{"id":231101,"date":"2020-09-28T09:00:00","date_gmt":"2020-09-28T08:00:00","guid":{"rendered":"https:\/\/eu.intelligentlabs.org\/kas-yra-5-mthf-metilfolatas\/"},"modified":"2025-09-19T09:52:41","modified_gmt":"2025-09-19T08:52:41","slug":"kas-yra-5-mthf-metilfolatas","status":"publish","type":"post","link":"https:\/\/eu.intelligentlabs.org\/lt-lt\/kas-yra-5-mthf-metilfolatas\/","title":{"rendered":"Kas yra 5-MTHF? Pla\u010diausias folato ir metilfolato gidas"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Kas yra 5-MTHF? \u0160is gidas yra skirtas suteikti jums vis\u0105 nauding\u0105 ir tyrimais patvirtint\u0105 informacij\u0105 apie vitamin\u0105 B9, folat\u0105, folio r\u016bg\u0161t\u012f, 5-MTHF ir kitus papildus ir maisto produktus, palaikan\u010dius sveik\u0105 B9 lyg\u012f. Su\u017einosite apie problemas, kurios gali suma\u017einti B9 iki nesveiko lygio &#8211; net vartojant maisto papildus ar valgant daug folat\u0173 turint\u012f maist\u0105 &#8211; ir kaip jas gydyti ar j\u0173 i\u0161vengti. Laikykite tai kaip D.U.K. esamam ir b\u016bsimam folato papild\u0173 vartotojui ar tiems, kurie papras\u010diausiai domisi. Vitamino B vartojimas yra pla\u010diai linksniuojama tema. Yra de\u0161imtys mokslini\u0173 tyrim\u0173 apie j\u0173 efektus, kaip jie teigiamai ir neigiamai s\u0105veikauja su valgomu maistu ir vartojamais vaistais, geriausias B9 formas ir daug kit\u0173 tem\u0173. Mes i\u0161kapst\u0117me visus \u0161iuos tyrimus, tad jums to daryti nebereik\u0117s. Jei turite bet koki\u0173 jums svarbi\u0173 klausim\u0173, kurie neatsakyti \u0161iame gide ARBA\u2026 Jums reikia daugiau informacijos apie vien\u0105 atsakym\u0173 ir\/arba j\u016bs jo nesuprantate ARBA\u2026 J\u016bs nesutinkate su bet kokia id\u0117ja \u0161iame gide\u2026 Nepasidid\u017eiuokite! Para\u0161ykite mums! <a href=\"https:\/\/eu.intelligentlabs.org\/lt-lt\/susisiekite-su-mumis\/\">Susisiekite su mumis<\/a> arba palikite komentar\u0105 \u017eemiau.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kas yra folatas?<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-49.jpeg\" alt=\"kiau\u0161iniai, pupel\u0117s ir duona yra folato \u0161altiniai\" class=\"wp-image-240725\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-49.jpeg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-49-300x150.jpeg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-49-1024x512.jpeg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-49-768x384.jpeg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-49-600x300.jpeg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u017dodis \u201efolatas\u201c yra naudojamas apib\u016bdinti maistini\u0173 med\u017eiag\u0173, randam\u0173 maiste, o ypa\u010d \u017ealiose lapin\u0117se dar\u017eov\u0117se, pupel\u0117se ir kiau\u0161iniuose, \u0161eimai. Ta yra nat\u016braliai randami ir vandenyje tirp\u016bs B9 vitaminai (1). \u012eprastai \u017eod\u012f \u201efolatas\u201c \u017emon\u0117s naudoja apib\u016bdinant vien\u0105 maistin\u0119 med\u017eiag\u0105. \u201eFolatai\u201c gali skamb\u0117ti kiek juokingai, nes \u0161i daugiskaitos forma naudojama re\u010diau. Daug folato randama maisto produktuose, tokiuose kaip lapinis kop\u016bstas, brokolis, citrusiniai vaisiai, \u0161paragai, bananai, pupos ir kepen\u0117l\u0117s (1). Pupos ir kepen\u0117l\u0117s suteikia daug daugiau nat\u016bralaus folato nei kiti auk\u0161\u010diau i\u0161vardinti maisto produktai. Jei \u017emogui reikia didelio folat\u0173 kiekio ar jo tr\u016bkumas jau\u010diamas net vartojant didel\u012f folat\u0173 kiek\u012f, labai realu, kad tai n\u0117ra geriausias b\u016bdas gauti folat\u0173. Ligos ir genetiniai faktoriai gali neleisti organizmui metabolizuoti folato, gaunamo i\u0161 maisto. Skaitykite toliau ir su\u017einokite apie tai daugiau.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kas yra folio r\u016bg\u0161tis?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Folio r\u016bg\u0161tis yra sintetin\u0117 ir vandenyje tirpi vitamino B9 forma. \u012eprastai ji kuriama kaip papildas. Folio r\u016bg\u0161ties yra daugumoje duonos, kepini\u0173 ir saus\u0173 pusry\u010di\u0173.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/what-is-5-mthf-methylfolate-a-comprehensive-jargon-free-guide-02.jpg\" alt=\"daugelyje \u0161ali\u0173 spage\u010diai yra sustiprinami folio r\u016bg\u0161timi\" class=\"wp-image-163312\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/what-is-5-mthf-methylfolate-a-comprehensive-jargon-free-guide-02.jpg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/what-is-5-mthf-methylfolate-a-comprehensive-jargon-free-guide-02-300x150.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/what-is-5-mthf-methylfolate-a-comprehensive-jargon-free-guide-02-1024x512.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/what-is-5-mthf-methylfolate-a-comprehensive-jargon-free-guide-02-768x384.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/what-is-5-mthf-methylfolate-a-comprehensive-jargon-free-guide-02-600x300.jpg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">1998 metais JAV nustat\u0117, kad folio r\u016bg\u0161tis turi b\u016bti pridedama \u012f tam tikrus gr\u016bdus, \u0161itaip masiniu lygiu u\u017etikrinant pakankam\u0105 B9 suvartojim\u0105. Nuo 2017, 86 \u0161alys \u012fstatymais nustat\u0117, kad kvietiniuose miltuose turi b\u016bti bent minimalus folio r\u016bg\u0161ties kiekis (2)(3). 16 i\u0161 86 t\u0105 pat\u012f nustat\u0117 ir kukur\u016bz\u0173 miltams. \u0160e\u0161ios tautos \u012f s\u0105ra\u0161\u0105 taip pat prid\u0117jo ir ry\u017ei\u0173 miltus.&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kas yra 5-MTHF?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">5-metiltetrahidrofolatas, arba 5-MTHF, yra nat\u016brali vitamino B9 forma, kuri\u0105 j\u016bs\u0173 k\u016bnas pasiruo\u0161\u0119s absorbuoti ir panaudoti mitybos tikslais. D\u0117l \u0161ios prie\u017easties dabar tai labai populiari folato forma, ypa\u010d tarp \u017emoni\u0173, turin\u010di\u0173 sunkum\u0173 metabolizuojant kitas B9 formas i\u0161 maisto ir papild\u0173. <strong>5-MTHF sinonimai:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>L-5-MTHF<\/li><li>L-metilfolatas<\/li><li>Kalcio-L-metilfolatas (tik jei jis suri\u0161tas su kalcio druska)<\/li><li>Metilfolatas<\/li><li>Levomefolio r\u016bg\u0161tis&nbsp;<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Pasteb\u0117kite, kad kai kuriuose i\u0161 auk\u0161\u010diau pamin\u0117t\u0173 pavadinim\u0173 naudojama \u201eL\u201c raid\u0117. Ji rei\u0161kia, kad dauguma \u017emoni\u0173 gali j\u0105 absorbuoti. \u201e6(S)\u201c vietoje \u201eL\u201c rei\u0161kia t\u0105 pat\u012f. Jei \u201eL\u201c pakei\u010diama \u201e6(R)\u201c, \u0161i formul\u0117 grei\u010diausiai menkai jums tepad\u0117s.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kuri\u0105 folato form\u0105 geriausiai absorbuoja ir naudoja j\u016bs\u0173 k\u016bnas?