{"id":221483,"date":"2022-05-16T09:00:00","date_gmt":"2022-05-16T08:00:00","guid":{"rendered":"https:\/\/eu.intelligentlabs.org\/uzivani-probiotik-s-antibiotiky-je-to-bezpecne\/"},"modified":"2025-09-23T11:43:05","modified_gmt":"2025-09-23T10:43:05","slug":"uzivani-probiotik-s-antibiotiky-je-to-bezpecne","status":"publish","type":"post","link":"https:\/\/eu.intelligentlabs.org\/cs-cz\/uzivani-probiotik-s-antibiotiky-je-to-bezpecne\/","title":{"rendered":"U\u017e\u00edv\u00e1n\u00ed probiotik s antibiotiky: Je to bezpe\u010dn\u00e9?"},"content":{"rendered":"\n\n\n

Pokud u\u017e\u00edv\u00e1te antibiotika a zaj\u00edm\u00e1 v\u00e1s, zda je bezpe\u010dn\u00e9 u\u017e\u00edvat je spole\u010dn\u011b s probiotiky, jste na spr\u00e1vn\u00e9m m\u00edst\u011b. V tomto \u010dl\u00e1nku si pov\u00edme o u\u017e\u00edv\u00e1n\u00ed probiotik s antibiotiky, kdy je u\u017e\u00edvat a o mo\u017en\u00fdch vedlej\u0161\u00edch \u00fa\u010dinc\u00edch jejich u\u017e\u00edv\u00e1n\u00ed ve stejn\u00e9m obdob\u00ed. <\/p>\n\n\n\n

Probiotick\u00e9 dopl\u0148ky<\/a> jsou st\u00e1le popul\u00e1rn\u011bj\u0161\u00ed a jejich soub\u011b\u017en\u00e9 u\u017e\u00edv\u00e1n\u00ed s antibiotiky je \u010dastou prax\u00ed. L\u00e9ka\u0159i se sezn\u00e1mili s konceptem zdrav\u00e9 st\u0159evn\u00ed fl\u00f3ry a st\u00e1le \u010dast\u011bji p\u0159edepisuj\u00ed probiotika spolu s antibiotiky. <\/p>\n\n\n\n

Na druhou stranu jsou pacienti tak\u00e9 dob\u0159e informov\u00e1ni o pozitivn\u00edch aspektech probiotik. V\u011bd\u00ed, \u017ee antibiotika mohou po\u0161kodit dobr\u00e9 bakterie ve st\u0159evech, a cht\u011bj\u00ed se chr\u00e1nit. Celkov\u011b se antibiotick\u00e1 l\u00e9\u010dba a p\u0159idru\u017een\u00e9 u\u017e\u00edv\u00e1n\u00ed probiotik staly rutinn\u00edm postupem mnoha l\u00e9ka\u0159\u016f. <\/p>\n\n\n\n

Pro\u010d je u\u017e\u00edv\u00e1n\u00ed antibiotik nezbytn\u00e9 <\/h2>\n\n\n\n

Antibiotika jsou l\u00e9ky schopn\u00e9 zachr\u00e1nit lidsk\u00e9 \u017eivoty. Medic\u00edna p\u0159ed a po jejich objeven\u00ed nen\u00ed stejn\u00e1. Jen d\u00edky antibiotik\u016fm se miliony lid\u00ed vyhnuly fat\u00e1ln\u00edmu n\u00e1sledku. Doslovn\u00fd v\u00fdznam slova antibiotikum je paradoxn\u011b “proti \u017eivotu”. N\u00e1zev vznikl spojen\u00edm latinsk\u00e9ho slova “anti”, co\u017e znamen\u00e1 proti, a \u0159eck\u00e9ho slova “bios”, co\u017e znamen\u00e1 \u017eivot(1)<\/a>. <\/p>\n\n\n\n

Antibiotika ni\u010d\u00ed bakterie, co\u017e z mikrobiologick\u00e9ho hlediska ospravedl\u0148uje jejich n\u00e1zev. Vhodn\u00e1 antibiotika mohou v\u00fdrazn\u011b zlep\u0161it p\u0159\u00edznaky a p\u0159in\u00e9st vyl\u00e9\u010den\u00ed u v\u00e1\u017en\u011b nemocn\u00fdch osob s nebezpe\u010dn\u00fdmi infekcemi. Nic nen\u00ed dokonal\u00e9, a to plat\u00ed i pro antibiotika. Krom\u011b toho, \u017ee ni\u010d\u00ed patogenn\u00ed bakterie, mohou tak\u00e9 negativn\u011b ovlivnit na\u0161i st\u0159evn\u00ed fl\u00f3ru. <\/p>\n\n\n\n

