u0148. (6)<\/p>\n\n\n\n
P\u00e1ni, nie\u010do aj pre v\u00e1s!<\/strong><\/h3>\n\n\n\nMu\u017ei, ktor\u00ed sa sna\u017eia po\u010da\u0165 die\u0165a, by sa tie\u017e mali ubezpe\u010di\u0165, \u017ee netrpia nedostatkom fol\u00e1tu. \u0160t\u00fadia z roku 2013 zistila, \u017ee mu\u017ei, ktor\u00ed nemaj\u00fa po\u010das obdobia, kedy sa pok\u00fa\u0161ali splodi\u0165 die\u0165a, zdrav\u00e9 hladiny tohto vitam\u00ednu, mohli prispie\u0165 k zna\u010dn\u00e9mu zv\u00fd\u0161eniu pravdepodobnosti vzniku deform\u00e1ci\u00ed. (10) \u017den\u00e1m sa dokona odpor\u00fa\u010da, aby za\u010dali s u\u017e\u00edvan\u00edm v\u00fd\u017eivov\u00fdch doplnkov u\u017e nieko\u013eko mesiacov pred po\u010dat\u00edm, aby sa zv\u00fd\u0161ila \u0161anca na po\u010datie a donosenie zdrav\u00e9ho die\u0165a\u0165a. (11)<\/p>\n\n\n\n
Mo\u017en\u00e9 zn\u00ed\u017eenie rizika vzniku depresie a \/ alebo lep\u0161\u00ed \u00fa\u010dinok antidepres\u00edv<\/strong><\/h3>\n\n\n\nDeplin\u00ae, liekov\u00e1 forma 5-MTHF, bola patentovan\u00e1 \u0161peci\u00e1lne na lie\u010dbu depresie a zvy\u0161ovanie \u00fa\u010dinku u\u017e\u00edvania antidepres\u00edv u pacientov s depresiou. Sp\u00f4sob, ak\u00fdm 5-MTHF pom\u00e1ha pri depresi\u00e1ch, nie je zn\u00e1my, ale \u0161t\u00fadie ukazuj\u00fa, \u017ee v\u00fd\u017eivov\u00e9 doplnky s jeho obsahom m\u00f4\u017eu by\u0165 u\u017eito\u010dn\u00e9. \u0160t\u00fadie zameran\u00e9 na depresiu zvy\u010dajne pou\u017e\u00edvaj\u00fa ve\u013emi vysok\u00e9 d\u00e1vky v porovnan\u00ed s be\u017en\u00fdm pou\u017eit\u00edm u\u017e\u00edvate\u013eov. <\/p>\n\n\n\n
V \u0161t\u00fadii z roku 2013, ktor\u00e1 zah\u0155\u0148ala viac ako 500 pacientov lie\u010den\u00fdch na depresiu, automatick\u00e9 telefonick\u00e9 prieskumy nazna\u010dili lep\u0161iu priemern\u00fa kvalitu \u017eivota a vy\u0161\u0161iu spokojnos\u0165 s liekmi na depresiu u\u017e po troch mesiacoch u\u017e\u00edvania. Zlep\u0161ila sa aj spokojnos\u0165 so vz\u0165ahmi s pr\u00edbuzn\u00fdmi, priate\u013emi, spolupracovn\u00edkmi, partnermi a nezn\u00e1mymi \u013eu\u010fmi. Celkov\u00e9 rozdiely po 95 d\u0148och boli naozaj signifikantn\u00e9. Subjekty pou\u017e\u00edvali super \u00fa\u010dinn\u00fa formu predp\u00edsan\u00e9ho 5-MTHF. Ka\u017ed\u00e1 d\u00e1vka bola bu\u010f 7,5 mg alebo 15 mg. Po\u010diato\u010dn\u00e1 d\u00e1vka pre be\u017en\u00fdch pou\u017e\u00edvate\u013eov 5-MTHF bez depresie je zvy\u010dajne 1 mg alebo e\u0161te ni\u017e\u0161ia. (12) <\/p>\n\n\n\n
Jedn\u00fdm z d\u00f4vodov t\u00fdchto v\u00fdhod u pacientov s depresiou m\u00f4\u017ee by\u0165 fakt, \u017ee fol\u00e1t je nevyhnutnou s\u00fa\u010das\u0165ou v\u00fdroby hlavn\u00fdch neurotransmiterov, ako je seroton\u00edn, dopam\u00edn a norepinefr\u00edn, a m\u00f4\u017ee ich pom\u00e1ha\u0165 aj regulova\u0165. (13) 5-MTHF m\u00f4\u017ee dobre fungova\u0165 aj pri niektor\u00fdch pr\u00edznakoch bipol\u00e1rnej poruchy. \u0160es\u0165t\u00fd\u017ed\u0148ov\u00e1 \u0161t\u00fadia s 10 \u00fa\u010dastn\u00edkmi s ve\u013ekou mierou depresie a bipol\u00e1rnou poruchou preuk\u00e1zala s\u013eubn\u00e9 v\u00fdsledky: (14)<\/strong> \u201eVedci zistili, \u017ee u pacientov s bipol\u00e1rnou poruchou u\u017e\u00edvaj\u00facich L-metylfol\u00e1t sa preuk\u00e1zalo zlep\u0161enie sympt\u00f3mov depresie, be\u017en\u00e9ho fungovania, sebapozn\u00e1vania a zn\u00ed\u017eenie samovra\u017eedn\u00fdch my\u0161lienok.\u201c<\/em> UPOZORNENIE: Ak trp\u00edte depresiou, v\u017edy sa pora\u010fte so svoj\u00edm lek\u00e1rom sk\u00f4r, ako za\u010dnete pou\u017e\u00edva\u0165 ak\u00fako\u013evek formu doplnku kyseliny listovej, a to aj v n\u00edzkych d\u00e1vkach.<\/p>\n\n\n\nRedukcia homocyste\u00ednu, z\u00e1palovej l\u00e1tky<\/strong><\/h3>\n\n\n\nHomocyste\u00edn je zl\u00fa\u010denina v \u013eudskom tele, ktor\u00e1 zvy\u0161uje z\u00e1pal. Mnoho chor\u00f4b m\u00e1 p\u00f4vod pr\u00e1ve v z\u00e1pale. Vysok\u00e9 hladiny homocyste\u00ednu m\u00f4\u017eu zvy\u0161ova\u0165 riziko<\/strong>: (18)<\/p>\n\n\n\n- Krvn\u00fdch zrazen\u00edn<\/li>
- M\u0155tvice<\/li>
- Alzheimer\u2019s Alzheimerovej choroby<\/li>
- Srdcov\u00e9ho infarktu<\/li>
- Ischemickej choroby srdca<\/li>
- Osteopor\u00f3zy<\/li>
- Ateroskler\u00f3zy<\/li><\/ul>\n\n\n\n
Vysok\u00e9 hladiny tejto zl\u00fa\u010deniny s\u00favisia s n\u00edzkou hladinou vitam\u00ednov B6, B9 a B12. T\u00e1to kombin\u00e1cia je siln\u00fdm prediktorom kognit\u00edvneho poklesu u mu\u017eov a pravdepodobne aj u \u017eien. (15) Zdrav\u00e9 hladiny v\u0161etk\u00fdch troch konkr\u00e9tnych vitam\u00ednov skupiny B s\u00fa d\u00f4le\u017eit\u00e9 pre udr\u017eanie homocyste\u00ednu pod kontrolou. 5-MTHF m\u00f4\u017ee zabr\u00e1ni\u0165 ur\u010dit\u00e9mu kognit\u00edvnemu poklesu, ale je ur\u010dite vhodn\u00e9 a odpor\u00fa\u010dan\u00e9, ak si budete udr\u017eiava\u0165 adekv\u00e1tne hladiny aj \u010fal\u0161\u00edch dvoch. (15) (16) (17) Medzi \u010fal\u0161ie pr\u00ed\u010diny vysokej hladiny homocyste\u00ednu patria: probl\u00e9my s hypotyre\u00f3zou, choroby obli\u010diek a psori\u00e1za. <\/p>\n\n\n\n
Neobvi\u0148ujte automaticky za tieto diagn\u00f3zy nedostatok vitam\u00ednu B. (18) Ako ste u\u017e \u010d\u00edtali vy\u0161\u0161ie, z\u00e1kony v desiatkach kraj\u00edn zn\u00ed\u017eili obsah homocyste\u00ednu nariaden\u00edm, aby boli m\u00faky obohaten\u00e9 kyselinou listovou. 24-t\u00fd\u017ed\u0148ov\u00e1 randomizovan\u00e1 placebo \u0161t\u00fadia preuk\u00e1zala, \u017ee 5-MTHF je pri zni\u017eovan\u00ed hlad\u00edn homocyste\u00ednu u zdrav\u00fdch \u013eud\u00ed ove\u013ea efekt\u00edvnej\u0161\u00ed ako kyselina listov\u00e1. (19)<\/p>\n\n\n\n
Mo\u017en\u00e9 zn\u00ed\u017eenie rizika m\u0155tvice a srdcov\u00e9ho infarktu<\/strong><\/h3>\n\n\n\n5-MTHF by mohol zlep\u0161i\u0165 zdravie srdca a krvn\u00e9ho obehu zn\u00ed\u017een\u00edm hladiny homocyste\u00ednu a \u010fal\u0161\u00edmi mechanizmami. Je to v\u0161ak komplikovan\u00e9. Riziko srdcov\u00e9ho infarktu alebo cievnej mozgovej pr\u00edhody by sa mohlo zn\u00ed\u017ei\u0165 iba vtedy, ak m\u00e1te nedostatok fol\u00e1tu. <\/p>\n\n\n\n<\/figure>\n\n\n\nPrin\u00e1\u0161ame zhrnutie k\u013e\u00fa\u010dov\u00fdch faktov, ktor\u00e9 s\u00fa zauj\u00edmav\u00e9 minim\u00e1lne tak, ako dobr\u00e1 detekt\u00edvka … \u0160t\u00fadia z roku 2015 zistila, \u017ee mu\u017ei, ktor\u00ed si dop\u013a\u0148ali kyselinu listov\u00fa a u\u017e\u00edvali enalapril, liek zni\u017euj\u00faci krvn\u00fd tlak, mali zn\u00ed\u017een\u00e9 riziko mozgovej pr\u00edhody po\u010das nasleduj\u00facich 4,5 rokov. V\u00fdsledky boli v\u00fdznamn\u00e9 pre skupinu s u\u017e\u00edvan\u00edm kyseliny listovej a enalaprilu v porovnan\u00ed so skupinou, ktor\u00e1 u\u017e\u00edvala iba enalapril. Zd\u00e1 sa, \u017ee aj star\u00e9 \u0161t\u00fadie zo 70. rokov ukazuj\u00fa zn\u00ed\u017een\u00e9 riziko m\u0155tvice a srdcov\u00e9ho infarktu v d\u00f4sledku zv\u00fd\u0161en\u00e9ho u\u017e\u00edvania fol\u00e1tov. (20) <\/p>\n\n\n\n
Na druhej strane niektor\u00e9 \u0161t\u00fadie z USA, zalo\u017een\u00e9 na placebe, nepreuk\u00e1zali zn\u00ed\u017eenie rizika m\u0155tvice alebo srdcov\u00e9ho infarktu. To by mohlo znamena\u0165, \u017ee fol\u00e1t vykazuje tento efekt\u00edvny \u00fa\u010dinok iba vtedy, ke\u010f ho maj\u00fa pacienti nedostatok. <\/p>\n\n\n\n
Pripome\u0148me, \u017ee USA za\u010dali posil\u0148ova\u0165 jeho obsah v obilnin\u00e1ch v roku 1998, \u010do by mohlo vysvetli\u0165 niektor\u00e9 v\u00fdsledky zo 70. rokov. \u013dudia mali vtedy jednoducho ni\u017e\u0161iu hladinu fol\u00e1tov. (20) \u010c\u00edna neposil\u0148uje obilniny obsahom fol\u00e1tov, \u010do znamen\u00e1, \u017ee aj ich popul\u00e1cia m\u00f4\u017ee trpie\u0165 jeho nedostatkom. Niektor\u00e9 zo star\u00fdch americk\u00fdch \u0161t\u00fadi\u00ed sledovali \u013eud\u00ed, ktor\u00ed mali v minulosti mozgov\u00fa pr\u00edhodu a infarkt. Ako reakciu na tieto udalosti mohli t\u00edto pacienti zn\u00ed\u017ei\u0165 riziko u\u017e\u00edvan\u00edm in\u00fdch liekov a potrav\u00edn, ako bola napr\u00edklad aj kyselina listov\u00e1. (20)<\/p>\n\n\n\n
\n\n\n\nAko zisti\u0165, \u010di trp\u00edte nedostatkom kyseliny listovej?<\/strong><\/h2>\n\n\n\nNiektor\u00e9 pr\u00edznaky signalizuj\u00fa, \u017ee nedostatok fol\u00e1tu sp\u00f4sobuje an\u00e9miu (nedostatok \u010derven\u00fdch krviniek) Chronick\u00e9 spomalenie organizmu a \u00fanava: <\/strong>(21)<\/p>\n\n\n\n- Neschopnos\u0165 sa poriadne nad\u00fdchnu\u0165<\/li>
- V\u00fdbu\u0161nos\u0165, mrzutos\u0165 a podr\u00e1\u017edenos\u0165<\/li>
- Poko\u017eka vyzer\u00e1 mimoriadne bledo<\/li>
- \u010eal\u0161ie pr\u00edznaky nedostatku kysl\u00edka v krvi, napr\u00edklad probl\u00e9my s pam\u00e4\u0165ou<\/li><\/ul>\n\n\n\n
\u010eal\u0161ie pr\u00edznaky nedostatku fol\u00e1tu<\/strong>: (22)<\/p>\n\n\n\n- Pred\u010dasn\u00e9 \u0161edivenie vlasov<\/li>
- Opuchnut\u00fd jazyk<\/li>
- Rany alebo vredy v \u00fastach<\/li>
- Die\u0165a m\u00e1 vroden\u00e9 chyby a deform\u00e1cie a vy ste jedn\u00fdm z rodi\u010dov<\/li>
- Hna\u010dka<\/li>
- Probl\u00e9my s rastom<\/li><\/ul>\n\n\n\n
Samodiagnostika nedostatku fol\u00e1tu je zlo\u017eit\u00e1. Je to \u010diasto\u010dne preto, \u017ee pr\u00edznaky nedostatku fol\u00e1tu a in\u00fdch vitam\u00ednov skupiny B sa navz\u00e1jom prekr\u00fdvaj\u00fa. V\u00e1\u0161 lek\u00e1r pravdepodobne vykon\u00e1 testy na vyl\u00fa\u010denie pr\u00ed\u010din a in\u00fdch pr\u00edznakov.<\/p>\n\n\n\n
\n\n\n\n\u010co sp\u00f4sobuje nedostatok fol\u00e1tu a kyseliny listovej?<\/strong><\/h2>\n\n\n\nStrava bez potrav\u00edn, ktor\u00e9 maj\u00fa vysok\u00fd obsah fol\u00e1tov<\/strong><\/h3>\n\n\n\nAk nejed\u00e1vate dostatok fazule, vajec, zelenej zeleniny a in\u00fdch potrav\u00edn alebo v\u00fd\u017eivov\u00fdch doplnkov bohat\u00fdch na fol\u00e1ty, pravdepodobne budete ma\u0165 nedostatok fol\u00e1tu v tele.<\/p>\n\n\n\n<\/figure>\n\n\n\n\u010co br\u00e1ni vstreb\u00e1vaniu fol\u00e1tov zo stravy a v\u00fd\u017eivov\u00fdch doplnkov<\/strong><\/h3>\n\n\n\nZl\u00e9 vstreb\u00e1vanie kyseliny listovej a fol\u00e1tov zo stravy m\u00f4\u017ee sp\u00f4sobi\u0165 ve\u013ea faktorov, vr\u00e1tane: <\/strong>(21)<\/p>\n\n\n\n- Ochorenie ako Crohnova choroba, celiakia, niektor\u00e9 druhy rakoviny a poruchy obli\u010diek<\/li>