&nbsp;<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Studija, kuri\u0105 publikavo \u017eurnalas British Journal of Pharmacology, palygino 6(S)-5-MTHF ir folio r\u016bg\u0161ties pasisavinim\u0105 \u017emogaus k\u016bne. Studijoje dalyvavo sveikos moterys, d\u0117l gen\u0173, reikaling\u0173 \u0161iam procesui, sutrikim\u0173, turin\u010dios problem\u0173 pasisavinant su maistu gaunamus folat\u0105 ir folio r\u016bg\u0161t\u012f. 6(S)-5-MTHF buvo daug naudingesnis vitamino B9 pristatymui \u012f kraujo plazm\u0105, kur jis gali daryti savo stebuklus. \u0160ioje studijoje tyr\u0117jai naudojo 6(S)-5-MTHF kartu su kalcio druska. Taip, pasisavinimo prasme tai \u017eenkliai priekyje\u2026 BET\u2026 Kitoje studijoje, atliktoje ant \u017eiurki\u0173, buvo lyginami kalcio pagrindo preparatas ir 6(S)-5-MTHF gliukozamino, o ne kalcio pagrindu. Tyr\u0117jai taip pat lygino juos abu ir folio r\u016bg\u0161t\u012f. Nustatyta, kad koncentracija kraujo plazmoje buvo 1,8 karto didesn\u0117 nei naudojant 5-MTHF su kalcio druska ir 3,1 karto didesn\u0117 nei naudojant folio r\u016bg\u0161t\u012f (5).<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-01-27-300x300.jpeg\" alt=\"1 mg 5MTHF l-metilfolato kaip quatrefolic acid maisto papildas\" class=\"wp-image-240752\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-01-27-300x300.jpeg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-01-27-150x150.jpeg 150w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-01-27-100x100.jpeg 100w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-01-27.jpeg 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u0160tai kod\u0117l Intelligent Labs naudoja b\u016btent 6(S)-5-MTHF suri\u0161t\u0105 su gliukozaminu, i\u0161gautu nenaudojant kiaukutini\u0173. Savo papilduose naudojame patentuot\u0105 formul\u0119, vadinam\u0105 Quatrefolic Acid\u00ae ir si\u016blome <a href=\"https:\/\/eu.intelligentlabs.org\/lt-lt\/produktas\/1mg-5-mthf-l-metilfolatas-kaip-quatrefolic-acid\/\">1 mg 5-MTHF<\/a> ir <a href=\"https:\/\/eu.intelligentlabs.org\/lt-lt\/produktas\/5mg-5-mthf-l-metilfolatas-kaip-quatrefolic-acid\/\">5 mg 5-MTHF<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>5-MTHF preki\u0173 \u017eenklai<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Metafolin\u00ae<\/strong> \u2013 5-MTHF papildas, kuriame naudojamas L-metilfolato kalcis. Jis si\u016blomas tik pardav\u0117j\u0173, kuriuos patvirtina papildo gamintojas. <strong>Deplin\u00ae<\/strong> \u2013 parduodamas tik su receptu. \u0160i 5-MTHF formul\u0117 buvo sukurta siekiant patenkinti depresija sergan\u010di\u0173 pacient\u0173 mitybos poreikius ir sustiprinti antidepresant\u0173 veikim\u0105. <strong>Quatrefolic Acid\u00ae<\/strong> \u2013 dar kart\u0105, tai yra formul\u0117, kuri\u0105 naudojame \u010dia, Intelligent Labs. Tarptautiniu lygiu patentuota Gnosis, tai yra viena labiausiai moksli\u0161kai pa\u017eengusi\u0173 formuli\u0173 visoje rinkoje. \u0160is 5-MTHF yra geriau absorbuojamas j\u016bs\u0173 k\u016bne, nes jo pagrindas yra gliukozaminas be kiaukutini\u0173, o ne kalcis. Intelligent Labs si\u016blo 2 5-MTHF papildus su dvejomis skirtingomis doz\u0117mis.\u00a0<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kokie yra Folato ir 5-MTHF privalumai sveikatai?<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Reikalingi b\u016btiniausioms k\u016bno funkcijoms<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B9 reikalingas gaminant: <\/strong>(6)(7)(8)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Energij\u0105 i\u0161 angliavandeni\u0173<\/li><li>DNR ir RNR<\/li><li>Raudon\u0105sias ir balt\u0105sias kraujo l\u0105steles<\/li><li>Melatonin\u0105, chemin\u0119 med\u017eiag\u0105, reguliuojan\u010di\u0105 mieg\u0105<\/li><li>Svarbius neurotransmiterius, tokius kaip norepinefrin\u0105, serotonin\u0105 ir dopamin\u0105<\/li><li>J\u016bs\u0173 nervinei sistemai<\/li><\/ul>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-04.jpg\" alt=\"kr\u016bmin\u0117s pupel\u0117s yra puikis maistinio folato \u0161altinis\" class=\"wp-image-161315\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-04.jpg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-04-300x150.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-04-1024x512.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-04-768x384.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-04-600x300.jpg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>U\u017ekerta keli\u0105 apsigimimams n\u0117\u0161tumo metu<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Sveikatos prie\u017ei\u016bros sektorius n\u0117\u0161tumo metu da\u017enai si\u016blo vartoti folato papildus ir \u0161itaip apsaugoti vaisi\u0173 nuo galim\u0173 apsigimim\u0173, toki\u0173 kaip nervinio vamzdelio defektas. Taip yra d\u0117l gerai i\u0161tirto folato tr\u016bkumo poveikio vaisiaus vystymuisi (9). Pakankamas folato kiekis yra b\u016btinas nervin\u0117s sistemos vystymuisi n\u0117\u0161tumo metu. Tai kriti\u0161kai svarbu nuo pat n\u0117\u0161tumo prad\u017eios. \u012eprastai moterys nesupranta, kad laukiasi, kol nepraeina kelios savait\u0117s. Net jei dar tik bandote pastoti, i\u0161ankstinis folato papild\u0173 vartojimas ir jo lygio palaikymas yra puiki id\u0117ja (6).&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>D\u0117mesio, t\u0117\u010diai: tai galioja ir jums!<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Vyrai, kurie kartu su savo gyvenimo draug\u0117mis bando susilaukti vaik\u0173, taip pat tur\u0117t\u0173 \u012fsitikinti, kad jiems netr\u016bksta folato. 2013 met\u0173 studijoje buvo nustatyta, kad bandant pastoti su vyru, kurio folato kiekis yra \u017eemiau nei sveikas lygis, \u017eenkliai i\u0161auga apsigimim\u0173 tikimyb\u0117 (10). Kai kurioms moterims taip pat gali b\u016bti rekomenduojamas \u0161i\u0173 papild\u0173 vartojimas kelis m\u0117nesius prie\u0161 bandant pastoti, \u0161itaip padidinant sveiko k\u016bdikio gimimo tikimyb\u0119 (11).&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/alone.jpg\" alt=\"mokslininkai nustat\u0117, kad 5-MTHF yra efektyvus depresijos simptomams\" class=\"wp-image-166149\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/alone.jpg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/alone-300x150.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/alone-1024x512.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/alone-768x384.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/alone-600x300.jpg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Gali suma\u017einti depresijos rizik\u0105 ir\/ar sustiprinti antidepresant\u0173 veikim\u0105<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Deplin\u00ae, receptin\u0117 5-MTHF forma, buvo patentuota specialiai depresijos gydymui ir antidepresant\u0173, vartojam\u0173 depresija sergan\u010di\u0173 \u017emoni\u0173, veikimo sustiprinimui. Ne\u017einoma, kaip tiksliai 5-MTHF padeda depresija sergantiems pacientams, bet tyrimai rodo, kad \u0161ie papildai gali b\u016bti naudingi. \u012eprastai, depresijos tyrimuose vartojama \u017eymiai didesn\u0117 doz\u0117 nei \u012fprasta rekomenduoti sveikai maitinantis. 