Z\u00e1va\u017en\u00e9 bakteri\u00e1ln\u00ed infekce jsou jasn\u00fdm d\u016fvodem pro p\u0159edepisov\u00e1n\u00ed antibiotik. P\u0159esto se tyto \u017eivot zachra\u0148uj\u00edc\u00ed l\u00e9ky pou\u017e\u00edvaj\u00ed mnohem v\u00edce, ne\u017e je nutn\u00e9. I kdy\u017e je nap\u0159\u00edklad v\u011bt\u0161ina infekc\u00ed horn\u00edch cest d\u00fdchac\u00edch (URTI) virov\u00e9ho p\u016fvodu, mnoho z nich se l\u00e9\u010d\u00ed antibiotiky. <\/p>\n\n\n\n

\"u\u017e\u00edv\u00e1n\u00ed<\/figure>\n\n\n\n

Strach z mo\u017en\u00fdch bakteri\u00e1ln\u00edch komplikac\u00ed motivuje l\u00e9ka\u0159e k tomu, aby uva\u017eoval o l\u00e9\u010db\u011b antibiotiky ve v\u0161ech p\u0159\u00edpadech, kdy p\u0159\u00edznaky m\u00edrn\u011b nazna\u010duj\u00ed mo\u017enou bakteri\u00e1ln\u00ed infekci. O\u010dek\u00e1v\u00e1n\u00ed pacient\u016f, \u017ee dostanou siln\u00fd a rychle p\u016fsob\u00edc\u00ed l\u00e9k ji\u017e od po\u010d\u00e1tku p\u0159\u00edznak\u016f, p\u0159edstavuj\u00ed pro zdravotn\u00edky velk\u00fd tlak. <\/p>\n\n\n\n

Na celosv\u011btov\u00e9 \u00farovni doch\u00e1z\u00ed k nadm\u011brn\u00e9mu p\u0159edepisov\u00e1n\u00ed antibiotik. D\u016fsledkem nadm\u011brn\u00e9ho u\u017e\u00edv\u00e1n\u00ed antibiotik v celosv\u011btov\u00e9m m\u011b\u0159\u00edtku je rezistence na antibiotika. Na individu\u00e1ln\u00ed \u00farovni se mo\u017enost ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f antibiotik zvy\u0161uje s jejich \u010dast\u00fdm u\u017e\u00edv\u00e1n\u00edm. <\/p>\n\n\n\n

Pro\u010d jsou probiotika d\u016fle\u017eit\u00e1? <\/h2>\n\n\n\n

N\u00e1zev probiotikum znamen\u00e1 “pro \u017eivot”, co\u017e je opak v\u00fdznamu slova antibiotikum. Probiotika, zn\u00e1m\u00e1 tak\u00e9 jako “dobr\u00e9 bakterie”, jsou \u017eiv\u00e9 mikroorganismy. Tyto \u017eiv\u00e9 kultury, p\u0159ij\u00edman\u00e9 potravou nebo jako dopln\u011bk stravy, jsou zdrav\u00ed prosp\u011b\u0161n\u00e9(2<\/a>). <\/p>\n\n\n\n

Antibiotika mohou ovlivnit rovnov\u00e1hu st\u0159evn\u00ed fl\u00f3ry s mo\u017enost\u00ed z\u00e1va\u017en\u00fdch vedlej\u0161\u00edch \u00fa\u010dink\u016f. N\u00e1\u0161 tr\u00e1vic\u00ed trakt host\u00ed v\u00edce ne\u017e 500 r\u016fzn\u00fdch druh\u016f bakteri\u00ed(2)<\/a>. Tyto “dobr\u00e9” bakterie z probiotik vytv\u00e1\u0159ej\u00ed ve st\u0159evech prost\u0159ed\u00ed, kter\u00e9 br\u00e1n\u00ed rozvoji patogenn\u00edch nebo “\u0161patn\u00fdch” mikroorganism\u016f. Pokud nejsou na\u0161e prosp\u011b\u0161n\u00e9 mikroby v rovnov\u00e1ze, je to z\u00e1klad pro zdravotn\u00ed probl\u00e9my. <\/p>\n\n\n\n

Probiotika se pou\u017e\u00edvaj\u00ed k prevenci dysbalance st\u0159evn\u00ed fl\u00f3ry nebo k l\u00e9\u010db\u011b zm\u011bn\u011bn\u00e9ho slo\u017een\u00ed st\u0159evn\u00edch mikrob\u016f. Mezi nej\u010dast\u011bji pou\u017e\u00edvan\u00e1 probiotika pat\u0159\u00ed druhy Lactobacillus<\/em> a Bifidobacterium<\/em>. Probiotika nejsou jako jin\u00e9 dopl\u0148ky stravy – jsou to \u017eiv\u00e9 mikroorganismy. Kdy\u017e je n\u00e1\u0161 slo\u017eit\u00fd st\u0159evn\u00ed mikrobiologick\u00fd sv\u011bt ohro\u017een nebo naru\u0161en, probiotika n\u00e1m pomohou. <\/p>\n\n\n\n

