{"id":219500,"date":"2021-04-05T09:00:00","date_gmt":"2021-04-05T08:00:00","guid":{"rendered":"https:\/\/eu.intelligentlabs.org\/co-je-to-fostatidylserin\/"},"modified":"2025-09-23T11:56:40","modified_gmt":"2025-09-23T10:56:40","slug":"co-je-to-fostatidylserin","status":"publish","type":"post","link":"https:\/\/eu.intelligentlabs.org\/cs-cz\/co-je-to-fostatidylserin\/","title":{"rendered":"Co je to Fosfatidylserin?"},"content":{"rendered":"\n

Co je fosfatidylserin? V\u0161ichni konzumujeme fosfatidylserin ka\u017ed\u00fd den, ale bohu\u017eel v\u011bt\u0161ina z n\u00e1s ho m\u00e1 i tak nedostatek. Fosfatidylserin je k dispozici v mnoha potravin\u00e1ch, v\u010detn\u011b s\u00f3ji (kter\u00e1 je hlavn\u00edm zdrojem), b\u00edl\u00fdch fazol\u00ed, vaje\u010dn\u00fdch \u017eloutk\u016f, ku\u0159ec\u00edch jater a hov\u011bz\u00edch jater. Bohu\u017eel je pro na\u0161e t\u011blo obt\u00ed\u017en\u00e9 absorbovat dostate\u010dn\u00e9 mno\u017estv\u00ed ze zdroj\u016f stravy. V tomto \u010dl\u00e1nku si vysv\u011btl\u00edme, co je to fosfatidylserin<\/strong> a jestli je skute\u010dn\u011b nej\u00fa\u010dinn\u011bj\u0161\u00ed p\u0159\u00edrodn\u00ed nootropikum.<\/strong> <\/p>\n\n\n\n

Co je fosfatidylserin? <\/h2>\n\n\n\n
\"Nervov\u00e1<\/figure>\n\n\n\n

Fosfatidylserin je fosfolipid bun\u011b\u010dn\u00e9 membr\u00e1ny, je sou\u010d\u00e1st\u00ed bun\u011b\u010dn\u00e9 membr\u00e1ny ka\u017ed\u00e9ho z na\u0161ich 20 bilion\u016f bun\u011bk<\/strong>. V t\u011ble tvo\u0159\u00ed p\u0159ibli\u017en\u011b 2\u201315 % na\u0161ich bun\u011b\u010dn\u00fdch membr\u00e1n, ale nejvy\u0161\u0161\u00ed koncentrace fosfatidylserinu se nach\u00e1zej\u00ed v mozku,<\/strong> kde je to obzvl\u00e1\u0161t\u011b d\u016fle\u017eit\u00e9 a kde tvo\u0159\u00ed 10\u201320 % z celkov\u00e9ho mno\u017estv\u00ed fosfolipid\u016f (1) . <\/p>\n\n\n\n

Z\u00e1kladn\u00ed jednotky mozku a nervov\u00e9ho syst\u00e9mu se naz\u00fdvaj\u00ed neurony (nervov\u00e9 bu\u0148ky). V\u00fdstupn\u00ed \u010d\u00e1st neuronu se naz\u00fdv\u00e1 axon (nervov\u00e9 vl\u00e1kno); kdy\u017e chce neuron mluvit s jin\u00fdm neuronem, vy\u0161le elektrickou zpr\u00e1vu p\u0159es axon. Axony jsou pokryty vrstvou zvanou myelinov\u00e1 pochva. Toto myelinov\u00e9 pouzdro chr\u00e1n\u00ed a izoluje axon a umo\u017e\u0148uje, aby se elektrick\u00e9 sign\u00e1ly p\u0159en\u00e1\u0161ely rychle a efektivn\u011b mezi neurony. <\/p>\n\n\n\n

Myelinov\u00e1 pochva je obzvl\u00e1\u0161t\u011b bohat\u00e1 na fosfatidylserin. <\/strong>V posledn\u00ed dob\u011b bylo zji\u0161t\u011bno, \u017ee fosfatidylserin zlep\u0161uje funkci neuron\u016f a pom\u00e1h\u00e1 p\u0159i funk\u010dn\u00ed regeneraci a obnoven\u00ed norm\u00e1ln\u00ed funkce po\u0161kozen\u00fdch neuron\u016f (2). <\/p>\n\n\n\n