2013 metais atliktoje studijoje, kurioje dalyvavo daugiau nei 500 pacient\u0173, vartojan\u010di\u0173 vaistus nuo depresijos, po trij\u0173 m\u0117nesi\u0173 automatizuotomis telefonin\u0117mis apklausomis buvo nustatyta geresn\u0117 vidutin\u0117 gyvenimo kokyb\u0117 ir i\u0161aug\u0119s pasitenkinimas j\u0173 vaistais nuo depresijos. Taip pat pager\u0117jo pasitenkinimas santykiais su artimaisiais, draugais, kolegomis, antrosiomis pus\u0117mis ir nepa\u017e\u012fstamaisiais. Bendri poky\u010diai po 95 dien\u0173 buvo labai ry\u0161k\u016bs. Tiriamieji vartojo itin didel\u0119 receptin\u0117s 5-MTHF formos doz\u0119. Kiekvienoje doz\u0117je buvo arba 7,5 mg, arba 15 mg. Pradin\u0117 normalaus 5-MTHF vartotojo, nesergan\u010dio depresija, doz\u0117 \u012fprastai yra 1 mg arba ma\u017eiau (12). Viena i\u0161 \u0161i\u0173 teigiam\u0173 poky\u010di\u0173 prie\u017eas\u010di\u0173 gali b\u016bti tai, kad folatas yra b\u016btina dalis pagrindini\u0173 neurotransmiteri\u0173, toki\u0173 kaip serotoninas, dopaminas ir norepinefrinas, gamybai ir gali pad\u0117ti juos sureguliuoti (13). 5-MTHF taip pat gali teigiamai atsiliepti ir kai kuriems bipolinio sutrikimo simptomams. <strong>\u0160e\u0161i\u0173 savai\u010di\u0173 studija, kurioje dalyvavo 10 depresija ir bipoliniu sutrikimu sergan\u010di\u0173 \u017emoni\u0173, parod\u0117 daug \u017eadan\u010dius rezultatus (14): <\/strong><em>\u201eTyr\u0117jai nustat\u0117, kad pacientams, sergantiems bipoliniu sutrikimu, ir vartojantiems L-metilfolat\u0105, pager\u0117jo depresijos simptomai, funkcionavimas, pa\u017einimas ir savi\u017eudi\u0161kos mintys.\u201c <\/em>PERSP\u0116JIMAS: Jei ken\u010diate nuo depresijos, prie\u0161 vartodami bet kok\u012f folato papild\u0105, net ir ma\u017eomis doz\u0117mis, pirmiausia pasitarkite su savo gydytoju.\u00a0<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Ma\u017eina u\u017edegiminio chemikalo homocisteino lyg\u012f<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Homocisteinas yra junginys \u017emogaus k\u016bne, didinantis u\u017edegim\u0105, Dauguma lig\u0173 kyla d\u0117l u\u017edegimo. Auk\u0161tas homocisteino lygis gali padidinti \u0161i\u0173 problem\u0173 rizik\u0105 (18):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kraujo kre\u0161uli\u0173<\/li><li>Insulto<\/li><li>Alzheimerio ligos<\/li><li>\u0160irdies sm\u016bgio<\/li><li>Koronarini\u0173 \u0161irdies lig\u0173<\/li><li>Osteoporoz\u0117s<\/li><li>Ateroskleroz\u0117s<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Auk\u0161tas \u0161io junginio lygis siejamas su \u017eemu vitamin\u0173 B6, B9 ir B12 lygiu. \u0160i kombinacija yra svarbus \u017eenklas apie galim\u0105 pa\u017einimo funkcijos smukim\u0105 vyrams, o tikriausiai ir moterims (15). Sveiki vis\u0173 \u0161i\u0173 trij\u0173 B vitamin\u0173 lygiai yra svarb\u016bs kontroliuojant homocisteino lyg\u012f. 5-MTHF vienas pats gali u\u017ekirsti keli\u0105 kai kuriems pa\u017einimo funkcijos sutrikimams, bet tikriausiai jums tai seksis daug geriau, jei taip pat palaikysite ir kit\u0173 dviej\u0173 vitamin\u0173 lyg\u012f (15)(16)(17). Kitos auk\u0161to homocisteino lygio prie\u017eastys gali b\u016bti: hipotiroz\u0117s problemos, inkst\u0173 ligos ir psoriaz\u0117. Tai rei\u0161kia: neprad\u0117kite i\u0161 karto kaltinti vitamino B tr\u016bkumo (18). Kaip jau skait\u0117te auk\u0161\u010diau, \u012fstatymai daugumoje \u0161ali\u0173 suma\u017eino homocisteino lyg\u012f d\u0117l privalomos folio r\u016bg\u0161ties miltuose. 24 savai\u010di\u0173 atsitiktini\u0173 im\u010di\u0173 placebo studija nustat\u0117, kad ma\u017einant sveik\u0173 \u017emoni\u0173 homocisteino lyg\u012f, 5-MTHF yra daug geresnis nei folio r\u016bg\u0161tis (19).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Gali suma\u017einti insulto ir infarkto rizik\u0105<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">5-MTHF gali pagerinti \u0161irdies ir kraujotakos b\u016bkl\u0119 suma\u017eindamas homocisteino lyg\u012f ir kitais b\u016bdais. Visgi, tai sud\u0117tinga. Jis gali suma\u017einti infarkto ar insulto rizik\u0105 tik jei jums tr\u016bksta folato.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-02-20.jpeg\" alt=\"5-MTHF ir folatas gali suma\u017einti insulto ir infarkto rizik\u0105\" class=\"wp-image-240779\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-02-20.jpeg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-02-20-300x150.jpeg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-02-20-1024x512.jpeg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-02-20-768x384.jpeg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-02-20-600x300.jpeg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u0160tai pagrindini\u0173 \u012frodym\u0173 santrauka, primenanti paslapting\u0105 istorij\u0105\u2026 2015 met\u0173 studija nustat\u0117, kad vyrai, vartoj\u0119 folio r\u016bg\u0161ties papildus ir enalapril\u012f (vaist\u0105, ma\u017einant\u012f kraujosp\u016bd\u012f), per 4,5 metus suma\u017eino savo infarkto rizik\u0105. Grup\u0117s, vartojusios folio r\u016bg\u0161t\u012f ir enalapril\u012f, rezultatai buvo daug \u017eenklesni nei grup\u0117s, vartojusios tik enalapril\u012f. Senos studijos, atliktos septyniasde\u0161imtaisiais, taip pat nustat\u0117 suma\u017e\u0117jusi\u0105 insulto ir infarkto rizik\u0105, i\u0161augus folato suvartojimui (20). I\u0161 kitos pus\u0117s, kai kurios JAV atliktos placebo studijos nenustat\u0117 infarkto ir insulto rizikos suma\u017e\u0117jimo. Tai gali reik\u0161ti, kad folatas turi tok\u012f poveik\u012f tik tada, kai \u017emon\u0117ms jo tr\u016bksta. Atminkite, kad JAV prad\u0117jo stiprinti savo gr\u016bdus 1998, o tai gal\u0117t\u0173 paai\u0161kinti kai kuriuos rezultatus, gautus septyniasde\u0161imtaisiais. \u017dmon\u0117s tur\u0117jo \u017eemesn\u012f folato lyg\u012f (20). Kinija nestiprina savo gr\u016bd\u0173, o tai rei\u0161kia, kad jos populiacijai jo tr\u016bksta. Kai kurios senos JAV studijos sek\u0117 \u017emones, tur\u0117jusius infarkto ir insulto istorij\u0105. Reaguojant \u012f \u0161iuos \u012fvykius, \u0161ie \u017emon\u0117s gal\u0117jo suma\u017einti savo rizik\u0105, vartodami kitus vaistus ir maist\u0105 (20).&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kaip \u017einoti, kad jums tr\u016bksta folato?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Keletas \u017eenkl\u0173, kad folatas kelia anemij\u0105 (raudon\u0173j\u0173 kraujo k\u016bneli\u0173 tr\u016bkum\u0105), l\u0117tin\u012f vangum\u0105 ir nuovarg\u012f (21):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Oro tr\u016bkumas<\/li><li>\u016amus charakteris, irzlumas ir dirglumas<\/li><li>Balta j\u016bs\u0173 oda atrodo itin i\u0161balusi<\/li><li>Kiti \u017eemo deguonies lygio kraujyje \u017eenklai, tokie kaip atminties problemos<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kiti folato nepakankamumo \u017eenklai: (22)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ankstyvas plauk\u0173 \u017eilimas&nbsp;<\/li><li>I\u0161tin\u0119s lie\u017euvis<\/li><li>\u017daizdos ar opos burnoje<\/li><li>J\u016bs esate vaiko, turin\u010dio \u012fgimt\u0173 defekt\u0173 ar deformacij\u0173, t\u0117tis arba mama<\/li><li>Viduriavimas<\/li><li>Augimo problemos<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Vistik, folato tr\u016bkumo sau nustatymas yra sud\u0117tingas. I\u0161 dalies taip yra d\u0117l bendr\u0173 folato ir kit\u0173 B grup\u0117s vitamin\u0173 tr\u016bkumo simptom\u0173. Nor\u0117damas suprasti simptom\u0173 prie\u017east\u012f, J\u016bs\u0173 gydytojas veikiausiai atliks kelet\u0105 test\u0173.