Pod\u00edvejte se na na\u0161e 50 miliard CFU, 10 kmen\u016f probiotik a prebiotik se slune\u010dn\u00ed vl\u00e1kninou a FOS<\/strong><\/a>. Ka\u017ed\u00e1 lahvi\u010dka v\u00e1m vysta\u010d\u00ed na dva m\u011bs\u00edce, tak\u017ee m\u00e1te dostatek podpory pro zdrav\u00ed va\u0161eho tr\u00e1vic\u00edho traktu. <\/p>\n\n\n\n

\"probiotika<\/figure>\n\n\n\n

Pro\u010d je u\u017e\u00edv\u00e1n\u00ed probiotik s antibiotiky tak d\u016fle\u017eit\u00e9? <\/h2>\n\n\n\n

Pojmenov\u00e1n\u00ed probiotik a antibiotik m\u00e1 smysl pouze tehdy, kdy\u017e se zamysl\u00edme nad jejich vlivem na st\u0159evn\u00ed fl\u00f3ru. Teprve pak by mohly b\u00fdt \u017eivot zachra\u0148uj\u00edc\u00ed l\u00e9ky, jako jsou antibiotika, spojeny se zni\u010den\u00edm n\u011bjak\u00e9 formy \u017eivota. Mohly by skute\u010dn\u011b po\u0161kodit “dobr\u00e9 bakterie” v na\u0161ich st\u0159evech a n\u00e1sledn\u011b v\u00e9st k p\u0159emno\u017een\u00ed patogenn\u00edch bakteri\u00ed. <\/p>\n\n\n\n

Dv\u011bma \u010dast\u00fdmi onemocn\u011bn\u00edmi, kter\u00e1 mohou vzniknout v d\u016fsledku l\u00e9\u010dby antibiotiky, jsou pr\u016fjmy spojen\u00e9 s antibiotiky a infekce Clostridium difficile(3)<\/a>. P\u0159\u00edle\u017eitostn\u011b se mohou vyskytnout \u017eivot ohro\u017euj\u00edc\u00ed infekce. Zm\u011bny homeost\u00e1zy st\u0159evn\u00ed fl\u00f3ry mohou souviset s \u0159adou onemocn\u011bn\u00ed a tyto souvislosti jsou p\u0159edm\u011btem intenzivn\u00edho v\u00fdzkumu. <\/p>\n\n\n\n

Probiotika pom\u00e1haj\u00ed p\u0159edch\u00e1zet pr\u016fjm\u016fm spojen\u00fdm s antibiotiky <\/h3>\n\n\n\n

Probiotika jsou mnoha l\u00e9ka\u0159i pova\u017eov\u00e1na za dopl\u0148ky stravy, kter\u00e9 jsou schopny p\u0159edch\u00e1zet vedlej\u0161\u00edm \u00fa\u010dink\u016fm antibiotik nebo je l\u00e9\u010dit na \u00farovni st\u0159evn\u00ed fl\u00f3ry. Existuje \u0159ada v\u011bdeck\u00fdch studi\u00ed podporuj\u00edc\u00edch u\u017e\u00edv\u00e1n\u00ed probiotik p\u0159i u\u017e\u00edv\u00e1n\u00ed antibiotik. Probiotika hraj\u00ed pozitivn\u00ed roli v prevenci pr\u016fjm\u016f spojen\u00fdch s antibiotiky u dosp\u011bl\u00e9 i d\u011btsk\u00e9 populace(4<\/a>). <\/p>\n\n\n\n

R\u016fzn\u00e9 probiotick\u00e9 prepar\u00e1ty nav\u00edc vykazuj\u00ed p\u0159\u00edzniv\u00e9 \u00fa\u010dinky a preventivn\u00ed v\u00fdsledky jsou zachov\u00e1ny p\u0159i r\u016fzn\u00fdch antibiotick\u00fdch re\u017eimech. Tak\u00e9 probiotika se \u00fasp\u011b\u0161n\u011b pou\u017e\u00edvaj\u00ed v r\u016fzn\u00fdch indikac\u00edch l\u00e9\u010dby antibiotiky(4<\/a>). <\/p>\n\n\n\n