Fosfatidylserin v mozku <\/h4>\n\n\n\n

Ned\u00e1vn\u00fd objev kritick\u00e9 role fosfatidylserinu<\/strong> p\u0159i aktivaci d\u016fle\u017eit\u00e9ho p\u0159enosu sign\u00e1lu a modulaci uvol\u0148ov\u00e1n\u00ed kl\u00ed\u010dov\u00fdch neurotransmiter\u016f (acetylcholin, norepinefrin, serotonin a dopamin) a funkce receptor\u016f obnovil z\u00e1jem o fosfatidylserin ve vztahu k mozkov\u00e9 funkci (3-5). <\/p>\n\n\n\n

Zde je obr\u00e1zek zn\u00e1zor\u0148uj\u00edc\u00ed fosfolipidovou dvojvrstvu bun\u011b\u010dn\u00fdch membr\u00e1n: <\/p>\n\n\n\n

\"Fosfatidylserin<\/figure>\n\n\n\n

Acetylcholin (Ach)<\/strong> je \u010dasto ozna\u010dov\u00e1n jako \u201einteligentn\u00ed\u201c neurotransmiter a je nezbytn\u00fd pro u\u010den\u00ed, pam\u011b\u0165 a zvy\u0161ov\u00e1n\u00ed pozornosti <\/p>\n\n\n\n

prost\u0159ednictv\u00edm \u201echolinergn\u00edch\u201c p\u0159enos\u016f (acetylcholinov\u00e9 synapsy). Je z acetyl-CoA a cholinu, a proto je cholin \u010dasto obsa\u017een v nootropn\u00edch z\u00e1sobn\u00edc\u00edch. Norepinefrin<\/strong> (aka noradrenalin) je spojov\u00e1n s du\u0161evn\u00ed energi\u00ed, soust\u0159ed\u011bn\u00edm a bd\u011blost\u00ed. Dopamin<\/strong> je spojen s motivac\u00ed a koncentrac\u00ed. Serotonin<\/strong> je spojen s dobrou n\u00e1ladou a lep\u0161en\u00fdm sp\u00e1nkem, nedostatek serotoninu je siln\u011b spojen s depres\u00ed a \u0161patnou koncentrac\u00ed. <\/p>\n\n\n\n

Jsou to pr\u00e1v\u011b tyto \u00fa\u010dinky neurotransmiter\u016f, d\u00edky nim\u017e si lid\u00e9 u\u017e\u00edvaj\u00edc\u00ed fosfatidylserin v\u0161imnou velmi jednozna\u010dn\u00e9ho rozd\u00edlu, kdy maj\u00ed pocit, \u017ee jejich mozky jsou ost\u0159ej\u0161\u00ed a jasn\u011bj\u0161\u00ed. Pomohou v\u00e1m snadn\u011bji se soust\u0159edit, pamatovat si jm\u00e9na a m\u00edsta z minulosti, vytv\u00e1\u0159et jasn\u011bj\u0161\u00ed a plynulej\u0161\u00ed v\u011bty, krom\u011b dobr\u00e9 n\u00e1lady a zlep\u0161en\u00e9ho sp\u00e1nku. <\/p>\n\n\n\n

Fosfatidylserin a jeho v\u00fdhody <\/h2>\n\n\n\n

Ned\u00e1vn\u00e9 studie uk\u00e1zaly, \u017ee or\u00e1ln\u00ed pod\u00e1v\u00e1n\u00ed fosfatidylserinu zlep\u0161uje po\u0161kozen\u00ed pam\u011bti<\/a>, ke kter\u00e9mu doch\u00e1z\u00ed b\u011bhem norm\u00e1ln\u00edho st\u00e1rnut\u00ed (6). <\/p>\n\n\n\n

\"Cholinergn\u00ed<\/figure>\n\n\n\n

Dal\u0161\u00ed kl\u00ed\u010dovou v\u00fdhodou fosfatidylserinu je jeho \u00fa\u010dinek na oblasti mozku v hypotalamu a hipokampu<\/strong>. Ob\u011b tyto oblasti spolupracuj\u00ed na regulaci uvol\u0148ov\u00e1n\u00ed kortizolu, co\u017e je hlavn\u00ed stresov\u00fd hormon t\u011bla uvol\u0148ovan\u00fd z k\u016fry nadledvin. Kortizol pracuje na zp\u011btnovazebn\u00ed smy\u010dce, tak\u017ee kdy\u017e se uvoln\u00ed dostate\u010dn\u00e9 mno\u017estv\u00ed, hypothalamus a hipokampus to vyc\u00edt\u00ed a sn\u00ed\u017e\u00ed mno\u017estv\u00ed CRH (hormon uvol\u0148uj\u00edc\u00ed kortikotropin) uvol\u0148ovan\u00fd z hypotalamu, co\u017e zp\u016fsob\u00ed, \u017ee hypof\u00fdza produkuje m\u00e9n\u011b ACTH (adrenokortikotropn\u00ed hormon) kter\u00fd \u0159\u00edk\u00e1 nadledvin\u00e1m, aby produkovaly m\u00e9n\u011b kortizolu. <\/p>\n\n\n\n

