Unul dintre cele mai mari riscuri ale sarcinilor nedorite este reprezentant de malforma\u021biile congenitale grave, cum ar fi defectele tubului neural sau NTD. Exemplele includ spina bifida (coloana vertebral\u0103 \u0219i m\u0103duva spin\u0103rii nu formeaz\u0103 corespunz\u0103tor) \u0219i anencefalita (aceasta afecteaz\u0103 creierul \u0219i craniul).Partea bun\u0103 este c\u0103 aceste NTD pot fi prevenite prin administrarea unei canit\u0103\u021bi suficiente de aciente de acid folic \u00eenainte \u0219i \u00een timpul sarcinii. Din p\u0103cate \u00eens\u0103, NTD-urile r\u0103m\u00e2n o problem\u0103 \u00een multe \u021b\u0103ri din \u00eentreaga lume (2<\/a>).<\/p>\n\n\n\n Din fericire, fortificarea cu acid folic \u00een r\u00e2ndul femeilor de v\u00e2rst\u0103 fertil\u0103 poate preveni 50-70% din NTD care apar \u00een fiecare an. Acest lucru este semnificativ, deoarece \u00eengrijirea unui copil n\u0103scut cu spina bifida nu este deloc ieftin\u0103 – costul total direct al \u00eengrijirii de durata vie\u021bii este estimat la aproximativ 792,000 (3<\/a>)!<\/p>\n\n\n\n Acestea fiind spuse, exist\u0103 diferite forme de folat \u0219i acid folic – NU sunt toate la fel! \u00cen sec\u021biunea urm\u0103toare, vom afla careform\u0103 de folat este cea mai bun\u0103 pentru s\u0103n\u0103tatea prenatal\u0103 a femeilor.<\/p>\n\n\n\n Folatul, acidul folic activat sunttoate diferite forme de vitamina B9<\/strong>, o vitamin\u0103 necesar\u0103 pentru multe procese biologice importante. Vitamina B9 joac\u0103 un rol important \u00een sinteza aminoacizilor, formarea s\u00e2ngelui, metabolismul homocisteinei, sistemul imunitar \u0219i diviziunea celular\u0103. De asemenea, ajut\u0103 la prevenirea defectelor tubului neural la un f\u0103t \u00een curs de dezvoltare (4<\/a>).<\/p>\n\n\n\n Folatul <\/strong>este forma natural\u0103 a vitaminei B9, prezent\u0103 \u00eentr-o mare varietate de alimente, cum ar fi legumele cu frunze verzi, ficatul de vit\u0103, ou\u0103le, nucile, fuctele \u0219i legumele. Este biodisponibil, dar este u\u0219or de distrus prin depozitarea incorect\u0103 a alimentelor, sp\u0103larea \u0219i g\u0103titul acestora (5<\/a>). Folatul este transformat \u00een intestin \u00een forma sa biologic activ\u0103, 5-MTHF sau 5-metiltetrahidrofolat, \u00eenainte de a instra \u00een fluxul sanguin (6<\/a>).<\/p>\n\n\n\n Acidul folic este versiunea sintetic\u0103 a folatului. Este mai stabil dec\u00e2t folatul, ceea ce \u00eel face s\u0103 fie forma preferat\u0103 a vitaminei B9 care este ad\u0103ugat\u0103 \u00een aimentele \u00eembog\u0103\u021bite, cum ar fi cerealele pentru micul dejun, pastele, p\u00e2inea, f\u0103ina \u0219i multe suplimente alimentare (5<\/a>).<\/p>\n\n\n\n Dar exist\u0103 o problem\u0103 cu acidul folic. Nu tot acesta este metabolizat \u0219i transformat \u00een 5-MTHF \u00een intestin, la fel ca folatul alimentar. Acest lucru poate dace ca acidul folic nemetabolizat<\/a> s\u0103 se acumuleze \u00een s\u00e2nge, duc\u00e2nd la unele probleme de s\u0103n\u0103tate (7<\/a>, 8<\/a>).<\/p>\n\n\n\n Acodul folic activat (5-MTHF) <\/strong>este principala form\u0103 de folat care se g\u0103se\u0219te \u00een s\u00e2nge. Prin administrarea de 5-MTHF, organismul dvs. nu mai trebuie s\u0103 fac\u0103 nicio conversie. De ce? Pentru c\u0103 este deja forma activ\u0103 de 5-MTHF – forma \u00een care se transform\u0103 folatul alimentar \u0219i acidul folic obi\u0219nuit (9<\/a>).<\/p>\n\n\n\n Acidul folic activat este forma potrivit\u0103 de vitamina B9 nu numai pentru femeile prenatale, ci \u0219i pentru persoanele cu muta\u021bia genetic\u0103 MTHFR.