Antibiotika jsou v d\u011btsk\u00e9 populaci p\u0159edepisov\u00e1na \u010dasto, a proto jsou pr\u016fjmy spojen\u00e9 s antibiotiky u d\u011bt\u00ed \u010dast\u00fdm probl\u00e9mem. I ty nejp\u0159\u00edsn\u011bj\u0161\u00ed systematick\u00e9 p\u0159ehledy uzn\u00e1vaj\u00ed schopnost antibiotik m\u011bnit mikrobi\u00e1ln\u00ed rovnov\u00e1hu v na\u0161em gastrointestin\u00e1ln\u00edm traktu(5<\/a>). <\/p>\n\n\n\n

Probiotika mohou vyu\u017e\u00edvat i d\u011bti v\u0161ech v\u011bkov\u00fdch kategori\u00ed<\/a>. . Ka\u017ed\u00e1 kapsle obsahuje 6 miliard CFU a nep\u0159etr\u017eit\u011b chr\u00e1n\u00ed b\u0159\u00ed\u0161ko va\u0161eho d\u00edt\u011bte.\u00a0<\/p>\n\n\n\n

Probiotika pom\u00e1haj\u00ed obnovit rovnov\u00e1hu st\u0159evn\u00ed fl\u00f3ry <\/h3>\n\n\n\n

Probiotika jsou tak\u00e9 uzn\u00e1v\u00e1na jako dopl\u0148ky stravy schopn\u00e9 obnovit st\u0159evn\u00ed fl\u00f3ru. Kmeny nej\u010dast\u011bji pou\u017e\u00edvan\u00e9 v probiotik\u00e1ch, konkr\u00e9tn\u011b Lactobacillus<\/em> a Bifidobacterium<\/em>, jsou \u00fa\u010dinn\u00e9 v prevenci pr\u016fjmu spojen\u00e9ho s antibiotiky zp\u016fsoben\u00e9ho \u010dasto pou\u017e\u00edvan\u00fdm antibiotikem kyselinou amoxicilin-klavulanovou (6)<\/a>. <\/p>\n\n\n\n

Zvl\u00e1\u0161t\u011b d\u011bsiv\u00fdm d\u016fsledkem nadm\u011brn\u00e9ho u\u017e\u00edv\u00e1n\u00ed antibiotik je infekce Clostridium difficile<\/a>. Tento typ infekce m\u016f\u017ee b\u00fdt \u017eivot ohro\u017euj\u00edc\u00ed, pokud je zp\u016fsoben multirezistentn\u00edmi kmeny tohoto mikroorganismu. Naru\u0161en\u00ed st\u0159evn\u00ed fl\u00f3ry antibiotiky m\u016f\u017ee v\u00e9st ke sn\u00ed\u017een\u00ed odolnosti v\u016f\u010di nebezpe\u010dn\u00fdm mikrob\u016fm, jako je Clostridium difficile(7)<\/a>. <\/p>\n\n\n\n

Na z\u00e1klad\u011b systematick\u00e9ho p\u0159ehledu a metaanal\u00fdzy 31 randomizovan\u00fdch kontrolovan\u00fdch studi\u00ed zahrnuj\u00edc\u00edch 8672 pacient\u016f existuj\u00ed d\u016fkazy, kter\u00e9 nazna\u010duj\u00ed schopnost probiotik p\u0159edch\u00e1zet pr\u016fjm\u016fm spojen\u00fdm s Clostridium difficile(7)<\/a>. Pr\u016fjem spojen\u00fd s Clostridium difficile p\u0159edstavuje nejz\u00e1va\u017en\u011bj\u0161\u00ed formu pr\u016fjmu spojen\u00e9ho s antibiotiky a je spojen s v\u00fdznamnou morbiditou a mortalitou(8<\/a>). <\/p>\n\n\n\n

\"probiotika<\/figure>\n\n\n\n

Probiotika pom\u00e1haj\u00ed zlep\u0161it v\u00fdsledky l\u00e9\u010dby antibiotiky <\/h2>\n\n\n\n

V n\u011bkter\u00fdch indikac\u00edch probiotika zlep\u0161uj\u00ed v\u00fdsledky l\u00e9\u010dby antibiotiky. P\u0159i pou\u017eit\u00ed s antibiotiky v l\u00e9\u010db\u011b recidivuj\u00edc\u00ed bakteri\u00e1ln\u00ed vagin\u00f3zy a aerobn\u00ed vaginitidy prodlu\u017euj\u00ed peror\u00e1ln\u00ed probiotika dobu remise (9)<\/a>. <\/p>\n\n\n\n