- Poruchy g\u00e9nu MTHFR, ktor\u00e9 s\u00fa be\u017en\u00e9<\/li>
- Interakcie s liekmi, ktor\u00e9 interferuj\u00fa s fol\u00e1tom<\/li>
- Nadmern\u00e9 u\u017e\u00edvanie alkoholu alebo antac\u00edd<\/li>
- Mut\u00e1cia g\u00e9nov zodpovedn\u00fdch za metaboliz\u00e1ciu fol\u00e1tu<\/li><\/ul>\n\n\n\n
Kyselina listov\u00e1 a pr\u00edrodn\u00fd fol\u00e1t v potravin\u00e1ch musia prejs\u0165 mnoh\u00fdmi chemick\u00fdmi reakciami, k\u00fdm sa z nich stane 5-MTHF, jedin\u00e1 u\u017eito\u010dn\u00e1 forma. V\u00e4\u010d\u0161ina z n\u00e1s metabolizuje fol\u00e1t a kyselinu listov\u00fa a efekt\u00edvne ich transformuje na 5-MTHF. Existuje g\u00e9n, ktor\u00fd riadi tento proces. Vol\u00e1 sa MTHFR a ka\u017ed\u00fd m\u00e1me jeho dve k\u00f3pie. Mnoh\u00ed z n\u00e1s v\u0161ak maj\u00fa vari\u00e1cie jednej alebo oboch t\u00fdchto g\u00e9nov\u00fdch k\u00f3pi\u00ed, ktor\u00e9 neumo\u017e\u0148uj\u00fa transform\u00e1cie na 5-MTHF. Ak je jedna k\u00f3pia g\u00e9nu nedostato\u010dn\u00e1 pre absorpciu fol\u00e1tu, \u00fa\u010dinnos\u0165 spracovania m\u00f4\u017ee by\u0165 ve\u013emi ovplyvnen\u00e1. Ak s\u00fa obe k\u00f3pie zl\u00e9, nebudete metabolizova\u0165 takmer \u017eiadne mno\u017estvo fol\u00e1tu alebo kyseliny listovej. (23) <\/p>\n\n\n\n
Ako zist\u00edte, \u017ee m\u00e1te jednu alebo dve zl\u00e9 mut\u00e1cie g\u00e9nu MTHFR? Budete musie\u0165 podst\u00fapi\u0165 test DNA a necha\u0165 ho posla\u0165 do medic\u00ednskeho laborat\u00f3ria. Laborat\u00f3ri\u00e1 na tento \u00fa\u010del n\u00e1jdete vo va\u0161om okol\u00ed aj online. Najsk\u00f4r si d\u00f4kladne pre\u0161tudujte, \u010do laborat\u00f3rium pon\u00faka alebo nechajte lek\u00e1ra vybra\u0165 laborat\u00f3rium za v\u00e1s. S\u00favislos\u0165 medzi obezitou a nedostato\u010dnou hladinou fol\u00e1tov je ve\u013emi siln\u00e1, ale zd\u00e1 sa, \u017ee nikto nepri\u0161iel na to, pre\u010do. <\/p>\n\n\n\n
Obezita<\/strong><\/p>\n\n\n\nV preh\u013eade \u0161t\u00fadi\u00ed publikovan\u00fdch v rokoch 2005 a\u017e 2015 sa sk\u00famali hladiny fol\u00e1tov u ob\u00e9znych \u017eien v \u201eplodnom veku\u201c so zvl\u00e1\u0161tnym d\u00f4razom na tehotn\u00e9 \u017eeny. Cie\u013eom vedcov bolo presk\u00fama\u0165 mo\u017en\u00e9 pr\u00ed\u010diny vysok\u00e9ho percenta deficitu fol\u00e1tu u t\u00fdchto \u017eien. Spomenuli by sme britsk\u00fa \u0161t\u00fadiu, ktor\u00e1 vyl\u00fa\u010dila faktory ako vitam\u00ednov\u00e9 doplnky, strava a vek. Pouk\u00e1zali by sme tie\u017e na nieko\u013eko \u010fal\u0161\u00edch \u0161t\u00fadi\u00ed, ktor\u00e9 vyl\u00fa\u010dili stravu ako pr\u00ed\u010dinu. Jedin\u00e9, \u010do bolo mo\u017en\u00e9 urobi\u0165, bolo odporu\u010di\u0165 viac \u0161t\u00fadi\u00ed o tejto skuto\u010dnosti plus tipy, ako v nich pokra\u010dova\u0165. (24) Dedukujeme: Samotn\u00e1 obezita alebo konkr\u00e9tne pr\u00ed\u010diny obezity by mohli zn\u00ed\u017ei\u0165 hladinu kyseliny listovej na nezdrav\u00fa \u00farove\u0148. Korel\u00e1cia je siln\u00e1 a v\u0161etky ot\u00e1zky sa t\u00fdkaj\u00fa toho, \u010do k \u010domu vedie. <\/p>\n\n\n\n
\u010eal\u0161ia \u0161t\u00fadia zaznamenala siln\u00fa korel\u00e1ciu medzi obezitou a nedostatkom fol\u00e1tov: V roku 2016 vedci presk\u00famali \u0161t\u00fadie so z\u00e1merom aktualizova\u0165 pokyny Americkej spolo\u010dnosti pre metabolick\u00fa a bariatrick\u00fa chirurgiu z roku 2008 t\u00fdkaj\u00face sa v\u00fd\u017eivy v bariatrickej chirurgii. Pokyny s\u00fa zalo\u017een\u00e9 na \u0161t\u00fadi\u00e1ch sk\u00famaj\u00facich hladinu \u017eiv\u00edn pred a po chirurgick\u00fdch z\u00e1krokoch na zn\u00ed\u017eenie hmotnosti. Nov\u00e9 odpor\u00fa\u010dania z roku 2016 odpor\u00fa\u010daj\u00fa skr\u00edning na nedostatok fol\u00e1tov pred t\u00fdmto typom oper\u00e1cie. D\u00f4vodom je fakt, \u017ee a\u017e 54% ob\u00e9znych pacientov m\u00e1 nedostatok fol\u00e1tov. (25) Vedci nemali v \u00famysle v tomto pr\u00edpade sk\u00fama\u0165 pr\u00ed\u010dinu a n\u00e1sledok. V\u0161\u00edmali si len s\u00favislos\u0165 a reagovali na \u0148u odpor\u00fa\u010dan\u00edm monitorovania a dopl\u0148ovania fol\u00e1tov pred chirurgick\u00fdm z\u00e1krokom.<\/p>\n\n\n\n
\n\n\n\nSp\u00f4sob, ako vyrie\u0161i\u0165 tento probl\u00e9m s g\u00e9nov\u00fdmi vari\u00e1ciami, je pou\u017ei\u0165 doplnok 5-MTHF, ktor\u00fd pre spr\u00e1vne pou\u017eitie v tele, nevy\u017eaduje s\u00e9riu chemick\u00fdch reakci\u00ed. In\u00fdmi slovami, 5-MTHF je u\u017e bioakt\u00edvny.<\/p>\n\n\n\n
<\/h3>\n\n\n\nNi\u010d\u00ed tepeln\u00e1 \u00faprava potrav\u00edn bohat\u00fdch na fol\u00e1ty, fol\u00e1ty samot<\/strong>n\u00e9<\/strong>?<\/strong><\/h2>\n\n\n\n<\/figure>\n\n\n\nTo, \u010di varenie zn\u00ed\u017ei obsah fol\u00e1tov v potravin\u00e1ch, z\u00e1vis\u00ed od jedla, sp\u00f4sobu varenia a \u010dasu varenia. Be\u017en\u00e9 \u010dasy varu m\u00f4\u017eu zredukova\u0165 zhruba polovicu kyseliny listovej v \u0161pen\u00e1te a brokolici, ale varen\u00edm v pare sa obsah kyseliny listovej v\u00f4bec nezn\u00ed\u017ei. Zd\u00e1 sa, \u017ee ani varenie zemiakov a grilovanie m\u00e4sa nezni\u017euje hladinu fol\u00e1tu, aj ke\u010f ich var\u00edte dlh\u0161ie ako zvy\u010dajne. (26) Varen\u00edm cibule sa zn\u00ed\u017ei obsah kyseliny listovej o 35%, zatia\u013e \u010do pri pe\u010den\u00ed sa z nej eliminuje iba 15%. Ukazuje sa tie\u017e, \u017ee varen\u00fd hr\u00e1\u0161ok si zachov\u00e1va najviac fol\u00e1tu v porovnan\u00ed s in\u00fdmi met\u00f3dami varenia. Ak var\u00edte fazu\u013eu dve hodiny a potom ju bu\u010f upe\u010diete alebo vypra\u017e\u00edte, strat\u00ed a\u017e 50% obsahu. Jedna \u0161t\u00fadia odpor\u00fa\u010da namo\u010di\u0165 ju do slanej vody a potom ju prevari\u0165 v \u010derstvej vode, aby sa zachovalo \u010do najviac v\u00fd\u017eivn\u00fdch l\u00e1tok. (27)<\/p>\n\n\n\n
\n\n\n\nPotrebuj\u00fa tehotn\u00e9 \u017eeny alebo \u017eeny sna\u017eiace sa otehotnie\u0165 extra pr\u00edjem kyseliny listovej? <\/strong><\/h2>\n\n\n\nV lek\u00e1rskej komunite v\u0161eobecne prevl\u00e1da n\u00e1zor,, \u017ee udr\u017eiava\u0165 hladinu fol\u00e1tu na rovnakej \u00farovni je dobr\u00fd n\u00e1pad. S najv\u00e4\u010d\u0161ou pravdepodobnos\u0165ou tak predch\u00e1dzate niektor\u00fdm typom vroden\u00fdch ch\u00fdb a siln\u00e1 korel\u00e1cia to len potvrdzuje. Ako u\u017e bolo uveden\u00e9 vy\u0161\u0161ie, v tele potrebujete ve\u013ea bioakt\u00edvneho fol\u00e1tu od chv\u00edle, ke\u010f otehotniete, aby ste zaistili spr\u00e1vny v\u00fdvoj nervov\u00e9ho syst\u00e9mu die\u0165a\u0165a. To by mohlo znamena\u0165, \u017ee tento proces je vhodn\u00e9 za\u010da\u0165 u\u017e od momentu, kedy sa st\u00e1le sna\u017e\u00edte otehotnie\u0165. Suplement\u00e1cia 5-MTHF je najistej\u0161\u00ed sp\u00f4sob, ako zisti\u0165, \u017ee va\u0161e telo skuto\u010dne absorbuje dostatok fol\u00e1tu. Ak ste tehotn\u00e1, pora\u010fte sa so svoj\u00edm lek\u00e1rom. Neu\u017e\u00edvajte v\u00fd\u017eivov\u00e9 doplnky bez pokynov lek\u00e1ra, ktor\u00e9 prisp\u00f4sob\u00ed na mieru va\u0161im jedine\u010dn\u00fdm okolnostiam a na z\u00e1klade d\u00f4kladn\u00e9ho laborat\u00f3rneho testovania.<\/p>\n\n\n\n
\n\n\n\nJe mo\u017en\u00e9 ma\u0165 v tele nadbytok kyseliny listovej?<\/strong><\/h2>\n\n\n\nV lek\u00e1rskej vede ide o kontroverzn\u00fa t\u00e9mu. Niektor\u00ed vedci tvrdia, \u017ee vo va\u0161om tele m\u00f4\u017ee kolova\u0165 a\u017e pr\u00edli\u0161 ve\u013ea kyseliny listovej, \u010do m\u00f4\u017ee sp\u00f4sobi\u0165 zdravotn\u00e9 probl\u00e9my. (28) Kv\u00f4li kontroverzii a potrebe \u010fal\u0161\u00edch \u0161t\u00fadi\u00ed m\u00f4\u017eete n\u00e1js\u0165 r\u00f4zne vl\u00e1dne zdravotn\u00edcke agent\u00fary, ktor\u00e9 sa odmietaj\u00fa v t\u00fdchto diskusi\u00e1ch postavi\u0165 na kohoko\u013evek stranu a odpor\u00fa\u010daj\u00fa spotrebite\u013eom, aby rad\u0161ej ni\u010d neu\u017e\u00edvali.. Ni\u010d z toho sa v\u0161ak pravdepodobne net\u00fdka 5-MTHF alebo fol\u00e1tu zo stravy, ktor\u00fd sa prirodzene vytv\u00e1ra v potravin\u00e1ch. \u010co m\u00f4\u017ee sp\u00f4sobi\u0165 pr\u00edli\u0161 ve\u013ea kyseliny listovej?<\/p>\n\n\n\n
Mo\u017enos\u0165 maskovania pr\u00edznakov nedostatku vitam\u00ednu B12<\/strong><\/h3>\n\n\n\nPr\u00edli\u0161 ve\u013ea kyseliny listovej vo va\u0161om tele m\u00f4\u017ee zamaskova\u0165 pr\u00edznaky megaloblastickej an\u00e9mie sp\u00f4sobenej nedostatkom vitam\u00ednu B12. Nejde o konsenzus. Pre vedcov je to st\u00e1le z\u00e1hada. Ak je to pravda, potom si lek\u00e1r m\u00f4\u017ee \u013eahko zm\u00fdli\u0165 stanoven\u00fa diagn\u00f3zu. To m\u00f4\u017ee zhor\u0161i\u0165 ak\u00e9ko\u013evek probl\u00e9my spojen\u00e9 s krvou a po\u0161kodi\u0165 v\u00e1\u0161 mozog a nervov\u00fd syst\u00e9m. Po\u0161kodenie mozgu m\u00f4\u017ee sp\u00f4sobi\u0165 r\u00fdchly kognit\u00edvny pokles a zm\u00e4tok v tele. (29) Existuje zhoda v tom, \u017ee tento probl\u00e9m sa net\u00fdka 5-MTHF, na ktor\u00fd sa menia ostatn\u00e9 formy, ke\u010f s\u00fa spr\u00e1vne metabolizovan\u00e9. <\/p>\n\n\n\n
Konzum\u00e1cia pr\u00edli\u0161 ve\u013ea fazule, pomaran\u010dov alebo zelenej zeleniny s vysok\u00fdm obsahom kyseliny listovej tie\u017e nie je probl\u00e9mom, o ktor\u00fd sa zdravotn\u00edci zrejme ob\u00e1vaj\u00fa. (39) Nedostatok vitam\u00ednu B12 sa pova\u017euje za v\u00e4\u010d\u0161\u00ed probl\u00e9m pre vegetari\u00e1nov a star\u0161\u00edch dospel\u00fdch ako pre v\u00e4\u010d\u0161inu ostatn\u00fdch. Vegetari\u00e1nska strava nedod\u00e1va dostatok tohto vitam\u00ednu a star\u0161\u00ed dospel\u00ed ho dokonca \u0165a\u017eko absorbuj\u00fa. Obe skupiny m\u00f4\u017eu dop\u013a\u0148a\u0165 vitam\u00edn B12 sublingv\u00e1lne (pod jazyk). <\/p>\n\n\n\n