Kdy\u017e se v\u0161ak chronicky zvy\u0161uj\u00ed hladiny kortizolu, nap\u0159\u00edklad kdy\u017e jsme chronicky stresovan\u00ed, hypothalamus a hipokampus ztr\u00e1cej\u00ed citlivost na kortizol, tak\u017ee uvol\u0148ov\u00e1n\u00ed CRH a ACTH nen\u00ed potla\u010deno, a tak nen\u00ed vypnuta produkce kortizolu v nadledvin\u00e1ch. To znamen\u00e1, \u017ee skon\u010d\u00edme s chronicky vysokou hladinou kortizolu. Fosfatidylserin m\u016f\u017ee znovu senzibilizovat bu\u0148ky hypotalamu a hipokampu na kortizol,<\/strong> tak\u017ee znovu \u201esly\u0161\u00ed\u201c zp\u011btnou vazbu a sni\u017euje CRH a ACTH, co\u017e sni\u017euje produkci kortizolu (5,6,7). <\/p>\n\n\n\n

Hladina fosfatidylserinu v t\u011ble kles\u00e1 se st\u00e1rnut\u00edm<\/strong> a sn\u00ed\u017een\u00ed fosfatidylserinu je spojeno s kognitivn\u00ed poruchou a patogenez\u00ed Alzheimerovy choroby<\/strong> (AD) (10, 11). <\/p>\n\n\n\n

\"Berte<\/figure>\n\n\n\n

D\u016fkazy v\u00fdzkumu pro \u00fa\u010dinky fosfatidylserinu jako nootropikum <\/h2>\n\n\n\n

Nejnov\u011bj\u0161\u00ed studie z roku 2020<\/strong> zjistila, \u017ee dopl\u0148ky stravy<\/a> obsahuj\u00edc\u00ed fosfatidylserin v\u00fdznamn\u011b zv\u00fd\u0161ily odolnost v\u016f\u010di oxida\u010dn\u00edmu stresu<\/strong>, sn\u00ed\u017eily reakci na st\u00e1rnut\u00ed a krom\u011b prodlou\u017een\u00ed d\u00e9lky \u017eivota mohly m\u00edt preventivn\u00ed \u00fa\u010dinek na nemoci souvisej\u00edc\u00ed s v\u011bkem (12).<\/strong> <\/p>\n\n\n\n

Oxida\u010dn\u00ed stres hraje kl\u00ed\u010dovou roli ve v\u00fdvoji nemoc\u00ed souvisej\u00edc\u00edch s v\u011bkem, v\u010detn\u011b artritidy, cukrovky, demence, rakoviny, ateroskler\u00f3zy, vaskul\u00e1rn\u00edch onemocn\u011bn\u00ed, obezity, osteopor\u00f3zy a metabolick\u00fdch syndrom\u016f, co\u017e bylo prok\u00e1z\u00e1no n\u011bkolika studiemi (13,14). <\/p>\n\n\n\n

Dal\u0161\u00ed ned\u00e1vn\u00e1 studie hodnot\u00edc\u00ed fosfatidylserin a jeho \u00falohy a d\u016fle\u017eitost zjistila, \u017ee suplementace (300-800 mg denn\u011b) bezpe\u010dn\u011b zpomaluje nebo zvrac\u00ed zm\u011bny a zhor\u0161en\u00ed nervov\u00fdch bun\u011bk a podporuje kognitivn\u00ed funkce<\/strong>. To zahrnuje formov\u00e1n\u00ed kr\u00e1tkodob\u00e9 pam\u011bti, konsolidaci dlouhodob\u00e9 pam\u011bti, schopnost vytv\u00e1\u0159et nov\u00e9 vzpom\u00ednky, schopnost z\u00edsk\u00e1vat vzpom\u00ednky, schopnost u\u010dit se a vybavovat si informace, schopnost soust\u0159edit pozornost a soust\u0159edit se, schopnost uva\u017eovat a \u0159e\u0161it probl\u00e9my, jazykov\u00e9 dovednosti a schopnost komunikovat. Podporuje tak\u00e9 pohybov\u00e9 funkce, zejm\u00e9na rychl\u00e9 reakce a reflexy (15). <\/p>\n\n\n\n