Pozn\u00e1mka: Pokud m\u00e1te tyto \u017eensk\u00e9 probl\u00e9my, n\u00e1\u0161 <\/em>Dopln\u011bk stravy pro \u017eeny s probiotiky a prebiotiky<\/em><\/strong><\/a> je speci\u00e1ln\u011b navr\u017een tak, aby v\u00e1m pomohl. Ka\u017ed\u00e1 kapsle obsahuje 5 miliard CFU, pr\u00e1\u0161ek z brusinkov\u00e9 \u0161\u0165\u00e1vy Crantiva a D-man\u00f3zu.<\/em> <\/p>\n\n\n\n

P\u0159i l\u00e9\u010db\u011b infekce Helicobacter pylori zahrnuje jeden z terapeutick\u00fdch re\u017eim\u016f u\u017e\u00edv\u00e1n\u00ed inhibitoru protonov\u00e9 pumpy, bizmutu a dvou antibiotik po dobu 14 dn\u016f. Pokud se k t\u00e9to \u010dty\u0159n\u00e1sobn\u00e9 terapii p\u0159id\u00e1 probiotikum, jsou kone\u010dn\u00e9 v\u00fdsledky v\u00edce ne\u017e uspokojiv\u00e9(10<\/a>). Tato l\u00e9\u010dba vykazuje dobr\u00e9 v\u00fdsledky nap\u0159\u00ed\u010d r\u016fzn\u00fdmi profily rezistence Helicobacter pylori v\u016f\u010di antibiotik\u016fm. <\/p>\n\n\n\n

Soub\u011b\u017en\u00e1 konzumace probiotick\u00fdch dopl\u0148k\u016f a antibiotik u d\u011btsk\u00e9 populace s recidivuj\u00edc\u00edmi infekcemi mo\u010dov\u00fdch cest vykazovala v\u011bt\u0161\u00ed \u00fa\u010dinnost ve srovn\u00e1n\u00ed s p\u0159\u00edpady, kdy byla u\u017e\u00edv\u00e1na pouze antibiotika(11)<\/a>. <\/p>\n\n\n\n

Nejlep\u0161\u00ed na\u010dasov\u00e1n\u00ed u\u017e\u00edv\u00e1n\u00ed probiotik s antibiotiky? <\/h2>\n\n\n\n

Existuj\u00ed r\u016fzn\u00e9 formy probiotick\u00fdch dopl\u0148k\u016f. K dispozici jsou nap\u0159\u00edklad probiotika ve form\u011b kapsl\u00ed nebo tablet. N\u00e1poje obsahuj\u00edc\u00ed probiotick\u00e9 kultury, jako je jogurt a kef\u00edr, jsou zn\u00e1m\u00e9 po cel\u00e9m sv\u011bt\u011b. Tyto prosp\u011b\u0161n\u00e9 mikroorganismy mus\u00ed obst\u00e1t v kysel\u00e9m prost\u0159ed\u00ed \u017ealudku, aby se dostaly do st\u0159ev, kde uplatn\u00ed sv\u016fj l\u00e9\u010debn\u00fd potenci\u00e1l. <\/p>\n\n\n\n

V z\u00e1vislosti na form\u011b probiotik jsou tyto dopl\u0148ky stravy by se m\u011bl u\u017e\u00edvat nala\u010dno nebo s j\u00eddlem.<\/strong><\/a>. Je velmi d\u016fle\u017eit\u00e9 p\u0159e\u010d\u00edst si pokyny pro pacienty, proto\u017ee neexistuje jedin\u00e9 pravidlo. Jako p\u0159\u00edklad mohou slou\u017eit probiotick\u00e9 dopl\u0148ky stravy bez enterick\u00e9ho obalu. M\u011bly by se u\u017e\u00edvat t\u011bsn\u011b p\u0159ed j\u00eddlem nebo s j\u00eddlem obsahuj\u00edc\u00edm tuky(12<\/a>). <\/p>\n\n\n\n

Tot\u00e9\u017e plat\u00ed i pro antibiotika. Jsou tak\u00e9 v r\u016fzn\u00fdch form\u00e1ch a mus\u00ed b\u00fdt schopny se dostat do st\u0159ev. N\u011bkter\u00e9 z nich se u\u017e\u00edvaj\u00ed nala\u010dno, jin\u00e9 s j\u00eddlem. Op\u011bt je velmi d\u016fle\u017eit\u00fd n\u00e1vod v\u00fdrobce pro pacienty a nelze jej zobecnit. <\/p>\n\n\n\n

Na druhou stranu je logick\u00e9, \u017ee sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed probiotik a antibiotik nen\u00ed dobr\u00fd n\u00e1pad. Jednodu\u0161e proto, \u017ee existuje mo\u017enost, \u017ee antibiotika zni\u010d\u00ed probiotick\u00e9 kmeny, jakmile se dostanou do kontaktu ve st\u0159evech. Probiotika obsahuj\u00edc\u00ed dobr\u00e9 bakterie by m\u011bla b\u00fdt od antibiotik odd\u011blena nejm\u00e9n\u011b dv\u011bma hod<\/strong> inami(2<\/a>). <\/p>\n\n\n\n