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kas sukelia folato tr\u016bkum\u0105?<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Mityb\u0105, kurioje nepakankamai folato turin\u010di\u0173 maisto produkt\u0173<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Jei nevalgote pakankamai pup\u0173, kiau\u0161ini\u0173, \u017eali\u0173 dar\u017eovi\u0173 ir kit\u0173 daug folato turin\u010di\u0173 maisto produkt\u0173 ar nevartojate jo papild\u0173, j\u016bs\u0173 k\u016bnas tikriausiai ken\u010dia nuo folato tr\u016bkumo.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-07.jpg\" alt=\"lapini\u0173 kop\u016bst\u0173 augintojai tiekia \u017emon\u0117ms nat\u016bral\u0173 folat\u0105\" class=\"wp-image-161329\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-07.jpg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-07-300x150.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-07-1024x512.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-07-768x384.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-07-600x300.jpg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Problemos, neleid\u017eian\u010dios jo \u012fsisavinti i\u0161 maisto ir jo papild\u0173<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Prast\u0105 folio r\u016bg\u0161ties ir maisto su folio r\u016bg\u0161timi pasisavinim\u0105 gali lemti daug dalyk\u0173, tarp kuri\u0173 (21):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ligos, tokios kaip Krono liga, celiakija, kai kurios v\u0117\u017eio r\u016b\u0161ys ir inkst\u0173 sutrikimai<\/li><li>Gana da\u017eni MTHFR geno sutrikimai<\/li><li>Vaist\u0173, veikian\u010di\u0173 kartu su folatu, vartojimas<\/li><li>Perteklinis alkoholio ir antacid\u0173 vartojimas<\/li><li>Gen\u0173, atsaking\u0173 u\u017e folato metabolizm\u0105, mutacijos<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Folio r\u016bg\u0161tis ir nat\u016bralus folatas maiste turi praeiti daugyb\u0119 chemini\u0173 reakcij\u0173 iki kol jie tampa 5-MTHF, vienintele vertinga forma. Dauguma m\u016bs\u0173 gali efektyviai metabolizuoti folat\u0105 ir folio r\u016bg\u0161t\u012f ir paversti juos 5-MTHF. Tai kontroliuoja vienas turimas genas. Jis vadinamas MTHFR ir kiekvienas i\u0161 m\u016bs\u0173 turime 2 jo kopijas. Visgi, dauguma m\u016bs\u0173 turi vieno ar abiej\u0173 \u0161i\u0173 gen\u0173 kopij\u0173 variacijas, neleid\u017eian\u010dias transformacijos \u012f 5-MTHF. Jei viena geno kopija bloga folato \u012fsisavinimui, efektyvumas gali \u017eenkliai smukti. Jei blogos abi kopijos, nemetabolizuosite daug folato ar folio r\u016bg\u0161ties (23). Kaip \u017einoti, kad turite vien\u0105 ar dvi blogas MTHFR geno kopijas? Jums prireiks atlikti DNR test\u0105, kur\u012f i\u0161analizuos medicinos laboratorija. Tuo u\u017esiiman\u010dias laboratorijas rasite tiek internete, tiek j\u016bs\u0173 gyvenamoje vietoje. Pirmiausia i\u0161analizuokite laboratorijas arba leiskite j\u0105 i\u0161rinkti j\u016bs\u0173 gydytojui. Lengviausias b\u016bdas i\u0161spr\u0119sti \u0161i\u0105 geno variacijos problem\u0105 yra 5-MTHF papild\u0173 vartojimas, kuriam nereikalinga daugyb\u0117 chemini\u0173 reakcij\u0173, kad j\u016bs\u0173 k\u016bnas j\u012f panaudot\u0173 tinkamai. Kitaip tariant, 5-MTHF jau yra bioaktyvus.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Nutukimas<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ry\u0161ys tarp nutukimo ir nepakankamo folato lygio yra labai stiprus, bet atrodo, kad niekas nei\u0161siai\u0161kino kod\u0117l. Studij\u0173, publikuot\u0173 tarp 2005 ir 2015 santrauka tyr\u0117 nutukusi\u0173 \u201evaisingo am\u017eiaus\u201c folato lygius, itin atsi\u017evelgiant \u012f n\u0117\u0161\u010dias moteris. Mokslinink\u0173 tikslas buvo nustatyti galimas didelio moter\u0173 folato tr\u016bkumo prie\u017eastis. Jie atkreip\u0117 d\u0117mes\u012f \u012f brit\u0173 studij\u0105, atmetusi\u0105 tokius faktorius, kaip vitamin\u0173 papild\u0173 vartojimas, mityba ir am\u017eius. Jie taip pat atkreip\u0117 d\u0117mes\u012f \u012f kelias studijas, atmetusias mityb\u0105, kaip vien\u0105 i\u0161 to prie\u017eas\u010di\u0173. Jie tegal\u0117jo rekomenduoti daugiau studij\u0173 \u0161ia tema ir kelet\u0105 patarim\u0173, kaip jas sukurti (24). Pagrindin\u0117 mintis: pats nutukimas, arba tam tikros nutukimo prie\u017eastys, gali suma\u017einti folato lyg\u012f iki nesveikos ribos. \u0160i koreliacija stipri, o pagrindinis klausimas i\u0161lieka: kas sukelia k\u0105. <strong>Kitas tyrimas nustat\u0117 stipri\u0105 koreliacij\u0105 tarp nutukimo ir folato tr\u016bkumo: <\/strong>2016 metais mokslininkai per\u017ei\u016br\u0117jo studijas, nor\u0117dami atnaujinti 2008 Amerikos Metabolin\u0117s ir bariatrin\u0117s chirurgijos mityb\u0105 Bariatrin\u0117s chirurgijos gair\u0117se. Gair\u0117s paremtos studijomis, tirian\u010diomis maistini\u0173 med\u017eiag\u0173 lygius prie\u0161 ir po operacij\u0173, skirt\u0173 svorio metimui. Naujosios 2016 m. gair\u0117s rekomenduoja i\u0161tirti galim\u0105 folato tr\u016bkum\u0105 prie\u0161 tokio tipo operacijas. To prie\u017eastis &#8211; iki 54% nutukusi\u0173 pacient\u0173 ken\u010dia nuo folato tr\u016bkumo (25). Mokslininkai neketino tirti to prie\u017eas\u010di\u0173 ir efekt\u0173. Jie tik \u012fvardino \u0161\u012f ry\u0161\u012f ir atsak\u0117 rekomenduodami prie\u0161-operacin\u012f folato lygio steb\u0117jim\u0105 ir jo papild\u0173 vartojim\u0105.&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Ar daug folato turin\u010di\u0173 maisto produkt\u0173 apdorojimas sunaikina folat\u0105?<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-03.jpeg\" alt=\"lapinis kop\u016bstas turi daug vitamino b9 savo nat\u016bralioje folato formoje\" class=\"wp-image-231078\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-03.jpeg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-03-300x150.jpeg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-03-1024x512.jpeg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-03-768x384.jpeg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/09\/image-03-600x300.jpeg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Ar gaminimas suma\u017eina folato lyg\u012f maiste, ar ne, priklauso nuo maisto produkto, gaminimo metodo ir gaminimo laiko. Normalus virimo laikas gali panaikinti apie pus\u0119 folato \u0161pinatuose ir brokoliuose, bet virimas garuose visi\u0161kai nesuma\u017eina folato kiekio. Bulvi\u0173 virimas ar m\u0117sos ruo\u0161imas ant groteli\u0173 taip pat neatrodo, kad suma\u017eina folato kiek\u012f, net jei gaminate juos ilgiau nei \u012fprasta (26). Svog\u016bn\u0173 virimas suma\u017eina folato lyg\u012f 35%, o j\u0173 kepimas &#8211; tik 15%. Taip pat paai\u0161k\u0117jo, kad \u017eirni\u0173 virimas i\u0161laiko daugiausia folato i\u0161 vis\u0173 apdorojimo b\u016bd\u0173. Jei 2 valandas virsite pupas ir tada jas kepsite ar virsite aliejuje, jos praras 50%. Viena studija rekomenduoja mirkyti jas s\u016briame vandenyje ir tada virti \u0161vie\u017eiame vandenyje, \u0161itaip i\u0161saugant daugum\u0105 maistini\u0173 med\u017eiag\u0173 (27).