Studie z roku 2011 testovala 18 mu\u017e\u016f ve vysoko\u0161kolsk\u00e9m v\u011bku po 14 dnech brali fosfatidylserin v d\u00e1vce 400 mg na s\u00e9riov\u00e9m ode\u010d\u00edtac\u00edm testu (tj. Od 100 do 7, 6 nebo 3 atd.). Zjistili, \u017ee skupina, kter\u00e1 brala fosfatidylserin, zkr\u00e1tila \u010das pot\u0159ebn\u00fd pro spr\u00e1vn\u00fd v\u00fdpo\u010det o 20 %, sn\u00ed\u017eila celkov\u00fd po\u010det chyb o 39 % a zv\u00fd\u0161ila po\u010det spr\u00e1vn\u00fdch v\u00fdpo\u010dt\u016f o 13 % oproti skupin\u011b s placebem (16). <\/p>\n\n\n\n

\"Fosfatidylserin<\/figure>\n\n\n\n

Dv\u011b otev\u0159en\u00e9 studie na star\u0161\u00edch \u00fa\u010dastn\u00edc\u00edch trp\u00edc\u00edch m\u00edrn\u00fdm kognitivn\u00edm poklesem (ztr\u00e1ta pam\u011bti zp\u016fsoben\u00e1 st\u00e1rnut\u00edm u lid\u00ed, kte\u0159\u00ed jsou jinak klinicky zdrav\u00ed) zjistili, \u017ee fosfatidylserin a 300mg denn\u011b zlep\u0161ila kognitivn\u00ed v\u00fdkonnost<\/strong> p\u0159i testech verb\u00e1ln\u00edho u\u010den\u00ed, verb\u00e1ln\u00edch vzpom\u00ednka, slovn\u00ed plynulost, vizu\u00e1ln\u00ed u\u010den\u00ed, pozornost, komunika\u010dn\u00ed dovednosti, iniciativa, socializace a sob\u011bsta\u010dnost (17,18). Podobn\u00e1 studie, kter\u00e1 prob\u00edhala 90 dn\u00ed, do\u0161la ke stejn\u00fdm v\u00fdsledk\u016fm, ale tak\u00e9 zjistila, \u017ee \u00fa\u010dastn\u00edci studie zlep\u0161ili svou schopnost vybavit si jm\u00e9na a tv\u00e1\u0159e (19). <\/p>\n\n\n\n

Dal\u0161\u00ed studie t\u00fdkaj\u00edc\u00ed se pam\u011bti a fosfatidylserinu zjistily, \u017ee u star\u0161\u00edch pacient\u016f, kte\u0159\u00ed c\u00edtili, \u017ee se jejich pam\u011b\u0165 zhor\u0161uje, do\u0161lo ke 42% zv\u00fd\u0161en\u00ed jejich schopnosti vybavit si slova (20) a dos\u00e1hnout v\u00fdznamn\u00e9ho zlep\u0161en\u00ed v rozpozn\u00e1v\u00e1n\u00ed pam\u011bti, vzpom\u00ednce na pam\u011b\u0165, v\u00fdkonn\u00e9 funkci a du\u0161evn\u00ed flexibilita (21) po dopln\u011bn\u00ed 300 mg denn\u011b. <\/p>\n\n\n\n

V roce 2015 bylo zji\u0161t\u011bno, \u017ee fosfatidylserin jako dopln\u011bk sni\u017euje hlavn\u00ed p\u0159\u00edznaky deprese u star\u0161\u00edch jedinc\u016f<\/strong> sn\u00ed\u017een\u00edm baz\u00e1ln\u00edch koncentrac\u00ed kortizolu (22). <\/p>\n\n\n\n

V roce 2016 studie prok\u00e1zala souvislost mezi dopl\u0148ky stravy, regulac\u00ed kortizolu, sp\u00e1nkem a mo\u017en\u00fdmi d\u016fsledky pro riziko Alzheimerovy choroby a \u017ee suplementace fosfatidylserin pom\u00e1h\u00e1 p\u0159i obnov\u011b koncentrac\u00ed kortizolu, co\u017e m\u016f\u017ee zm\u00edrnit poruchy sp\u00e1nku a regulovat kvalitu sp\u00e1nku,<\/strong> co\u017e usnad\u0148uje clearance mozku a pozitivn\u011b zachovat nebo zv\u00fd\u0161it mozkov\u00e9 funkce a n\u00e1sledn\u011b sn\u00ed\u017eit riziko kognitivn\u00edch poruch a demence (23). <\/p>\n\n\n\n