Pokud u\u017e\u00edv\u00e1te dopl\u0148ky stravy Saccharomyces bulardii<\/em>, je d\u016fle\u017eit\u00e9 v\u011bd\u011bt, \u017ee se jedn\u00e1 o kvasinky, kter\u00e9 jsou p\u0159irozen\u011b odoln\u00e9 v\u016f\u010di antibakteri\u00e1ln\u00edm antibiotik\u016fm(13)<\/a>. Tento druh probiotik m\u016f\u017ee b\u00fdt citliv\u00fd na antimykotika. <\/p>\n\n\n\n

\"u\u017e\u00edv\u00e1n\u00ed<\/figure>\n\n\n\n

M\u016f\u017eete u\u017e\u00edvat probiotika s antibiotiky bez vedlej\u0161\u00edch \u00fa\u010dink\u016f? <\/h2>\n\n\n\n

V\u0161echny l\u00e9ky a dopl\u0148ky stravy mohou v\u00e9st k ne\u017e\u00e1douc\u00edm \u00fa\u010dink\u016fm. Antibiotika a probiotika nejsou v\u00fdjimkou. U\u017e\u00edv\u00e1n\u00ed dvou l\u00e1tek ve stejn\u00e9m obdob\u00ed zvy\u0161uje mo\u017enost ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f. Vedle pr\u016fjmu spojen\u00e9ho s antibiotiky a pr\u016fjmu spojen\u00e9ho s Clostridium difficile mohou antibiotika vyvolat z\u00e1va\u017en\u00e9 alergick\u00e9 reakce. <\/p>\n\n\n\n

Probiotik\u016fm by se m\u011bli vyhnout pacienti v kritick\u00e9m stavu na jednotk\u00e1ch intenzivn\u00ed p\u00e9\u010de, kriticky nemocn\u00ed kojenci a v\u0161ichni jedinci, jejich\u017e imunitn\u00ed syst\u00e9m je v\u00e1\u017en\u011b oslaben (<\/strong>14<\/strong><\/a>).<\/strong> <\/p>\n\n\n\n

V l\u00e9ka\u0159sk\u00e9 literatu\u0159e je t\u011b\u017ek\u00e9 naj\u00edt n\u011bco konkr\u00e9tn\u00edho o ne\u017e\u00e1douc\u00edch \u00fa\u010dinc\u00edch v p\u0159\u00edpadech, kdy se antibiotika a probiotika pou\u017e\u00edvaj\u00ed spole\u010dn\u011b. N\u011bkter\u00e9 studie nav\u00edc prok\u00e1zaly, \u017ee p\u0159id\u00e1n\u00edm probiotik k antibiotik\u016fm se sni\u017euje v\u00fdskyt ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f souvisej\u00edc\u00edch s l\u00e9\u010dbou a zlep\u0161uje se compliance pacient\u016f (10)<\/a>. <\/p>\n\n\n\n

Probiotick\u00e1 bakterie Lactobacillus plantarum<\/em> je schopna zabr\u00e1nit n\u011bkter\u00fdm m\u00edrn\u011bj\u0161\u00edm gastrointestin\u00e1ln\u00edm p\u0159\u00edznak\u016fm spojen\u00fdm s u\u017e\u00edv\u00e1n\u00edm antibiotik(15)<\/a>. Suplementace probiotiky p\u0159i eradikaci Helicobacter pylori<\/em> m\u016f\u017ee b\u00fdt \u00fa\u010dinn\u00e1 p\u0159i sni\u017eov\u00e1n\u00ed ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f souvisej\u00edc\u00edch s l\u00e9\u010dbou(16<\/a>). Probiotick\u00e9 kvasinky Saccharomyces bulardii<\/em> jsou tak\u00e9 schopny sn\u00ed\u017eit v\u00fdskyt celkov\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f a n\u011bkter\u00fdch gastrointestin\u00e1ln\u00edch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f eradika\u010dn\u00ed l\u00e9\u010dby Helicobacter pylori(17)<\/a>. <\/p>\n\n\n\n

U\u017e\u00edv\u00e1n\u00ed probiotik s dlouhodob\u00fdmi antibiotiky <\/h2>\n\n\n\n