<\/p>\n\n\n\n Iat\u0103 un infografic care prezint\u0103 ptincipalele diferen\u021be dintre aceste 3 forme: <\/p>\n\n\n\n Personale cu varia\u021bia generic\u0103 MTHFR, mai exact variantele C677T i A1298C, au probleme \u00een metabolizarea folatului \u0219i a acidului folic. Aceste variante generice pot cauza diverse probleme de s\u0103n\u0103tate, cum ar fi deficien\u021be de vitamine (inclusiv niveluri sc\u0103zute de folat \u00een s\u00e2nge), niveluri ridicate de homocistein\u0103 (un risc ridicat de boli de inim\u0103), avorturi spontane recurente \u0219i copii cu defecte ale tubului neural (10<\/a>).<\/p>\n\n\n\n Dac\u0103 sunte\u021bi o femeie care \u00eencearc\u0103 s\u0103 conceap\u0103 \u0219i ave\u021bi aceast\u0103 varia\u021bie MTHFR, atunci trebuie s\u0103 lua\u021bi acid folic activat, astfel \u00eenc\u00e2t organismul dvs. s\u0103 poat\u0103 utiliza pe deplin aceast\u0103 vitamin\u0103.Exist\u0103 dou\u0103 tipuri populare de acid folic activat:<\/p>\n\n\n\n Ei bine, un studiu din 2016 a constatat c\u0103 5-MTHF din sarea de glucozamin\u0103 a fost de 1,8 ori mai bine absorbit dec\u00e2t 5-MTHF din sarea de calciu. De asemenea, a fost de 3,1 ori mai biodisponibil dec\u00e2t acidul folic obi\u0219nuit (11<\/a>).<\/p>\n\n\n\n Datorit\u0103 biodisponibilit\u0103\u021bii sale superioare, acidul folic activat din sarea de glucozamin\u0103 este cea mai bun\u0103 alegere pentru femeile aflate la v\u00e2rsta fertil\u0103, precum \u0219i pentru orice persoan\u0103 cu polimorfisme.<\/strong><\/p>\n\n\n\n \u00cen suplimentele noastre de la Intelligent Labs 5-MTHF<\/a>, folosim o formul\u0103 patentat\u0103 numit\u0103 Quatrefolic Acid\u00ae, care este derivat\u0103 din sarea de glucozamin\u0103 \u0219i nu provine din crustacee, ceea ce o face potrivit\u0103 pentru consumul vegetarian \u0219i vegan. <\/p>\n\n\n\n Conform unui studiu din 2013 realiza de Obeid et al., acidul folic activat este cea mai bun\u0103 alegere pentru femeile \u00eens\u0103rcinate \u00een compara\u021bie cu acidul folic \u0219i acidul folic obi\u0219nuit (12<\/a>). Iat\u0103 c\u00e2teva constat\u0103ri notabile din cercetarea lor:<\/p>\n\n\n\n Conform CDC<\/a>, este nevoie de \u201ec\u00e2teva luni de consum regulat de folat pentru a ajunge la niveluri de concentra\u021bie de folat \u00een s\u00e2nge suficient de ridicate pentru a preveni NTD\u201d.<\/p>\n\n\n\n Acest lucru \u00eenseamn\u0103 c\u0103 femeile ar trebui s\u0103 \u00eenceap\u0103 s\u0103 ia 5-MTHF din sarea de glucozamin\u0103 cu c\u00e2teva luni \u00eenainte de concep\u021bie p\u00e2n\u0103 \u00een primul trimestru de sarcin\u0103<\/strong>, deoarece au nevoi mai mari de folat \u00een aceast\u0103 perioad\u0103.<\/p>\n\n\n\n Folatul este fundamental pentru cre\u0219terea \u0219i dezvoltarea f\u0103tului. Prin existen\u021ba unor rezerve suficiente de folat \u00eenainte de concep\u021bie, pot fi prevenite NTD-urile, astfel \u00eenc\u00e2t este esen\u021bial ca mamele s\u0103 poat\u0103 utiliza pe deplin folatul pe care \u00eel iau (13<\/a>).<\/p>\n\n\n\n De asemenea, acela\u0219i lucru este valabil \u0219i pentru ta\u021bi. B\u0103rba\u021bii trebuie s\u0103 aib\u0103, de asemenea, niveluri suficiente de folat pentru a contribui la asigurarea unei sarcini reu\u0219ite. Citi\u021bi acest articol pentru a afla mai multe despre beneficiile acidului folic pentru b\u0103rba\u021bi<\/a>.<\/p>\n\n\n\n Utilizarea formei corecte de folat – \u00een acest caz, acid folic activat – este important\u0103 nu numai pentru s\u0103n\u0103tatea prenatal\u0103, ci \u0219i pentru cei care au probleme \u00een metabolizarea folatului alimentar \u0219i a acidului folic. Biodisponibilitatea ridicat\u0103 a 5-MTHF \u00eenseamn\u0103 c\u0103 po\u021bi prodita de toate beneficiile uimitoare pentru s\u0103n\u0103tate ale folatului (citi\u021bi aici ghidul nostru complet despre folat \u0219i 5-MTHF pentru mai multe informa\u021bii<\/a>).<\/p>\n\n\n\n \u00cen ceea ce prive\u0219te cel mai bun supliment 5-MTHF pentru sarcin\u0103? Consulta\u021bi suplimentele noastre 1MG 5-MTHF<\/a> \u0219i 5MG 5-MTHF<\/a> din magazinul Intelligent Labs.