{"id":230258,"date":"2022-07-11T09:00:00","date_gmt":"2022-07-11T08:00:00","guid":{"rendered":"https:\/\/eu.intelligentlabs.org\/aktiveeritud-foolhape-normaalse-raseduse-kulgemise-jaoks\/"},"modified":"2025-09-19T08:55:41","modified_gmt":"2025-09-19T07:55:41","slug":"aktiveeritud-foolhape-normaalse-raseduse-kulgemise-jaoks","status":"publish","type":"post","link":"https:\/\/eu.intelligentlabs.org\/et-ee\/aktiveeritud-foolhape-normaalse-raseduse-kulgemise-jaoks\/","title":{"rendered":"Miks 5-MTHF aktiveeritud foolhape on normaalse raseduse kulgemise jaoks parim?"},"content":{"rendered":"\n

Vastutustundlik lapsevanemaks saamine algab enne lapse s\u00fcndi. Teatud tegevused, nagu tasakaalustatud toitumine, treenimine ja rasedatele m\u00f5eldud vitamiinide v\u00f5tmine aitavad tagada normaalse raseduse kulgu. Selles blogipostituses k\u00e4sitleme \u00fchte k\u00f5ige olulisemat vitamiini, mida tulevane ema v\u00f5iks v\u00f5tta –  aktiveeritud foolhapet.<\/p>\n\n\n\n

Miks v\u00f5tta foolhapet lapse planeerimisel ja raseduse ajal?<\/strong><\/h2>\n\n\n\n

Seksuaalselt aktiivsete naiste jaoks on foolhappe v\u00f5tmine h\u00e4davajalik. Juhtub liiga palju “\u00f5nnetusi” ja nii m\u00f5nedki naised saavad teada, et nad on rasedad alles paar kuud hiljem!<\/p>\n\n\n\n

Aastatel 2015\u20132019 oli kogu maailmas 121 miljonit soovimatut rasedust. See t\u00e4hendab ligikaudu 64 planeerimata rasedust 1000 naise kohta vanuses 15\u201349 aastat (1). Soovimatu rasedus v\u00f5ib kujutada terviseriski nii emale kui lapsele, kuna normaalne rasedus ei ole sellisel juhul alati tagatud.<\/p>\n\n\n\n

\u00dcks suurimaid soovimatute raseduste riske on t\u00f5sised s\u00fcnnidefektid, nagu neuraaltoru defektid v\u00f5i
NTD-d. N\u00e4iteks spina bifida (selg ja seljaaju ei moodustu korralikult) ja anentsefaalia (see m\u00f5jutab aju ja kolju). Hea on see, et neid NTD-sid saab ennetada, v\u00f5ttes raseduse planeerimisel ja lapseoote ajal piisavalt foolhapet. Kahjuks on NTD-d endiselt probleemiks paljudes riikides (2).<\/p>\n\n\n\n

\u00d5nneks v\u00f5ib foolhappe fertiilses eas naiste seas \u00e4ra hoida 50\u201370% igal aastal esinevatest NTD-dest. See on m\u00e4rkimisv\u00e4\u00e4rne tulemus, sest spina bifidaga s\u00fcndinud lapse eest hoolitsemine ei ole \u00fcldse rahakotis\u00f5bralik tegevus\u2013 hoolduse kogukulud kogu elu jooksul on hinnanguliselt umbes 792 000 dollarit (3).<\/p>\n\n\n\n

Nagu juba enne mainitud, folaadi ja foolhappe on erinevad vormid. Edasi selgitame, milline folaadi vorm on lapseootel naise tervise jaoks parim.<\/p>\n\n\n\n

\"aktiveeritud<\/figure>\n\n\n\n

Folaadi erinevad vormid \u2013 miks on aktiveeritud foolhape parim raseduse ajal<\/strong><\/h2>\n\n\n\n

Folaat, foolhape ja aktiveeritud foolhape on B9-vitamiini erinevad vormid<\/strong> ning ta on vajalik paljude oluliste bioloogiliste protsesside jaoks. Just B9-vitamiin m\u00e4ngib v\u00f5tmerolli aminohapete s\u00fcnteesis, vereloomes, homots\u00fcsteiini metabolismis, immuuns\u00fcsteemis ja rakkude jagunemises. Samuti aitab see v\u00e4ltida neuraaltoru defekte areneval lootel (4).<\/p>\n\n\n\n

