What is folate?<\/strong><\/h2>\n\n\n\n![\"Eggs,](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-02.jpg\")
<\/a><\/figure>\n\n\n\nSlovo \u201cfol\u00e1t\u201d popisuje skupinu \u017eivin, kter\u00e9 se nach\u00e1zej\u00ed v potravin\u00e1ch, zejm\u00e9na v zelen\u00e9 listov\u00e9 zelenin\u011b, fazol\u00edch a vejc\u00edch. Jedn\u00e1 se o p\u0159irozen\u011b se vyskytuj\u00edc\u00ed a ve vod\u011b rozpustn\u00e9 formy vitaminu B9. (1)<\/p>\n\n\n\n
V obecn\u00e9 mluv\u011b lze pou\u017e\u00edt jak jednotn\u00e9 \u010d\u00edslo \u201cfol\u00e1t\u201d, tak mno\u017en\u00e9 \u010d\u00edslo \u201cfol\u00e1ty\u201d .<\/p>\n\n\n\n
Mezi potraviny bohat\u00e9 na fol\u00e1ty pat\u0159\u00ed nap\u0159\u00edklad kapusta, brokolice, citrusov\u00e9 plody, ch\u0159est, ban\u00e1ny, fazole nebo t\u0159eba j\u00e1tra. (1)<\/p>\n\n\n\n
Fazole a j\u00e1tra jsou zdrojem mnohem p\u0159irozen\u011bj\u0161\u00ed formy fol\u00e1tu ne\u017e ostatn\u00ed v\u00fd\u0161e uveden\u00e9 potraviny. <\/p>\n\n\n\n
Pokud m\u00e1 n\u011bkdo vy\u0161\u0161\u00ed pot\u0159ebu fol\u00e1tu nebo jej m\u00e1 nedostatek, p\u0159esto\u017ee jej konzumuje v dostate\u010dn\u00e9m mno\u017estv\u00ed, je velmi pravd\u011bpodobn\u00e9, \u017ee pr\u00e1v\u011b j\u00eddlo nebude ten nejvhodn\u011bj\u0161\u00ed zp\u016fsob, jak fol\u00e1t t\u011blu dodat. Existuj\u00ed nemoci a genetick\u00e9 faktory, kter\u00e9 mohou n\u011bkter\u00fdm lidem znemo\u017enit metabolismus fol\u00e1t\u016f p\u0159ijat\u00fdch z potravin. Pokra\u010dujte pros\u00edm ve \u010dten\u00ed pro dal\u0161\u00ed podrobnosti.<\/p>\n\n\n\n
Co je kyselina listov\u00e1?<\/strong><\/h2>\n\n\n\nKyselina listov\u00e1 je syntetick\u00e1 a ve vod\u011b rozpustn\u00e1 forma vitam\u00ednu B9. Obvykle je synteticky vyr\u00e1b\u011bna a potraviny jsou o n\u00ed fortifikov\u00e1ny. B\u011b\u017en\u011b se vyskytuje zejm\u00e9na v pe\u010divu, chlebu a cere\u00e1li\u00edch. <\/p>\n\n\n\n
<\/a>V roce 1998 bylo v USA na\u0159\u00edzeno p\u0159id\u00e1v\u00e1n\u00ed kyseliny listov\u00e9 do konkr\u00e9tn\u00edch obiln\u00fdch zrn, aby byl zaji\u0161t\u011bn odpov\u00eddaj\u00edc\u00ed p\u0159\u00edjem B9 v masov\u00e9m m\u011b\u0159\u00edtku. <\/p>\n\n\n\nOd roku 2017 pak 86 zem\u00ed uz\u00e1konilo, \u017ee p\u0161eni\u010dn\u00e1 mouka mus\u00ed obsahovat ur\u010ditou minim\u00e1ln\u00ed hodnotu kyseliny listov\u00e9. (2)(3)<\/p>\n\n\n\n
16 z t\u011bchto 86 zem\u00ed pak ud\u011blalo tot\u00e9\u017e i pro kuku\u0159i\u010dnou mouku. \u0160est zem\u00ed do tohoto seznamu p\u0159idalo tak\u00e9 r\u00fd\u017eovou mouku.<\/p>\n\n\n\n
