Seksu\u0101li akt\u012bv\u0101m sieviet\u0113m oblig\u0101ti vajadz\u0113tu lietot folijsk\u0101bi. Reiz\u0113m gad\u0101s zin\u0101mi “negad\u012bjumi”, un daudzas sievietes pat uzzina, ka ir st\u0101vokl\u012b, tikai da\u017eus m\u0113ne\u0161us v\u0113l\u0101k!<\/p>\n\n\n\n
No 2015. l\u012bdz 2019. gadam vis\u0101 pasaul\u0113 bija 121 miljons neparedz\u0113tu gr\u016btniec\u012bbu; tas noz\u012bm\u0113 aptuveni 64 nepl\u0101notas gr\u016btniec\u012bbas uz 1000 sieviet\u0113m vecum\u0101 no 15 l\u012bdz 49 gadiem (1<\/a>). Nepl\u0101nota gr\u016btniec\u012bba var apdraud\u0113t gan m\u0101tes, gan b\u0113rna vesel\u012bbu, jo netiek veikti prevent\u012bvi pas\u0101kumi, lai nodro\u0161in\u0101tu vesel\u012bgu gr\u016btniec\u012bbu.<\/p>\n\n\n\n Viens no liel\u0101kajiem neparedz\u0113tas gr\u016btniec\u012bbas riskiem ir smagi iedzimti defekti, piem\u0113ram, nervu caurules defekti vai NTD. Pie t\u0101diem pieder spina bifida (mugurkauls un muguras smadzenes neveidojas pareizi) un anencef\u0101lija (tas ietekm\u0113 smadzenes un galvaskausu). Lab\u0101 lieta ir t\u0101da, ka \u0161\u012bs NTD var nov\u0113rst, lietojot pietiekami daudz folijsk\u0101bes pirms gr\u016btniec\u012bbas un gr\u016btniec\u012bbas laik\u0101. Diem\u017e\u0113l NTD joproj\u0101m ir probl\u0113ma daudz\u0101s pasaules valst\u012bs (2<\/a>). <\/p>\n\n\n\n Par laimi, reprodukt\u012bv\u0101 vecuma sieviet\u0113m uztura bag\u0101tin\u0101\u0161ana ar folsk\u0101bi stiprin\u0101\u0161ana var nov\u0113rst 50\u201370% NTD, kas rodas katru gadu. Tas ir svar\u012bgi, jo r\u016bpes par b\u0113rnu, kur\u0161 dzimis ar mugurkaula mugurkaulu, nemaz nav l\u0113tas \u2014 kop\u0113j\u0101s tie\u0161\u0101s apr\u016bpes izmaksas m\u016b\u017ea garum\u0101 tiek l\u0113stas aptuveni 792 000 USD apm\u0113r\u0101. (3<\/a>)!\u00a0<\/p>\n\n\n\n To sakot, ir da\u017e\u0101das fol\u0101tu un folijsk\u0101bes formas – t\u0101s NAV vien\u0101das! N\u0101kamaj\u0101 sada\u013c\u0101 m\u0113s uzzin\u0101sim, kura fol\u0101tu forma ir vislab\u0101k\u0101 sievie\u0161u pirmsdzemd\u012bbu vesel\u012bbai.<\/p>\n\n\n\n Fol\u0101ts, folijsk\u0101be un aktiv\u0113t\u0101 folijsk\u0101be ir da\u017e\u0101das B9 vitam\u012bna formas, kas ir nepiecie\u0161amas daudziem svar\u012bgiem biolo\u0123iskiem procesiem. B9 vitam\u012bnam ir galven\u0101 loma aminosk\u0101bju sint\u0113z\u0113, asins veido\u0161an\u0101, homociste\u012bna metabolism\u0101, im\u016bnsist\u0113m\u0101 un \u0161\u016bnu dal\u012b\u0161an\u0101. T\u0101 ar\u012b pal\u012bdz nov\u0113rst nervu caurules defektus aug\u013ca att\u012bst\u012bb\u0101 (4<\/a>).