{"id":237584,"date":"2021-06-28T09:00:00","date_gmt":"2021-06-28T08:00:00","guid":{"rendered":"https:\/\/eu.intelligentlabs.org\/postul-intermitent-autofagie\/"},"modified":"2021-06-28T09:00:00","modified_gmt":"2021-06-28T08:00:00","slug":"postul-intermitent-autofagie","status":"publish","type":"post","link":"https:\/\/eu.intelligentlabs.org\/ro-ro\/postul-intermitent-autofagie\/","title":{"rendered":"Descoperirea \u0218tiin\u021bei Autofagiei \u2013 Dincolo de Dietele Populare de Post"},"content":{"rendered":"\n\n\n<p> <\/p>\n\n\n\n<p>Postul intermitent a fost <strong>cea <\/strong>mai popular\u0103 diet\u0103 din 2020. Fie c\u0103 f\u0103cea\u021bi doar 16:8, 5:2 sau post doar \u00een zilele lucr\u0103toare, <a href=\"https:\/\/www.prnewswire.com\/news-releases\/intermittent-fasting-is-now-the-1-diet-in-the-us-and-fast-bar-is-the-only-brand-specifically-formulated-to-curb-hunger-without-breaking-your-fast-301177033.html#:~:text=19%2C%202020%20%2FPRNewswire%2F%20%2D%2D,in%20the%20past%2024%20months.\" target=\"_blank\" rel=\"noreferrer noopener\">17 milioane de persoane din SUA au s\u0103ri pe acest trend.<\/a> Precum toate dietele la mod\u0103, oamenii \u0219i celebrit\u0103\u021bile au umplut Instagram-ul cu pove\u0219tile lor de succes \u0219i toat\u0103 lumea a fost cucerit\u0103.<\/p>\n\n\n\n<p>Dar, v-a\u021bi \u00eentrebat vreodat\u0103 <strong>ce se \u00eent\u00e2mpl\u0103 \u00een corp c\u00e2nd face\u021bi post intermitent?<\/strong><\/p>\n\n\n\n<p>Cunoa\u0219te\u021bi <strong>\u0219tiin\u021ba din spatele autofagiei \u0219i a postului?<\/strong><\/p>\n\n\n\n<p>Ast\u0103zi, sunt aici pentru a detalia \u0219tiin\u021ba autofagiei \u0219i a postului intermitent pentru a avea o \u00een\u021belegere profund\u0103 a ceea ce se \u00eent\u00e2mpl\u0103 \u00een corpul dvs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Ce Este Autofagia?<\/strong><\/h3>\n\n\n\n<p>Autofagia vine din cuvintele \u201aauto\u2019 \u0219i \u201afagie\u2019. \u201aAuto\u2019 \u00eenseamn\u0103 <em>sine, <\/em>\u201afagie\u2019 \u00eenseamn\u0103 <em>\u201am\u00e2ncare\u2019. Combinate, autofagia \u00eenseamn\u0103 la propriu \u201aauto-m\u00e2ncare\u2019. <\/em>Este o form\u0103 de auto-canibalizare, dar NU \u00eentr-un sens negativ. Este modul natural al corpului de a se cur\u0103\u021ba de celulele moarte, d\u0103unate \u0219i b\u0103tr\u00e2ne. F\u0103c\u00e2nd asta, corpul poate produce celule noi, regenerate \u0219i s\u0103n\u0103toase.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Despre Cum Suntem \u00centotdeauna Bloca\u021bi \u00een Modul de Festin<\/strong><\/h3>\n\n\n\n<p>\u00cen cei 2 milioane de ani de evolu\u021bie de c\u00e2nd oamenii au derivat din marile maimu\u021be, au fost momente c\u00e2nd m\u00e2ncarea era bogat\u0103 \u00een mediu. Au fost \u0219i momente c\u00e2nd m\u00e2ncarea era sc\u0103zut\u0103. Totu\u0219i, ast\u0103zi, pentru majoritatea \u021b\u0103rilor dezvoltate cel pu\u021bin, exist\u0103 o abunden\u021b\u0103 de calorii tot timpul Astfel, \u00een via\u021ba normal\u0103, nu mai este voie s\u0103 trecem prin <strong>ciclul de festin \u0219i foamete <\/strong>a\u0219a cum a fost nevoie odat\u0103. \u00cen schimb, <strong>suntem mereu bloca\u021bi \u00een \u201amodul de festin\u2019.<\/strong><\/p>\n\n\n\n<p>Problema cu asta este c\u0103 am evoluat s\u0103 trecem prin festin \u0219i foamete, astfel, corpurile noastre func\u021bioneaz\u0103 cel mai bine c\u00e2nd sunt expuse la am\u00e2ndou\u0103.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>C\u00e2nd avem suficient\u0103 m\u00e2ncare, celulele corpului pot cre\u0219te \u0219i se pot reproduce. Dar c\u00e2nd nu avem suficient\u0103 m\u00e2ncare, corpul poate \u201aopri \u00eentrerup\u0103torul metabolic\u2019 (<a href=\"http:\/\/Stephen D. Anton, Keelin Moehl, William T. Donahoo, Krisztina Marosi, Stephanie Lee, Arch G. Mainous, III, Christiaan Leeuwenburgh, and Mark P. Mattson, Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting, Obesity (Silver Spring). 