Co je 5-MTHF?<\/strong><\/h2>\n\n\n\n5-methyltetrahydrofol\u00e1t neboli tak\u00e9 5-MTHF je p\u0159\u00edrodn\u00ed forma vitam\u00ednu B9, kterou t\u011blo dok\u00e1\u017ee absorbovat a vyu\u017e\u00edt pro v\u00fd\u017eivov\u00e9 \u00fa\u010dely. Z tohoto d\u016fvodu je to v sou\u010dasnosti velice popul\u00e1rn\u00ed forma fol\u00e1tu, a to zejm\u00e9na mezi lidmi, u nich\u017e se vyskytl probl\u00e9m metabolizovat B9 z j\u00eddla nebo jin\u00fdch dopl\u0148k\u016f.<\/p>\n\n\n\n
Synonyma 5-MTHF:<\/p>\n\n\n\n
\n- L-5-MTHF<\/li>\n\n\n\n
- L-methylfol\u00e1t<\/li>\n\n\n\n
- L-methylfol\u00e1t v\u00e1penat\u00fd (pouze pokud je v\u00e1z\u00e1n na v\u00e1penatou s\u016fl)<\/li>\n\n\n\n
- Methylfol\u00e1t<\/li>\n\n\n\n
- Kyselina levomefolov\u00e1<\/li>\n<\/ul>\n\n\n\n
V\u0161imn\u011bte si pros\u00edm p\u00edsmene \u201cL\u201d u n\u011bkter\u00fdch z v\u00fd\u0161e uveden\u00fdch jmen. Toto p\u00edsmeno indikuje, \u017ee je vst\u0159ebateln\u00fd u drtiv\u00e9 v\u011bt\u0161iny lid\u00ed. \u201c6(S)\u201d nam\u00edsto \u201cL\u201d znamen\u00e1 tot\u00e9\u017e.<\/p>\n\n\n\n
V p\u0159\u00edpad\u011b, \u017ee \u201cL\u201d je nahrazeno \u201c6(R),\u201d tak V\u00e1m tento prepar\u00e1t asi p\u0159\u00edli\u0161 nepom\u016f\u017ee.<\/p>\n\n\n\n
Jak\u00e1 forma 5-MTHF je pro Va\u0161e t\u011blo nejl\u00e9pe vst\u0159ebateln\u00e1 & vyu\u017eiteln\u00e1?<\/strong><\/h2>\n\n\n\nStudie publikovan\u00e1 v British Journal of Pharmacology porovn\u00e1vala absorpci 6 (S) -5-MTHF v t\u011ble s kyselinou listovou. P\u0159edm\u011btem testov\u00e1n\u00ed byly zdrav\u00e9 \u017eeny, kter\u00e9 m\u011bly kv\u016fli defektn\u00edm gen\u016fm, pot\u0159ebn\u00fdm ke zpracov\u00e1n\u00ed t\u011bchto \u017eivin probl\u00e9m s absorpc\u00ed fol\u00e1tu z potravin nebo ve form\u011b kyseliny listov\u00e9. 6(S)-5-MTHF dok\u00e1zal mnohem l\u00e9pe dostat vitam\u00edn B do krevn\u00ed plazmy, odkud pak mohl za\u010d\u00edt v t\u011ble \u00fa\u010dinkovat. <\/p>\n\n\n\n
V t\u00e9to studii v\u011bdci pou\u017eili 6(S)-5-MTHF, kter\u00fd byl v\u00e1z\u00e1n na v\u00e1penatou s\u016fl a ano, co se vst\u0159eb\u00e1v\u00e1n\u00ed t\u00fd\u010de, p\u0159ekonal kyselinu listovou\u2026<\/p>\n\n\n\n
ALE\u2026<\/p>\n\n\n\n
Jin\u00e1 studie porovn\u00e1vala u potkan\u016f l\u00e1tky na b\u00e1zi v\u00e1pn\u00edku s jinou formou 6 (S) -5-MTHF v\u00e1zanou na glukosamin nam\u00edsto v\u00e1pn\u00edku. Ob\u011b tyto formy porovnali v\u011bdci tak\u00e9 s kyselinou listovou. Studie u prok\u00e1zala u glukosaminov\u00e9 soli 6 (S) -5-MTHF 1,8kr\u00e1t vy\u0161\u0161\u00ed maxim\u00e1ln\u00ed plazmatick\u00e9 hladiny v krvi ne\u017e u v\u00e1penat\u00e9 soli 5-MTHF a 3,1kr\u00e1t vy\u0161\u0161\u00ed hladiny ne\u017e u kyseliny listov\u00e9. (5)<\/p>\n\n\n