<\/h3>\n\n\n\n<\/figure>\n\n\n\nPoruchy sp\u00e1nku a zv\u00fd\u0161en\u00e1 n\u00e1ladovos\u0165<\/strong><\/h3>\n\n\n\nPr\u00edli\u0161 ve\u013ea kyseliny listovej, najm\u00e4 ak sa u\u017e\u00edva v doplnkoch v\u00fd\u017eivy, m\u00f4\u017ee sp\u00f4sobi\u0165 probl\u00e9my so sp\u00e1nkom a podr\u00e1\u017edenos\u0165. (30)<\/p>\n\n\n\n
Nevo\u013enos\u0165 a strata chuti do jedla<\/strong><\/h3>\n\n\n\nNiektor\u00ed \u013eudia m\u00f4\u017eu strati\u0165 chu\u0165 do jedla alebo ochorie\u0165, najm\u00e4 ak prij\u00edmaj\u00fa pr\u00edli\u0161 ve\u013ea kyseliny listovej z v\u00fd\u017eivov\u00fdch doplnkov alebo multivitam\u00ednov. (30)<\/p>\n\n\n\n
Rie\u0161enie<\/strong><\/h3>\n\n\n\nAk u\u017e\u00edvate v\u00fd\u017eivov\u00fd doplnok s obsahom fol\u00e1tu, uistite sa, \u017ee je v bioakt\u00edvnej forme: 5-MTHF. Pre\u010d\u00edtajte si etikety na va\u0161ich multivitam\u00ednoch. Obsahuj\u00fa pr\u00edli\u0161 ve\u013ea kyseliny listovej? V\u00e4\u010d\u0161ina dospel\u00fdch by mala prij\u00edma\u0165 asi 0,5 mg kyseliny listovej denne. Pre\u010d\u00edtajte si etikety aj na chlebe a obilnin\u00e1ch. Ak u\u017e\u00edvate doplnok 5-MTHF, potom sa sna\u017ete udr\u017eiava\u0165 kyselinu listov\u00fa v obohaten\u00fdch potravin\u00e1ch na minime a vyh\u00fdbajte sa multivitam\u00ednom obsahuj\u00facim kyselinu listov\u00fa. M\u00f4\u017ee, ale nemus\u00ed to by\u0165 probl\u00e9m, ktor\u00fd interferuje s 5-MTHF. <\/p>\n\n\n\n
\u00darad pre doplnky v\u00fd\u017eivy N\u00e1rodn\u00e9ho \u00fastavu zdravotn\u00edctva USA stanovil odpor\u00fa\u010dan\u00fa denn\u00fa horn\u00fa hranicu 1 mg pre kyselinu listov\u00fa, ktor\u00e1 poch\u00e1dza z obohaten\u00fdch obiln\u00edn a doplnkov. Nestanovili v\u0161ak limit pre fol\u00e1ty poch\u00e1dzaj\u00face zo zeleniny alebo z 5-MTHF. (29) Pod\u013ea Harvardsk\u00e9ho zdravotn\u00e9ho in\u0161tit\u00fatu sa kyselina listov\u00e1 z obiln\u00edn m\u00f4\u017ee v tele r\u00fdchlo hromadi\u0165 (31). Pozrite si \u00fadaje ni\u017e\u0161ie. Be\u017en\u00e9 potraviny obohaten\u00e9 o kyselinu listov\u00fa:<\/strong><\/p>\n\n\n\n- Miska \u0161peci\u00e1lnych K cere\u00e1li\u00ed: 0,394 mg<\/li>
- Porcia pracl\u00edkov: 0.172mg<\/li>
- 1 porcia varen\u00fdch \u0161pagiet: 0.166mg<\/li>
- 1 multivitam\u00edn: 0.4mg<\/li><\/ul>\n\n\n\n
Celkom<\/strong> = 1,132mg. Nie je \u0165a\u017ek\u00e9 prekona\u0165 t\u00fato horn\u00fa hranicu za jeden de\u0148, tak\u017ee si d\u00e1vajte pozor na konzum\u00e1ciu obiln\u00edn a vitam\u00ednov, najm\u00e4 ak hor\u0161ie metabolizujete kyselinu listov\u00fa. Tie\u017e sa presved\u010dte, \u017ee m\u00e1te dostatok vitam\u00ednu B12 a \u017ee ho va\u0161e telo naozaj aj zu\u017eitkuje. <\/p>\n\n\n\n
\n\n\n\n<\/figure>\n\n\n\nExistuj\u00fa v\u00fdhody u\u017e\u00edvania 5-MTHF v porovnan\u00ed s in\u00fdmi formami fol\u00e1tu?<\/strong><\/h2>\n\n\n\n5-MTHF pr svoju \u00fa\u010dinnos\u0165 nevy\u017eaduje, aby v tele prebiehali chemick\u00e9 reakcie<\/strong><\/h3>\n\n\n\nKyselina listov\u00e1, ktor\u00e1 je syntetick\u00e1, vy\u017eaduje viac chemick\u00fdch reakci\u00ed, k\u00fdm sa z nej stane bioakt\u00edvny 5-MTHF. Fol\u00e1t v strave, ktor\u00fd sa prirodzene vytv\u00e1ra v potravin\u00e1ch, tie\u017e vy\u017eaduje chemick\u00e9 reakcie predt\u00fdm, ako sa z neho stane 5-MTHF, ale menej ako kyselina listov\u00e1. In\u00fdmi slovami, po u\u017eit\u00ed 5-MTHF vo v\u00fd\u017eivovom doplnku m\u00e1 va\u0161e telo menej pr\u00e1ce. Nie s\u00fa potrebn\u00e9 \u017eiadne dodato\u010dn\u00e9 chemick\u00e9 reakcie.<\/p>\n\n\n\n
Interakcie s men\u0161\u00edm po\u010dtom liekov ako pri kyseline listovej<\/strong><\/h3>\n\n\n\nAby sa 5-MTHF stal bioakt\u00edvnym, nie je potrebn\u00e1 metabolick\u00e1 premena, je menej pravdepodobn\u00e9, \u017ee bude reagova\u0165 s liekmi a zn\u00ed\u017ei ich \u00fa\u010dinnos\u0165. (33) Psychiatri ho miluj\u00fa, preto\u017ee t\u00e1to forma fol\u00e1tu m\u00f4\u017ee prech\u00e1dza\u0165 priamo cez hematoencefalick\u00fa bari\u00e9ru a priamo do mozgu. Krvno-mozgov\u00e1 bari\u00e9ra zabra\u0148uje mnoh\u00fdm l\u00e1tkam prenikn\u00fa\u0165 do mozgu cez obehov\u00fd syst\u00e9m. 5-MTHF m\u00f4\u017ee prenika\u0165 priamo do nervov\u00e9ho syst\u00e9mu. (32) Je to zvy\u010dajne vinou metabolizmu, ktor\u00fd sp\u00f4sobuje, \u017ee kyselina listov\u00e1 interferuje s liekmi.<\/p>\n\n\n\n
Nezakr\u00fdva pr\u00edznaky nedostatku vitam\u00ednu B12<\/strong><\/h3>\n\n\n\nAj ke\u010f fol\u00e1t m\u00f4\u017ee zakr\u00fdva\u0165 po\u0161kodenie nervov\u00e9ho syst\u00e9mu sp\u00f4soben\u00e9 krvn\u00fdmi poruchami s\u00favisiacimi s nedostatkom B12, je dok\u00e1zan\u00e9, \u017ee 5-MTHF tento probl\u00e9m nesp\u00f4sobuje. (34)<\/p>\n\n\n\n
\n\n\n\nAk\u00e1 by mala by\u0165 prv\u00e1 d\u00e1vka tohto doplnku?<\/strong><\/h2>\n\n\n\nV\u00e4\u010d\u0161ina u\u017e\u00edvate\u013eov za\u010d\u00edna s 1 mg alebo e\u0161te menej 5-MTHF denne pri be\u017enom pou\u017e\u00edvan\u00ed. Niektor\u00e9 situ\u00e1cie m\u00f4\u017eu vy\u017eadova\u0165 5 mg alebo viac a v\u00e1\u0161 lek\u00e1r v\u00e1m v tomto pr\u00edpade dok\u00e1\u017ee poradi\u0165 asi najlep\u0161ie, ke\u010f\u017ee pozn\u00e1 v\u00e1\u0161 zdravotn\u00fd stav. Pam\u00e4tajte, \u017ee viac nemus\u00ed by\u0165 nevyhnutne lep\u0161ie, najm\u00e4 pokia\u013e ide o u\u017e\u00edvanie akejko\u013evek formy fol\u00e1tu.<\/p>\n\n\n\n
\n\n\n\nKto by NEMAL U\u017d\u00cdVA\u0164 5-MTHF?<\/strong><\/h2>\n\n\n\nAk ste alergick\u00fd na 5-MTHF, nemali by ste ho samozrejme \u010falej u\u017e\u00edva\u0165. Ak sa v\u00e1m objav\u00ed \u017eih\u013eavka, zvieranie na hrudn\u00edku alebo d\u00fdchavi\u010dnos\u0165, pova\u017eujte to za n\u00fadzov\u00e9 situ\u00e1cie a pohotovostn\u00e9 reakcie v\u00e1\u0161ho organizmu . Pred doplnen\u00edm 5-MTHF sa pora\u010fte so svoj\u00edm lek\u00e1rom, najm\u00e4 ak:<\/strong> (35)<\/p>\n\n\n\n- ste alergick\u00fd na kyselinu listov\u00fa obsiahnut\u00fa v obilnin\u00e1ch alebo multivitam\u00ednoch<\/li>
- v minulosti v\u00e1m bol diagnostikovan\u00fd nedostatok vitam\u00ednu B12<\/li>
- m\u00e1te bipol\u00e1rnu poruchu<\/li>
- ste tehotn\u00e1 alebo doj\u010d\u00edte alebo sa sna\u017e\u00edte otehotnie\u0165 (kv\u00f4li ur\u010deniu spr\u00e1vneho d\u00e1vkovania, ktor\u00e9 sa m\u00f4\u017ee l\u00ed\u0161i\u0165 od pr\u00edpadu k pr\u00edpadu)<\/li><\/ul>\n\n\n\n
\n\n\n\nBude 5-MTHF reagova\u0165 na lieky, ktor\u00e9 u\u017e\u00edvam?<\/strong><\/h2>\n\n\n\nPri 5-MTHF je menej pravdepodobn\u00e9, \u017ee bude interagova\u0165 s liekmi v porovnan\u00ed s kyselinou listovou (33), ale ur\u010dite neberte toto tvrdenie ako z\u00e1v\u00e4zn\u00fa inform\u00e1ciu. Ur\u010dite by ste sa mali porozpr\u00e1va\u0165 aj so svoj\u00edm lek\u00e1rom. Kyselina listov\u00e1 m\u00f4\u017ee zn\u00ed\u017ei\u0165 \u00fa\u010dinnos\u0165 v\u00e4\u010d\u0161iny liekov na z\u00e1chvaty, ako aj \u00fa\u010dinky pyrimetam\u00ednu (Daraprim), ktor\u00fdm sa lie\u010dia parazitick\u00e9 infekcie. Metotrex\u00e1t je liek, ktor\u00fd zni\u017euje aktivitu fol\u00e1tu v bunk\u00e1ch. (36) (37) Na druhej strane \u0161t\u00fadia interakci\u00ed kyseliny listovej s lamotrig\u00ednom odporu\u010dila suplement\u00e1ciu 5-MTHF ako alternat\u00edvny sp\u00f4sob prij\u00edmania kyseliny listovej pre pou\u017e\u00edvate\u013eov tohto lie\u010diva. Lie\u010divo sa pou\u017e\u00edva na prevenciu z\u00e1chvatov, vedcov v\u0161ak zauj\u00edmali najm\u00e4 poruchy n\u00e1lady, ako je bipol\u00e1rna depresia. Poznamenali, \u017ee 5-MTHF nemus\u00ed prech\u00e1dza\u0165 chemick\u00fdmi reakciami sk\u00f4r, ako ich mozog a in\u00e9 syst\u00e9my tela m\u00f4\u017eu re\u00e1lne pou\u017ei\u0165, tak\u017ee je menej pravdepodobn\u00e9, \u017ee bud\u00fa interferova\u0165 s lamotrig\u00ednom. (38)<\/p>\n\n\n\n
\n\n\n\n<\/figure>\n\n\n\nAko a kde m\u00e1m skladova\u0165 svoje v\u00fd\u017eivov\u00e9 doplnky s obsahom 5-MTHF?<\/strong><\/h2>\n\n\n\nJedna renomovan\u00e1 klinika v Clevelande odpor\u00fa\u010da na svojej webovej str\u00e1nke nasledovn\u00e9: \u201eSkladujte pri izbovej teplote od 15 do 30 stup\u0148ov C. Chr\u00e1\u0148te pred svetlom. Tento doplnok v\u00fd\u017eivy sa r\u00fdchlo rozklad\u00e1 a deaktivuje pri p\u00f4soben\u00ed tepla alebo svetla. Nepou\u017eit\u00fd liek po d\u00e1tume exspir\u00e1cie vyho\u010fte.\u201c (37) My v Intelligent Labs pou\u017e\u00edvame neprieh\u013eadn\u00e9 \u010dierne balenie, aby sme ochr\u00e1nili produkt pred p\u00f4soben\u00edm svetla. Skladujte v\u00fd\u017eivov\u00e9 doplnky tak, aby k nim nemali pr\u00edstup mal\u00e9 deti. 5-MTHF je relat\u00edvne bezpe\u010dn\u00fd a pred\u00e1vkovanie nie je smrte\u013en\u00e9. Be\u017enou praxou by pre ka\u017ed\u00e9ho z n\u00e1s malo by\u0165 heslo\u201elep\u0161ie sa spr\u00e1va\u0165 bezpe\u010dne ako nesk\u00f4r \u013eutova\u0165\u201c.<\/p>\n\n\n\n
\n\n\n\nO sprievodcovi<\/strong><\/h2>\n\n\n\nD\u00fafame, \u017ee tento \u010dl\u00e1nok je pre v\u00e1s u\u017eito\u010dn\u00fd. Z d\u00f4vodu neust\u00e1le sa vyv\u00edjaj\u00facej lek\u00e1rskej vedy nepredpokladajte, \u017ee sme v\u00e1m poskytli \u00faplne v\u0161etky inform\u00e1cie, ktor\u00e9 potrebujete vedie\u0165. Ak ste sa do\u010d\u00edtali a\u017e sem, vedzte, \u017ee aj vedci samotn\u00ed diskutuj\u00fa o niektor\u00fdch oblastiach spomenut\u00fdch v tomto \u010dl\u00e1nku. Pam\u00e4tajte tie\u017e, \u017ee tieto inform\u00e1cie nenahr\u00e1dzaj\u00fa rady v\u00e1\u0161ho lek\u00e1ra. Nem\u00f4\u017eeme tvrdi\u0165, \u017ee 5-MTHF je liekom alebo lie\u010dbou na ak\u00fako\u013evek chorobu. Tie\u017e nem\u00f4\u017eeme tvrdi\u0165, \u017ee n\u00e1\u0161 obsah \u010dl\u00e1nku v\u00e1m m\u00f4\u017ee pom\u00f4c\u0165 pri samodiagnostike. Iba v\u00e1\u0161 lek\u00e1r m\u00f4\u017ee poskytn\u00fa\u0165 spr\u00e1vnu diagn\u00f3zu a lie\u010dbu adekv\u00e1tnu v\u00e1\u0161mu zdravotn\u00e9mu stavu. <\/p>\n\n\n\n