Suplementace fosfatidylserinu byla nav\u00edc spojena s pocitem men\u0161\u00edho stresu a lep\u0161\u00ed n\u00e1lady u mlad\u00fdch dosp\u011bl\u00fdch<\/strong>, kdy\u017e u\u017e\u00edvali 300 mg ka\u017ed\u00fd den po dobu jednoho m\u011bs\u00edce (24). <\/p>\n\n\n\n

Zji\u0161t\u011bn\u00ed tak\u00e9 nazna\u010duj\u00ed, \u017ee fosfatidylserin je \u00fa\u010dinn\u00fdm dopl\u0148kem v boji proti stresu vyvolan\u00e9mu cvi\u010den\u00edm<\/strong> a prevenci fyziologick\u00e9ho zhor\u0161en\u00ed, kter\u00e9 m\u016f\u017ee doprov\u00e1zet p\u0159\u00edli\u0161 mnoho cvi\u010den\u00ed<\/strong>. Fosfatidylserin a jeho dopl\u0148ov\u00e1n\u00ed podporuje po\u017eadovan\u00fd hormon\u00e1ln\u00ed stav pro sportovce t\u00edm, \u017ee otupuje zv\u00fd\u0161en\u00ed hladiny kortizolu (25,26). <\/p>\n\n\n\n

Fosfatidylserin m\u016f\u017ee tak\u00e9 pomoci p\u0159i symptomech spojen\u00fdch s ADHD<\/strong>. Nap\u0159\u00edklad japonsk\u00e1 studie z roku 2014 zjistila, \u017ee d\u011bti ve v\u011bku 4\u201314 let, kter\u00e9 dopl\u0148ovaly 200 mg fosfatidylserinu denn\u011b, v\u00fdznamn\u011b zlep\u0161ily svou kr\u00e1tkodobou pam\u011b\u0165, probl\u00e9my s nepozornost\u00ed a impulzivitu (27). <\/p>\n\n\n\n

\"Fosfatidylserin<\/figure>\n\n\n\n

Jak\u00e9 je nejlep\u0161\u00ed d\u00e1vkov\u00e1n\u00ed fosfatidylserinu? <\/h2>\n\n\n\n

Doporu\u010den\u00e1 d\u00e1vka fosfatidylserinu je 100 mg u\u017e\u00edvan\u00fdch 3x denn\u011b s j\u00eddlem<\/a>. Uk\u00e1zalo se, \u017ee tato d\u00e1vka pom\u00e1h\u00e1 lidem trp\u00edc\u00edm kognitivn\u00edm poklesem a lidem, kte\u0159\u00ed cht\u011bj\u00ed zlep\u0161it sv\u00e9 kognitivn\u00ed funkce (28). <\/p>\n\n\n\n

U ka\u017ed\u00e9ho dopl\u0148ku je v\u0161ak d\u016fle\u017eit\u00e9 posoudit \u00farovn\u011b dopl\u0148ov\u00e1n\u00ed na z\u00e1klad\u011b va\u0161ich osobn\u00edch po\u017eadavk\u016f, neexistuje \u017e\u00e1dn\u00e1 univerz\u00e1ln\u00ed velikost. To plat\u00ed zejm\u00e9na pro lidi, kte\u0159\u00ed hledaj\u00ed fosfatidylserin, kter\u00fd pom\u00e1h\u00e1 sni\u017eovat vysok\u00e9 hladiny kortizolu a pom\u00e1h\u00e1 tak p\u0159i stresu. Ve v\u011bdeck\u00fdch studi\u00edch jsme zjistili, \u017ee lid\u00e9 s vysokou hladinou kortizolu mohou pot\u0159ebovat v\u00edce ne\u017e 300 mg denn\u011b, aby to zm\u011bnili, a mohou pot\u0159ebovat a\u017e 800 mg denn\u011b (15). <\/p>\n\n\n\n

Jakmile v\u0161ak t\u011blo vytvo\u0159\u00ed hladinu fosfatidylserinu a hladina kortizolu se vr\u00e1t\u00ed k norm\u00e1lu, lze tuto vysokou d\u00e1vku fosfatidylserinu sn\u00ed\u017eit na norm\u00e1ln\u00ed hodnotu. Kl\u00ed\u010dovou v\u011bc\u00ed je zdrav\u00fd rozum a v\u011bdom\u00ed v\u0161ech zm\u011bn ve va\u0161ich p\u0159\u00edznac\u00edch. Za\u010dn\u011bte d\u00e1vkou 100 mg denn\u011b a pomalu se zvy\u0161ujte p\u0159id\u00e1v\u00e1n\u00edm 100 mg denn\u011b ka\u017ed\u00fdch 4 a\u017e 5 dn\u00ed. Pokud kdykoli po zv\u00fd\u0161en\u00ed d\u00e1vky zjist\u00edte, \u017ee jste st\u00e1le v\u00edce \u201erozru\u0161eni\u201cnebo pokud je ovlivn\u011bn v\u00e1\u0161 sp\u00e1nek, je to zn\u00e1mka toho, \u017ee jste p\u0159ekro\u010dili spr\u00e1vnou \u00farove\u0148 d\u00e1vky pro v\u00e1s, a m\u011bli byste d\u00e1vku sn\u00ed\u017eit. <\/p>\n\n\n\n