\n![\"1mg](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/o-que-e-5-mthf-o-melhor-guia-sobre-folato-e-metilfolato-04-4.jpg\")
<\/a><\/figure>\n<\/div>\n\n\nProto v Intelligent Labs pou\u017e\u00edv\u00e1me Glukosaminovou s\u016fl 6(S)-5-methyltetrahydrofol\u00e1tu (5-MTHF), bez obsahu alergenu – sko\u0159\u00e1pek. V na\u0161ich dopl\u0148c\u00edch pou\u017e\u00edv\u00e1me patentovan\u00fd vzorec s n\u00e1zvem Quatrefolic Acid\u00ae a nab\u00edz\u00edme jej ve form\u011b 1mg 5-MTHF<\/a> a 5mg 5-MTHF.<\/a><\/p>\n\n\n\nV \u010dem jsou fol\u00e1ty & 5-MTHF p\u0159\u00ednosn\u00e9 pro zdrav\u00ed?<\/strong><\/h2>\n\n\n\nNezbytn\u00e9 pro udr\u017een\u00ed z\u00e1kladn\u00edch funkc\u00ed lidsk\u00e9ho t\u011bla<\/strong><\/h3>\n\n\n\nB9 je nutn\u00fd pro tvorbu: (6)(7)(8)<\/p>\n\n\n\n
\n- Energie ze sacharid\u016f<\/li>\n\n\n\n
- DNA & RNA<\/li>\n\n\n\n
- \u010cerven\u00fdch & b\u00edl\u00fdch krvinek<\/li>\n\n\n\n
- Melatoninu, l\u00e1tky kter\u00e1 reguluje sp\u00e1nek<\/li>\n\n\n\n
- D\u016fle\u017eit\u00fdch neurotransmiter\u016f, jak\u00fdmi jsou norepinefrin, serotonin & dopamin<\/li>\n\n\n\n
- Va\u0161eho nervov\u00e9ho syst\u00e9mu<\/li>\n<\/ul>\n\n\n\n
<\/a><\/h3>\n\n\n\nB\u011bhem t\u011bhotenstv\u00ed p\u0159edch\u00e1zej\u00ed v\u00fdskytu vrozen\u00fdch vad<\/strong><\/h3>\n\n\n\nZdravotn\u00edci \u010dasto tvrd\u00ed, \u017ee \u017eeny by b\u011bhem t\u011bhotenstv\u00ed m\u011bly u\u017e\u00edvat fol\u00e1ty, aby se zabr\u00e1nilo vrozen\u00fdm vad\u00e1m a po\u0161kozen\u00ed nervov\u00e9ho syst\u00e9mu plodu. \u00da\u010dinky nedostatku fol\u00e1t\u016f na v\u00fdvoj d\u00edt\u011bte byly dlouho studov\u00e1ny, a proto jsou tato doporu\u010den\u00ed rozhodn\u011b na m\u00edst\u011b. (9)<\/p>\n\n\n\n
Pro v\u00fdvoj nervov\u00e9ho syst\u00e9mu b\u011bhem t\u011bhotenstv\u00ed je zapot\u0159eb\u00ed dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. To je z\u00e1sadn\u00ed od za\u010d\u00e1tku t\u011bhotenstv\u00ed, a dokonce se doporu\u010duje fol\u00e1ty za\u010d\u00edt u\u017e\u00edvat ji\u017e b\u011bhem jeho pl\u00e1nov\u00e1n\u00ed. \u017deny obvykle zjist\u00ed, \u017ee jsou t\u011bhotn\u00e9 a\u017e po p\u00e1r t\u00fddnech, proto je dobr\u00e9 si ji\u017e b\u011bhem snahy o ot\u011bhotn\u011bn\u00ed, doplnit hladinu fol\u00e1t\u016f na dostate\u010dnou \u00farove\u0148. (6)<\/p>\n\n\n\n
POZOR, tat\u00ednci: tohle je i pro V\u00e1s!<\/p>\n\n\n\n