<\/p>\n\n\n\n Fol\u0101ts ir dabiska B9 vitam\u012bna forma, kas atrodas da\u017e\u0101dos p\u0101rtikas produktos, piem\u0113ram, za\u013cajos lapu d\u0101rze\u0146os, liellopu akn\u0101s, ol\u0101s, riekstos, aug\u013cos un p\u0101k\u0161augos. Tas ir biolo\u0123iski pieejams, ta\u010du to viegli izn\u012bcina, nepareizi uzglab\u0101jot, mazg\u0101jot un gatavojot \u0113dienu (5). Fol\u0101ts zarn\u0101s tiek p\u0101rv\u0113rsts biolo\u0123iski akt\u012bvaj\u0101 form\u0101, 5-MTHF vai 5-metiltetrahidrofol\u0101t\u0101, pirms non\u0101k asinsrit\u0113 (6<\/a>).<\/p>\n\n\n\n Folijsk\u0101be ir fol\u0101ta sint\u0113tisk\u0101 versija. T\u0101 ir stabil\u0101ks par fol\u0101tu, padarot to par v\u0113lamo B9 vitam\u012bna formu, ko pievieno bag\u0101tin\u0101tiem p\u0101rtikas produktiem, piem\u0113ram, brokastu p\u0101rsl\u0101m, makaroniem, maizei, miltiem un daudziem uztura bag\u0101tin\u0101t\u0101jiem (5<\/a>). <\/p>\n\n\n\n Neskatoties uz to, folijsk\u0101bei ir zin\u0101mas probl\u0113mas. T\u0101s netiek piln\u012bb\u0101 metaboliz\u0113tas un p\u0101rv\u0113rstas par 5-MTHF zarn\u0101s, k\u0101 tas notiek uztura fol\u0101tu. Tas var izrais\u012bt nemetaboliz\u0113ta folijsk\u0101bes<\/a> uzkr\u0101\u0161anos asin\u012bs, kas var novest pie nopietn\u0101m vesel\u012bbas probl\u0113m\u0101m (7, 8<\/a>).<\/p>\n\n\n\n T\u0101d\u0113j\u0101di m\u0113s non\u0101kam pie n\u0101kam\u0101s sint\u0113tisk\u0101 fol\u0101ta paaudzes \u2013 aktiv\u0113t\u0101s folijsk\u0101bes.<\/p>\n\n\n\n Aktiv\u0113t\u0101 folijsk\u0101be (5-MTHF) ir galven\u0101 fol\u0101tu forma, kas atrodama asin\u012bs. Lietojot 5-MTHF, j\u016bsu \u0137ermenim vairs nav j\u0101veic nek\u0101das konversijas. K\u0101p\u0113c? Jo t\u0101 jau ir akt\u012bv\u0101 5-MTHF forma \u2013 forma, kur\u0101 tiek p\u0101rveidots uztura fol\u0101ts un parast\u0101 folijsk\u0101be (9<\/a>).<\/p>\n\n\n\n Aktiv\u0113t\u0101 folijsk\u0101be ir pareiz\u0101 B9 vitam\u012bna forma ne tikai sieviet\u0113m pirmsdzemd\u012bbu period\u0101, bet ar\u012b person\u0101m ar MTHFR \u0123en\u0113tisko mut\u0101ciju.<\/p>\n\n\n\n \u0160eit ir infografika, kur\u0101 izkl\u0101st\u012btas galven\u0101s at\u0161\u0137ir\u012bbas starp \u0161\u012bm 3 veidlap\u0101m:<\/p>\n\n\n\n Cilv\u0113kiem ar MTHFR \u0123en\u0113tisko vari\u0101ciju, \u012bpa\u0161i C677T un A1298C variantiem, ir probl\u0113mas ar fol\u0101tu un folijsk\u0101bes metabolismu. \u0160ie \u0123en\u0113tiskie varianti var izrais\u012bt da\u017e\u0101das vesel\u012bbas probl\u0113mas, piem\u0113ram, vitam\u012bnu tr\u016bkumu (tostarp zemu fol\u0101tu l\u012bmeni asin\u012bs), augstu homociste\u012bna l\u012bmeni (augstu sirds slim\u012bbu risku), atk\u0101rtotus spont\u0101nos abortus un mazu\u013cus ar nervu caurules defektiem (10<\/a>).<\/p>\n\n\n\n Ja esat sieviete, kura m\u0113\u0123ina gr\u016btniec\u012bbu un jums ir \u0161\u012b MTHFR vari\u0101cija, tad jums ir j\u0101lieto aktiv\u0113t\u0101 folijsk\u0101be, lai j\u016bsu \u0137ermenis var\u0113tu piln\u012bb\u0101 izmantot \u0161o vitam\u012bnu. <\/p>\n\n\n\n Ir divi popul\u0101ri aktiv\u0113t\u0101s folijsk\u0101bes veidi:<\/p>\n\n\n\n T\u0101tad, k\u0101p\u0113c \u0161\u012b at\u0161\u0137ir\u012bba starp \u0161\u012bm div\u0101m aktiv\u0113t\u0101s folijsk\u0101bes form\u0101m ir svar\u012bga?