Reference: <\/strong><\/p>\n\n\n\n

(1) Zanotti, A., Rubini, R., Calderini, G. a Toffano, G., 1987, Fosfatidylserin a jeho farmakologick\u00e9 vlastnosti: \u00fa\u010dinky na pam\u011b\u0165ovou funkci, v: \u201e\u017diviny a funkce mozku,\u201c WB Essman, ed., Karger, Basel, str. 95\u2013102. <\/p>\n\n\n\n

(2) Abay ZC, Wong MY, Teoh JS, Vijayaraghavan T, Hilliard MA, Neumann B (2017) Sign\u00e1ly save-me fosfatidylserinu \u0159\u00edd\u00ed funk\u010dn\u00ed zotaven\u00ed p\u0159eru\u0161en\u00fdch axon\u016f u Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 114, E10196\u2013E10205. 13. <\/p>\n\n\n\n

(3) Kim, H. Y., Huang, B. X., & Spector, A. A. (2014). Fosfatidylserin v mozku: metabolismus a funkce. Pokrok ve v\u00fdzkumu lipid\u016f, 56, 1\u201318. <\/p>\n\n\n\n

(4) Crook TH, Tinklenberg J, Yesavage J, Petrie W, Nunzi MG, Massari DC. \u00da\u010dinky fosfatidylserinu na po\u0161kozen\u00ed pam\u011bti spojen\u00e9 s v\u011bkem. Neurology 1991;41:644\u20139. <\/p>\n\n\n\n

(5) Crook T, Petrie W, Wells C, Massari DC. \u00da\u010dinky fosfatidylserinu na Alzheimerovu chorobu. Psychopharmacol Bull 1992;28:61\u20136. <\/p>\n\n\n\n

(6) Lee B, Sur BJ, Han JJ, Shim I, Her S, Lee YS, Lee HJ, Hahm DH (2015) Peror\u00e1ln\u00ed pod\u00e1n\u00ed lecithin-transphos-phatidylovan\u00fd fosfatidylserin zlep\u0161uje pam\u011b\u0165 u star\u0161\u00edch potkan\u016f. Prog Neuropsychopharmacol BiolPsychiatry 56:1\u201310. <\/p>\n\n\n\n

(7) Monteleone P, Maj M, Beinat L, Natale M, Kemali D, Blunting chronick\u00e9 pod\u00e1v\u00e1n\u00ed fosfatidylserinu stresovou aktivac\u00ed osy hypotalamo-hypof\u00fdza-nadledvina u zdrav\u00fdch mu\u017e\u016f. Eur J Clin Pharmacol. 1992;42(4):385-8. <\/p>\n\n\n\n

(8) Monteleone P, Beinat L, Tanzillo C, Maj M, Kemali D, \u00da\u010dinky fosfatidylserinu na neuroendokrinn\u00ed reakci na fyzick\u00fd stres u lid\u00ed, Neuroendocrinology. Z\u00e1\u0159\u00ed 1990; 52 (3): 243-8. <\/p>\n\n\n\n

(9) Hellhammer J, Hero T, Franz N, Contreras C, Schubert M. Omega-3 mastn\u00e9 kyseliny pod\u00e1van\u00e9 ve fosfatidylserinu zlep\u0161ily ur\u010dit\u00e9 aspekty vysok\u00e9ho chronick\u00e9ho stresu u mu\u017e\u016f. Nutr Res. Duben 2012; 32 (4): 241-50. <\/p>\n\n\n\n

(10) Cunnane SC, Schneider JA, Tangney C, Tremblay-Mercier J, Fortier M, Bennett DA, Morris MC (2012) Profily plazmatick\u00fdch a mozkov\u00fdch mastn\u00fdch kyselin u m\u00edrn\u00e9 kognitivn\u00ed poruchy a Alzheimerovy choroby. J Alzheimer Dis 29:691\u2013697. <\/p>\n\n\n\n

(11) Suleimanova RR, Hudz EA, Melnychuk DO, Kalachniuk LH (2017) V\u011bkov\u00e1 zm\u011bna fosfolipid\u016f sterletu v j\u00e1trech a h\u0159betn\u00edch svalech. Ukr Biochem J 89: 71\u201375. <\/p>\n\n\n\n