I mu\u017ei, kte\u0159\u00ed se sna\u017e\u00ed zplodit potomka by se m\u011bli, \u017ee netrp\u00ed nedostatkem fol\u00e1t\u016f. Studie z roku 2013 zjistila, \u017ee u mu\u017e\u016f, kter\u00fdm zdrav\u00e1 hladina tohoto vitam\u00ednu b\u011bhem snahy o po\u010det\u00ed sch\u00e1z\u00ed, hroz\u00ed zna\u010dn\u00e9 zv\u00fd\u0161en\u00ed pravd\u011bpodobnost\u00ed deformit. (10)<\/p>\n\n\n\n
N\u011bkter\u00fdm \u017een\u00e1m tedy m\u016f\u017ee b\u00fdt doporu\u010deno za\u010d\u00edt dopl\u0148ovat fol\u00e1ty ji\u017e n\u011bkolik m\u011bs\u00edc\u016f p\u0159ed po\u010det\u00edm, aby se zv\u00fd\u0161ila jistota zdrav\u00e9ho d\u00edt\u011bte. (11) <\/p>\n\n\n\n![\"The](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/alone.jpg\")
<\/a><\/figure>\n\n\n\nMohou sni\u017eovat riziko vzniku deprese a\/nebo podpo\u0159it \u00fa\u010dinek antidepresiv<\/strong><\/h3>\n\n\n\nVe studii z roku 2013 v\u00edce ne\u017e 500 pacient\u016f, jim\u017e byl pod\u00e1v\u00e1n l\u00e9k na depresi v automatizovan\u00e9m telefonn\u00edm pr\u016fzkumu nazna\u010dovalo, \u017ee poci\u0165ovali lep\u0161\u00ed pr\u016fm\u011brnou kvalitu \u017eivota a zv\u00fd\u0161enou spokojenost s jejich l\u00e9ky ji\u017e po t\u0159ech m\u011bs\u00edc\u00edch u\u017e\u00edv\u00e1n\u00ed. Sou\u010dasn\u011b tak\u00e9 uvedli, \u017ee m\u011bli lep\u0161\u00ed vztahy s rodinou, p\u0159\u00e1teli, kolegy, partnery, ale dokonce i s ostatn\u00edmi lidmi, s nimi\u017e nebyli v \u017e\u00e1dn\u00e9m bli\u017e\u0161\u00edm vztahu. Celkov\u00fd rozd\u00edl byl tud\u00ed\u017e po 95 dnech celkem znateln\u00fd. Testovan\u00ed jedinci u\u017e\u00edvali p\u0159edepsanou a velmi silnou formu 5-MTHF. Ka\u017ed\u00e1 d\u00e1vka obsahovala 7.5 nebo 15mg. Obvykl\u00e1 po\u010d\u00e1te\u010dn\u00ed d\u00e1vka pro b\u011b\u017en\u00e9 u\u017eivatele, kte\u0159\u00ed depres\u00ed netrp\u00ed je 1mg nebo i m\u00e9n\u011b. (12)<\/p>\n\n\n\n
Jedn\u00edm z d\u016fvod\u016f, pro\u010d je u\u017e\u00edv\u00e1n\u00ed 5-MTHF vhodn\u00e9 u pacient\u016f s depres\u00ed, je i to, \u017ee fol\u00e1ty jsou nezbytnou sou\u010d\u00e1st\u00ed produkce hlavn\u00edch neurotransmiter\u016f, jako je serotonin, dopamin a norepinefrin a m\u016f\u017ee napom\u00e1hat jejich regulaci. (13) <\/p>\n\n\n\n
5-MTHF m\u016f\u017ee tak\u00e9 p\u0159\u00edzniv\u011b m\u00edrnit n\u011bkter\u00e9 symptomy bipol\u00e1rn\u00ed poruchy.<\/p>\n\n\n\n
\u0160estit\u00fddenn\u00ed studie prov\u00e1d\u011bn\u00e1 na 10 lidech trp\u00edc\u00edch velkou depres\u00ed a bipol\u00e1rn\u00ed poruchou uk\u00e1zala slibn\u00e9 v\u00fdsledky: (14)<\/p>\n\n\n\n