<\/p>\n\n\n\n 2016. gada p\u0113t\u012bjums atkl\u0101ja, ka 5-MTHF no glikozam\u012bna s\u0101ls tika absorb\u0113ts 1,8 reizes lab\u0101k nek\u0101 5-MTHF no kalcija s\u0101ls. T\u0101 bija ar\u012b 3,1 reizi biopieejam\u0101ka nek\u0101 parast\u0101 folijsk\u0101be (11<\/a>). <\/p>\n\n\n\n Pateicoties izcilajai biopieejam\u012bbai, aktiv\u0113t\u0101 folijsk\u0101be no glikozam\u012bna s\u0101ls ir lab\u0101k\u0101 izv\u0113le sieviet\u0113m reprodukt\u012bv\u0101 vecum\u0101, k\u0101 ar\u012b ikvienam, kam ir MTHFR g\u0113nu polimorfisms.<\/p>\n\n\n\n M\u016bsu Intelligent Labs 5-MTHF uztura bag\u0101tin\u0101t\u0101jos<\/a>, m\u0113s izmantojam patent\u0113tu formulu Quatrefolic Acid\u00ae, kas ieg\u016bta no glikozam\u012bna s\u0101ls, kas nav v\u0113\u017eveid\u012bgo, padarot to piem\u0113rotu ve\u0123et\u0101rie\u0161iem un veg\u0101niem.<\/p>\n\n\n\n Saska\u0146\u0101 ar 2013. gada p\u0113t\u012bjumu, ko veica Obeid et al., aktiv\u0113t\u0101 folijsk\u0101be ir lab\u0101ka izv\u0113le gr\u016btniec\u0113m, sal\u012bdzinot ar fol\u0101tu un parasto folijsk\u0101bi (12). \u0160eit ir da\u017ei iev\u0113rojami vi\u0146u p\u0113t\u012bjumu atkl\u0101jumi: <\/p>\n\n\n\n Atsaucoties uz CDC<\/a>, ir nepiecie\u0161ami vair\u0101ki m\u0113ne\u0161i regul\u0101ras fol\u0101tu lieto\u0161anu, lai sasniegtu pietiekami augstu fol\u0101ta koncentr\u0101ciju asin\u012bs uni nov\u0113rstu NTD.\u201d<\/p>\n\n\n\n Tas noz\u012bm\u0113, ka sieviet\u0113m j\u0101s\u0101k lietot 5-MTHF no glikozam\u012bna s\u0101ls da\u017eus m\u0113ne\u0161us pirms ie\u0146em\u0161anas l\u012bdz pirmajam gr\u016btniec\u012bbas trimestrim, jo \u200b\u200b\u0161aj\u0101 period\u0101 vi\u0146\u0101m ir liel\u0101kas fol\u0101tu vajadz\u012bbas.<\/p>\n\n\n\n Fol\u0101ts ir b\u016btisks aug\u013ca aug\u0161anai un att\u012bst\u012bbai. Ja pirms ie\u0146em\u0161anas ir pietiekami daudz fol\u0101tu kr\u0101jumu, NTD var nov\u0113rst, t\u0101p\u0113c ir \u013coti svar\u012bgi, lai m\u0101tes var\u0113tu piln\u012bb\u0101 izmantot uz\u0146emto fol\u0101tu (13<\/a>).<\/p>\n\n\n\n T\u0101pat tas pats attiecas uz t\u0113tiem. V\u012brie\u0161iem ar\u012b j\u0101b\u016bt pietiekamam fol\u0101tu l\u012bmenim, lai pal\u012bdz\u0113tu nodro\u0161in\u0101t veiksm\u012bgu gr\u016btniec\u012bbu. Izlasiet \u0161o, lai uzzin\u0101tu vair\u0101k par folijsk\u0101bes priek\u0161roc\u012bbas v\u012brie\u0161iem<\/a>.<\/p>\n\n\n\n Pareizas fol\u0101tu formas \u2013 \u0161aj\u0101 gad\u012bjum\u0101 aktiv\u0113t\u0101s folijsk\u0101bes \u2013 lieto\u0161ana ir svar\u012bga ne tikai pirmsdzemd\u012bbu vesel\u012bbai, bet ar\u012b tiem, kam ir probl\u0113mas ar uztura fol\u0101tu un folijsk\u0101bes metabolismu. 