(12) Kim, B., Park, S. Fosfatidylserin moduluje reakci na oxida\u010dn\u00ed stres prost\u0159ednictv\u00edm hormoneze a prodlu\u017euje \u017eivotnost prost\u0159ednictv\u00edm DAF-16 u Caenorhabditis elegans. Biogerontology (2020). <\/p>\n\n\n\n

(13) Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., & Abete, P. (2018). Oxida\u010dn\u00ed stres, st\u00e1rnut\u00ed a nemoci. Klinick\u00e9 intervence ve st\u00e1rnut\u00ed, 13, 757\u2013772. <\/p>\n\n\n\n

(14) H Van Remmen, Oxida\u010dn\u00ed stres a nemoci souvisej\u00edc\u00ed s v\u011bkem, Innovation in Aging, svazek 2, \u010d\u00edslo Suppl_1, 1. listopadu 2018, strana 347. <\/p>\n\n\n\n

(15) Michael J. Glade Ph.D., Kyl Smith DC, Fosfatidylserin a lidsk\u00fd mozek, V\u00fd\u017eiva 31 (2015) 781\u2013786 <\/p>\n\n\n\n

(16) Parker AG1, Gordon J, Thornton A, Byars A, Lubker J, Bartlett M, Byrd M, Oliver J, Simbo S, Rasmussen C, Greenwood M, Kreider RB, \u00da\u010dinky IQ PLUS Zam\u011b\u0159en\u00ed na kognitivn\u00ed funkce, n\u00e1ladu a endokrinn\u00ed v\u00fdvoj u akutn\u00edch akutn\u00edch onemocn\u011bn\u00ed, J Int Soc Sports Nutr. 21. \u0159\u00edjna 2011; 8:16. <\/p>\n\n\n\n

(17) Kidd, Parris. (1996). Fosfatidylserin; Membr\u00e1nov\u00e1 \u017eivina pro pam\u011b\u0165. Klinick\u00e9 a mechanick\u00e9 hodnocen\u00ed. Alternativn\u00ed. Medic\u00edna Rev..1 <\/p>\n\n\n\n

(18) Caffara P, Santamaria V. \u00da\u010dinky fosfatidylserinu u pacient\u016f s m\u00edrn\u00fdm kognitivn\u00edm poklesem. Otev\u0159en\u00fd soud. Clin Trials J 1987; 24: 109\u201314. <\/p>\n\n\n\n

(19)] Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer B. Otev\u0159en\u00e1 studie fosfatidylserinu odvozen\u00e9ho z rostlin pro l\u00e9\u010dbu kognitivn\u00edho poklesu souvisej\u00edc\u00edho s v\u011bkem. Isr J Psychiatry Relat Sci 2000;37:302\u20137. <\/p>\n\n\n\n

(20) Richter Y, Herzog Y, Cohen T, Steinhart Y. Vliv fosfatidylserinu obsahuj\u00edc\u00edho omega-3 mastn\u00e9 kyseliny na pam\u011b\u0165ov\u00e9 schopnosti u subjekt\u016f se subjektivn\u00edmi st\u00ed\u017enostmi na pam\u011b\u0165: pilotn\u00ed studie. Clin Interv Aging 2010; 5: 313\u20136. <\/p>\n\n\n\n

(21) Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S. \u00da\u010dinek s\u00f3ji odvodil fosfatidylserin na kognitivn\u00ed v\u00fdkon u star\u0161\u00edch osob se subjektivn\u00edmi st\u00ed\u017enostmi na pam\u011b\u0165: pilotn\u00ed studie. Clin Interv Aging 2013; 8: 557\u201363. <\/p>\n\n\n\n

(22) Komori T. \u00da\u010dinky fosfatidylserinu a dopl\u0148ku obsahuj\u00edc\u00edho omega-3 mastn\u00e9 kyseliny na depresi v pozdn\u00edm \u017eivot\u011b. Ment Illn 2015;7:5647. <\/p>\n\n\n\n

(23) Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016). Sdru\u017een\u00ed mezi sp\u00e1nkem, regulac\u00ed kortizolu a stravou: Mo\u017en\u00e9 d\u016fsledky pro riziko Alzheimerovy choroby. Pokroky ve v\u00fd\u017eiv\u011b (Bethesda, MD), 7 (4), 679\u2013689. <\/p>\n\n\n\n