“V\u00fdzkumn\u00edci zjistili, \u017ee pacienti s bipol\u00e1rn\u00ed poruchou u\u017e\u00edvaj\u00edc\u00ed L-methylfol\u00e1t vykazovali zlep\u0161en\u00ed p\u0159\u00edznak\u016f deprese, fungov\u00e1n\u00ed, kognice a sebevra\u017eedn\u00fdch my\u0161lenek.<\/em><\/p>\n\n\n\nVAROV\u00c1N\u00cd: Pakli\u017ee trp\u00edte jakoukoliv formou deprese, v\u017edy se pora\u010fte s l\u00e9ka\u0159em p\u0159edt\u00edm, ne\u017e za\u010dnete u\u017e\u00edvat fol\u00e1tov\u00e9 dopl\u0148ky, a to i v p\u0159\u00edpad\u011b u\u017e\u00edv\u00e1n\u00ed n\u00edzk\u00fdch d\u00e1vek. <\/p>\n\n\n\n
Sn\u00ed\u017eit hladinu toxick\u00e9 aminokyseliny – homocysteinu<\/strong><\/h3>\n\n\n\nHomocystein je aminokyselina vyskytuj\u00edc\u00ed se v lidsk\u00e9m t\u011ble, kter\u00e1 vyvol\u00e1v\u00e1 z\u00e1n\u011bt. Mnoho nemoc\u00ed je zp\u016fsobeno pr\u00e1v\u011b z\u00e1n\u011btem.<\/p>\n\n\n\n
Vysok\u00e1 hladina homocysteinu m\u016f\u017ee v\u00e9st ke zv\u00fd\u0161en\u00e9mu riziku vzniku: (18)<\/p>\n\n\n\n
\n- Krevn\u00edch sra\u017eenin<\/li>\n\n\n\n
- Mozkov\u00e9 p\u0159\u00edhody<\/li>\n\n\n\n
- Alzheimerovy choroby<\/li>\n\n\n\n
- Infarktu myokardu<\/li>\n\n\n\n
- Ischemick\u00e9 choroby srde\u010dn\u00ed<\/li>\n\n\n\n
- Osteopor\u00f3zy<\/li>\n\n\n\n
- Arteroskler\u00f3zy<\/li>\n<\/ul>\n\n\n\n
Vysok\u00e9 hladiny t\u00e9to l\u00e1tky jsou tak\u00e9 spojov\u00e1ny s n\u00edzk\u00fdmi hladinami vitam\u00edn\u016f B6, B9 a B12. Tato kombinace je siln\u00fdm prediktorem kognitivn\u00edho poklesu u mu\u017e\u016f a pravd\u011bpodobn\u011b i u \u017een. (15) <\/p>\n\n\n\n
Zdrav\u00e9 hladiny v\u0161ech t\u0159\u00ed t\u011bchto typ\u016f vitam\u00ednu B jsou d\u016fle\u017eit\u00e9 pro udr\u017een\u00ed hladiny homocysteinu pod kontrolou. A\u010dkoliv m\u016f\u017ee 5-MTHF do ur\u010dit\u00e9 m\u00edry kognitivn\u00edmu poklesu zabr\u00e1nit s\u00e1m o sob\u011b, ud\u011bl\u00e1te l\u00e9pe, kdy\u017e budete na zdrav\u00e9 \u00farovni udr\u017eovat i zbyl\u00e9 dva typy. (15) (16) (17)<\/p>\n\n\n\n
Mezi dal\u0161\u00ed p\u0159\u00ed\u010diny vysok\u00e9 hladiny homocysteinu pat\u0159\u00ed: probl\u00e9my se \u0161t\u00edtnou \u017el\u00e1zou, onemocn\u011bn\u00ed ledvin a psori\u00e1za. To znamen\u00e1, \u017ee ne v\u017edy je na vin\u011b nedostatek vitam\u00ednu B. (18) <\/p>\n\n\n\n
Jak jste se ji\u017e do\u010detli v\u00fd\u0161e, zm\u011bna z\u00e1kon\u016f v des\u00edtk\u00e1ch zem\u00ed sn\u00ed\u017eila hladinu homocysteinu t\u00edm, \u017ee zavedla, aby byly mouky obohaceny o kyselinou listovou. 24 t\u00fddenn\u00ed randomizovan\u00e1 studie s placebem uk\u00e1zala, \u017ee p\u0159i sni\u017eov\u00e1n\u00ed hladiny homocysteinu u zdrav\u00fdch lid\u00ed je 5-MTHF je mnohem efektivn\u011bj\u0161\u00ed ne\u017e kyselina listov\u00e1. (19)<\/p>\n\n\n\n