2018 Feb; 26(2): 254\u2013268\">1<\/a>), care \u00een schimb se concentreaz\u0103 pe \u00eent\u0103rirea r\u0103spunsului celulelor noastre la stres.<\/li><li>Celulele fac asta prin descompunerea componentelor celulare defective, re\u00eennoirea \u0219i regenerarea acestora \u0219i sporirea produc\u021biei de elemente precum antioxidan\u021bi.<\/li><li>P\u0103r\u021bile descompuse pot fi folosite pentru produc\u021bia unor noi componente celulare sau energie.<\/li><\/ul>\n\n\n\n<p>Pentru ca oamenii s\u0103 fie s\u0103n\u0103to\u0219i, ideal, avem nevoie de un bun echilibru \u00eentre cele dou\u0103.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Post Intermitent: Avantaje \u0219i Dezavantaje<\/strong><\/h4>\n\n\n\n<p><strong>Avantaje: <\/strong>Prea mult\u0103 m\u00e2ncare, proteinele d\u0103unate \u0219i celelalte p\u0103r\u021bi ale celulei pot cre\u0219te, duc\u00e2nd la nefunc\u021bionarea cum trebuie a celulelor. Dup\u0103, pentru c\u0103 celulele \u00eenseamn\u0103 tot din corpul nostru, inclusiv organele noastre, totul \u00eencepe s\u0103 func\u021bioneze gre\u0219it.<\/p>\n\n\n\n<p><strong>Dezavantaje: <\/strong>Totu\u0219i, prea mult\u0103 foamete poate cauza probleme pentru c\u0103 petrecem prea mult timp descompun\u00e2nd celulele \u00een proces de reparare f\u0103r\u0103 s\u0103 furnizeze energie.<\/p>\n\n\n\n<p>Chiar avem nevoie de un echilibru \u00eentre cele dou\u0103 func\u021bii. Postul intermitent ne permite s\u0103 facem asta pentru c\u0103 poate imita perioada de foamete \u0219i poate combina cu u\u0219urin\u021b\u0103 pu\u021bin\u0103 foamete.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>MTOR vs. Autofagia<\/strong><\/h3>\n\n\n\n<p>Echilibrul \u00eentre <strong>festin <\/strong>\u0219i <strong><u>foamete <\/u><\/strong>joac\u0103 \u00een cele dou\u0103 procese celulare opuse care au loc \u00een corpul nostru \u00een acela\u0219i timp; acestea sunt <strong>mTOR <\/strong>\u0219i <strong><u>Autofagia.<\/u><\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>m-Tor \u2013 O Enzim\u0103, Insula Pa\u0219telui \u0219i La Ce Viseaz\u0103 Bodybuilders!<\/strong><\/h4>\n\n\n\n<p>Primul, <strong>mTOR, este procesul de cre\u0219tere. <\/strong>mTOR \u00eenseamn\u0103 \u201ascop mecanic de rapamicin\u2019.<\/p>\n\n\n\n<p>Este un nume amuzant, dar este un motiv bun \u00een spetele acestuia. A fost <strong>numit dup\u0103 o bacterie de sol care a fost g\u0103sit\u0103 pentru prima dat\u0103 pe Insula Pa\u0219telui <\/strong>\u00een 1960. Insula Pa\u0219telui este o insul\u0103 din Pacific la 2000 de mile de coasta Chile, faimoas\u0103 pentru c\u0103 are Situl de Mo\u0219tenire Mondial cu peste 1000 de statui antice. Insula Pa\u0219telui este, de asemenea, cunoscut\u0103 de <strong>locuitorii insulei, Rapa Nui, astfel, bacteria a fost numit\u0103 rapamicin dup\u0103 insula Rapa Nui.<\/strong><\/p>\n\n\n\n<p><strong>mTOR <\/strong>nu este bacteria solului. <strong>De fapt, este o enzim\u0103 produs\u0103 de corpurile noastre. <\/strong>Dar bacteria solului rapamicin stimuleaz\u0103 activitatea mTOR, astfel c\u0103 enzima a devenit cunoscut\u0103 ca \u201a\u021binta\u2019 rapamicin. C\u00e2nd enzimele sunt stimulate, celulele \u00eencep s\u0103 creasc\u0103, s\u0103 fac\u0103 proteine \u0219i s\u0103 se reproduc\u0103 mai repede. <strong>mTOR este bine cunoscut\u0103 de bodybuilders \u0219i al\u021bi atle\u021bi de for\u021b\u0103 care \u00eencearc\u0103 s\u0103 stimuleze c\u00e2t mai mult posibil.