V n\u011bkter\u00fdch klinick\u00fdch situac\u00edch se antibiotika pou\u017e\u00edvaj\u00ed mnohem d\u00e9le ne\u017e t\u00fdden nebo dva. Dlouhodob\u011bj\u0161\u00ed u\u017e\u00edv\u00e1n\u00ed zvy\u0161uje pravd\u011bpodobnost v\u00fdskytu ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f, p\u0159esto\u017ee jsou probiotika obecn\u011b pova\u017eov\u00e1na za bezpe\u010dn\u00e9 a dob\u0159e sn\u00e1\u0161en\u00e9 dopl\u0148ky stravy(1)<\/a>. U mnoha indikac\u00ed se u\u017e\u00edvaj\u00ed po dobu n\u011bkolika m\u011bs\u00edc\u016f s vynikaj\u00edc\u00edm bezpe\u010dnostn\u00edm profilem. <\/p>\n\n\n\n

Vhodn\u00fdm p\u0159\u00edkladem soub\u011b\u017en\u00e9ho dlouhodob\u00e9ho u\u017e\u00edv\u00e1n\u00ed antibiotik a probiotik je v\u00fdskyt opakovan\u00fdch infekc\u00ed mo\u010dov\u00fdch cest u d\u011btsk\u00e9 populace. N\u011bkter\u00e9 studie zd\u016fraz\u0148uj\u00ed bezpe\u010dnost a \u00fa\u010dinnost dlouhodob\u00e9ho u\u017e\u00edv\u00e1n\u00ed probiotik s antibiotiky(11)<\/a>. To nen\u00ed p\u0159ekvapiv\u00e9, proto\u017ee \u010detn\u00e9 v\u011bdeck\u00e9 \u010dl\u00e1nky ukazuj\u00ed, \u017ee probiotika \u00fasp\u011b\u0161n\u011b napravuj\u00ed st\u0159evn\u00ed fl\u00f3ru, kdy\u017e je jej\u00ed rovnov\u00e1ha naru\u0161ena. <\/p>\n\n\n\n

Z\u00e1v\u011br <\/h2>\n\n\n\n

Jak jste se dozv\u011bd\u011bli v tomto \u010dl\u00e1nku, u\u017e\u00edv\u00e1n\u00ed probiotik s antibiotiky je obecn\u011b p\u0159ijateln\u00e9. M\u011bjte na pam\u011bti pravidlo dvou hodin, tj. u\u017e\u00edvejte probiotika 2 hodiny po u\u017eit\u00ed antibiotik (nebo naopak). Pro dosa\u017een\u00ed nejlep\u0161\u00edch v\u00fdsledk\u016f si nezapome\u0148te p\u0159e\u010d\u00edst pokyny v\u00fdrobce antibiotik i prebiotik. <\/p>\n\n\n\n

Reference<\/h2>\n\n\n\n

(1) Brightman C. Antibiotics in general practice. Trends in Urology & Men\u2018s Health. 2014;Nov\/Dec:39-43.<\/p>\n\n\n\n

(2) Williams NT. Probiotics. Am J Health-Syst Pharm. 2010; 67:449-458.<\/p>\n\n\n\n

(3) Rehman A, Heinsen FA, Koenen ME, Venema K, Knecht H, Hellmig S, et al. Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine. BMC Microbiology. 2012;12(47)<\/p>\n\n\n\n

(4) Videlock EJ, Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2012;35(12):1355-1369.<\/p>\n\n\n\n

(5) Johnston BC, Goldenberg JZ, Vandvik PO, Sun X, Guyatt GH. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database of Systematic. 2011;11:CD004827.<\/p>\n\n\n\n

(6) Garc\u00eda Trallero O, Herrera Serrano L, Bibi\u00e1n Ingl\u00e9s M, Roche Vall\u00e9s D, Rodr\u00edguez AM. Effect of the administration of a probiotic with a combination of Lactobacillus and Bifidobacterium strains on antibiotic-associated diarrhea. Rev Esp Quimioter. 2019;32(3):268-272.<\/p>\n\n\n\n

(7) Goldenberg_JZ, Yap_C, Lytvyn_L, Lo_CKF, Beardsley_J, Mertz_D, Johnston_BC. Probiotics for the prevention of Clostridium di_icile-associated diarrhea in adults and children. Cochrane Database of Systematic Reviews 2017;12:CD006095.<\/p>\n\n\n\n

(8) Selinger CP, Bell A, Cairns A, Lockett M, Sebastian S, Haslam N. Probiotic VSL#3 prevents antibiotic-associated diarrhoea in a double-blind, randomized, placebo-controlled clinical trial. J Hosp Infect. 2013;84(2):159-165.<\/p>\n\n\n\n