<\/p>\n\n\n\n\n 1) Bearak, Jonathan, et al. \u201cUnintended Pregnancy and Abortion by Income, Region, and the Legal Status of Abortion: Estimates from a Comprehensive Model for 1990\u20132019.\u201d The Lancet Global Health, vol. 8, no. 9, 2020, pp. e1152\u201361. Crossref, https:\/\/doi.org\/10.1016\/s2214-109x(20)30315-6.<\/p>\n\n\n\n 2) \u201cKey Findings: Global Burden of Neural Tube Defects.\u201d Centers for Disease Control and Prevention, 25 Sept. 2018, www.cdc.gov\/ncbddd\/birthdefectscount\/features\/kf-neutral-tube-defects-burden.html.<\/p>\n\n\n\n 3) \u201cData and Statistics.\u201d Centers for Disease Control and Prevention, 24 Sept. 2018, www.cdc.gov\/ncbddd\/birthdefectscount\/data.html#:%7E:text=In%20the%20United%20States%2C%203%2C000,defects%20each%20year%20(3).<\/p>\n\n\n\n 4) \u201cEU Register of Nutrition and Health Claims Made on Foods (v.3.6).\u201d European Commission Food Safety, ec.europa.eu\/food\/safety\/labelling_nutrition\/claims\/register\/public\/?event=search. Accessed 21 Mar. 2022.<\/p>\n\n\n\n 5) \u201cGeneral Information About NTDs, Folic Acid, and Folate.\u201d Centers for Disease Control and Prevention, 8 July 2021, www.cdc.gov\/ncbddd\/folicacid\/faqs\/faqs-general-info.html.<\/p>\n\n\n\n 6) Alpers, David H. \u201cAbsorption and blood\/cellular transport of folate and cobalamin: Pharmacokinetic and physiological considerations.\u201d Biochimie vol. 126 (2016): 52-6. doi:10.1016\/j.biochi.2015.11.006<\/p>\n\n\n\n 7) Valera-Gran, Desir\u00e9e et al. \u201cEffect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study.\u201d The American journal of clinical nutrition vol. 106,3 (2017): 878-887. doi:10.3945\/ajcn.117.152769<\/p>\n\n\n\n 8) Plumptre, Lesley et al. \u201cHigh concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood.\u201d The American journal of clinical nutrition vol. 102,4 (2015): 848-57. doi:10.3945\/ajcn.115.110783<\/p>\n\n\n\n 9) Scaglione, Francesco, and Giscardo Panzavolta. \u201cFolate, folic acid and 5-methyltetrahydrofolate are not the same thing.\u201d Xenobiotica; the fate of foreign compounds in biological systems vol. 44,5 (2014): 480-8. doi:10.3109\/00498254.2013.845705<\/p>\n\n\n\n 10) \u201cMTHFR Gene Variant | Genetic and Rare Diseases Information Center (GARD) \u2013 an NCATS Program.\u201d NIH GARD, rarediseases.info.nih.gov\/diseases\/10953\/mthfr-gene-variant. Accessed 21 Mar. 2022.<\/p>\n\n\n\n 11) Miraglia, Niccol\u00f2 et al. \u201cEnhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats.\u201d Minerva ginecologica vol. 68,2 (2016): 99-105.<\/p>\n\n\n\n 12) Obeid, Rima, Holzgreve, Wolfgang and Pietrzik, Klaus. \u201cIs 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?\u201d Journal of Perinatal Medicine, vol. 41, no. 5, 2013, pp. 469-483. https:\/\/doi.org\/10.1515\/jpm-2012-0256<\/p>\n\n\n\n 13) Ferrazzi, Enrico et al. \u201cFolic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy.\u201d European journal of obstetrics, gynecology, and reproductive biology vol. 253 (2020): 312-319. doi:10.1016\/j.ejogrb.2020.06.012<\/p>\n\n\n\n<\/details>\n\n<\/div>\n \n<\/div>\n\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" Parentingul responsabil \u00eencepe cu mult \u00eenainte de apari\u021bia copilului. Luarea anumitor m\u0103suri, cum ar fi o diet\u0103 echilibrat\u0103, exerci\u021bii fizice \u0219i administrative de vitamine prenatale, ajut\u0103 la \u00eembun\u0103t\u0103\u021birea \u0219anselorunei sarcini s\u0103n\u0103toase. \u00cen aceast\u0103 postare pe blog, vom aborda una dintre cele mai importante vitamine pe care o viitoare mam\u0103 le poate lua, \u0219i anume, acidul…<\/p>\n","protected":false},"author":2,"featured_media":129329,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[3068],"tags":[],"coauthors":[],"class_list":["post-253675","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-ro-ro"],"taxonomy_info":{"category":[{"value":3068,"label":"Uncategorized @ro-ro"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2022\/03\/5-mthf-activated-folic-acid-for-prenatal-health-01-1024x512.jpg",1024,512,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/ro-ro\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":3068,"name":"Uncategorized @ro-ro","slug":"uncategorized-ro-ro","term_group":0,"term_taxonomy_id":3068,"taxonomy":"category","description":"","parent":0,"count":65,"filter":"raw","cat_ID":3068,"category_count":65,"category_description":"","cat_name":"Uncategorized @ro-ro","category_nicename":"uncategorized-ro-ro","category_parent":0}],"tag_info":false,"wpml":{"language":"ro-ro","is_original":false,"original_post_id":130686,"translations":{"cs-cz":{"id":221612,"language":"cs-cz","is_original":false},"de-at":{"id":169259,"language":"de-at","is_original":false},"de-de":{"id":75417,"language":"de-de","is_original":false},"en-gb":{"id":130686,"language":"en-gb","is_original":true},"en-ie":{"id":164126,"language":"en-ie","is_original":false},"en-mt":{"id":165499,"language":"en-mt","is_original":false},"es-es":{"id":74994,"language":"es-es","is_original":false},"et-ee":{"id":230258,"language":"et-ee","is_original":false},"fr-fr":{"id":129328,"language":"fr-fr","is_original":false},"hu-hu":{"id":225136,"language":"hu-hu","is_original":false},"it-it":{"id":75244,"language":"it-it","is_original":false},"lt-lt":{"id":237153,"language":"lt-lt","is_original":false},"lv-lv":{"id":230629,"language":"lv-lv","is_original":false},"nl-nl":{"id":175346,"language":"nl-nl","is_original":false},"pt-pt":{"id":168951,"language":"pt-pt","is_original":false},"ro-ro":{"id":253675,"language":"ro-ro","is_original":false},"sl-si":{"id":239024,"language":"sl-si","is_original":false}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/posts\/253675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/comments?post=253675"}],"version-history":[{"count":0,"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/posts\/253675\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/media\/129329"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/media?parent=253675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/categories?post=253675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/tags?post=253675"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/ro-ro\/wp-json\/wp\/v2\/coauthors?post=253675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"acest](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/por-que-el-acido-folico-activado-5-mthf-es-mejor-para-la-salud-prenatal-03-1024x512.jpeg\")
<\/figure>\n\n\n\nDiferitele forme de folat – \u0219i de ce acidul folic activat este cea mai bun\u0103 form\u0103 pentru sus\u021binerea s\u0103n\u0103t\u0103\u021bii prenatale<\/h2>\n\n\n\n
Diferen\u021bele dintre folat, acid folic \u0219i acid folic activat<\/h3>\n\n\n\n
Acest lucru ne aduce la urm\u0103toarea genera\u021bie de folat sintetic – acidul folic activat.<\/h4>\n\n\n\n
![\"diferitele](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/acido-folico-no-metabolizado-que-es-y-como-prevenirlo-01-492x1024.png\")
<\/figure>\n\n\n\n\n\nCum poate ajuta 5-MTHD femeile (\u0219i b\u0103rba\u021bii) cu poliformisme genetice MTHFR<\/h3>\n\n\n\n
A\u0219adar, de ce este important\u0103 aceast\u0103 distinc\u021bie \u00eentre aceste forme de acid folic activat?<\/h4>\n\n\n\n
![\"suplimentul](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/por-que-el-acido-folico-activado-5-mthf-es-mejor-para-la-salud-prenatal-02.jpeg\")
<\/figure>\n\n\n\nCare sunt alte beneficii ale acidului folic activat 5-MTHF?<\/h2>\n\n\n\n
C\u00e2nd este cel mai bun moment pentru a \u00eencepe s\u0103 lua\u021bi acid folic activat pentru sarcin\u0103?<\/h2>\n\n\n\n
Cuvinte de final <\/h2>\n\n\n\n
Referin\u021be<\/summary>\n\n