Erinevused folaadi, foolhappe ja aktiveeritud foolhappe vahel<\/strong><\/h3>\n\n\n\n

Folaat <\/strong>on vitamiini B9 loomulik vorm, mida leidub paljudes toitudes nagu: rohelised lehtk\u00f6\u00f6giviljad, veisemaks, munad, p\u00e4hklid, puuviljad ja kaunviljad. See on biosaadav aine, kuid toidu eba\u00f5ige s\u00e4ilitamise, pesemise ja toiduvalmistamise korral h\u00e4vib kergesti (5). Enne vereringesse sattumist muudetakse foolhape soolestikus bioloogiliselt aktiivseks vormiks, 5-MTHF-ks v\u00f5i 5-met\u00fc\u00fcltetrah\u00fcdrofolaadiks (6).<\/p>\n\n\n\n

Foolhape <\/strong>on folaadi s\u00fcnteetiline versioon. See on stabiilsem kui folaat, mist\u00f5ttu on see B9-vitamiini eelistatud vorm, mida lisatakse juurde erinevatele toitudele, nagu hommikus\u00f6\u00f6gihelbed, pasta, leib, jahu ja paljud toidulisandid (5).<\/p>\n\n\n\n

Kuid foolhappega on \u00fcks probleem. Selle terve kogus ei metaboliseeru ega muundu soolestikus 5-MTHF-ks nagu toidust saadav folaat. See v\u00f5ib p\u00f5hjustada metaboliseerimata foolhappe<\/strong> <\/a>kogunemist veres, mis p\u00f5hjustab m\u00f5ningaid terviseprobleeme (7, 8).<\/p>\n\n\n\n

See viib meid j\u00e4rgmise p\u00f5lvkonna s\u00fcnteetilise folaadi ehk aktiveeritud foolhappe juurde.<\/strong><\/p>\n\n\n\n

Aktiveeritud foolhape (5-MTHF) <\/strong>on peamine folaadi vorm, mida leidub veres. Kui v\u00f5tate 5-MTHF-i, ei pea teie keha enam metaboliseerima seda. Miks? Sest see on juba aktiivne 5-MTHF vorm \u2013 vorm, milleks meie keha muudab toidust saadavat folaat ja tavalise foolhapet (9).<\/p>\n\n\n\n

Aktiveeritud foolhape on B9-vitamiini \u00f5ige vorm mitte ainult rasedate naiste hulgas, vaid ka MTHFR-i geneetilise mutatsiooniga inimestele.<\/p>\n\n\n\n

Siin on inglisekeelne infograafik, mis kirjeldab peamisi erinevusi nende kolme vormi vahel.<\/p>\n\n\n\n

\"Vitamiini<\/figure>\n\n\n\n

Kuidas 5-MTHF saab aidata naisi (ja mehi), kellel on MTHFR geeni pol\u00fcmorfism<\/strong><\/h3>\n\n\n\n

MTHFR-i geneetilise variatsiooniga inimestel, eriti C677T ja A1298C variantidega, on probleeme folaadi ja foolhappe metaboliseerimisega. Need geneetilised variandid v\u00f5ivad p\u00f5hjustada mitmesuguseid terviseprobleeme, nagu vitamiinipuudus (sealhulgas madal folaadi tase veres), k\u00f5rge homots\u00fcsteiini tase (suur risk s\u00fcdamehaiguste tekkeks), korduvad raseduse katkemised ja neuraaltoru defektidega lapsed (10).<\/p>\n\n\n\n

Kui te soovite rasestuda ja teil esineb MTHFR variatsioon, peate v\u00f5tma aktiveeritud foolhapet, et teie keha saaks sellest vitamiinist kasu.<\/p>\n\n\n\n

Aktiveeritud foolhapet on kahte t\u00fc\u00fcpi:<\/p>\n\n\n\n

L-met\u00fc\u00fclfolaadi kaltsiumsool \u2013 see on kaltsiumisoolast saadud aktiveeritud foolhape<\/p>\n\n\n\n