Mohou sn\u00ed\u017eit riziko vzniku c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody & infarktu myokardu<\/strong><\/h3>\n\n\n\n5-MTHF by mohl zlep\u0161it zdrav\u00ed srdce a krevn\u00edho ob\u011bhu jednak sn\u00ed\u017een\u00edm homocysteinu ale i jin\u00fdmi mechanismy. Je to v\u0161ak komplikovan\u011bj\u0161\u00ed, jeliko\u017e riziko infarktu myokardu (IM) nebo c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody dok\u00e1\u017ee sn\u00ed\u017eit pouze v p\u0159\u00edpad\u011b, \u017ee m\u00e1te nedostatek fol\u00e1t\u016f.<\/p>\n\n\n\n
<\/a>Here is a summary of the key facts of this mysterious story\u2026<\/p>\n\n\n\nA 2015 study found that men who supplemented with folic acid while taking enalapril, a blood pressure lowering medicine, reduced their risk of stroke for 4.5 years. The results were significant for the group that used the combination of folic acid and enalapril compared with the group that used enalapril alone. Old studies from the 1970s also seem to show a lower risk of stroke and MI with increased folate intake. (20)<\/p>\n\n\n\n
On the other hand, some placebo-based studies in the United States have not shown a reduction in the risk of stroke or heart attack. This could mean that folate has this effect only if it is used by people who suffer from its deficiency. Recall also that the United States began enriching flour in 1998, which could explain the results of the 1970s, when people had lower folate levels. (20)<\/p>\n\n\n\n
China does not enrich flour or cereal grains with folic acid, which means that its population may be deficient. Some of the old American studies looked at people who had a history of stroke and MI. In response to these events, these people were able to reduce the risk with drugs and foods other than folate. (20)<\/p>\n\n\n\n
How do you know if you have a folate deficiency?<\/strong><\/h2>\n\n\n\nSome signs that you have a folate deficiency may include anemia (lack of red blood cells), chronic weakness & fatigue: (21)<\/p>\n\n\n\n
\n- Stuffiness<\/li>\n\n\n\n
- Flammability, resentment & irritability<\/li>\n\n\n\n
- Your skin is extremely pale<\/li>\n\n\n\n
- And other signs of low oxygen levels, such as memory problems<\/li>\n<\/ul>\n\n\n\n
Other signs of folate deficiency: (22)<\/p>\n\n\n\n
\n- Premature graying of hair<\/li>\n\n\n\n
- Swollen tongue<\/li>\n\n\n\n
- Ulcers or aphthae in the mouth<\/li>\n\n\n\n