<\/strong><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Autofagia \u2013 \u0218tiin\u021ba din Spatele Postului<\/strong><\/h4>\n\n\n\n<p>Procesul opus mTOR este numit <strong><u>Autofagie, c\u00e2nd celulele \u00eencep s\u0103 descompun\u0103 p\u0103r\u021bile b\u0103tr\u00e2ne \u0219i d\u0103un\u0103toare. <\/u><\/strong>Pentru aceste procese sunt opuse, c\u00e2nd mTOR este stimulat, Autofagia este \u00een mod corespunz\u0103tor sc\u0103zut\u0103. \u0218i c\u00e2nd Autofagia este stimulat\u0103, mTOR este sc\u0103zut.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Cum Func\u021bioneaz\u0103 Autofagia Mai Precis?<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>\u00cen autofagie, celulele formeaz\u0103 structuri speciale numite fagofore.<\/li><li>Fagoforele sunt membrane care cresc \u00eencet \u0219i creeaz\u0103 o form\u0103 de minge acoperit\u0103 de membrane.<\/li><li>Membranele sunt f\u0103cute din ceva numit bi-strat lipidic.<\/li><li>Lipidele sunt molecule pe baz\u0103 de gr\u0103sime \u0219i bi-straturile lipidice \u00eenconjoar\u0103 organele din celulele noastre, toate cele 20 miliarde!<\/li><li>Organele celulei efectueaz\u0103 func\u021bii diferite \u00een celulele noastre \u0219i pot fi asem\u0103nate pu\u021bin precum organele din corpul nostru.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-05-1024x615.jpg\" alt=\"etapele autofagiei\" class=\"wp-image-131106\" width=\"683\" height=\"410\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-05-1024x615.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-05-300x180.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-05-768x461.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-05-600x360.jpg 600w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-05.jpg 1413w\" sizes=\"auto, (max-width: 683px) 100vw, 683px\" \/><\/figure>\n\n\n\n<p><strong>Formarea Fagoforei<\/strong><\/p>\n\n\n\n<p>\u00cen timp ce mingea, sau fagofora se formeaz\u0103, se mi\u0219c\u0103 \u00een jurul celulei. Adun\u0103 proteinele \u0219i celelalte organe c\u0103rora li s-a dar un <strong>rol special <\/strong>care spune fagoforei c\u0103 au fost selectate s\u0103 fie descompuse. Acest marker special se nume\u0219te <strong>ubiquitin. <\/strong>Dup\u0103, fagofora se mi\u0219c\u0103 \u00een jurul celulei \u0219i adun\u0103 toate proteinele \u0219i organele.<\/p>\n\n\n\n<p><strong>Completarea form\u0103rii fagoforei<\/strong><\/p>\n\n\n\n<p>Membranele se formeaz\u0103 complet \u00een jurul proteinelor \u0219i organelor. C\u00e2nd se \u00eent\u00e2mpl\u0103 asta, numele structurii se schimb\u0103 de la fagofor\u0103 la <strong>autofagozom\u0103. <\/strong>Aceast\u0103 autofagozom\u0103 se mi\u0219c\u0103 spre lisozime \u0219i fuzioneaz\u0103 cu aceasta. Un lisozima este un organ care poate fi considerat stomacul celulei, de\u0219i nu este chiar a\u0219a \u00eentruc\u00e2t o celul\u0103 con\u021bine multiple lisozime!<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/2-4-1024x683.jpeg\" alt=\"autofagozomul fuzioneaz\u0103 cu lizozomul\" class=\"wp-image-150547\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/2-4-1024x683.jpeg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/2-4-300x200.jpeg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/2-4-768x512.jpeg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/2-4-600x400.jpeg 600w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/2-4.jpeg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>Autofagozomul mai mare fuzioneaz\u0103 cu lizozomul portocaliu<\/figcaption><\/figure>\n\n\n\n<p>Totu\u0219i, precum \u00een stomacul nostru, con\u021binutul lisozimelor este acidic \u0219i poate con\u021bine enzime digestive care descompun proteinele \u0219i organele. Odat\u0103 descompuse \u00een aminoacizi individuali, aceste pot fi utilizate din nou pentru construirea unor noi proteine, organe \u0219i chiar \u0219i celule. Sau pot fi utilizate pentru produc\u021bia energiei de ficat \u00eentr-un proces cunoscut ca gluconeogenez\u0103. Aminoacizii folosi\u021bi pentru celule noi \u0219i proteine fac asta prin stimularea de enzimele mTOR, astfel \u00eenc\u00e2t ciclul se completeaz\u0103 singur \u00een timp ce corpul trece de la autofagie la mTOR.