L-5-met\u00fc\u00fcltetrah\u00fcdrofolaat (teise nimega 5-MTHF) \u2013 see on gl\u00fckoosamiinisoolast saadud aktiveeritud foolhape<\/p>\n\n\n\n

Niisiis, miks on nende kahe aktiveeritud foolhappe vorme oluline eristada?<\/strong>

2016. aasta uuring n\u00e4itas, et gl\u00fckoosamiinisoolast saadud 5-MTHF imendub 1,8 korda paremini kui kaltsiumisoolast saadud 5-MTHF. Samuti on see 3,1 korda biosaadavam v\u00f5rreldes tavalise foolhappega (11).<\/p>\n\n\n\n

Suurema biosaadavuse t\u00f5ttu on gl\u00fckoosamiinisoolast saadud aktiveeritud foolhape parim valik nii fertiilses eas naistele kui ka k\u00f5igile, kellel esineb MTHFR geeni pol\u00fcmorfism.<\/strong><\/p>\n\n\n\n

Intelligent Labs 5-MTHF toidulisandites<\/a> <\/strong>kasutame patenteeritud varianti nimega Quatrefolic Acid\u00ae, mis on saadud gl\u00fckoosamiinisoolast (mitte koorikloomadest), mist\u00f5ttu sobib see nii taimetoitlastele kui ka veganitele.<\/p>\n\n\n\n

\"Intelligent<\/figure>\n\n\n\n

 Millised on 5-MTHF-ga aktiveeritud foolhappe teised eelised?<\/strong><\/h2>\n\n\n\n

 2013. aasta uuringu kohaselt, mida viis l\u00e4bi Obeid jt autorid leidsid, et aktiveeritud foolhape sobib rasedatele paremini kui folaat ja tavaline foolhape (12). Siin on m\u00f5ned nende uurimist\u00f6\u00f6 m\u00e4rkimisv\u00e4\u00e4rsed leiud:<\/p>\n\n\n\n

MTHRF-i mutatsioonidega naised reageerivad 5-MTHF-i v\u00f5tmisel paremini plasma folaadimarkeritele, mis v\u00f5ib aidata v\u00e4ltida imikutel NTD-d.<\/p>\n\n\n\n

5-MTHF on raseduse ja postnataalse depressiooni korral efektiivsem kui folaat ja foolhape.<\/p>\n\n\n\n

Erinevalt tavalisest foolhappest ei p\u00f5hjusta 5-MTHF veres metaboliseerimata foolhapet.<\/p>\n\n\n\n

Mitmed uuringud kinnitavad, et 5-MTHF on ohutu ning rasedad, kes v\u00f5tsid 1,13 mg p\u00e4evas, k\u00f5rvaltoimeid ei m\u00e4rganud.<\/p>\n\n\n\n

Millal peaksid raseduse ajal aktiveeritud foolhappe v\u00f5tmisega alustama?<\/strong><\/h2>\n\n\n\n

CDC <\/a>andmete kohaselt tuleb v\u00f5tta foolhapet regulaarselt mitu kuud, et saavutada piisavalt k\u00f5rge vere folaadikontsentratsiooni tase, mis on aitab \u00e4ra hoida NTD-sid.<\/p>\n\n\n\n

See t\u00e4hendab, et naised peaksid alustama gl\u00fckoosamiinisoola 5-MTHF-i v\u00f5tmist paar kuud enne rasedaks j\u00e4\u00e4mist ning kuni raseduse esimese trimestrini v\u00e4lja, sest sellel perioodi on naisel suurim folaadi vajadus.<\/p>\n\n\n\n

Foolhape on loote kasvu ja arengu jaoks \u00fclioluline. Kui enne viljastumist on piisavalt folaadivarusid, siis saab NTD-sid \u00e4ra hoida. Seet\u00f5ttu on \u00fclioluline, et tulevased emad kasutaksid folaati juba enne (13).<\/p>\n\n\n\n

Sama kehtib ka isade kohta. Ka meestel peab olema piisav folaadi tase, et tagada eduka raseduse. Lugege seda artiklit, et saada rohkem teavet foolhappe eeliste kohta meestele.<\/strong><\/a><\/p>\n\n\n\n