\n\n\n\nVedecky potvrden\u00e9 zdroje<\/strong><\/h3>\n\n\n\n- Folic Acid. WebMD. https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1017\/folic-acid<\/a>.<\/li>
- Pach\u00f3n H, Codling K. Fortification with Folic Acid. Asia-Pacific Conference on Human Genetics. http:\/\/ffinetwork.org\/about\/calendar\/2017\/documents\/Fortification_with_Folic_Acid.pdf<\/a>.<\/li>
- Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients. 2011;3(3):370-84. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3257747\/<\/a><\/li>
- Prinz-Langenohl R, Br\u00e4mswig S, Tobolski O, et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C–>T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009;158(8):2014-21. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2807663\/<\/a><\/li>
- Miraglia N, Agostinetto M, Bianchi D, Valoti E. Enhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats. Minerva Ginecol. 2016;68(2):99-105. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27008238<\/a><\/li>
- Estroff Mareno H. The Folate Factor: Among the busiest of B vitamins, folate has a special role in depression treatment. Psychology Today. https:\/\/www.psychologytoday.com\/us\/articles\/201901\/the-folate-factor<\/a><\/li>
- Folate deficiency. MedlinePlus. U.S. National Library of Medicine. https:\/\/medlineplus.gov\/ency\/article\/000354.htm<\/a>.<\/li>
- Fuqua K. Vitamins to Help Break Down Carbs. SFGate. https:\/\/healthyeating.sfgate.com\/vitamins-break-down-carbs-4715.html<\/a>.<\/li>
- Hibbard BM. THE ROLE OF FOLIC ACID IN PREGNANCY*. With Particular Reference to Anaemia, Abruption and Abortion. BJOG: An International Journal of Obstetrics and Gynaecology. 1964;71(4):529-542. doi:10.1111\/j.1471-0528.1964.tb04317.x Retrieved from https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/j.1471-0528.1964.tb04317.x<\/a><\/li>
- Lambrot R, Xu C, Saint-Phar S, et al. Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes. Nature Communications. 2013;4(1). doi:10.1038\/ncomms3889 Retrieved from https:\/\/www.nature.com\/articles\/ncomms3889<\/a><\/li>
- Mayo Clinic Staff. Folate (Folic Acid). Mayo Clinic. https:\/\/www.mayoclinic.org\/drugs-supplements-folate\/art-20364625<\/a>.<\/li>
- Shelton RC, Sloan Manning J, Barrentine LW, Tipa EV. Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial. Prim Care Companion CNS Disord. 2013;15(4):PCC.13m01520. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3869616\/<\/a><\/li>
- Fava M, Mischoulon D. Folate in depression: efficacy, safety, differences in formulations, and clinical issues. J Clin Psychiatry. 2009;70 Suppl 5:12-7. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19909688<\/a><\/li>
- Kiefer D. L-methylfolate for Bipolar Disorder. Relias Media. https:\/\/www.reliasmedia.com\/articles\/141976-l-methylfolate-for-bipolar-disorder<\/a>.<\/li>
- Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005;82(3):627-35. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16155277<\/a><\/li>
- Malouf R, Grimley Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst Rev. 2008;8( 4):CD004514. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18843658<\/a><\/li>
- Ford AH, Flicker L, Alfonso H, et al. Vitamins B(12), B(6), and folic acid for cognition in older men. Neurology. 2010;75(17):1540-7. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20861451<\/a><\/li>
- Anthony K. High Homocysteine Level (Hyperhomocysteinemia). Healthline. https:\/\/www.healthline.com\/health\/homocysteine-levels<\/a>.<\/li>
- Venn BJ, Green TJ, Moser R, Mann JI. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003;77(3):658-62. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12600857<\/a><\/li>
- Corliss J. Folic acid, a B vitamin, lowers stroke risk in people with high blood pressure. Harvard Health Blog. Harvard Health Publishing. https:\/\/www.health.harvard.edu\/blog\/folic-acid-a-b-vitamin-lowers-stroke-risk-in-people-with-high-blood-pressure-201503187810<\/a>.<\/li>
- Cufasso J. Folate Deficiency. Healthline. https:\/\/www.healthline.com\/health\/folate-deficiency<\/a>.<\/li>
- Folic acid in diet. MedlinePlus. https:\/\/medlineplus.gov\/ency\/article\/002408.htm<\/a>.<\/li>
- MTHFR gene variant. Genetic and Rare Diseases Information Center. National Center for Advancing Translational Sciences. U.S. National Institutes of Health. https:\/\/rarediseases.info.nih.gov\/diseases\/10953\/mthfr-gene-mutation<\/a>.<\/li>
- Maffoni S, De Giuseppe R, Stanford FC, Cena H. Folate status in women of childbearing age with obesity: a review. Nutr Res Rev. 2017;30(2):265-71. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6232191<\/a><\/li>
- Parrott J, Frank L, Rabena R, Craggs-Dino L, Isom KA, Greiman L. American Society for Metabolic and Bariatric Surgery Integrated Health Nutritional Guidelines for the Surgical Weight Loss Patient 2016 Update: Micronutrients. Surgery for Obesity and Related Diseases. 2017;13(5):727-741. doi:10.1016\/j.soard.2016.12.018. Retrieved from https:\/\/asmbs.org\/app\/uploads\/2008\/09\/ASMBS-Nutritional-Guidelines-2016-Update.pdf<\/a><\/li>
- McKillop DJ, Pentieva K, Daly D, et al. The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet. Br J Nutr. 2002;88(6):681-8. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12493090<\/a><\/li>
- Fabbri ADT, Crosby GA. A review of the impact of preparation and cooking on the nutritional quality of vegetables and legumes. International Journal of Gastronomy and Food Science. 2016;3:2-11. doi:10.1016\/j.ijgfs.2015.11.001 Retrieved from https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1878450X15000207<\/a><\/li>
- Folic Acid. Office on Women\u2019s Health. U.S. Department of Health and Human Services. https:\/\/www.womenshealth.gov\/a-z-topics\/folic-acid<\/a>.<\/li>
- Folate. Office of Dietary Supplements. U.S. National Institutes of Health. https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/<\/a>.<\/li>
- Mayo Clinic Staff. Folate (Folic Acid). Mayo Clinic. https:\/\/www.mayoclinic.org\/drugs-supplements-folate\/art-20364625<\/a>.<\/li>
- Folic acid: Too much of a good thing? Harvard Heart Letter. Harvard Health Publishing. https:\/\/www.health.harvard.edu\/newsletter_article\/Folic_acid_Too_much_of_a_good_thing<\/a>.<\/li>
- Folate and Brain: Is 5-MTHF (methylfolate) better for the brain than folic acid?. MTHFR Support Australia. https:\/\/mthfrsupport.com.au\/2017\/04\/folate-and-brain\/<\/a>.<\/li>
- Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014;44(5):480-8. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24494987<\/a><\/li>
- Obeid R, Holzgreve W, Pietrzik K. Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects. J Perinat Med. 2013;41(5):469-83. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23482308<\/a><\/li>
- Multum C. L-Methylfolate. Drugs.com<\/a>. https:\/\/www.drugs.com\/mtm\/l-methylfolate.html<\/a><\/li>
- Vitamins and Supplements: Folic Acid. WebMD. https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1017\/folic-acid<\/a>.<\/li>
- Folic Acid, Vitamin B9 tablets. Cleveland Clinic Health Library. https:\/\/my.clevelandclinic.org\/health\/drugs\/18719-folic-acid-vitamin-b9-tablets<\/a>.<\/li>
- Mischoulon D, Zajecka J, Freeman MP, Fava M. Does folic acid interfere with lamotrigine? The Lancet Psychiatry. 2016;3(8):704-705. doi:10.1016\/s2215-0366(16)30167-5. Retrieved from https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(16)30167-5\/fulltext<\/a><\/li>
- Lamers Y, Prinz-Langenohl R, Moser R, Pietrzik K. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. Am J Clin Nutr. 2004;79(3):473-8. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14985224<\/a><\/li><\/ol>\n\n\n\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
\u010co je 5-MTHF? Tento \u010dl\u00e1nok je zameran\u00fd na to, aby v\u00e1m poskytol v\u0161etky u\u017eito\u010dn\u00e9 a na d\u00f4kazoch zalo\u017een\u00e9 inform\u00e1cie o vitam\u00edne B9, fol\u00e1te, kyseline listovej, 5-MTHF a v\u00fd\u017eivov\u00fdch doplnkoch a potravin\u00e1ch, ktor\u00e9 udr\u017euj\u00fa va\u0161u hladinu vitam\u00ednu B9 na adekv\u00e1tnej \u00farovni. Dozviete sa o probl\u00e9moch, ktor\u00e9 m\u00f4\u017eu zn\u00ed\u017ei\u0165 hladinu B9 na nezdravo n\u00edzku hladinu – aj…<\/p>\n","protected":false},"author":2,"featured_media":161286,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[3174,3172,3173],"tags":[3175],"coauthors":[],"class_list":["post-238091","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-novinky","category-vyziva","category-zdravie","tag-5-mthf"],"taxonomy_info":{"category":[{"value":3174,"label":"Novinky"},{"value":3172,"label":"V\u00fd\u017eiva"},{"value":3173,"label":"Zdravie"}],"post_tag":[{"value":3175,"label":"5-MTHF"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-12-1024x512.jpg",1024,512,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/sk-sk\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":3174,"name":"Novinky","slug":"novinky","term_group":0,"term_taxonomy_id":3174,"taxonomy":"category","description":"","parent":0,"count":18,"filter":"raw","cat_ID":3174,"category_count":18,"category_description":"","cat_name":"Novinky","category_nicename":"novinky","category_parent":0},{"term_id":3172,"name":"V\u00fd\u017eiva","slug":"vyziva","term_group":0,"term_taxonomy_id":3172,"taxonomy":"category","description":"","parent":0,"count":46,"filter":"raw","cat_ID":3172,"category_count":46,"category_description":"","cat_name":"V\u00fd\u017eiva","category_nicename":"vyziva","category_parent":0},{"term_id":3173,"name":"Zdravie","slug":"zdravie","term_group":0,"term_taxonomy_id":3173,"taxonomy":"category","description":"","parent":0,"count":21,"filter":"raw","cat_ID":3173,"category_count":21,"category_description":"","cat_name":"Zdravie","category_nicename":"zdravie","category_parent":0}],"tag_info":[{"term_id":3175,"name":"5-MTHF","slug":"5-mthf","term_group":0,"term_taxonomy_id":3175,"taxonomy":"post_tag","description":"","parent":0,"count":2,"filter":"raw"}],"wpml":{"language":"sk-sk","is_original":true,"original_post_id":238091,"translations":{"sk-sk":{"id":238091,"language":"sk-sk","is_original":true}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/comments?post=238091"}],"version-history":[{"count":1,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091\/revisions"}],"predecessor-version":[{"id":238687,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091\/revisions\/238687"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/media\/161286"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/media?parent=238091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/categories?post=238091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/tags?post=238091"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/coauthors?post=238091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- L-5-MTHF<\/li>