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"849\" height=\"848\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-06.jpg\" alt=\"Autofagie \u0219i mitofagie\" class=\"wp-image-131107\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-06.jpg 849w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-06-300x300.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-06-150x150.jpg 150w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-06-768x767.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-06-600x599.jpg 600w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-06-100x100.jpg 100w\" sizes=\"auto, (max-width: 849px) 100vw, 849px\" \/><\/figure>\n\n\n\n<p>De asemenea exist\u0103 tipuri specifice de autofagie care au de-a face cu mitocondria. Asta se \u00eent\u00e2mpl\u0103 prin degradarea selectiv\u0103 a mitocondriei prin procesul numit <strong>mitofagie. <\/strong>&nbsp;Mitocondria \u0219i organele, sunt motoarele celulelor noastre \u0219i ne produc energia. Avem un mare num\u0103r \u00een fiecare, 2000 sau mai multe.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Cum Stimuleaz\u0103 Postul Autofagia \u0219i Mitofagia<\/strong><\/h3>\n\n\n\n<p><strong>C\u00e2nd \u021binem post, este o reducere a energiei venind \u00een corpul nostru prin m\u00e2ncare. <\/strong>&nbsp;Asta conduce la un mic dezechilibru de energie \u00eentruc\u00e2t este folosit\u0103 mai mult\u0103 energie dec\u00e2t produs\u0103. <strong>O enzim\u0103 special\u0103 \u00een corp, monitorizeaz\u0103 constant acest echilibru de energie, aceast\u0103 enzim\u0103 se nume\u0219te AMPK <\/strong><strong>(adenosine monophosphate-activated protein kinase).<\/strong><strong><\/strong><\/p>\n\n\n\n<p>Face asta prin semnalizarea ra\u021biei AMP-la-ATP.<\/p>\n\n\n\n<p>ATP elibereaz\u0103 energie \u0219i o molecul\u0103 de fosfat \u0219i este descompus \u00een ADP. C\u00e2nd energia este sc\u0103zut\u0103, 2 DP sunt al\u0103turate pentru a face ATP, care las\u0103 un AMP. (ATP este o molecul\u0103 de adenozin\u0103 cu 3 fosfa\u021bi al\u0103tura\u021bi, ADP este o molecul\u0103 e adenozin\u0103 cu 2 fosfa\u021bi ata\u0219a\u021bi \u0219i AMP este adenozin\u0103 cu 1 fosfat ata\u0219at).<\/p>\n\n\n\n<p>ATP = Adenozin\u0103 Tri Fosfat (3 Fosfa\u021bi)<\/p>\n\n\n\n<p>ADP = Adenozin\u0103 Di Fosfat (2 Fosfa\u021bi)<\/p>\n\n\n\n<p>AMP = Adenozin\u0103 Mono Fosfat (1 Fosfat)<\/p>\n\n\n\n<p>C\u00e2nd 2 ADP se unesc (2 fosfa\u021bi plus 2 fosfa\u021bi), produce ATP (3 fosfa\u021bi) cu AMP (1 fosfat r\u0103mas).<\/p>\n\n\n\n<p>C\u00e2nd ra\u021bia de AMP cre\u0219te \u00een compara\u021bie cu ATP, semnaleaz\u0103 c\u0103 este mai pu\u021bin\u0103 energie disponibil\u0103 \u0219i a\u0219a AMPK este stimulat. C\u00e2nd AMPK este stimulat, anun\u021b\u0103 celelalte proteine numite ULK1 care conduc la produc\u021bia de membrane care devin fagofore.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"724\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-07-1024x724.jpg\" alt=\"Beneficiile postului intermitent\" class=\"wp-image-131108\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-07-1024x724.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-07-300x212.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-07-768x543.