- Your baby was born with a congenital defect & deformities<\/li>\n\n\n\n
- Diarrhea<\/li>\n\n\n\n
- Growth problems<\/li>\n<\/ul>\n\n\n\n
Self-diagnosis of folate deficiency is difficult in part because the symptoms of folate and vitamin B deficiency are very similar. Your doctor will probably perform tests to find out the cause of your problems.<\/p>\n\n\n\n
What causes folate deficiency?<\/strong><\/h2>\n\n\n\nA diet that is not rich enough in folate<\/strong><\/h3>\n\n\n\nPokud nekonzumujete dostate\u010dn\u00e9 mno\u017estv\u00ed fazol\u00ed,vajec, zelen\u00e9 zeleniny a dal\u0161\u00edch potravin nebo dopl\u0148k\u016f bohat\u00fdch na fol\u00e1ty, pravd\u011bpodobn\u011b budete m\u00edt ve sv\u00e9m t\u011ble nedostatek fol\u00e1tu.<\/p>\n\n\n\n
<\/a>Probl\u00e9my, kter\u00e9 zabra\u0148uj\u00ed absorpci fol\u00e1tu z j\u00eddla & dopl\u0148k\u016f stravy<\/strong><\/h3>\n\n\n\n\u0160patn\u00e9 vst\u0159eb\u00e1v\u00e1n\u00ed kyseliny listov\u00e9 a fol\u00e1t\u016f z potravin m\u016f\u017ee b\u00fdt zap\u0159\u00ed\u010din\u011bno mnoha d\u016fvody, v\u010detn\u011b: (21)<\/p>\n\n\n\n
\n- Nemoc\u00ed, jako nap\u0159\u00edklad Crohnova choroba, celiakie, n\u011bkter\u00e9 druhy rakoviny & poruchy ledvin<\/li>\n\n\n\n
- Poruch genu MTHFR, kter\u00e9 jsou relativn\u011b b\u011b\u017en\u00e9<\/li>\n\n\n\n
- Interakc\u00ed s l\u00e9ky, kter\u00e9 reaguj\u00ed s fol\u00e1tem\u00a0<\/li>\n\n\n\n
- Nadm\u011brn\u00e9ho u\u017e\u00edv\u00e1n\u00ed alkoholu nebo antacid<\/li>\n\n\n\n
- Mutac\u00ed gen\u016f odpov\u011bdn\u00fdch za metabolizaci fol\u00e1tu<\/li>\n<\/ul>\n\n\n\n
Kyselina listov\u00e1 a p\u0159\u00edrodn\u00ed fol\u00e1ty v potravin\u00e1ch mus\u00ed proj\u00edt n\u011bkolika chemick\u00fdmi reakcemi, ne\u017e se zm\u011bn\u00ed v u\u017eite\u010dnou formu 5-MTHF.<\/p>\n\n\n\n
V\u011bt\u0161ina efektivn\u011b metabolizuje a \u00fa\u010dinn\u011b transformuje kyselinu listovou na 5-MTHF. Tento proces je \u0159\u00edzen speci\u00e1ln\u00edm genem, kter\u00fd se naz\u00fdv\u00e1 MTHFR a lid\u00e9 ho maj\u00ed ve dvou kopi\u00edch. Mnoho z n\u00e1s m\u00e1 v\u0161ak varianty jedn\u00e9 nebo obou t\u011bchto genov\u00fdch kopi\u00ed, kter\u00e9 transformaci na 5-MTHF neumo\u017e\u0148uj\u00ed. Pokud je jedna kopie tohoto genu \u0161patn\u00e1, efektivita metabolizmu m\u016f\u017ee b\u00fdt zna\u010dn\u011b naru\u0161ena. Pakli\u017ee jsou \u0161patn\u00e9 ob\u011b kopie, Va\u0161e t\u011blo p\u0159\u00edli\u0161 fol\u00e1tu ani kyseliny listov\u00e9 metabolizovat nebude. (23)<\/p>\n\n\n\n