\u00a0<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Ar n\u0117\u0161\u010dios ar besilaukian\u010dios moterys turi vartoti folato papildus?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Medicinos bendruomen\u0117je pla\u010diai priimta, kad folato lygio palaikymas normos ribose yra gera id\u0117ja. Tikriausiai tai u\u017ekerta keli\u0105 kai kuriems apsigimimas, o koreliacija tarp to labai stipri. Kaip jau min\u0117ta auk\u0161\u010diau, nuo pat momento, kai pastosite, j\u016bs\u0173 k\u016bnui reik\u0117s daug bioaktyvaus folato, norint u\u017etikriti, kad k\u016bdikio nervin\u0117 sistema vystysis tinkama. Tai gali reik\u0161ti, kad papildus vartoti tur\u0117tum\u0117te prad\u0117ti dar tik bandant pastoti. 5-MTHF papild\u0173 vartojimas yra vienas i\u0161 tikriausi\u0173 b\u016bd\u0173 \u017einoti, kad j\u016bs\u0173 k\u016bnas pasisavins pakankamai folato. Jei laukiat\u0117s, pasiteiraukite to savo gydytojo. Nesirinkite tiesiog pa\u017eaisti su maisto papildais neatsi\u017evelgiant \u012f j\u016bs\u0173 asmenin\u0119 ir unikali\u0105 b\u016bsen\u0105 ir visapusi\u0161kus laboratorinius tyrimus.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Ar j\u016bs\u0173 k\u016bne gali b\u016bti per daug folato?&nbsp;<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Medicinos moksle tai yra kontraversi\u0161ka problema. Kai kurie mokslininkai sako, kad savo k\u016bne galite tur\u0117ti per daug folio r\u016bg\u0161ties ir tai gali sukelti sveikatos problem\u0173 (28). D\u0117l \u0161ios kontraversijos ir didesnio mokslini\u0173 tyrim\u0173 skai\u010diaus poreikio, galite pasteb\u0117ti, kad valstybin\u0117s sveikatos institucijos atsisako palaikyti vien\u0105 ar kit\u0105 nuomon\u0119 \u0161iuose debatuose ir pataria \u017emon\u0117ms atsi\u017evelgti \u012f galim\u0105 rizik\u0105 ir b\u016bti atsargiems. Veikiausiai tai n\u0117ra problema 5-MTHF ar maistiniam folatui, nat\u016braliai randamam maisto produktuose. K\u0105 gali padaryti folio r\u016bg\u0161ties pervir\u0161is?<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Gali u\u017emaskuoti B12 tr\u016bkumo \u017eenklus&nbsp;<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Per didelis folio r\u016bg\u0161ties lygis j\u016bs\u0173 k\u016bne gali u\u017emaskuoti megaloblastin\u0117s anemijos, sukeltos vitamino B12 tr\u016bkumo, \u017eenklus. D\u0117l to n\u0117ra sutariama &#8211; tai vis dar yra paslaptis mokslininkams. Jei tai tiesa, gydytojai gali praleisti \u0161i\u0105 diagnoz\u0119. Tai gali pabloginti bet kokia su krauju susijusias problemas ir pakenkti j\u016bs\u0173 smegenims ir nerv\u0173 sistemai. \u017dala smegenims gali sukelti staig\u0173 pa\u017einimo funkcijos smukim\u0105 ir sumi\u0161im\u0105 (29). Vistik sutariama d\u0117l to, kad tai n\u0117ra 5-MTHF, kuriuo metabolizuojant virsta kitos formos, problema. Per didelio pup\u0173, apelsin\u0173 ar \u017eali\u0173 dar\u017eovi\u0173, turin\u010di\u0173 didel\u012f folat\u0173 kiek\u012f, valgymas taip pat n\u0117ra problema, d\u0117l kurios nerimaut\u0173 ekspertai (39). Vitamino B12 tr\u016bkumas yra didesn\u0117 problema vegetarams ir vyresnio am\u017eiaus \u017emon\u0117ms, nei daugumai kit\u0173. Vegetari\u0161ka mityba nesuteikia pakankamai \u0161io vitamino, o vyresnio am\u017eiaus \u017emon\u0117ms sunkiau j\u012f pasisavinti. Abi grup\u0117s gali vartoti polie\u017euvinius B12 papildus.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/was-ist-5-mthf-der-ultimative-guide-zu-folat-und-methylfolat-11.jpg\" alt=\"ant sofos mieganti moteris\" class=\"wp-image-152269\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/was-ist-5-mthf-der-ultimative-guide-zu-folat-und-methylfolat-11.jpg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/was-ist-5-mthf-der-ultimative-guide-zu-folat-und-methylfolat-11-300x150.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/was-ist-5-mthf-der-ultimative-guide-zu-folat-und-methylfolat-11-1024x512.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/was-ist-5-mthf-der-ultimative-guide-zu-folat-und-methylfolat-11-768x384.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/was-ist-5-mthf-der-ultimative-guide-zu-folat-und-methylfolat-11-600x300.jpg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Miego sutrikimai ir nuotaikos problemos<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Per daug folio r\u016bg\u0161ties, o ypa\u010d vartojant jos papildus, gali sukelti miego sutrikimus ir irzlum\u0105 (30).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Pykinimas ir apetito stoka<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Kai kurie \u017emon\u0117s gali jausti apetito stok\u0105 ar pykinim\u0105, ypa\u010d jei jie gauna per daug folio r\u016bg\u0161ties i\u0161 maisto papild\u0173 ar multivitamin\u0173 (30).&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Sprendimas<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Vartodami folato papildus, \u012fsitikinkite, kad jie yra bioaktyvioje savo formoje: 5-MTHF. Skaitykite etiketes ant savo multivitamin\u0173. Ar juose yra per daug folio r\u016bg\u0161ties? Dauguma suaugusi\u0173j\u0173 tur\u0117t\u0173 suvartoti apie 0,5 mg folio r\u016bg\u0161ties per dien\u0105. Taip pat skaitykite etiketes ant savo duonos ir saus\u0173 pusry\u010di\u0173. Jei vartojate 5-MTHF papildus, stenkit\u0117s vartoti ma\u017eiau padidinto folio kiekio maisto produkt\u0173 ir venkite multivitamin\u0173, kuriuose yra folio r\u016bg\u0161ties. Tai gal yra, o gal ir n\u0117ra problema, atsiliepianti 5-MTHF. JAV Nacionalinis maisto papild\u0173 sveikatos institutas nustat\u0117, kad maksimalus rekomenduojamas folio kiekis, gaunamas i\u0161 praturtint\u0173 gr\u016bd\u0173 ar maisto papild\u0173, yra 1 mg. Jie nenustat\u0117 ribos folatui, gaunamam i\u0161 dar\u017eovi\u0173 ar 5-MTHF (29). Pasak Harvard Health Letter, folio r\u016bg\u0161tis, gaunama i\u0161 gr\u016bd\u0173, gali greitai susid\u0117ti (31). Pa\u017evelkite \u012f s\u0105ra\u0161\u0105 \u017eemiau. <strong>\u012eprasti maisto produktai, praturtinti folio r\u016bg\u0161timi:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dubuo \u012fprast\u0173 Special K saus\u0173 pusry\u010di\u0173: 0,394 mg<\/li><li>Riestaini\u0173 porcija: 0,172 mg<\/li><li>Stiklin\u0117 virt\u0173 makaron\u0173: 0,166 mg<\/li><li>1 multivitaminas: 0,4 mg<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>I\u0161 viso<\/strong> = 1,132 mg. Nesunku vir\u0161yti t\u0105 vir\u0161utin\u0119 rekomenduojam\u0105 dienos norm\u0105, tad sekite savo vartojamus gr\u016bdus ir vitaminus, o ypa\u010d jei jums sunkiau metabolizuoti folio r\u016bg\u0161t\u012f. Taip pat jums b\u016bt\u0173 pravartu \u012fsitikinti, kad suvartojate pakankamai B12 ir kad j\u016bs\u0173 k\u016bnas j\u012f naudoja.