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-07-600x424.jpg 600w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2021\/05\/breaking-down-the-science-of-autophagy-beyond-popular-fasting-diets-07.jpg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>NAD+ \u0219i Sirtuins <\/strong><strong><\/strong><\/h4>\n\n\n\n<p><strong>Postul spore\u0219te \u0219i nivelurile de NAD+, forma oxidat\u0103 de NADH, <\/strong>care este o form\u0103 activ\u0103 a <strong>Vitaminei B3 (<\/strong>vital\u0103 \u00een produc\u021bia de energie).<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p><strong>Sirtuinele sunt o familie de proteine care stimuleaz\u0103 direct autofagia<\/strong><\/p><\/blockquote>\n\n\n\n<p><strong>Produc\u021bia de energie \u00een mitocondrie rezult\u0103 \u00een mai mult NADH care devine NAD+. <\/strong>Acesta spore\u0219te ra\u021bia de NAD+ la NADH stimul\u00e2nd produc\u021bia de Sirtuine.<\/p>\n\n\n\n<p><strong>Sirtuinele sunt o familie de proteine care stimuleaz\u0103 direct autofagia. <\/strong>Produc\u021bia lor este asociat\u0103 \u0219i cu o sporire a repara\u021biei AND-ului (<a href=\"http:\/\/Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010;110: 911\u2013916\">2<\/a>).<\/p>\n\n\n\n<p>At\u00e2t AMPK c\u00e2t \u0219i Sirtuins activeaz\u0103 alte gene care au multe alte beneficii de s\u0103n\u0103tate, cele mai cunoscute fiind familia FoxO, TFEB, PGC-La \u0219i P53.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Activarea familie FoxO este asociat\u0103 cu cre\u0219terea rezisten\u021bei la sport, o via\u021b\u0103 mai lung\u0103, mai pu\u021bine incidente tumorice (i.e. cancer). Asta fiind din cauza celulelor disfunc\u021bionale f\u0103cute s\u0103 comit\u0103 suicid celular (apoptoz\u0103) mai degrab\u0103 dec\u00e2t s\u0103 continue cre\u0219terea \u0219i s\u0103 devin\u0103 poten\u021biale tumori (<a href=\"http:\/\/Eric L Greer &amp; Anne Brunet, FOXO transcription factors at the interface between longevity and tumor suppression, Oncogene volume 24, pages7410\u20137425(2005)\">3<\/a>).<\/li><li>TFEB stimuleaz\u0103 produc\u021bia unor noi lisozime, deci este direct implicat \u00een autofagie.<\/li><li>P53 este cunoscut drept \u201agardianul genomului\u2019 pentru c\u0103 previne muta\u021biile AND-ului (<a href=\"http:\/\/Read AP, Strachan T (1999). \u201cChapter 18: Cancer Genetics\u201d. Human molecular genetics 2. New York: Wiley.\">4<\/a>) \u0219i opre\u0219te formarea tumorilor (<a href=\"http:\/\/Surget S, Khoury MP, Bourdon JC (December 2013). \u201cUncovering the role of p53 splice variants in human malignancy: a clinical perspective\u201d. OncoTargets and Therapy. 7: 57\u201368\">5<\/a>).<\/li><li>PGC-la este gena primar\u0103 implicat\u0103 \u00een stimularea produc\u021biei noii mitocondrii. Cu c\u00e2t avem mai multe mitocondrii, cu at\u00e2t mai pu\u021bin stres este \u00een mitocondria existent\u0103 pentru a produce energia de care avem nevoie. Asta face ca produc\u021bia de energie s\u0103 fie mai eficient\u0103, cu c\u00e2t mai pu\u021bini radicali liberi avem.<br><br><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Rolul Cetozei \u00een Autofagie<\/strong><strong><\/strong><\/h3>\n\n\n\n<p><strong>Postul intermitent <\/strong>conduce \u0219i la descompunerea \u021besutului gras, <strong>sporind nivelul de acizi gra\u0219i liberi care ajung \u00een ficat. Acesta spore\u0219te cantitatea cetonelor produse (<a href=\"http:\/\/Stephen D. Anton, Keelin Moehl, William T. Donahoo, Krisztina Marosi, Stephanie Lee, Arch G. Mainous, III, Christiaan Leeuwenburgh, and Mark P. Mattson, Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting, Obesity (Silver Spring). 2018 Feb; 26(2): 254\u2013268\">1<\/a>).