(24) Benton D, Donohoe RT, Sillance B, Nabb S: Vliv suplementace fosfatidylserinu na n\u00e1ladu a srde\u010dn\u00ed frekvenci v p\u0159\u00edpad\u011b akutn\u00edho stresu. Nutr Neurosci. 2001, 4 (3): 169-178. <\/p>\n\n\n\n

(25) Starks, M.A., Starks, S.L., Kingsley, M. et al. \u00da\u010dinky fosfatidylserinu na endokrinn\u00ed reakci na cvi\u010den\u00ed st\u0159edn\u00ed intenzity. J Int Soc Sports Nutr 5,<\/strong> 11 (2008). <\/p>\n\n\n\n

(26) Hellhammer, J., Vogt, D., Franz, N., Freitas, U., & Rutenberg, D. (2014). Komplex fosfatidylserinu a kyseliny fosfatidov\u00e9 na b\u00e1zi s\u00f3ji (PAS) normalizuje stresovou reaktivitu osy hypotalamus-hypof\u00fdza-nadledviny u chronicky stresovan\u00fdch mu\u017esk\u00fdch subjekt\u016f: randomizovan\u00e1, placebem kontrolovan\u00e1 studie. Lipidy ve zdrav\u00ed a nemoci, 13, 121. <\/p>\n\n\n\n

(27) Hirayama S, Terasawa K, Rabeler R, Hirayama T, Inoue T, Tatsumi Y, Purpura M, J\u00e4ger R, The effect of phosphatidylserine on memory and pr\u00edznaky poruchy pozornosti s hyperaktivitou: randomizovan\u00e9, dvojit\u011b zaslepen\u00e9, placebem kontrolovan\u00e1 klinick\u00e1 studie, J Hum Nutr Diet. 2014 Duben; 27 Suppl 2: 284-91. <\/p>\n\n\n\n

(28) \u201eFosfatidylserin\u201c, Examine.com<\/a>, zve\u0159ejn\u011bn\u00fd 10. dubna 2013, posledn\u00ed aktualizace 14. \u010dervna 2018. <\/p>\n","protected":false},"excerpt":{"rendered":"

Co je fosfatidylserin? V\u0161ichni konzumujeme fosfatidylserin ka\u017ed\u00fd den, ale bohu\u017eel v\u011bt\u0161ina z n\u00e1s ho m\u00e1 i tak nedostatek. Fosfatidylserin je k dispozici v mnoha potravin\u00e1ch, v\u010detn\u011b s\u00f3ji (kter\u00e1 je hlavn\u00edm zdrojem), b\u00edl\u00fdch fazol\u00ed, vaje\u010dn\u00fdch \u017eloutk\u016f, ku\u0159ec\u00edch jater a hov\u011bz\u00edch jater. Bohu\u017eel je pro na\u0161e t\u011blo obt\u00ed\u017en\u00e9 absorbovat dostate\u010dn\u00e9 mno\u017estv\u00ed ze zdroj\u016f stravy. V tomto \u010dl\u00e1nku si vysv\u011btl\u00edme, co je to fosfatidylserin a jestli je…<\/p>\n","protected":false},"author":2,"featured_media":132171,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"categories":[2621],"tags":[],"coauthors":[],"class_list":["post-219500","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-vyziva"],"taxonomy_info":{"category":[{"value":2621,"label":"V\u00fd\u017eiva"}]},"featured_image_src_large":["https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2018\/02\/phosphatidylserine-the-most-effective-natural-nootropic-02-1024x512.jpg",1024,512,true],"author_info":{"display_name":"David Pashley","author_link":"https:\/\/eu.intelligentlabs.org\/cs-cz\/author\/david\/"},"comment_info":0,"category_info":[{"term_id":2621,"name":"V\u00fd\u017eiva","slug":"vyziva","term_group":0,"term_taxonomy_id":2621,"taxonomy":"category","description":"","parent":0,"count":61,"filter":"raw","cat_ID":2621,"category_count":61,"category_description":"","cat_name":"V\u00fd\u017eiva","category_nicename":"vyziva","category_parent":0}],"tag_info":false,"wpml":{"language":"cs-cz","is_original":true,"original_post_id":219500,"translations":{"cs-cz":{"id":219500,"language":"cs-cz","is_original":true}}},"_links":{"self":[{"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/posts\/219500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/comments?post=219500"}],"version-history":[{"count":1,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/posts\/219500\/revisions"}],"predecessor-version":[{"id":252153,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/posts\/219500\/revisions\/252153"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/media\/132171"}],"wp:attachment":[{"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/media?parent=219500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/categories?post=219500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/tags?post=219500"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/eu.intelligentlabs.org\/cs-cz\/wp-json\/wp\/v2\/coauthors?post=219500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}