5-MTHF augst\u0101 biolo\u0123isk\u0101 pieejam\u012bba noz\u012bm\u0113, ka varat izmantot visas apbr\u012bnojam\u0101s fol\u0101tu priek\u0161roc\u012bbas vesel\u012bbai (izlasiet piln\u012bgo fol\u0101tu un 5-MTHF metilfol\u0101ta ce\u013cvedi<\/a> \u0161eit, lai ieg\u016btu vair\u0101k inform\u0101cijas).Kas attiecas uz lab\u0101ko 5-MTHF uztura bag\u0101tin\u0101t\u0101ja gr\u016btniec\u012bbas laik\u0101? Izm\u0113\u0123iniet 1MG 5-MTHF<\/a> uztura bag\u0101tin\u0101t\u0101jus Intelligent Labs veikal\u0101.<\/p>\n","protected":false},"excerpt":{"rendered":" R\u016bpes par b\u0113rniem s\u0101kas v\u0113l pirms dzim\u0161anas. Noteiktu darb\u012bbu veik\u0161ana, piem\u0113ram, sabalans\u0113ta uztura \u0113\u0161ana, vingro\u0161ana un pirmsdzemd\u012bbu vitam\u012bnu lieto\u0161ana pal\u012bdz uzlabot vesel\u012bgas gr\u016btniec\u012bbas izredzes. \u0160aj\u0101 rakst\u0101 m\u0113s apskat\u012bsim vienu no svar\u012bg\u0101kajiem vitam\u012bniem, k\u0101du var uz\u0146emt topo\u0161\u0101 mamma – aktiv\u0113to folijsk\u0101bi.\u00a0 K\u0101p\u0113c lietot folijsk\u0101bi ie\u0146em\u0161anai un gr\u016btniec\u012bbai? Seksu\u0101li akt\u012bv\u0101m sieviet\u0113m oblig\u0101ti vajadz\u0113tu lietot folijsk\u0101bi. Reiz\u0113m gad\u0101s…<\/p>\n","protected":false},"author":2,"featured_media":129329,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[2958],"tags":[2963],"coauthors":[],"class_list":["post-230629","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uzturs","tag-5-mthf"],"taxonomy_info":{"category":[{"value":2958,"label":"Uzturs"}],"post_tag":[{"value":2963,"label":"5-MTHF"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2022\/03\/5-mthf-activated-folic-acid-for-prenatal-health-01-1024x512.jpg",1024,512,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/lv-lv\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":2958,"name":"Uzturs","slug":"uzturs","term_group":0,"term_taxonomy_id":2958,"taxonomy":"category","description":"","parent":0,"count":42,"filter":"raw","cat_ID":2958,"category_count":42,"category_description":"","cat_name":"Uzturs","category_nicename":"uzturs","category_parent":0}],"tag_info":[{"term_id":2963,"name":"5-MTHF","slug":"5-mthf","term_group":0,"term_taxonomy_id":2963,"taxonomy":"post_tag","description":"","parent":0,"count":3,"filter":"raw"}],"wpml":{"language":"lv-lv","is_original":false,"original_post_id":130686,"translations":{"cs-cz":{"id":221612,"language":"cs-cz","is_original":false},"de-at":{"id":169259,"language":"de-at","is_original":false},"de-de":{"id":75417,"language":"de-de","is_original":false},"en-gb":{"id":130686,"language":"en-gb","is_original":true},"en-ie":{"id":164126,"language":"en-