L\u00f5pus\u00f5nad<\/strong><\/h2>\n\n\n\n

\u00d5ige folaadi ehk aktiveeritud foolhappe\u00a0 kasutamine on oluline mitte ainult normaalse raseduse jaoks, vaid ka neile, kellel on probleeme toidust saadava folaadi ja foolhappe omastamisega. 5-MTHF k\u00f5rge biosaadavus t\u00e4hendab, et saate tunda k\u00f5iki folaadi h\u00e4mmastavaid tervisega seotud eeliseid. Lisateabe saamiseks lugege meie folaadi ja 5-MTHF met\u00fc\u00fclfolaadi juhendit siit.<\/a><\/strong>
Mis puudutab k\u00fcsimust, kust leida parim 5-MTHF-i raseduse ajal? Tutvuge meie 1MG 5-MTHF<\/a><\/strong> ja 5MG 5-MTHF<\/strong> toidulisanditega Intelligent Labsi e-poes.
[vc_row el_id=”References”][vc_column][vc_toggle title=”Allikad” el_class=”faqs”]<\/p>\n\n\n\n

1) Bearak, Jonathan, et al. \u201cUnintended Pregnancy and Abortion by Income, Region, and the Legal Status of Abortion: Estimates from a Comprehensive Model for 1990\u20132019.\u201d The Lancet Global Health, vol. 8, no. 9, 2020, pp. e1152\u201361. Crossref, https:\/\/doi.org\/10.1016\/s2214-109x(20)30315-6.<\/p>\n\n\n\n

2) \u201cKey Findings: Global Burden of Neural Tube Defects.\u201d Centers for Disease Control and Prevention, 25 Sept. 2018, www.cdc.gov\/ncbddd\/birthdefectscount\/features\/kf-neutral-tube-defects-burden.html.<\/p>\n\n\n\n

3) \u201cData and Statistics.\u201d Centers for Disease Control and Prevention, 24 Sept. 2018, www.cdc.gov\/ncbddd\/birthdefectscount\/data.html#:%7E:text=In%20the%20United%20States%2C%203%2C000,defects%20each%20year%20(3).<\/p>\n\n\n\n

4) \u201cEU Register of Nutrition and Health Claims Made on Foods (v.3.6).\u201d European Commission Food Safety, ec.europa.eu\/food\/safety\/labelling_nutrition\/claims\/register\/public\/?event=search. Accessed 21 Mar. 2022.<\/p>\n\n\n\n

5) \u201cGeneral Information About NTDs, Folic Acid, and Folate.\u201d Centers for Disease Control and Prevention, 8 July 2021, www.cdc.gov\/ncbddd\/folicacid\/faqs\/faqs-general-info.html.<\/p>\n\n\n\n

6) Alpers, David H. \u201cAbsorption and blood\/cellular transport of folate and cobalamin: Pharmacokinetic and physiological considerations.\u201d Biochimie vol. 126 (2016): 52-6. doi:10.1016\/j.biochi.2015.11.006<\/p>\n\n\n\n

7) Valera-Gran, Desir\u00e9e et al. \u201cEffect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study.\u201d The American journal of clinical nutrition vol. 106,3 (2017): 878-887. doi:10.3945\/ajcn.117.152769<\/p>\n\n\n\n

8) Plumptre, Lesley et al. \u201cHigh concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood.\u201d The American journal of clinical nutrition vol. 102,4 (2015): 848-57. doi:10.3945\/ajcn.115.110783<\/p>\n\n\n\n

9) Scaglione, Francesco, and Giscardo Panzavolta. \u201cFolate, folic acid and 5-methyltetrahydrofolate are not the same thing.\u201d Xenobiotica; the fate of foreign compounds in biological systems vol. 44,5 (2014): 480-8. doi:10.3109\/00498254.2013.845705<\/p>\n\n\n\n

10) \u201cMTHFR Gene Variant | Genetic and Rare Diseases Information Center (GARD) \u2013 an NCATS Program.\u201d NIH GARD, rarediseases.info.nih.gov\/diseases\/10953\/mthfr-gene-variant. Accessed 21 Mar. 2022.<\/p>\n\n\n\n