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"600\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-10.jpg\" alt=\"gr\u016bdai ir dar\u017eov\u0117s yra vitamino b9 \u0161altiniai\" class=\"wp-image-161350\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-10.jpg 1200w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-10-300x150.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-10-1024x512.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-10-768x384.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-10-600x300.jpg 600w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Ar 5-MTHF turi prana\u0161um\u0173 prie\u0161 kitas folato formas?<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Tam, kad 5-MTHF b\u016bt\u0173 naudingas k\u016bnui, nereikalingos jokios chemin\u0117s reakcijos<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Folio r\u016bg\u0161tis, kuri yra sintetin\u0117, reikalauja daug chemini\u0173 reakcij\u0173 iki kol ji tampa bioaktyviu 5-MTHF. Tam, kad Maistinis folatas, kuris nat\u016braliai susidaro maisto produktuose, tapt\u0173 5-MTHF, taip pat reikalingos chemin\u0117s reakcijos, bet j\u0173 reikia ma\u017eiau nei folio r\u016bg\u0161\u010diai. Kitaip tariant, vartojant 5-MTHF papildus, j\u016bs\u0173 k\u016bnui nereik\u0117s tiek daug dirbti. Nereikalingos jokios chemin\u0117s reakcijos.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>S\u0105veikauja su ma\u017eiau vaistini\u0173 preparat\u0173 nei folio r\u016bg\u0161tis&nbsp;<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Kadangi tam, kad 5-MTHF tapt\u0173 bioaktyvus, nereikalingi jokie metaboliniai vyksmai, ma\u017eiau tik\u0117tina ir tai, kad jis s\u0105veikaus su vaistais ar suma\u017eins j\u0173 efektyvum\u0105 (33). Tai labai m\u0117gsta psichiatrai, kadangi \u0161i folato forma gali tiesiogiai kirsti kraujo-smegen\u0173 barjer\u0105 ir patekti \u012f smegenis. Kraujo-smegen\u0173 barjeras u\u017ekerta keli\u0105 med\u017eiagoms kraujotakos sistema patekti \u012f smegenis. 5-MTHF gali patekti tiesiai 5 nervin\u0119 sistem\u0105 (32). Tai \u012fprastai yra metabolizmo procesas, sukeliantis folio r\u016bg\u0161ties ir kit\u0173 vaist\u0173 s\u0105veik\u0105.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Neu\u017emaskuoja B12 nepakankamumo simptom\u0173&nbsp;<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Nors folatas gali u\u017emaskuoti nervin\u0117s sistemos \u017eal\u0105, sukelt\u0105 kraujo sutrikim\u0173, susijusi\u0173 su B12 tr\u016bkumu, pla\u010diai \u017einoma, kad 5-MTHF to nedaro (34).&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Nuo kokios doz\u0117s tur\u0117\u010diau prad\u0117ti?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Dauguma \u017emoni\u0173 pradeda nuo 1 mg ar net ma\u017eiau kasdien vartojamo 5-MTHF. Tam tikroms situacijoms gali prireikti 5 mg ar daugiau, o medicinos profesionalai \u012fprastai yra pasiruo\u0161\u0119 supa\u017eindinti jus su \u0161iuo pasirinkimu. Tik atminkite, kad kalbant apie bet koki\u0105 folato form\u0105, daugiau neb\u016btinai rei\u0161kia geriau.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kas netur\u0117t\u0173 vartoti 5-MTHF?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Akivaizdu, kad netur\u0117tum\u0117te vartoti 5-MTHF, jei esate jam alergi\u0161ki. Jei jums pasirei\u0161kia dilg\u0117lin\u0117, spaudimas kr\u016btin\u0117s srityje ar dusulys, laikykite tai kriti\u0161ka pad\u0117timi. <strong>Prie\u0161 vartodami 5-MTHF papildus kreipkit\u0117s \u012f savo gydytoj\u0105, jei (35):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Esate alergi\u0161ki folio r\u016bg\u0161\u010diai gr\u016bduose ir multivitaminuose<\/li><li>Anks\u010diau jums buvo diagnozuotas B12 nepakankamumas<\/li><li>Sergate bipoliniu sutrikimu<\/li><li>Laukiat\u0117s, esate maitinanti mama arba planuojate pastoti (to reikia tam, kad b\u016bt\u0173 nustatyta tinkama doz\u0117, kuri gali kisti)<\/li><\/ul>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Ar 5-MTHF reaguos \u012f mano vartojamus vaistus?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tai, kad 5-MTHF s\u0105veikaus su j\u016bs\u0173 vartojamais vaistais tik\u0117tina ma\u017eiau, nei folio r\u016bg\u0161ties atveju (33), bet nepriimkite to kaip medicininio patarimo. Tai tur\u0117tum\u0117te aptarti su savo gydytoju. Folio r\u016bg\u0161tis gali suma\u017einti daugumos vaist\u0173 nuo traukuli\u0173 bei pirimetamino (Daraprim), naudojamo gydant parazitines infekcijas, efektyvum\u0105. Metotreksatas yra vaistas, suma\u017einantis folio aktyvum\u0105 l\u0105stel\u0117se (36)(37). I\u0161 kitos pus\u0117s, studija, tyrusi folato s\u0105veik\u0105 su lamotriginu, vaisto vartotojams kaip alternatyv\u0105 folatams rekomenduoja 5-MTHF papildus. Vaistas yra vartojamas siekiant i\u0161vengti traukuli\u0173, bet mokslininkai itin dom\u0117josi nuotaikos sutrikimais, tokiais kaip bipolin\u0117 depresija. Jie nustat\u0117, kad 5-MTHF nereikalingos jokios chemin\u0117s reakcijos prie\u0161 smegenims ir kitoms k\u016bno sistemoms j\u012f naudojant, tad ma\u017eiau tik\u0117tina, kad jis s\u0105veikaus su lamotriginu (38).&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"512\" src=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-11-1024x512.jpg\" alt=\"laikykite savo 5-MTHF ir kitus maisto papildus vaist\u0173 spintel\u0117je\" class=\"wp-image-161357\" srcset=\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-11-1024x512.jpg 1024w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-11-300x150.jpg 300w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-11-768x384.jpg 768w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-11-600x300.jpg 600w, https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-11.jpg 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Kaip tur\u0117\u010diau laikyti savo 5-MTHF papildus?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0160tai k\u0105 savo svetain\u0117je rekomenduoja gerai \u017einoma Klivlando klinika: \u201elaikykite kambario temperat\u016broje tarp 59 ir 86 laipsni\u0173 pagal Farenheit\u0105 (15 ir 30 laipsni\u0173 pagal Celsij\u0173). Saugokite nuo \u0161viesos. Susid\u016br\u0119 su kar\u0161\u010diu ar \u0161viesa, \u0161ie preparatai greitai skyla ir tampa nebeaktyv\u016bs. I\u0161meskite bet kokius nenaudotus vaistus, kai baigiasi j\u0173 galiojimo data\u201c (37). Intelligent Labs naudoja nepermatomus juodus buteliukus, pilnai apsaugan\u010dius nuo \u0161viesos. Pra\u0161ome laikyti savo papildus vaikams nepasiekiamoje vietoje. 5-MTHF yra palyginti saugus preparatas, o jo perdozavimas n\u0117ra mirtinas. Net ir \u017einant tai, vistiek tur\u0117tum\u0117te b\u016bti atsag\u016bs.