ie","is_original":false},"en-mt":{"id":165499,"language":"en-mt","is_original":false},"es-es":{"id":74994,"language":"es-es","is_original":false},"et-ee":{"id":230258,"language":"et-ee","is_original":false},"fr-fr":{"id":129328,"language":"fr-fr","is_original":false},"hu-hu":{"id":225136,"language":"hu-hu","is_original":false},"it-it":{"id":75244,"language":"it-it","is_original":false},"lt-lt":{"id":237153,"language":"lt-lt","is_original":false},"lv-lv":{"id":230629,"language":"lv-lv","is_original":false},"nl-nl":{"id":175346,"language":"nl-nl","is_original":false},"pt-pt":{"id":168951,"language":"pt-pt","is_original":false},"ro-ro":{"id":253675,"language":"ro-ro","is_original":false},"sl-si":{"id":239024,"language":"sl-si","is_original":false}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/posts\/230629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/comments?post=230629"}],"version-history":[{"count":1,"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/posts\/230629\/revisions"}],"predecessor-version":[{"id":230674,"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/posts\/230629\/revisions\/230674"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/media\/129329"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/media?parent=230629"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/categories?post=230629"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/tags?post=230629"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lv-lv\/wp-json\/wp\/v2\/coauthors?post=230629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"aktiv\u0113t\u0101](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/por-que-el-acido-folico-activado-5-mthf-es-mejor-para-la-salud-prenatal-03-1024x512.jpeg\")
<\/figure>\n\n\n\nDa\u017e\u0101das fol\u0101tu formas \u2013 un k\u0101p\u0113c aktiv\u0113t\u0101 folijsk\u0101be ir lab\u0101k\u0101 forma pirmsdzemd\u012bbu vesel\u012bbas atbalstam<\/strong><\/h2>\n\n\n\n
At\u0161\u0137ir\u012bbas starp fol\u0101tu, folijsk\u0101bi un aktiv\u0113to folijsk\u0101bi<\/strong><\/h3>\n\n\n\n
![\"da\u017e\u0101das](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/acido-folico-no-metabolizado-que-es-y-como-prevenirlo-01-492x1024.png\")
<\/figure>\n\n\n\nK\u0101 5-MTHF var pal\u012bdz\u0113t sieviet\u0113m (un v\u012brie\u0161iem) ar MTHFR g\u0113nu polimorfismu<\/strong><\/h3>\n\n\n\n
![\"Intelligent](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/por-que-el-acido-folico-activado-5-mthf-es-mejor-para-la-salud-prenatal-02.jpeg\")
<\/figure>\n\n\n\nK\u0101das ir citas 5-MTHF aktiv\u0113t\u0101s folijsk\u0101bes priek\u0161roc\u012bbas?<\/strong><\/h2>\n\n\n\n
Kad ir lab\u0101kais laiks s\u0101kt lietot aktiv\u0113to folijsk\u0101bi gr\u016btniec\u012bbas laik\u0101?<\/strong><\/h2>\n\n\n\n
Nosl\u0113gum\u0101<\/strong><\/h2>\n\n\n\n