11) Miraglia, Niccol\u00f2 et al. \u201cEnhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats.\u201d Minerva ginecologica vol. 68,2 (2016): 99-105.<\/p>\n\n\n\n

12) Obeid, Rima, Holzgreve, Wolfgang and Pietrzik, Klaus. \u201cIs 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?\u201d Journal of Perinatal Medicine, vol. 41, no. 5, 2013, pp. 469-483. https:\/\/doi.org\/10.1515\/jpm-2012-0256<\/p>\n\n\n\n

13) Ferrazzi, Enrico et al. \u201cFolic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy.\u201d European journal of obstetrics, gynecology, and reproductive biology vol. 253 (2020): 312-319. doi:10.1016\/j.ejogrb.2020.06.012 [\/vc_toggle][\/vc_column][\/vc_row]<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"

Vastutustundlik lapsevanemaks saamine algab enne lapse s\u00fcndi. Teatud tegevused, nagu tasakaalustatud toitumine, treenimine ja rasedatele m\u00f5eldud vitamiinide v\u00f5tmine aitavad tagada normaalse raseduse kulgu. Selles blogipostituses k\u00e4sitleme \u00fchte k\u00f5ige olulisemat vitamiini, mida tulevane ema v\u00f5iks v\u00f5tta –  aktiveeritud foolhapet. Miks v\u00f5tta foolhapet lapse planeerimisel ja raseduse ajal? Seksuaalselt aktiivsete naiste jaoks on foolhappe v\u00f5tmine h\u00e4davajalik. Juhtub…<\/p>\n","protected":false},"author":2,"featured_media":129329,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[2812],"tags":[],"coauthors":[],"class_list":["post-230258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-et-ee"],"taxonomy_info":{"category":[{"value":2812,"label":"Uncategorized @et-ee"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2022\/03\/5-mthf-activated-folic-acid-for-prenatal-health-01-1024x512.jpg",1024,512,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/et-ee\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":2812,"name":"Uncategorized @et-ee","slug":"uncategorized-et-ee","term_group":0,"term_taxonomy_id":2812,"taxonomy":"category","description":"","parent":0,"count":36,"filter":"raw","cat_ID":2812,"category_count":36,"category_description":"","cat_name":"Uncategorized @et-ee","category_nicename":"uncategorized-et-ee","category_parent":0}],"tag_info":false,"wpml":{"language":"et-ee","is_original":false,"original_post_id":130686,"translations":{"cs-cz":{"id":221612,"language":"cs-cz","is_original":false},"de-at":{"id":169259,"language":"de-at","is_original":false},"de-de":{"id":75417,"language":"de-de","is_original":false},"en-gb":{"id":130686,"language":"en-gb","is_original":true},"en-ie":{"id":164126,"language":"en-ie","is_original":false},"en-mt":{"id":165499,"language":"en-mt","is_original":false},"es-es":{"id":74994,"language":"es-es","is_original":false},"et-ee":{"id":230258,"language":"et-ee","is_original":false},"fr-fr":{"id":129328,"language":"fr-fr","is_original":false},"hu-hu":{"id":225136,"language":"hu-hu","is_original":false},"it-it":{"id":75244,"language":"it-it","is_original":false},"lt-lt":{"id":237153,"language":"lt-lt","is_original":false},"lv-lv":{"id":230629,"language":"lv-lv","is_original":false},"nl-nl":{"id":175346,"language":"nl-nl","is_original":false},"pt-pt":{"id":168951,"language":"pt-pt","is_original":false},"ro-ro":{"id":253675,"language":"ro-ro","is_original":false},"sl-si":{"id":239024,"language":"sl-si","is_original":false}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/posts\/230258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/comments?post=230258"}],"version-history":[{"count":1,"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/posts\/230258\/revisions"}],"predecessor-version":[{"id":239072,"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/posts\/230258\/revisions\/239072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/media\/129329"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/media?parent=230258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/categories?post=230258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/tags?post=230258"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/et-ee\/wp-json\/wp\/v2\/coauthors?post=230258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}