<\/strong><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p><strong>Cetonele sunt molecule pe baz\u0103 de gr\u0103sime care pot produce energie.<\/strong><\/p><\/blockquote>\n\n\n\n<p><strong>Cetonele sunt molecule pe baz\u0103 de gr\u0103sime care pot produce energie foarte eficient. <\/strong>Cetonele arse pentru energie produc mai pu\u021bini radicali liberi \u0219i utilizarea lor reduce inflamarea. Cetonele stimuleaz\u0103 \u0219i produc\u021bia de BDNF (creier-derivate factori neurotrofici). BDNF este un hormon de cre\u0219tere pentru creier \u0219i stimuleaz\u0103 cre\u0219terea noilor celule cerebrale (neuroni). De asemenea, promoveaz\u0103 noi sinapse care sunt conexiunile \u00eentre neuroni (<a href=\"http:\/\/Stephen D. Anton, Keelin Moehl, William T. Donahoo, Krisztina Marosi, Stephanie Lee, Arch G. Mainous, III, Christiaan Leeuwenburgh, and Mark P. Mattson, Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting, Obesity (Silver Spring). 2018 Feb; 26(2): 254\u2013268\">1<\/a>). Cu c\u00e2t avem mai multe conexiuni sau sinapse, cu at\u00e2t mai multe putem \u00eenv\u0103\u021ba \u0219i \u00een\u021belege.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>De Ce Sunt Dietele de Post at\u00e2t de Populare \u00een 2021?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>Deci cum se traduce aceast\u0103 \u0219tiin\u021b\u0103 a postului intermitent \u00een beneficii de s\u0103n\u0103tate?<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Pierdere \u00een greutate<\/strong><strong><\/strong><\/h4>\n\n\n\n<p>Multe persoane decid s\u0103 \u00eencerce postul pentru beneficiile sale de pierdere \u00een greutate. Studii au demonstrat c\u0103, \u00een medie, subiec\u021bii pierd \u00een jur de 2,5% \u0219i 9,9% din greutatea lor corporal\u0103 \u00een perioada de 3-6 luni de desf\u0103\u0219urare a studiilor de post (<a href=\"http:\/\/Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E. Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr [Internet] 2005;81:69\u201373\">7<\/a>,<a href=\"http:\/\/Byrne NMM, Sainsbury A, King NAA, Hills APP, Wood REE. Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study. Int J Obes [Internet] 2017:1\u201310\">8<\/a>). Aceast\u0103 pierdere \u00een greutate a demonstrat c\u0103 a fost din masa gr\u0103simii \u0219i nu din cea a mu\u0219chilor.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Postul Poate Ajuta la Reglarea Nivelului de Glucoz\u0103 \u0219i de Insulin\u0103<\/strong><strong><\/strong><\/h4>\n\n\n\n<p>Postul intermitent a demonstrat c\u0103 scade nivelurile de glucoz\u0103 \u0219i de insulin\u0103 \u00een diabetici (<a href=\"http:\/\/Deng X, Cheng J, Zhang Y, Li N, Chen L. Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats. Acta Diabetol. 2010;47(suppl 1):177\u201385\">10<\/a>), persoane obeze (<a href=\"http:\/\/Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E. Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr [Internet] 2005;81:69\u201373\">7<\/a>) \u0219i indivizii non-obezi (<a href=\"http:\/\/M\u2019guil M, Ragala MA, El Guessabi L, Fellat S, Chraibi A, Chabraoui L, et al. Is Ramadan fasting safe in type 2 diabetic patients in view of the lack of significant effect of fasting on clinical and biochemical parameters, blood pressure, and glycemic control ? Clin Exp Hypertens. 2008;30:339\u201357\">11<\/a>). \u00cen plus, un studiu asupra unor femei tinere supraponderale a descoperit o sc\u0103dere a colesterolului LDL, trigliceridelor \u0219i a presiunii cardiace. Au g\u0103sit \u0219i o sc\u0103dere a markerilor inflamatori C-reactivi \u0219i a hormonului leptin\u0103 care cre\u0219te cu obezitatea.