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Apie \u0161\u012f gid\u0105<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tikim\u0117s, kad jums pad\u0117jo \u0161is gidas. Medicinos mokslas nuolat tobul\u0117ja, tad netik\u0117kite, kad \u010dia pamin\u0117jome visi\u0161kai vis\u0105 jums reikaling\u0105 informacij\u0105. Jei perskait\u0117te vis\u0105 straipsn\u012f, jau \u017einote, kad d\u0117l kai kuri\u0173 min\u0117t\u0173 dalyk\u0173 nesutaria net mokslininkai. Taip pat atminkite, kad informacija n\u0117ra alternatyva gydytojo patarimui. Negalime tvirtinti, kad 5-MTHF yra vaistas bet kokiai ligai gydyti. Taip pat negalime tvirtinti, kad m\u016bs\u0173 informacija gali pad\u0117ti jums patiems ka\u017ek\u0105 diagnozuoti. Tik gydytojas gali pateikti jums diagnoz\u0119 ir jai rekomenduojam\u0105 gydym\u0105.&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\" \/>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Moksliniai \u0161altiniai<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\"><li>Folic Acid. WebMD. <a href=\"https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1017\/folic-acid\" rel=\"noopener\">https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1017\/folic-acid<\/a>.<\/li><li>Pach\u00f3n H, Codling K. Fortification with Folic Acid. Asia-Pacific Conference on Human Genetics. <a href=\"http:\/\/ffinetwork.org\/about\/calendar\/2017\/documents\/Fortification_with_Folic_Acid.pdf\" rel=\"noopener\">http:\/\/ffinetwork.org\/about\/calendar\/2017\/documents\/Fortification_with_Folic_Acid.pdf<\/a>.<\/li><li>Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients. 2011;3(3):370-84. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3257747\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3257747\/<\/a><\/li><li>Prinz-Langenohl R, Br\u00e4mswig S, Tobolski O, et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C&#8211;&gt;T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009;158(8):2014-21. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2807663\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2807663\/<\/a><\/li><li>Miraglia N, Agostinetto M, Bianchi D, Valoti E. Enhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats. Minerva Ginecol. 2016;68(2):99-105. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27008238\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27008238<\/a><\/li><li>Estroff Mareno H. The Folate Factor: Among the busiest of B vitamins, folate has a special role in depression treatment. Psychology Today. <a href=\"https:\/\/www.psychologytoday.com\/us\/articles\/201901\/the-folate-factor\" rel=\"noopener\">https:\/\/www.psychologytoday.com\/us\/articles\/201901\/the-folate-factor<\/a><\/li><li>Folate deficiency. MedlinePlus. U.S. National Library of Medicine. <a href=\"https:\/\/medlineplus.gov\/ency\/article\/000354.htm\" rel=\"noopener\">https:\/\/medlineplus.gov\/ency\/article\/000354.htm<\/a>.<\/li><li>Fuqua K. Vitamins to Help Break Down Carbs. SFGate. <a href=\"https:\/\/healthyeating.sfgate.com\/vitamins-break-down-carbs-4715.html\" rel=\"noopener\">https:\/\/healthyeating.sfgate.com\/vitamins-break-down-carbs-4715.html<\/a>.<\/li><li>Hibbard BM. THE ROLE OF FOLIC ACID IN PREGNANCY*. With Particular Reference to Anaemia, Abruption and Abortion. BJOG: An International Journal of Obstetrics and Gynaecology. 1964;71(4):529-542. doi:10.1111\/j.1471-0528.1964.tb04317.x Retrieved from <a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/j.1471-0528.1964.tb04317.x\" rel=\"noopener\">https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/j.1471-0528.1964.tb04317.x<\/a><\/li><li>Lambrot R, Xu C, Saint-Phar S, et al. Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes. Nature Communications. 2013;4(1). doi:10.1038\/ncomms3889 Retrieved from <a href=\"https:\/\/www.nature.com\/articles\/ncomms3889\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/ncomms3889<\/a><\/li><li>Mayo Clinic Staff. Folate (Folic Acid). Mayo Clinic. <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements-folate\/art-20364625\" rel=\"noopener\">https:\/\/www.mayoclinic.org\/drugs-supplements-folate\/art-20364625<\/a>.<\/li><li>Shelton RC, Sloan Manning J, Barrentine LW, Tipa EV. Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial. Prim Care Companion CNS Disord. 2013;15(4):PCC.13m01520. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3869616\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3869616\/<\/a><\/li><li>Fava M, Mischoulon D. Folate in depression: efficacy, safety, differences in formulations, and clinical issues. J Clin Psychiatry. 2009;70 Suppl 5:12-7. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19909688\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19909688<\/a><\/li><li>Kiefer D. L-methylfolate for Bipolar Disorder. Relias Media. <a href=\"https:\/\/www.reliasmedia.com\/articles\/141976-l-methylfolate-for-bipolar-disorder\" rel=\"noopener\">https:\/\/www.reliasmedia.com\/articles\/141976-l-methylfolate-for-bipolar-disorder<\/a>.<\/li><li>Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005;82(3):627-35. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16155277\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16155277<\/a><\/li><li>Malouf R, Grimley Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst Rev. 2008;8( 4):CD004514. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18843658\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18843658<\/a><\/li><li>Ford AH, Flicker L, Alfonso H, et al. Vitamins B(12), B(6), and folic acid for cognition in older men. Neurology. 2010;75(17):1540-7. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20861451\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20861451<\/a><\/li><li>Anthony K. High Homocysteine Level (Hyperhomocysteinemia). Healthline. <a href=\"https:\/\/www.healthline.com\/health\/homocysteine-levels\" rel=\"noopener\">https:\/\/www.healthline.com\/health\/homocysteine-levels<\/a>.<\/li><li>Venn BJ, Green TJ, Moser R, Mann JI. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003;77(3):658-62. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12600857\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12600857<\/a><\/li><li>Corliss J. Folic acid, a B vitamin, lowers stroke risk in people with high blood pressure. Harvard Health Blog. Harvard Health Publishing. <a href=\"https:\/\/www.health.harvard.edu\/blog\/folic-acid-a-b-vitamin-lowers-stroke-risk-in-people-with-high-blood-pressure-201503187810\" rel=\"noopener\">https:\/\/www.health.harvard.edu\/blog\/folic-acid-a-b-vitamin-lowers-stroke-risk-in-people-with-high-blood-pressure-201503187810<\/a>.<\/li><li>Cufasso J. Folate Deficiency. Healthline. <a href=\"https:\/\/www.healthline.com\/health\/folate-deficiency\" rel=\"noopener\">https:\/\/www.healthline.com\/health\/folate-deficiency<\/a>.<\/li><li>Folic acid in diet. MedlinePlus. <a href=\"https:\/\/medlineplus.gov\/ency\/article\/002408.htm\" rel=\"noopener\">https:\/\/medlineplus.gov\/ency\/article\/002408.htm<\/a>.<\/li><li>MTHFR gene variant. Genetic and Rare Diseases Information Center. National Center for Advancing Translational Sciences. U.S. National Institutes of Health.&nbsp; <a href=\"https:\/\/rarediseases.info.nih.gov\/diseases\/10953\/mthfr-gene-mutation\" rel=\"noopener\">https:\/\/rarediseases.info.nih.gov\/diseases\/10953\/mthfr-gene-mutation<\/a>.