(9) Heczko PB, Tomusiak A, Adamski P, Jakimiuk AJ, Stefa\u0144ski G, Miko\u0142ajczyk-Cicho\u0144ska A, et al. Supplementation of standard antibiotic therapy with oral probiotics for bacterial vaginosis and aerobic vaginitis: a randomised, double-blind, placebo-controlled trial. BMC Womens Health. 2015;15:115.<\/p>\n\n\n\n

(10) Poonyam P, Chotivitayatarakorn P, Vilaichone RK. High Effective of 14-Day High-Dose PPI- Bismuth-Containing Quadruple Therapy with Probiotics Supplement for Helicobacter Pylori Eradication: A Double Blinded-Randomized Placebo-Controlled Study. Asian Pac J Cancer Prev. 2019;20(9):2859-2864.<\/p>\n\n\n\n

(11) Mohseni MJ, Aryan Z, Emamzadeh-Fard S, Paydary K, Mofid V, Joudaki H, et al. Combination of Probiotics and Antibiotics in the Prevention of Recurrent Urinary Tract Infection in Children. Iran J Pediatr. 2013;23(4): 430\u2013438.<\/p>\n\n\n\n

(12) Tompkins TA, Mainville I, Arcand Y. The impact of meals on a probiotic during transit through a model of the human upper gastrointestinal tract. Benef Microbes. 2011;2(4):295-303.<\/p>\n\n\n\n

(13) Czerucka D, Piche T, Rampal P. Review article: yeast as probiotics \u2013Saccharomyces boulardii. Alimentary Pharmacology and Therapeutics. 2007;26(6):767-778.<\/p>\n\n\n\n

(14) Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M. A systematic review of the safety of probiotics. Expert Opin Drug Saf. 2014;13(2):227-239.<\/p>\n\n\n\n

(15) L\u00f6nnermark E, Friman V, Lappas G, Sandberg T, Berggren A, Adlerberth I. Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics. J Clin Gastroenterol. 2010;44(2):106-112.<\/p>\n\n\n\n

(16) Lv Z, Wang B, Zhou X, Wang F, Xie Y, Zheng H, et al. Efficacy and safety of probiotics as adjuvant agents for Helicobacter pylori infection: A meta\u2011analysis. Exp Ther Med. 2015;9(3):707-716.<\/p>\n\n\n\n

(17) Zhou BG, Chen LX, Li B, Wan LY, Ai YW. Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta-analysis with trial sequential analysis. Helicobacter. 2019;24(5):e12651.<\/p>\n","protected":false},"excerpt":{"rendered":"

Pokud u\u017e\u00edv\u00e1te antibiotika a zaj\u00edm\u00e1 v\u00e1s, zda je bezpe\u010dn\u00e9 u\u017e\u00edvat je spole\u010dn\u011b s probiotiky, jste na spr\u00e1vn\u00e9m m\u00edst\u011b. V tomto \u010dl\u00e1nku si pov\u00edme o u\u017e\u00edv\u00e1n\u00ed probiotik s antibiotiky, kdy je u\u017e\u00edvat a o mo\u017en\u00fdch vedlej\u0161\u00edch \u00fa\u010dinc\u00edch jejich u\u017e\u00edv\u00e1n\u00ed ve stejn\u00e9m obdob\u00ed.  Probiotick\u00e9 dopl\u0148ky jsou st\u00e1le popul\u00e1rn\u011bj\u0161\u00ed a jejich soub\u011b\u017en\u00e9 u\u017e\u00edv\u00e1n\u00ed s antibiotiky je \u010dastou prax\u00ed….<\/p>\n","protected":false},"author":2,"featured_media":129467,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[2621],"tags":[],"coauthors":[],"class_list":["post-221483","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vyziva"],"taxonomy_info":{"category":[{"value":2621,"label":"V\u00fd\u017eiva"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2020\/06\/taking-probiotics-with-antibiotics-is-it-safe-to-do-so-01-1024x548.jpg",1024,548,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/cs-cz\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":2621,"name":"V\u00fd\u017eiva","slug":"vyziva","term_group":0,"term_taxonomy_id":2621,"taxonomy":"category","description":"","parent":0,"count":61,"filter":"raw","cat_ID":2621,"category_count":61,"category_description":"","cat_name":"V\u00fd\u017eiva","category_nicename":"vyziva","category_parent":0}],"tag_info":false,"wpml":{"language":"cs-cz","is_original":true,"original_post_id":221483,"translations":{"cs-cz":{"id":221483,"language":"cs-cz","is_original":true}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/posts\/221483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/comments?post=221483"}],"version-history":[{"count":1,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/posts\/221483\/revisions"}],"predecessor-version":[{"id":251086,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/posts\/221483\/revisions\/251086"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/media\/129467"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/media?parent=221483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/categories?post=221483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/tags?post=221483"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/coauthors?post=221483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}