- L-metylfol\u00e1t<\/li>
- L-metylfol\u00e1t v\u00e1penat\u00fd (iba ak je viazan\u00fd na v\u00e1penat\u00fa so\u013e)<\/li>
- Metylfol\u00e1t<\/li>
- Kyselina levomefolov\u00e1<\/li><\/ul>\n\n\n\n
U niektor\u00fdch vy\u0161\u0161ie uveden\u00fdch n\u00e1zvov si v\u0161imnite \u201eL\u201c. Toto p\u00edsmeno nazna\u010duje, \u017ee ve\u013ek\u00e1 v\u00e4\u010d\u0161ina \u013eud\u00ed ho dok\u00e1\u017ee absorbova\u0165. \u201c6 (S)\u201c namiesto \u201eL\u201c takisto ozna\u010duje tento pr\u00edpad. Ak je \u201eL\u201c nahraden\u00e9 \u201e6 (R)\u201c, potom v\u00e1m oto zlo\u017eenie pravdepodobne ve\u013emi nepom\u00f4\u017ee.<\/p>\n\n\n\n
\n\n\n\nKtor\u00e9 formy fol\u00e1tu dok\u00e1\u017ee na\u0161e telo najlep\u0161ie absorbova\u0165 a zu\u017eitkova\u0165? <\/strong><\/h2>\n\n\n\n
<\/figure><\/div>\n\n\n\n\u0160t\u00fadia publikovan\u00e1 v British Journal of Pharmacology porovn\u00e1vala absorpciu 6 (S) -5-MTHF v tele s kyselinou listovou. Subjekty boli zdrav\u00e9 \u017eeny, ktor\u00e9 mali probl\u00e9my so vstreb\u00e1van\u00edm fol\u00e1tu a kyseliny listovej zo stravy, preto\u017ee ich g\u00e9ny potrebn\u00e9 na spracovanie t\u00fdchto \u017eiv\u00edn boli chybn\u00e9. 6 (S) -5-MTHF reagoval ove\u013ea lep\u0161ie v z\u00edskavan\u00ed pou\u017eite\u013en\u00e9ho vitam\u00ednu B9 do krvnej plazmy, kde sa za\u010d\u00edna tento magick\u00fd proces. <\/p>\n\n\n\n
V tejto \u0161t\u00fadii vedci pou\u017eili 6 (S) -5-MTHF, ktor\u00fd sa viazal na v\u00e1penat\u00fa so\u013e. \u00c1no, predmetom v\u00fdskumu bola kyselina listov\u00e1, pokia\u013e ide o absorpciu … ALE … \u010eal\u0161ia \u0161t\u00fadia porovn\u00e1vala l\u00e1tky na b\u00e1ze v\u00e1pnika s inou formou 6 (S) -5-MTHF viazanou na glukozam\u00edn namiesto v\u00e1pniku u potkanov. Vedci tie\u017e porovnali obe formy s kyselinou listovou. \u0160t\u00fadia uk\u00e1zala 1,8-kr\u00e1t vy\u0161\u0161iu maxim\u00e1lnu hladinu v plazme ako 5-MTHF viazan\u00e9ho na v\u00e1penat\u00fa so\u013e a 3,1-kr\u00e1t vy\u0161\u0161iu hladinu ako u kyseliny listovej. (5) Preto Intelligent Labs pou\u017e\u00edva 6 (S) -5-MTHF naviazan\u00fd na glukozam\u00edn bez obsahu m\u00e4kk\u00fd\u0161ov. V na\u0161ich doplnkoch pou\u017e\u00edvame patentovan\u00fd vzorec s n\u00e1zvom Quatrefolic Acid\u00ae a pon\u00fakame dve verzie: 1mg 5-MTHF<\/a> and 5mg 5-MTHF<\/a><\/p>\n\n\n\n
5-MTHF existuje aj pod in\u00fdmi n\u00e1zvami<\/strong><\/h2>\n\n\n\n
Metafolin\u00ae<\/strong> – doplnok 5-MTHF vyu\u017e\u00edvaj\u00faci L-metylfol\u00e1t v\u00e1penat\u00fd. Je k dispoz\u00edcii iba prostredn\u00edctvom predajcov s licenciou udelenou jej autormi. Deplin\u00ae<\/strong> – T\u00e1to 5-MTHF formula, ktor\u00e1 je dostupn\u00e1 na lek\u00e1rsky predpis, bola vyvinut\u00e1 tak, aby uspokojila nutri\u010dn\u00e9 potreby pacientov s depresiou a zv\u00fd\u0161ila aktivitu antidepres\u00edv. Quatrefolic Acid\u00ae<\/strong> – op\u00e4\u0165 sme pri zl\u00fa\u010denine, ktor\u00fa pou\u017e\u00edvame aj my v Intelligent Labs. Je medzin\u00e1rodne patentovan\u00e1 spolo\u010dnos\u0165ou Gnosis a je to vedecky najvyspelej\u0161ia formula 5-MTHF na trhu. Tento 5-MTHF je lep\u0161ie absorbovan\u00fd v na\u0161om organizme, preto\u017ee je viazan\u00fd na glukozam\u00edn bez obsahu m\u00e4kk\u00fd\u0161ov namiesto v\u00e1pnika. Spolo\u010dnos\u0165 Intelligent Labs m\u00e1 k dispoz\u00edcii dva doplnky s obsahom 5-MTHF v dvoch r\u00f4znych d\u00e1vkach.<\/p>\n\n\n\n
\n\n\n\nAk\u00e9 zdravotn\u00e9 benefity pre n\u00e1\u0161 organizmus m\u00e1 fol\u00e1t a 5-MTHF?<\/strong><\/h2>\n\n\n\n
Je potrebn\u00fd pre z\u00e1kladn\u00e9 telesn\u00e9 funkcie<\/strong><\/h3>\n\n\n\n
B9 je potrebn\u00fd najm\u00e4 pri t\u00fdchto \u010dinnostiach:<\/strong> (6)(7)(8)<\/p>\n\n\n\n
- Energia zo sacharidov<\/li>
- DNA & RNA<\/li>
- \u010cerven\u00e9 a biele krvinky<\/li>
- Melaton\u00edn, chemick\u00e1 l\u00e1tka, ktor\u00e1 reguluje sp\u00e1nok<\/li>
- D\u00f4le\u017eit\u00e9 neurotransmitery ako norepinefr\u00edn, seroton\u00edn a dopam\u00edn<\/li>
- Nervov\u00fd syst\u00e9m<\/li><\/ul>\n\n\n\n<\/figure>\n\n\n\n
Zabra\u0148uje vzniku vroden\u00fdch ch\u00fdb plodu po\u010das tehotenstva<\/strong><\/h3>\n\n\n\n
Poskytovatelia zdravotnej starostlivosti \u010dasto odpor\u00fa\u010daj\u00fa, aby si tehotn\u00e9 \u017eeny dop\u013a\u0148ali fol\u00e1t u\u017e po\u010das tehotenstva, aby sa zabr\u00e1nilo vroden\u00fdm chyb\u00e1m, ako s\u00fa poruchy neur\u00e1lnej trubice. D\u00f4vod je jednoduch\u00fd – \u00fa\u010dinok nedostatku fol\u00e1tov na v\u00fdvoj die\u0165a\u0165a bol sk\u00faman\u00fd pomerne extenz\u00edvne. (9) Na v\u00fdvoj nervov\u00e9ho syst\u00e9mu po\u010das tehotenstva je potrebn\u00fd dostatok fol\u00e1tu, ie to k\u013e\u00fa\u010dov\u00e1 f\u00e1za u\u017e od samotn\u00e9ho za\u010diatku tehotenstva. \u017deny si zvy\u010dajne neuvedomuj\u00fa, \u017ee s\u00fa tehotn\u00e9, \u010dastokr\u00e1t na to pr\u00eddu a\u017e po nieko\u013ek\u00fdch t\u00fd\u017ed\u0148och. Aj ke\u010f sa st\u00e1le sna\u017e\u00edte otehotnie\u0165, je dobr\u00e9 sa uisti\u0165, \u017ee hladina va\u0161ej kyseliny listovej v organizme m\u00e1 adekv\u00e1tne spr\u00e1vnu \u00farove\u0148. (6)<\/p>\n\n\n\n
P\u00e1ni, nie\u010do aj pre v\u00e1s!<\/strong><\/h3>\n\n\n\n
Mu\u017ei, ktor\u00ed sa sna\u017eia po\u010da\u0165 die\u0165a, by sa tie\u017e mali ubezpe\u010di\u0165, \u017ee netrpia nedostatkom fol\u00e1tu. \u0160t\u00fadia z roku 2013 zistila, \u017ee mu\u017ei, ktor\u00ed nemaj\u00fa po\u010das obdobia, kedy sa pok\u00fa\u0161ali splodi\u0165 die\u0165a, zdrav\u00e9 hladiny tohto vitam\u00ednu, mohli prispie\u0165 k zna\u010dn\u00e9mu zv\u00fd\u0161eniu pravdepodobnosti vzniku deform\u00e1ci\u00ed. (10) \u017den\u00e1m sa dokona odpor\u00fa\u010da, aby za\u010dali s u\u017e\u00edvan\u00edm v\u00fd\u017eivov\u00fdch doplnkov u\u017e nieko\u013eko mesiacov pred po\u010dat\u00edm, aby sa zv\u00fd\u0161ila \u0161anca na po\u010datie a donosenie zdrav\u00e9ho die\u0165a\u0165a. (11)<\/p>\n\n\n\n
Mo\u017en\u00e9 zn\u00ed\u017eenie rizika vzniku depresie a \/ alebo lep\u0161\u00ed \u00fa\u010dinok antidepres\u00edv<\/strong><\/h3>\n\n\n\n
Deplin\u00ae, liekov\u00e1 forma 5-MTHF, bola patentovan\u00e1 \u0161peci\u00e1lne na lie\u010dbu depresie a zvy\u0161ovanie \u00fa\u010dinku u\u017e\u00edvania antidepres\u00edv u pacientov s depresiou. Sp\u00f4sob, ak\u00fdm 5-MTHF pom\u00e1ha pri depresi\u00e1ch, nie je zn\u00e1my, ale \u0161t\u00fadie ukazuj\u00fa, \u017ee v\u00fd\u017eivov\u00e9 doplnky s jeho obsahom m\u00f4\u017eu by\u0165 u\u017eito\u010dn\u00e9. \u0160t\u00fadie zameran\u00e9 na depresiu zvy\u010dajne pou\u017e\u00edvaj\u00fa ve\u013emi vysok\u00e9 d\u00e1vky v porovnan\u00ed s be\u017en\u00fdm pou\u017eit\u00edm u\u017e\u00edvate\u013eov. <\/p>\n\n\n\n
V \u0161t\u00fadii z roku 2013, ktor\u00e1 zah\u0155\u0148ala viac ako 500 pacientov lie\u010den\u00fdch na depresiu, automatick\u00e9 telefonick\u00e9 prieskumy nazna\u010dili lep\u0161iu priemern\u00fa kvalitu \u017eivota a vy\u0161\u0161iu spokojnos\u0165 s liekmi na depresiu u\u017e po troch mesiacoch u\u017e\u00edvania. Zlep\u0161ila sa aj spokojnos\u0165 so vz\u0165ahmi s pr\u00edbuzn\u00fdmi, priate\u013emi, spolupracovn\u00edkmi, partnermi a nezn\u00e1mymi \u013eu\u010fmi. Celkov\u00e9 rozdiely po 95 d\u0148och boli naozaj signifikantn\u00e9. Subjekty pou\u017e\u00edvali super \u00fa\u010dinn\u00fa formu predp\u00edsan\u00e9ho 5-MTHF. Ka\u017ed\u00e1 d\u00e1vka bola bu\u010f 7,5 mg alebo 15 mg. Po\u010diato\u010dn\u00e1 d\u00e1vka pre be\u017en\u00fdch pou\u017e\u00edvate\u013eov 5-MTHF bez depresie je zvy\u010dajne 1 mg alebo e\u0161te ni\u017e\u0161ia. (12) <\/p>\n\n\n\n
Jedn\u00fdm z d\u00f4vodov t\u00fdchto v\u00fdhod u pacientov s depresiou m\u00f4\u017ee by\u0165 fakt, \u017ee fol\u00e1t je nevyhnutnou s\u00fa\u010das\u0165ou v\u00fdroby hlavn\u00fdch neurotransmiterov, ako je seroton\u00edn, dopam\u00edn a norepinefr\u00edn, a m\u00f4\u017ee ich pom\u00e1ha\u0165 aj regulova\u0165. (13) 5-MTHF m\u00f4\u017ee dobre fungova\u0165 aj pri niektor\u00fdch pr\u00edznakoch bipol\u00e1rnej poruchy. \u0160es\u0165t\u00fd\u017ed\u0148ov\u00e1 \u0161t\u00fadia s 10 \u00fa\u010dastn\u00edkmi s ve\u013ekou mierou depresie a bipol\u00e1rnou poruchou preuk\u00e1zala s\u013eubn\u00e9 v\u00fdsledky: (14)<\/strong> \u201eVedci zistili, \u017ee u pacientov s bipol\u00e1rnou poruchou u\u017e\u00edvaj\u00facich L-metylfol\u00e1t sa preuk\u00e1zalo zlep\u0161enie sympt\u00f3mov depresie, be\u017en\u00e9ho fungovania, sebapozn\u00e1vania a zn\u00ed\u017eenie samovra\u017eedn\u00fdch my\u0161lienok.\u201c<\/em> UPOZORNENIE: Ak trp\u00edte depresiou, v\u017edy sa pora\u010fte so svoj\u00edm lek\u00e1rom sk\u00f4r, ako za\u010dnete pou\u017e\u00edva\u0165 ak\u00fako\u013evek formu doplnku kyseliny listovej, a to aj v n\u00edzkych d\u00e1vkach.<\/p>\n\n\n\n