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Postul Ajut\u0103 la Reglarea Testosteronului<\/strong><strong><\/strong><\/h4>\n\n\n\n<p>Au descoperit \u0219i o cre\u0219tere a SHBG (hormonul de sex) care ajut\u0103 la reducerea efectelor testosteronului. Totu\u0219i, c\u00e2nd testosteronul cre\u0219te prea mult la femei, poate avea efecte secundare nedorite (<a href=\"http:\/\/Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women. Int J Obes. 2011;35:714\u201327\">12<\/a>).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Postul Intermitent Poate Avea Efecte de Anti-\u00cemb\u0103tr\u00e2nire<\/strong><\/h4>\n\n\n\n<p>Majoritatea studiilor despre postul intermitent \u0219i \u00eemb\u0103tr\u00e2nire au fost conduse pe <strong>animale. <\/strong>Motivul este simpli \u2013 este dificil s\u0103 conduci aceste studii pe oameni pe care nu \u00eei po\u021bi urm\u0103ri toat\u0103 via\u021ba, cel pu\u021bin nu c\u00e2t timp te asiguri c\u0103 urm\u0103resc protocolul postului intermitent.<\/p>\n\n\n\n<p>Totu\u0219i, stimularea cu AMPK \u0219i Sirtuins \u00een timpul postului intermitent sunt asociate puternic cu cre\u0219terea duratei vie\u021bii la animale.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Studiile au ar\u0103tat c\u0103 postul intermitent cre\u0219te durata de via\u021b\u0103 la \u0219oareci \u0219i maimu\u021be \u0219i este mai pu\u021bin probabil ca ace\u0219tia s\u0103 dezvolte boli asociate cu \u00eemb\u0103tr\u00e2nirea (<a href=\"http:\/\/Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. Mattson MP, Wan RJ, Nutr Biochem. 2005 Mar; 16(3):129-37\">13<\/a>). Un studiu \u00een \u0219oareci a descoperi c\u0103 cei care au \u021binut post au evitat \u0219i sc\u0103derea \u00een mas\u0103 muscular\u0103 care apare odat\u0103 cu \u00eemb\u0103tr\u00e2nirea (<a href=\"http:\/\/Van Norren K, Rusli F, Van Dijk M, Lute C, Nagel J, Dijk FJ, Dwarkasing J, Boekschoten MV, Luiking Y, Witkamp RF, M\u00fcller M, Steegenga WT, Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice. J Cachexia Sarcopenia Muscle. 2015 Sep; 6(3):253-68\">9<\/a>).<\/p><\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Concluzie: Chiar se Merit\u0103 Stimularea Autofagiei cu Postul Intermitent?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>Postul intermitent poate avea c\u00e2teva beneficii de s\u0103n\u0103tate pozitive:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Poate stimula autofagia.<\/li><li>Este asociat cu cre\u0219terea duratei de via\u021b\u0103.<\/li><li>Poate stimula produc\u021bia de noi mitocondrii.<\/li><li>Poate reduce inflama\u021bia precum \u0219i \u00eembun\u0103t\u0103\u021birea cardiovascular\u0103.<\/li><li>Ajut\u0103 la pierderea \u00een greutate.<\/li><li>\u0218i poate ajuta la reducerea nivelurilor \u00eenalte de testosteron la femei.<\/li><\/ul>\n\n\n\n<p>Totu\u0219i, \u00een timp ce sunt ni\u0219te beneficii excelente, nu am men\u021bionat <strong>o poten\u021bial\u0103 problem\u0103 cu postul. <\/strong>\u0218i asta este c\u0103 trebuie s\u0103 ne asigur\u0103m c\u0103 doar \u021bine post \u0219i nu ne \u00eenfomet\u0103m.<\/p>\n\n\n\n<p>C\u00e2nd postul este \u021binut corect, nu ar trebui s\u0103 fie ceva care s\u0103 produc\u0103 efecte negative precum ame\u021beal\u0103, sl\u0103biciune, iritabilitate sau orice altceva foarte negativ.<\/p>\n\n\n\n<p><strong>Este NORMAL s\u0103 v\u0103 fie pu\u021bin\u0103 foame. Totu\u0219i, c\u00e2nd v\u0103 sim\u021bi\u021bi r\u0103u sau crede\u021bi c\u0103 nu mai pute\u021bi a\u0219tepta p\u00e2n\u0103 la ur\u0103toarea mas\u0103, a\u021bi ini\u021biat r\u0103spunsul la \u00eenfometare.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>R\u0103spunsul la \u00eenfometare <\/strong>apare c\u00e2nd nu producem suficiente cetone pentru a hr\u0103ni creierul. \u00cen schimb, pentru nu are suficient\u0103 energie venind \u00een timp ce m\u00e2nc\u0103, creierul nostru. Percepe o lips\u0103 periculoas\u0103 de m\u00e2ncare. Atunci face tot ce poate pentru a ne opri din ceea ce facem pentru a economisi energie f\u0103c\u00e2ndu-ne s\u0103 ne sim\u021bim le\u0219ina\u021bi.