<\/li><li>Maffoni S, De Giuseppe R, Stanford FC, Cena H. Folate status in women of childbearing age with obesity: a review. Nutr Res Rev. 2017;30(2):265-71. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6232191\/\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6232191\/<\/a><\/li><\/ol>\n\n\n\n<ol class=\"wp-block-list\" start=\"25\"><li>Parrott J, Frank L, Rabena R, Craggs-Dino L, Isom KA, Greiman L. American Society for Metabolic and Bariatric Surgery Integrated Health Nutritional Guidelines for the Surgical Weight Loss Patient 2016 Update: Micronutrients. Surgery for Obesity and Related Diseases. 2017;13(5):727-741. doi:10.1016\/j.soard.2016.12.018. Retrieved from <a href=\"https:\/\/asmbs.org\/app\/uploads\/2008\/09\/ASMBS-Nutritional-Guidelines-2016-Update.pdf\" rel=\"noopener\">https:\/\/asmbs.org\/app\/uploads\/2008\/09\/ASMBS-Nutritional-Guidelines-2016-Update.pdf<\/a><\/li><li>McKillop DJ, Pentieva K, Daly D, et al. The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet. Br J Nutr. 2002;88(6):681-8. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12493090\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12493090<\/a><\/li><li>Fabbri ADT, Crosby GA. A review of the impact of preparation and cooking on the nutritional quality of vegetables and legumes. International Journal of Gastronomy and Food Science. 2016;3:2-11. doi:10.1016\/j.ijgfs.2015.11.001 Retrieved from <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1878450X15000207\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1878450X15000207<\/a><\/li><li>Folic Acid. Office on Women\u2019s Health. U.S. Department of Health and Human Services. <a href=\"https:\/\/www.womenshealth.gov\/a-z-topics\/folic-acid\" rel=\"noopener\">https:\/\/www.womenshealth.gov\/a-z-topics\/folic-acid<\/a>.<\/li><li>Folate. Office of Dietary Supplements. U.S. National Institutes of Health. <a href=\"https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/\" rel=\"noopener\">https:\/\/ods.od.nih.gov\/factsheets\/Folate-HealthProfessional\/<\/a>.<\/li><li>Mayo Clinic Staff. Folate (Folic Acid). Mayo Clinic. <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements-folate\/art-20364625\" rel=\"noopener\">https:\/\/www.mayoclinic.org\/drugs-supplements-folate\/art-20364625<\/a>.<\/li><li>Folic acid: Too much of a good thing? Harvard Heart Letter. Harvard Health Publishing. <a href=\"https:\/\/www.health.harvard.edu\/newsletter_article\/Folic_acid_Too_much_of_a_good_thing\" rel=\"noopener\">https:\/\/www.health.harvard.edu\/newsletter_article\/Folic_acid_Too_much_of_a_good_thing<\/a>.<\/li><li>Folate and Brain: Is 5-MTHF (methylfolate) better for the brain than folic acid?. MTHFR Support Australia. <a href=\"https:\/\/mthfrsupport.com.au\/2017\/04\/folate-and-brain\/\" rel=\"noopener\">https:\/\/mthfrsupport.com.au\/2017\/04\/folate-and-brain\/<\/a>.<\/li><li>Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014;44(5):480-8. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24494987\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24494987<\/a><\/li><li>Obeid R, Holzgreve W, Pietrzik K. Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects. J Perinat Med. 2013;41(5):469-83. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23482308\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23482308<\/a><\/li><li>Multum C. L-Methylfolate. <a href=\"http:\/\/drugs.com\/\" rel=\"noopener\">Drugs.com<\/a>. <a href=\"https:\/\/www.drugs.com\/mtm\/l-methylfolate.html\" rel=\"noopener\">https:\/\/www.drugs.com\/mtm\/l-methylfolate.html<\/a><\/li><li>Vitamins and Supplements: Folic Acid. WebMD. <a href=\"https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1017\/folic-acid\" rel=\"noopener\">https:\/\/www.webmd.com\/vitamins\/ai\/ingredientmono-1017\/folic-acid<\/a>.<\/li><li>Folic Acid, Vitamin B9 tablets. Cleveland Clinic Health Library. <a href=\"https:\/\/my.clevelandclinic.org\/health\/drugs\/18719-folic-acid-vitamin-b9-tablets\" rel=\"noopener\">https:\/\/my.clevelandclinic.org\/health\/drugs\/18719-folic-acid-vitamin-b9-tablets<\/a>.<\/li><li>Mischoulon D, Zajecka J, Freeman MP, Fava M. Does folic acid interfere with lamotrigine? The Lancet Psychiatry. 2016;3(8):704-705. doi:10.1016\/s2215-0366(16)30167-5. Retrieved from <a href=\"https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(16)30167-5\/fulltext\" rel=\"noopener\">https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(16)30167-5\/fulltext<\/a><\/li><li>Lamers Y, Prinz-Langenohl R, Moser R, Pietrzik K. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. Am J Clin Nutr. 2004;79(3):473-8. Retrieved from <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14985224\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14985224<\/a><\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Kas yra 5-MTHF? \u0160is gidas yra skirtas suteikti jums vis\u0105 nauding\u0105 ir tyrimais patvirtint\u0105 informacij\u0105 apie vitamin\u0105 B9, folat\u0105, folio r\u016bg\u0161t\u012f, 5-MTHF ir kitus papildus ir maisto produktus, palaikan\u010dius sveik\u0105 B9 lyg\u012f. Su\u017einosite apie problemas, kurios gali suma\u017einti B9 iki nesveiko lygio &#8211; net vartojant maisto papildus ar valgant daug folat\u0173 turint\u012f maist\u0105 &#8211; ir&#8230;<\/p>\n","protected":false},"author":2,"featured_media":161286,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[3015],"tags":[],"coauthors":[],"class_list":["post-231101","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mityba"],"taxonomy_info":{"category":[{"value":3015,"label":"Mityba"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-12-1024x512.jpg",1024,512,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/lt-lt\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":3015,"name":"Mityba","slug":"mityba","term_group":0,"term_taxonomy_id":3015,"taxonomy":"category","description":"","parent":0,"count":45,"filter":"raw","cat_ID":3015,"category_count":45,"category_description":"","cat_name":"Mityba","category_nicename":"mityba","category_parent":0}],"tag_info":false,"wpml":{"language":"lt-lt","is_original":true,"original_post_id":231101,"translations":{"lt-lt":{"id":231101,"language":"lt-lt","is_original":true}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/posts\/231101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/comments?post=231101"}],"version-history":[{"count":3,"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/posts\/231101\/revisions"}],"predecessor-version":[{"id":240806,"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/posts\/231101\/revisions\/240806"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/media\/161286"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/media?parent=231101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/categories?post=231101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/tags?post=231101"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/lt-lt\/wp-json\/wp\/v2\/coauthors?post=231101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}