Redukcia homocyste\u00ednu, z\u00e1palovej l\u00e1tky<\/strong><\/h3>\n\n\n\n
Homocyste\u00edn je zl\u00fa\u010denina v \u013eudskom tele, ktor\u00e1 zvy\u0161uje z\u00e1pal. Mnoho chor\u00f4b m\u00e1 p\u00f4vod pr\u00e1ve v z\u00e1pale. Vysok\u00e9 hladiny homocyste\u00ednu m\u00f4\u017eu zvy\u0161ova\u0165 riziko<\/strong>: (18)<\/p>\n\n\n\n
- Krvn\u00fdch zrazen\u00edn<\/li>
- M\u0155tvice<\/li>
- Alzheimer\u2019s Alzheimerovej choroby<\/li>
- Srdcov\u00e9ho infarktu<\/li>
- Ischemickej choroby srdca<\/li>
- Osteopor\u00f3zy<\/li>
- Ateroskler\u00f3zy<\/li><\/ul>\n\n\n\n
Vysok\u00e9 hladiny tejto zl\u00fa\u010deniny s\u00favisia s n\u00edzkou hladinou vitam\u00ednov B6, B9 a B12. T\u00e1to kombin\u00e1cia je siln\u00fdm prediktorom kognit\u00edvneho poklesu u mu\u017eov a pravdepodobne aj u \u017eien. (15) Zdrav\u00e9 hladiny v\u0161etk\u00fdch troch konkr\u00e9tnych vitam\u00ednov skupiny B s\u00fa d\u00f4le\u017eit\u00e9 pre udr\u017eanie homocyste\u00ednu pod kontrolou. 5-MTHF m\u00f4\u017ee zabr\u00e1ni\u0165 ur\u010dit\u00e9mu kognit\u00edvnemu poklesu, ale je ur\u010dite vhodn\u00e9 a odpor\u00fa\u010dan\u00e9, ak si budete udr\u017eiava\u0165 adekv\u00e1tne hladiny aj \u010fal\u0161\u00edch dvoch. (15) (16) (17) Medzi \u010fal\u0161ie pr\u00ed\u010diny vysokej hladiny homocyste\u00ednu patria: probl\u00e9my s hypotyre\u00f3zou, choroby obli\u010diek a psori\u00e1za. <\/p>\n\n\n\n
Neobvi\u0148ujte automaticky za tieto diagn\u00f3zy nedostatok vitam\u00ednu B. (18) Ako ste u\u017e \u010d\u00edtali vy\u0161\u0161ie, z\u00e1kony v desiatkach kraj\u00edn zn\u00ed\u017eili obsah homocyste\u00ednu nariaden\u00edm, aby boli m\u00faky obohaten\u00e9 kyselinou listovou. 24-t\u00fd\u017ed\u0148ov\u00e1 randomizovan\u00e1 placebo \u0161t\u00fadia preuk\u00e1zala, \u017ee 5-MTHF je pri zni\u017eovan\u00ed hlad\u00edn homocyste\u00ednu u zdrav\u00fdch \u013eud\u00ed ove\u013ea efekt\u00edvnej\u0161\u00ed ako kyselina listov\u00e1. (19)<\/p>\n\n\n\n
Mo\u017en\u00e9 zn\u00ed\u017eenie rizika m\u0155tvice a srdcov\u00e9ho infarktu<\/strong><\/h3>\n\n\n\n
5-MTHF by mohol zlep\u0161i\u0165 zdravie srdca a krvn\u00e9ho obehu zn\u00ed\u017een\u00edm hladiny homocyste\u00ednu a \u010fal\u0161\u00edmi mechanizmami. Je to v\u0161ak komplikovan\u00e9. Riziko srdcov\u00e9ho infarktu alebo cievnej mozgovej pr\u00edhody by sa mohlo zn\u00ed\u017ei\u0165 iba vtedy, ak m\u00e1te nedostatok fol\u00e1tu. <\/p>\n\n\n\n
<\/figure>\n\n\n\nPrin\u00e1\u0161ame zhrnutie k\u013e\u00fa\u010dov\u00fdch faktov, ktor\u00e9 s\u00fa zauj\u00edmav\u00e9 minim\u00e1lne tak, ako dobr\u00e1 detekt\u00edvka … \u0160t\u00fadia z roku 2015 zistila, \u017ee mu\u017ei, ktor\u00ed si dop\u013a\u0148ali kyselinu listov\u00fa a u\u017e\u00edvali enalapril, liek zni\u017euj\u00faci krvn\u00fd tlak, mali zn\u00ed\u017een\u00e9 riziko mozgovej pr\u00edhody po\u010das nasleduj\u00facich 4,5 rokov. V\u00fdsledky boli v\u00fdznamn\u00e9 pre skupinu s u\u017e\u00edvan\u00edm kyseliny listovej a enalaprilu v porovnan\u00ed so skupinou, ktor\u00e1 u\u017e\u00edvala iba enalapril. Zd\u00e1 sa, \u017ee aj star\u00e9 \u0161t\u00fadie zo 70. rokov ukazuj\u00fa zn\u00ed\u017een\u00e9 riziko m\u0155tvice a srdcov\u00e9ho infarktu v d\u00f4sledku zv\u00fd\u0161en\u00e9ho u\u017e\u00edvania fol\u00e1tov. (20) <\/p>\n\n\n\n
Na druhej strane niektor\u00e9 \u0161t\u00fadie z USA, zalo\u017een\u00e9 na placebe, nepreuk\u00e1zali zn\u00ed\u017eenie rizika m\u0155tvice alebo srdcov\u00e9ho infarktu. To by mohlo znamena\u0165, \u017ee fol\u00e1t vykazuje tento efekt\u00edvny \u00fa\u010dinok iba vtedy, ke\u010f ho maj\u00fa pacienti nedostatok. <\/p>\n\n\n\n
Pripome\u0148me, \u017ee USA za\u010dali posil\u0148ova\u0165 jeho obsah v obilnin\u00e1ch v roku 1998, \u010do by mohlo vysvetli\u0165 niektor\u00e9 v\u00fdsledky zo 70. rokov. \u013dudia mali vtedy jednoducho ni\u017e\u0161iu hladinu fol\u00e1tov. (20) \u010c\u00edna neposil\u0148uje obilniny obsahom fol\u00e1tov, \u010do znamen\u00e1, \u017ee aj ich popul\u00e1cia m\u00f4\u017ee trpie\u0165 jeho nedostatkom. Niektor\u00e9 zo star\u00fdch americk\u00fdch \u0161t\u00fadi\u00ed sledovali \u013eud\u00ed, ktor\u00ed mali v minulosti mozgov\u00fa pr\u00edhodu a infarkt. Ako reakciu na tieto udalosti mohli t\u00edto pacienti zn\u00ed\u017ei\u0165 riziko u\u017e\u00edvan\u00edm in\u00fdch liekov a potrav\u00edn, ako bola napr\u00edklad aj kyselina listov\u00e1. (20)<\/p>\n\n\n\n
\n\n\n\nAko zisti\u0165, \u010di trp\u00edte nedostatkom kyseliny listovej?<\/strong><\/h2>\n\n\n\n
Niektor\u00e9 pr\u00edznaky signalizuj\u00fa, \u017ee nedostatok fol\u00e1tu sp\u00f4sobuje an\u00e9miu (nedostatok \u010derven\u00fdch krviniek) Chronick\u00e9 spomalenie organizmu a \u00fanava: <\/strong>(21)<\/p>\n\n\n\n
- Neschopnos\u0165 sa poriadne nad\u00fdchnu\u0165<\/li>
- V\u00fdbu\u0161nos\u0165, mrzutos\u0165 a podr\u00e1\u017edenos\u0165<\/li>
- Poko\u017eka vyzer\u00e1 mimoriadne bledo<\/li>
- \u010eal\u0161ie pr\u00edznaky nedostatku kysl\u00edka v krvi, napr\u00edklad probl\u00e9my s pam\u00e4\u0165ou<\/li><\/ul>\n\n\n\n
\u010eal\u0161ie pr\u00edznaky nedostatku fol\u00e1tu<\/strong>: (22)<\/p>\n\n\n\n
- Pred\u010dasn\u00e9 \u0161edivenie vlasov<\/li>
- Opuchnut\u00fd jazyk<\/li>
- Rany alebo vredy v \u00fastach<\/li>
- Die\u0165a m\u00e1 vroden\u00e9 chyby a deform\u00e1cie a vy ste jedn\u00fdm z rodi\u010dov<\/li>
- Hna\u010dka<\/li>
- Probl\u00e9my s rastom<\/li><\/ul>\n\n\n\n
Samodiagnostika nedostatku fol\u00e1tu je zlo\u017eit\u00e1. Je to \u010diasto\u010dne preto, \u017ee pr\u00edznaky nedostatku fol\u00e1tu a in\u00fdch vitam\u00ednov skupiny B sa navz\u00e1jom prekr\u00fdvaj\u00fa. V\u00e1\u0161 lek\u00e1r pravdepodobne vykon\u00e1 testy na vyl\u00fa\u010denie pr\u00ed\u010din a in\u00fdch pr\u00edznakov.<\/p>\n\n\n\n
\n\n\n\n\u010co sp\u00f4sobuje nedostatok fol\u00e1tu a kyseliny listovej?<\/strong><\/h2>\n\n\n\n
Strava bez potrav\u00edn, ktor\u00e9 maj\u00fa vysok\u00fd obsah fol\u00e1tov<\/strong><\/h3>\n\n\n\n
Ak nejed\u00e1vate dostatok fazule, vajec, zelenej zeleniny a in\u00fdch potrav\u00edn alebo v\u00fd\u017eivov\u00fdch doplnkov bohat\u00fdch na fol\u00e1ty, pravdepodobne budete ma\u0165 nedostatok fol\u00e1tu v tele.<\/p>\n\n\n\n
<\/figure>\n\n\n\n\u010co br\u00e1ni vstreb\u00e1vaniu fol\u00e1tov zo stravy a v\u00fd\u017eivov\u00fdch doplnkov<\/strong><\/h3>\n\n\n\n
Zl\u00e9 vstreb\u00e1vanie kyseliny listovej a fol\u00e1tov zo stravy m\u00f4\u017ee sp\u00f4sobi\u0165 ve\u013ea faktorov, vr\u00e1tane: <\/strong>(21)<\/p>\n\n\n\n
- Ochorenie ako Crohnova choroba, celiakia, niektor\u00e9 druhy rakoviny a poruchy obli\u010diek<\/li>
- Poruchy g\u00e9nu MTHFR, ktor\u00e9 s\u00fa be\u017en\u00e9<\/li>
- Interakcie s liekmi, ktor\u00e9 interferuj\u00fa s fol\u00e1tom<\/li>
- Nadmern\u00e9 u\u017e\u00edvanie alkoholu alebo antac\u00edd<\/li>
- Mut\u00e1cia g\u00e9nov zodpovedn\u00fdch za metaboliz\u00e1ciu fol\u00e1tu<\/li><\/ul>\n\n\n\n
Kyselina listov\u00e1 a pr\u00edrodn\u00fd fol\u00e1t v potravin\u00e1ch musia prejs\u0165 mnoh\u00fdmi chemick\u00fdmi reakciami, k\u00fdm sa z nich stane 5-MTHF, jedin\u00e1 u\u017eito\u010dn\u00e1 forma. V\u00e4\u010d\u0161ina z n\u00e1s metabolizuje fol\u00e1t a kyselinu listov\u00fa a efekt\u00edvne ich transformuje na 5-MTHF. Existuje g\u00e9n, ktor\u00fd riadi tento proces. Vol\u00e1 sa MTHFR a ka\u017ed\u00fd m\u00e1me jeho dve k\u00f3pie. Mnoh\u00ed z n\u00e1s v\u0161ak maj\u00fa vari\u00e1cie jednej alebo oboch t\u00fdchto g\u00e9nov\u00fdch k\u00f3pi\u00ed, ktor\u00e9 neumo\u017e\u0148uj\u00fa transform\u00e1cie na 5-MTHF. Ak je jedna k\u00f3pia g\u00e9nu nedostato\u010dn\u00e1 pre absorpciu fol\u00e1tu, \u00fa\u010dinnos\u0165 spracovania m\u00f4\u017ee by\u0165 ve\u013emi ovplyvnen\u00e1. Ak s\u00fa obe k\u00f3pie zl\u00e9, nebudete metabolizova\u0165 takmer \u017eiadne mno\u017estvo fol\u00e1tu alebo kyseliny listovej. (23) <\/p>\n\n\n\n
Ako zist\u00edte, \u017ee m\u00e1te jednu alebo dve zl\u00e9 mut\u00e1cie g\u00e9nu MTHFR? Budete musie\u0165 podst\u00fapi\u0165 test DNA a necha\u0165 ho posla\u0165 do medic\u00ednskeho laborat\u00f3ria. Laborat\u00f3ri\u00e1 na tento \u00fa\u010del n\u00e1jdete vo va\u0161om okol\u00ed aj online. Najsk\u00f4r si d\u00f4kladne pre\u0161tudujte, \u010do laborat\u00f3rium pon\u00faka alebo nechajte lek\u00e1ra vybra\u0165 laborat\u00f3rium za v\u00e1s. S\u00favislos\u0165 medzi obezitou a nedostato\u010dnou hladinou fol\u00e1tov je ve\u013emi siln\u00e1, ale zd\u00e1 sa, \u017ee nikto nepri\u0161iel na to, pre\u010do. <\/p>\n\n\n\n
Obezita<\/strong><\/p>\n\n\n\n
V preh\u013eade \u0161t\u00fadi\u00ed publikovan\u00fdch v rokoch 2005 a\u017e 2015 sa sk\u00famali hladiny fol\u00e1tov u ob\u00e9znych \u017eien v \u201eplodnom veku\u201c so zvl\u00e1\u0161tnym d\u00f4razom na tehotn\u00e9 \u017eeny. Cie\u013eom vedcov bolo presk\u00fama\u0165 mo\u017en\u00e9 pr\u00ed\u010diny vysok\u00e9ho percenta deficitu fol\u00e1tu u t\u00fdchto \u017eien. Spomenuli by sme britsk\u00fa \u0161t\u00fadiu, ktor\u00e1 vyl\u00fa\u010dila faktory ako vitam\u00ednov\u00e9 doplnky, strava a vek. Pouk\u00e1zali by sme tie\u017e na nieko\u013eko \u010fal\u0161\u00edch \u0161t\u00fadi\u00ed, ktor\u00e9 vyl\u00fa\u010dili stravu ako pr\u00ed\u010dinu. Jedin\u00e9, \u010do bolo mo\u017en\u00e9 urobi\u0165, bolo odporu\u010di\u0165 viac \u0161t\u00fadi\u00ed o tejto skuto\u010dnosti plus tipy, ako v nich pokra\u010dova\u0165. (24) Dedukujeme: Samotn\u00e1 obezita alebo konkr\u00e9tne pr\u00ed\u010diny obezity by mohli zn\u00ed\u017ei\u0165 hladinu kyseliny listovej na nezdrav\u00fa \u00farove\u0148. Korel\u00e1cia je siln\u00e1 a v\u0161etky ot\u00e1zky sa t\u00fdkaj\u00fa toho, \u010do k \u010domu vedie. <\/p>\n\n\n\n