<\/p>\n\n\n\n<p>Am scris un g<a href=\"https:\/\/eu.intelligentlabs.org\/ro-ro\/post-intermitent-dieta\/\" target=\"_blank\" rel=\"noreferrer noopener\">hid detaliat despre cum putem evita r\u0103spunsul la \u00eenfometare<\/a>, a\u0219a c\u0103 citi\u021bi-l \u00eenainte de a decide.<\/p>\n\n\n\n<p>Cu informa\u021biile potrivite \u0219i \u00een\u021beleg\u00e2nd cum func\u021bioneaz\u0103 postul intermitent, majoritatea ar trebui s\u0103-l \u00eencerce \u0219i s\u0103 simt\u0103 toate poten\u021bialele beneficii \u00een s\u0103n\u0103tatea lor!<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Referin\u021be<\/strong><\/h4>\n\n\n\n<p>(1) Stephen D. Anton, Keelin Moehl, William T. Donahoo, Krisztina Marosi, Stephanie Lee, Arch G. Mainous, III, Christiaan Leeuwenburgh, and Mark P. Mattson, Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting, Obesity (Silver Spring). 2018 Feb; 26(2): 254\u2013268.<\/p>\n\n\n\n<p>(2) Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010;110: 911\u2013916<\/p>\n\n\n\n<p>(3) Eric L Greer &amp; Anne Brunet, FOXO transcription factors at the interface between longevity and tumor suppression, Oncogene volume 24, pages7410\u20137425(2005)<\/p>\n\n\n\n<p>(4) Read AP, Strachan T (1999). \u201cChapter 18: Cancer Genetics\u201d. Human molecular genetics 2. New York: Wiley.<\/p>\n\n\n\n<p>(5) Surget S, Khoury MP, Bourdon JC (December 2013). \u201cUncovering the role of p53 splice variants in human malignancy: a clinical perspective\u201d. OncoTargets and Therapy. 7: 57\u201368.<\/p>\n\n\n\n<p>(6) Sanchis-Gomar F, Garc\u00eda-Gim\u00e9nez JL, G\u00f3mez-Cabrera MC, Pallard\u00f3 FV (2014). \u201cMitochondrial biogenesis in health and disease. Molecular and therapeutic approaches\u201d. Curr. Pharm. Des. 20 (35): 5619\u20135633.<\/p>\n\n\n\n<p>(7) Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E. Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr [Internet] 2005;81:69\u201373.<\/p>\n\n\n\n<p>(8) Byrne NMM, Sainsbury A, King NAA, Hills APP, Wood REE. Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study. Int J Obes [Internet] 2017:1\u201310.<\/p>\n\n\n\n<p>(9) Van Norren K, Rusli F, Van Dijk M, Lute C, Nagel J, Dijk FJ, Dwarkasing J, Boekschoten MV, Luiking Y, Witkamp RF, M\u00fcller M, Steegenga WT, Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice.<br>J Cachexia Sarcopenia Muscle. 2015 Sep; 6(3):253-68.<\/p>\n\n\n\n<p>(10) Deng X, Cheng J, Zhang Y, Li N, Chen L. Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats. Acta Diabetol. 2010;47(suppl 1):177\u201385.<\/p>\n\n\n\n<p>(11) M\u2019guil M, Ragala MA, El Guessabi L, Fellat S, Chraibi A, Chabraoui L, et al. Is Ramadan fasting safe in type 2 diabetic patients in view of the lack of significant effect of fasting on clinical and biochemical parameters, blood pressure, and glycemic control ? Clin Exp Hypertens. 2008;30:339\u201357.<\/p>\n\n\n\n<p>(12) Harvie MN, Pegington M, Mattson MP, Frystyk J, Dillon B, Evans G, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women. Int J Obes. 2011;35:714\u201327.<\/p>\n\n\n\n<p>(13) Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. Mattson MP, Wan RJ, Nutr Biochem. 2005 Mar; 16(3):129-37.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Postul intermitent a fost cea mai popular\u0103 diet\u0103 din 2020. Fie c\u0103 f\u0103cea\u021bi doar 16:8, 5:2 sau post doar \u00een zilele lucr\u0103toare, 17 milioane de persoane din SUA au s\u0103ri pe acest trend. 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