\u010eal\u0161ia \u0161t\u00fadia zaznamenala siln\u00fa korel\u00e1ciu medzi obezitou a nedostatkom fol\u00e1tov: V roku 2016 vedci presk\u00famali \u0161t\u00fadie so z\u00e1merom aktualizova\u0165 pokyny Americkej spolo\u010dnosti pre metabolick\u00fa a bariatrick\u00fa chirurgiu z roku 2008 t\u00fdkaj\u00face sa v\u00fd\u017eivy v bariatrickej chirurgii. Pokyny s\u00fa zalo\u017een\u00e9 na \u0161t\u00fadi\u00e1ch sk\u00famaj\u00facich hladinu \u017eiv\u00edn pred a po chirurgick\u00fdch z\u00e1krokoch na zn\u00ed\u017eenie hmotnosti. Nov\u00e9 odpor\u00fa\u010dania z roku 2016 odpor\u00fa\u010daj\u00fa skr\u00edning na nedostatok fol\u00e1tov pred t\u00fdmto typom oper\u00e1cie. D\u00f4vodom je fakt, \u017ee a\u017e 54% ob\u00e9znych pacientov m\u00e1 nedostatok fol\u00e1tov. (25) Vedci nemali v \u00famysle v tomto pr\u00edpade sk\u00fama\u0165 pr\u00ed\u010dinu a n\u00e1sledok. V\u0161\u00edmali si len s\u00favislos\u0165 a reagovali na \u0148u odpor\u00fa\u010dan\u00edm monitorovania a dopl\u0148ovania fol\u00e1tov pred chirurgick\u00fdm z\u00e1krokom.<\/p>\n\n\n\n
\n\n\n\nSp\u00f4sob, ako vyrie\u0161i\u0165 tento probl\u00e9m s g\u00e9nov\u00fdmi vari\u00e1ciami, je pou\u017ei\u0165 doplnok 5-MTHF, ktor\u00fd pre spr\u00e1vne pou\u017eitie v tele, nevy\u017eaduje s\u00e9riu chemick\u00fdch reakci\u00ed. In\u00fdmi slovami, 5-MTHF je u\u017e bioakt\u00edvny.<\/p>\n\n\n\n
<\/h3>\n\n\n\n
Ni\u010d\u00ed tepeln\u00e1 \u00faprava potrav\u00edn bohat\u00fdch na fol\u00e1ty, fol\u00e1ty samot<\/strong>n\u00e9<\/strong>?<\/strong><\/h2>\n\n\n\n
<\/figure>\n\n\n\nTo, \u010di varenie zn\u00ed\u017ei obsah fol\u00e1tov v potravin\u00e1ch, z\u00e1vis\u00ed od jedla, sp\u00f4sobu varenia a \u010dasu varenia. Be\u017en\u00e9 \u010dasy varu m\u00f4\u017eu zredukova\u0165 zhruba polovicu kyseliny listovej v \u0161pen\u00e1te a brokolici, ale varen\u00edm v pare sa obsah kyseliny listovej v\u00f4bec nezn\u00ed\u017ei. Zd\u00e1 sa, \u017ee ani varenie zemiakov a grilovanie m\u00e4sa nezni\u017euje hladinu fol\u00e1tu, aj ke\u010f ich var\u00edte dlh\u0161ie ako zvy\u010dajne. (26) Varen\u00edm cibule sa zn\u00ed\u017ei obsah kyseliny listovej o 35%, zatia\u013e \u010do pri pe\u010den\u00ed sa z nej eliminuje iba 15%. Ukazuje sa tie\u017e, \u017ee varen\u00fd hr\u00e1\u0161ok si zachov\u00e1va najviac fol\u00e1tu v porovnan\u00ed s in\u00fdmi met\u00f3dami varenia. Ak var\u00edte fazu\u013eu dve hodiny a potom ju bu\u010f upe\u010diete alebo vypra\u017e\u00edte, strat\u00ed a\u017e 50% obsahu. Jedna \u0161t\u00fadia odpor\u00fa\u010da namo\u010di\u0165 ju do slanej vody a potom ju prevari\u0165 v \u010derstvej vode, aby sa zachovalo \u010do najviac v\u00fd\u017eivn\u00fdch l\u00e1tok. (27)<\/p>\n\n\n\n
\n\n\n\nPotrebuj\u00fa tehotn\u00e9 \u017eeny alebo \u017eeny sna\u017eiace sa otehotnie\u0165 extra pr\u00edjem kyseliny listovej? <\/strong><\/h2>\n\n\n\n
V lek\u00e1rskej komunite v\u0161eobecne prevl\u00e1da n\u00e1zor,, \u017ee udr\u017eiava\u0165 hladinu fol\u00e1tu na rovnakej \u00farovni je dobr\u00fd n\u00e1pad. S najv\u00e4\u010d\u0161ou pravdepodobnos\u0165ou tak predch\u00e1dzate niektor\u00fdm typom vroden\u00fdch ch\u00fdb a siln\u00e1 korel\u00e1cia to len potvrdzuje. Ako u\u017e bolo uveden\u00e9 vy\u0161\u0161ie, v tele potrebujete ve\u013ea bioakt\u00edvneho fol\u00e1tu od chv\u00edle, ke\u010f otehotniete, aby ste zaistili spr\u00e1vny v\u00fdvoj nervov\u00e9ho syst\u00e9mu die\u0165a\u0165a. To by mohlo znamena\u0165, \u017ee tento proces je vhodn\u00e9 za\u010da\u0165 u\u017e od momentu, kedy sa st\u00e1le sna\u017e\u00edte otehotnie\u0165. Suplement\u00e1cia 5-MTHF je najistej\u0161\u00ed sp\u00f4sob, ako zisti\u0165, \u017ee va\u0161e telo skuto\u010dne absorbuje dostatok fol\u00e1tu. Ak ste tehotn\u00e1, pora\u010fte sa so svoj\u00edm lek\u00e1rom. Neu\u017e\u00edvajte v\u00fd\u017eivov\u00e9 doplnky bez pokynov lek\u00e1ra, ktor\u00e9 prisp\u00f4sob\u00ed na mieru va\u0161im jedine\u010dn\u00fdm okolnostiam a na z\u00e1klade d\u00f4kladn\u00e9ho laborat\u00f3rneho testovania.<\/p>\n\n\n\n
\n\n\n\nJe mo\u017en\u00e9 ma\u0165 v tele nadbytok kyseliny listovej?<\/strong><\/h2>\n\n\n\n
V lek\u00e1rskej vede ide o kontroverzn\u00fa t\u00e9mu. Niektor\u00ed vedci tvrdia, \u017ee vo va\u0161om tele m\u00f4\u017ee kolova\u0165 a\u017e pr\u00edli\u0161 ve\u013ea kyseliny listovej, \u010do m\u00f4\u017ee sp\u00f4sobi\u0165 zdravotn\u00e9 probl\u00e9my. (28) Kv\u00f4li kontroverzii a potrebe \u010fal\u0161\u00edch \u0161t\u00fadi\u00ed m\u00f4\u017eete n\u00e1js\u0165 r\u00f4zne vl\u00e1dne zdravotn\u00edcke agent\u00fary, ktor\u00e9 sa odmietaj\u00fa v t\u00fdchto diskusi\u00e1ch postavi\u0165 na kohoko\u013evek stranu a odpor\u00fa\u010daj\u00fa spotrebite\u013eom, aby rad\u0161ej ni\u010d neu\u017e\u00edvali.. Ni\u010d z toho sa v\u0161ak pravdepodobne net\u00fdka 5-MTHF alebo fol\u00e1tu zo stravy, ktor\u00fd sa prirodzene vytv\u00e1ra v potravin\u00e1ch. \u010co m\u00f4\u017ee sp\u00f4sobi\u0165 pr\u00edli\u0161 ve\u013ea kyseliny listovej?<\/p>\n\n\n\n
Mo\u017enos\u0165 maskovania pr\u00edznakov nedostatku vitam\u00ednu B12<\/strong><\/h3>\n\n\n\n
Pr\u00edli\u0161 ve\u013ea kyseliny listovej vo va\u0161om tele m\u00f4\u017ee zamaskova\u0165 pr\u00edznaky megaloblastickej an\u00e9mie sp\u00f4sobenej nedostatkom vitam\u00ednu B12. Nejde o konsenzus. Pre vedcov je to st\u00e1le z\u00e1hada. Ak je to pravda, potom si lek\u00e1r m\u00f4\u017ee \u013eahko zm\u00fdli\u0165 stanoven\u00fa diagn\u00f3zu. To m\u00f4\u017ee zhor\u0161i\u0165 ak\u00e9ko\u013evek probl\u00e9my spojen\u00e9 s krvou a po\u0161kodi\u0165 v\u00e1\u0161 mozog a nervov\u00fd syst\u00e9m. Po\u0161kodenie mozgu m\u00f4\u017ee sp\u00f4sobi\u0165 r\u00fdchly kognit\u00edvny pokles a zm\u00e4tok v tele. (29) Existuje zhoda v tom, \u017ee tento probl\u00e9m sa net\u00fdka 5-MTHF, na ktor\u00fd sa menia ostatn\u00e9 formy, ke\u010f s\u00fa spr\u00e1vne metabolizovan\u00e9. <\/p>\n\n\n\n
Konzum\u00e1cia pr\u00edli\u0161 ve\u013ea fazule, pomaran\u010dov alebo zelenej zeleniny s vysok\u00fdm obsahom kyseliny listovej tie\u017e nie je probl\u00e9mom, o ktor\u00fd sa zdravotn\u00edci zrejme ob\u00e1vaj\u00fa. (39) Nedostatok vitam\u00ednu B12 sa pova\u017euje za v\u00e4\u010d\u0161\u00ed probl\u00e9m pre vegetari\u00e1nov a star\u0161\u00edch dospel\u00fdch ako pre v\u00e4\u010d\u0161inu ostatn\u00fdch. Vegetari\u00e1nska strava nedod\u00e1va dostatok tohto vitam\u00ednu a star\u0161\u00ed dospel\u00ed ho dokonca \u0165a\u017eko absorbuj\u00fa. Obe skupiny m\u00f4\u017eu dop\u013a\u0148a\u0165 vitam\u00edn B12 sublingv\u00e1lne (pod jazyk). <\/p>\n\n\n\n
<\/h3>\n\n\n\n
<\/figure>\n\n\n\nPoruchy sp\u00e1nku a zv\u00fd\u0161en\u00e1 n\u00e1ladovos\u0165<\/strong><\/h3>\n\n\n\n
Pr\u00edli\u0161 ve\u013ea kyseliny listovej, najm\u00e4 ak sa u\u017e\u00edva v doplnkoch v\u00fd\u017eivy, m\u00f4\u017ee sp\u00f4sobi\u0165 probl\u00e9my so sp\u00e1nkom a podr\u00e1\u017edenos\u0165. (30)<\/p>\n\n\n\n
Nevo\u013enos\u0165 a strata chuti do jedla<\/strong><\/h3>\n\n\n\n
Niektor\u00ed \u013eudia m\u00f4\u017eu strati\u0165 chu\u0165 do jedla alebo ochorie\u0165, najm\u00e4 ak prij\u00edmaj\u00fa pr\u00edli\u0161 ve\u013ea kyseliny listovej z v\u00fd\u017eivov\u00fdch doplnkov alebo multivitam\u00ednov. (30)<\/p>\n\n\n\n
Rie\u0161enie<\/strong><\/h3>\n\n\n\n
Ak u\u017e\u00edvate v\u00fd\u017eivov\u00fd doplnok s obsahom fol\u00e1tu, uistite sa, \u017ee je v bioakt\u00edvnej forme: 5-MTHF. Pre\u010d\u00edtajte si etikety na va\u0161ich multivitam\u00ednoch. Obsahuj\u00fa pr\u00edli\u0161 ve\u013ea kyseliny listovej? V\u00e4\u010d\u0161ina dospel\u00fdch by mala prij\u00edma\u0165 asi 0,5 mg kyseliny listovej denne. Pre\u010d\u00edtajte si etikety aj na chlebe a obilnin\u00e1ch. Ak u\u017e\u00edvate doplnok 5-MTHF, potom sa sna\u017ete udr\u017eiava\u0165 kyselinu listov\u00fa v obohaten\u00fdch potravin\u00e1ch na minime a vyh\u00fdbajte sa multivitam\u00ednom obsahuj\u00facim kyselinu listov\u00fa. M\u00f4\u017ee, ale nemus\u00ed to by\u0165 probl\u00e9m, ktor\u00fd interferuje s 5-MTHF. <\/p>\n\n\n\n
\u00darad pre doplnky v\u00fd\u017eivy N\u00e1rodn\u00e9ho \u00fastavu zdravotn\u00edctva USA stanovil odpor\u00fa\u010dan\u00fa denn\u00fa horn\u00fa hranicu 1 mg pre kyselinu listov\u00fa, ktor\u00e1 poch\u00e1dza z obohaten\u00fdch obiln\u00edn a doplnkov. Nestanovili v\u0161ak limit pre fol\u00e1ty poch\u00e1dzaj\u00face zo zeleniny alebo z 5-MTHF. (29) Pod\u013ea Harvardsk\u00e9ho zdravotn\u00e9ho in\u0161tit\u00fatu sa kyselina listov\u00e1 z obiln\u00edn m\u00f4\u017ee v tele r\u00fdchlo hromadi\u0165 (31). Pozrite si \u00fadaje ni\u017e\u0161ie. Be\u017en\u00e9 potraviny obohaten\u00e9 o kyselinu listov\u00fa:<\/strong><\/p>\n\n\n\n
- Miska \u0161peci\u00e1lnych K cere\u00e1li\u00ed: 0,394 mg<\/li>
- Porcia pracl\u00edkov: 0.172mg<\/li>
- 1 porcia varen\u00fdch \u0161pagiet: 0.166mg<\/li>
- 1 multivitam\u00edn: 0.4mg<\/li><\/ul>\n\n\n\n
Celkom<\/strong> = 1,132mg. Nie je \u0165a\u017ek\u00e9 prekona\u0165 t\u00fato horn\u00fa hranicu za jeden de\u0148, tak\u017ee si d\u00e1vajte pozor na konzum\u00e1ciu obiln\u00edn a vitam\u00ednov, najm\u00e4 ak hor\u0161ie metabolizujete kyselinu listov\u00fa. Tie\u017e sa presved\u010dte, \u017ee m\u00e1te dostatok vitam\u00ednu B12 a \u017ee ho va\u0161e telo naozaj aj zu\u017eitkuje. <\/p>\n\n\n\n
\n\n\n\n<\/figure>\n\n\n\nExistuj\u00fa v\u00fdhody u\u017e\u00edvania 5-MTHF v porovnan\u00ed s in\u00fdmi formami fol\u00e1tu?<\/strong><\/h2>\n\n\n\n
5-MTHF pr svoju \u00fa\u010dinnos\u0165 nevy\u017eaduje, aby v tele prebiehali chemick\u00e9 reakcie<\/strong><\/h3>\n\n\n\n
Kyselina listov\u00e1, ktor\u00e1 je syntetick\u00e1, vy\u017eaduje viac chemick\u00fdch reakci\u00ed, k\u00fdm sa z nej stane bioakt\u00edvny 5-MTHF. Fol\u00e1t v strave, ktor\u00fd sa prirodzene vytv\u00e1ra v potravin\u00e1ch, tie\u017e vy\u017eaduje chemick\u00e9 reakcie predt\u00fdm, ako sa z neho stane 5-MTHF, ale menej ako kyselina listov\u00e1. In\u00fdmi slovami, po u\u017eit\u00ed 5-MTHF vo v\u00fd\u017eivovom doplnku m\u00e1 va\u0161e telo menej pr\u00e1ce. Nie s\u00fa potrebn\u00e9 \u017eiadne dodato\u010dn\u00e9 chemick\u00e9 reakcie.<\/p>\n\n\n\n
Interakcie s men\u0161\u00edm po\u010dtom liekov ako pri kyseline listovej<\/strong><\/h3>\n\n\n\n
Aby sa 5-MTHF stal bioakt\u00edvnym, nie je potrebn\u00e1 metabolick\u00e1 premena, je menej pravdepodobn\u00e9, \u017ee bude reagova\u0165 s liekmi a zn\u00ed\u017ei ich \u00fa\u010dinnos\u0165. (33) Psychiatri ho miluj\u00fa, preto\u017ee t\u00e1to forma fol\u00e1tu m\u00f4\u017ee prech\u00e1dza\u0165 priamo cez hematoencefalick\u00fa bari\u00e9ru a priamo do mozgu. Krvno-mozgov\u00e1 bari\u00e9ra zabra\u0148uje mnoh\u00fdm l\u00e1tkam prenikn\u00fa\u0165 do mozgu cez obehov\u00fd syst\u00e9m. 5-MTHF m\u00f4\u017ee prenika\u0165 priamo do nervov\u00e9ho syst\u00e9mu. (32) Je to zvy\u010dajne vinou metabolizmu, ktor\u00fd sp\u00f4sobuje, \u017ee kyselina listov\u00e1 interferuje s liekmi.<\/p>\n\n\n\n
Nezakr\u00fdva pr\u00edznaky nedostatku vitam\u00ednu B12<\/strong><\/h3>\n\n\n\n
Aj ke\u010f fol\u00e1t m\u00f4\u017ee zakr\u00fdva\u0165 po\u0161kodenie nervov\u00e9ho syst\u00e9mu sp\u00f4soben\u00e9 krvn\u00fdmi poruchami s\u00favisiacimi s nedostatkom B12, je dok\u00e1zan\u00e9, \u017ee 5-MTHF tento probl\u00e9m nesp\u00f4sobuje. (34)<\/p>\n\n\n\n
\n\n\n\nAk\u00e1 by mala by\u0165 prv\u00e1 d\u00e1vka tohto doplnku?<\/strong><\/h2>\n\n\n\n
V\u00e4\u010d\u0161ina u\u017e\u00edvate\u013eov za\u010d\u00edna s 1 mg alebo e\u0161te menej 5-MTHF denne pri be\u017enom pou\u017e\u00edvan\u00ed. Niektor\u00e9 situ\u00e1cie m\u00f4\u017eu vy\u017eadova\u0165 5 mg alebo viac a v\u00e1\u0161 lek\u00e1r v\u00e1m v tomto pr\u00edpade dok\u00e1\u017ee poradi\u0165 asi najlep\u0161ie, ke\u010f\u017ee pozn\u00e1 v\u00e1\u0161 zdravotn\u00fd stav. Pam\u00e4tajte, \u017ee viac nemus\u00ed by\u0165 nevyhnutne lep\u0161ie, najm\u00e4 pokia\u013e ide o u\u017e\u00edvanie akejko\u013evek formy fol\u00e1tu.<\/p>\n\n\n\n
\n\n\n\nKto by NEMAL U\u017d\u00cdVA\u0164 5-MTHF?<\/strong><\/h2>\n\n\n\n
Ak ste alergick\u00fd na 5-MTHF, nemali by ste ho samozrejme \u010falej u\u017e\u00edva\u0165. Ak sa v\u00e1m objav\u00ed \u017eih\u013eavka, zvieranie na hrudn\u00edku alebo d\u00fdchavi\u010dnos\u0165, pova\u017eujte to za n\u00fadzov\u00e9 situ\u00e1cie a pohotovostn\u00e9 reakcie v\u00e1\u0161ho organizmu . Pred doplnen\u00edm 5-MTHF sa pora\u010fte so svoj\u00edm lek\u00e1rom, najm\u00e4 ak:<\/strong> (35)<\/p>\n\n\n\n
- ste alergick\u00fd na kyselinu listov\u00fa obsiahnut\u00fa v obilnin\u00e1ch alebo multivitam\u00ednoch<\/li>
- v minulosti v\u00e1m bol diagnostikovan\u00fd nedostatok vitam\u00ednu B12<\/li>
- m\u00e1te bipol\u00e1rnu poruchu<\/li>
- ste tehotn\u00e1 alebo doj\u010d\u00edte alebo sa sna\u017e\u00edte otehotnie\u0165 (kv\u00f4li ur\u010deniu spr\u00e1vneho d\u00e1vkovania, ktor\u00e9 sa m\u00f4\u017ee l\u00ed\u0161i\u0165 od pr\u00edpadu k pr\u00edpadu)<\/li><\/ul>\n\n\n\n
\n\n\n\nBude 5-MTHF reagova\u0165 na lieky, ktor\u00e9 u\u017e\u00edvam?<\/strong><\/h2>\n\n\n\n
Pri 5-MTHF je menej pravdepodobn\u00e9, \u017ee bude interagova\u0165 s liekmi v porovnan\u00ed s kyselinou listovou (33), ale ur\u010dite neberte toto tvrdenie ako z\u00e1v\u00e4zn\u00fa inform\u00e1ciu. Ur\u010dite by ste sa mali porozpr\u00e1va\u0165 aj so svoj\u00edm lek\u00e1rom. Kyselina listov\u00e1 m\u00f4\u017ee zn\u00ed\u017ei\u0165 \u00fa\u010dinnos\u0165 v\u00e4\u010d\u0161iny liekov na z\u00e1chvaty, ako aj \u00fa\u010dinky pyrimetam\u00ednu (Daraprim), ktor\u00fdm sa lie\u010dia parazitick\u00e9 infekcie. Metotrex\u00e1t je liek, ktor\u00fd zni\u017euje aktivitu fol\u00e1tu v bunk\u00e1ch. (36) (37) Na druhej strane \u0161t\u00fadia interakci\u00ed kyseliny listovej s lamotrig\u00ednom odporu\u010dila suplement\u00e1ciu 5-MTHF ako alternat\u00edvny sp\u00f4sob prij\u00edmania kyseliny listovej pre pou\u017e\u00edvate\u013eov tohto lie\u010diva. Lie\u010divo sa pou\u017e\u00edva na prevenciu z\u00e1chvatov, vedcov v\u0161ak zauj\u00edmali najm\u00e4 poruchy n\u00e1lady, ako je bipol\u00e1rna depresia. Poznamenali, \u017ee 5-MTHF nemus\u00ed prech\u00e1dza\u0165 chemick\u00fdmi reakciami sk\u00f4r, ako ich mozog a in\u00e9 syst\u00e9my tela m\u00f4\u017eu re\u00e1lne pou\u017ei\u0165, tak\u017ee je menej pravdepodobn\u00e9, \u017ee bud\u00fa interferova\u0165 s lamotrig\u00ednom. (38)<\/p>\n\n\n\n
\n\n\n\n<\/figure>\n\n\n\nAko a kde m\u00e1m skladova\u0165 svoje v\u00fd\u017eivov\u00e9 doplnky s obsahom 5-MTHF?<\/strong><\/h2>\n\n\n\n
Jedna renomovan\u00e1 klinika v Clevelande odpor\u00fa\u010da na svojej webovej str\u00e1nke nasledovn\u00e9: \u201eSkladujte pri izbovej teplote od 15 do 30 stup\u0148ov C. Chr\u00e1\u0148te pred svetlom. Tento doplnok v\u00fd\u017eivy sa r\u00fdchlo rozklad\u00e1 a deaktivuje pri p\u00f4soben\u00ed tepla alebo svetla. Nepou\u017eit\u00fd liek po d\u00e1tume exspir\u00e1cie vyho\u010fte.\u201c (37) My v Intelligent Labs pou\u017e\u00edvame neprieh\u013eadn\u00e9 \u010dierne balenie, aby sme ochr\u00e1nili produkt pred p\u00f4soben\u00edm svetla. Skladujte v\u00fd\u017eivov\u00e9 doplnky tak, aby k nim nemali pr\u00edstup mal\u00e9 deti. 5-MTHF je relat\u00edvne bezpe\u010dn\u00fd a pred\u00e1vkovanie nie je smrte\u013en\u00e9. Be\u017enou praxou by pre ka\u017ed\u00e9ho z n\u00e1s malo by\u0165 heslo\u201elep\u0161ie sa spr\u00e1va\u0165 bezpe\u010dne ako nesk\u00f4r \u013eutova\u0165\u201c.<\/p>\n\n\n\n
\n\n\n\nO sprievodcovi<\/strong><\/h2>\n\n\n\n
D\u00fafame, \u017ee tento \u010dl\u00e1nok je pre v\u00e1s u\u017eito\u010dn\u00fd. Z d\u00f4vodu neust\u00e1le sa vyv\u00edjaj\u00facej lek\u00e1rskej vedy nepredpokladajte, \u017ee sme v\u00e1m poskytli \u00faplne v\u0161etky inform\u00e1cie, ktor\u00e9 potrebujete vedie\u0165. Ak ste sa do\u010d\u00edtali a\u017e sem, vedzte, \u017ee aj vedci samotn\u00ed diskutuj\u00fa o niektor\u00fdch oblastiach spomenut\u00fdch v tomto \u010dl\u00e1nku. Pam\u00e4tajte tie\u017e, \u017ee tieto inform\u00e1cie nenahr\u00e1dzaj\u00fa rady v\u00e1\u0161ho lek\u00e1ra. Nem\u00f4\u017eeme tvrdi\u0165, \u017ee 5-MTHF je liekom alebo lie\u010dbou na ak\u00fako\u013evek chorobu. Tie\u017e nem\u00f4\u017eeme tvrdi\u0165, \u017ee n\u00e1\u0161 obsah \u010dl\u00e1nku v\u00e1m m\u00f4\u017ee pom\u00f4c\u0165 pri samodiagnostike. Iba v\u00e1\u0161 lek\u00e1r m\u00f4\u017ee poskytn\u00fa\u0165 spr\u00e1vnu diagn\u00f3zu a lie\u010dbu adekv\u00e1tnu v\u00e1\u0161mu zdravotn\u00e9mu stavu. <\/p>\n\n\n\n
\n\n\n\nVedecky potvrden\u00e9 zdroje<\/strong><\/h3>\n\n\n\n
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<\/p>\n","protected":false},"excerpt":{"rendered":"
\u010co je 5-MTHF? Tento \u010dl\u00e1nok je zameran\u00fd na to, aby v\u00e1m poskytol v\u0161etky u\u017eito\u010dn\u00e9 a na d\u00f4kazoch zalo\u017een\u00e9 inform\u00e1cie o vitam\u00edne B9, fol\u00e1te, kyseline listovej, 5-MTHF a v\u00fd\u017eivov\u00fdch doplnkoch a potravin\u00e1ch, ktor\u00e9 udr\u017euj\u00fa va\u0161u hladinu vitam\u00ednu B9 na adekv\u00e1tnej \u00farovni. Dozviete sa o probl\u00e9moch, ktor\u00e9 m\u00f4\u017eu zn\u00ed\u017ei\u0165 hladinu B9 na nezdravo n\u00edzku hladinu – aj…<\/p>\n","protected":false},"author":2,"featured_media":161286,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[3174,3172,3173],"tags":[3175],"coauthors":[],"class_list":["post-238091","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-novinky","category-vyziva","category-zdravie","tag-5-mthf"],"taxonomy_info":{"category":[{"value":3174,"label":"Novinky"},{"value":3172,"label":"V\u00fd\u017eiva"},{"value":3173,"label":"Zdravie"}],"post_tag":[{"value":3175,"label":"5-MTHF"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-12-1024x512.jpg",1024,512,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/sk-sk\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":3174,"name":"Novinky","slug":"novinky","term_group":0,"term_taxonomy_id":3174,"taxonomy":"category","description":"","parent":0,"count":18,"filter":"raw","cat_ID":3174,"category_count":18,"category_description":"","cat_name":"Novinky","category_nicename":"novinky","category_parent":0},{"term_id":3172,"name":"V\u00fd\u017eiva","slug":"vyziva","term_group":0,"term_taxonomy_id":3172,"taxonomy":"category","description":"","parent":0,"count":46,"filter":"raw","cat_ID":3172,"category_count":46,"category_description":"","cat_name":"V\u00fd\u017eiva","category_nicename":"vyziva","category_parent":0},{"term_id":3173,"name":"Zdravie","slug":"zdravie","term_group":0,"term_taxonomy_id":3173,"taxonomy":"category","description":"","parent":0,"count":21,"filter":"raw","cat_ID":3173,"category_count":21,"category_description":"","cat_name":"Zdravie","category_nicename":"zdravie","category_parent":0}],"tag_info":[{"term_id":3175,"name":"5-MTHF","slug":"5-mthf","term_group":0,"term_taxonomy_id":3175,"taxonomy":"post_tag","description":"","parent":0,"count":2,"filter":"raw"}],"wpml":{"language":"sk-sk","is_original":true,"original_post_id":238091,"translations":{"sk-sk":{"id":238091,"language":"sk-sk","is_original":true}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/comments?post=238091"}],"version-history":[{"count":1,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091\/revisions"}],"predecessor-version":[{"id":238687,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/posts\/238091\/revisions\/238687"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/media\/161286"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/media?parent=238091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/categories?post=238091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/tags?post=238091"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/sk-sk\/wp-json\/wp\/v2\/coauthors?post=238091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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