Jak zjist\u00edte, jestli pr\u00e1v\u011b Vy nem\u00e1te jednu nebo ob\u011b dv\u011b \u0161patn\u00e9 kopie genu MTHFR? K tomu je t\u0159eba prov\u00e9st test DNA a nechat jej poslat do laborato\u0159e. Tyto laborato\u0159e lze naj\u00edt i online a m\u016f\u017eete je vyhledat sami nebo se zeptat Va\u0161eho l\u00e9ka\u0159e. <\/p>\n\n\n\n
V p\u0159\u00edpad\u011b, \u017ee se V\u00e1s tento probl\u00e9m genov\u00e9 variace t\u00fdk\u00e1, nejjednodu\u0161\u0161\u00ed zp\u016fsob, jak jej vy\u0159e\u0161it je u\u017e\u00edvat dopln\u011bk stravy 5-MTHF. Tento dopln\u011bk um\u00ed t\u011blo spr\u00e1vn\u011b vyu\u017e\u00edt bez dal\u0161\u00edch chemick\u00fdch reakc\u00ed, jeliko\u017e 5-MTHF je ji\u017e bioaktivn\u00ed.<\/p>\n\n\n\n
Obezitou<\/strong><\/h3>\n\n\n\nExistuje n\u00e1padn\u00e1 souvislost mezi obezitou a nedostate\u010dnou hladinou fol\u00e1tu, av\u0161ak zd\u00e1 se, \u017ee nikdo nep\u0159i\u0161el na to, pro\u010d.<\/p>\n\n\n\n
P\u0159ezkum studi\u00ed publikovan\u00fdch v letech 2005 a\u017e 2015 zkoumal hladiny fol\u00e1t\u016f u ob\u00e9zn\u00edch \u017een \u201ev plodn\u00e9m v\u011bku\u201c se zvl\u00e1\u0161tn\u00edm zam\u011b\u0159en\u00edm na t\u011bhotn\u00e9 \u017eeny. C\u00edlem v\u011bdc\u016f bylo u t\u011bchto \u017een zjistit mo\u017en\u00e9 p\u0159\u00ed\u010diny vysok\u00e9ho procenta deficitu fol\u00e1t\u016f. Objevena byla britsk\u00e1 studie, kter\u00e1 vylu\u010dovala faktory, jako jsou strava, vitam\u00edny a v\u011bk. Tato studie odkazovala tak\u00e9 na n\u011bkolik dal\u0161\u00edch studi\u00ed, kter\u00e9 stravu jako p\u0159\u00ed\u010dinu tak\u00e9 vylu\u010dovaly. V\u011bdci v t\u00e9to studii pouze uvedli, \u017ee je t\u0159eba prov\u00e9st v\u00edce b\u00e1d\u00e1n\u00ed na toto t\u00e9ma a uvedli rady, jak\u00fdm zp\u016fsobem je sestavit. (24)<\/p>\n\n\n\n
V\u011bc se m\u00e1 tak, \u017ee obezita sama o sob\u011b nebo i jej\u00ed konkr\u00e9tn\u00ed p\u0159\u00ed\u010diny by mohly v\u00e9st ke sn\u00ed\u017een\u00ed obsahu fol\u00e1t\u016f na nezdravou \u00farove\u0148. Korelace je siln\u00e1 a v\u0161echny ot\u00e1zky se t\u00fdkaj\u00ed toho, co k \u010demu vede.<\/p>\n\n\n\n
Dal\u0161\u00ed studie zaznamenala silnou souvislost mezi obezitou a deficitem fol\u00e1tu:<\/p>\n\n\n\n
V roce 2016 v\u011bdci p\u0159ezkoum\u00e1vali studie s c\u00edlem aktualizovat Sm\u011brnici pro bariatrickou chirurgii Americk\u00e9 spole\u010dnosti pro v\u00fd\u017eivu metabolick\u00e9 a bariatrick\u00e9 chirurgie, z roku 2008. Sm\u011brnice je zalo\u017eena na studi\u00edch zji\u0161\u0165uj\u00edc\u00edch hladinu \u017eivin p\u0159ed a po chirurgick\u00fdch z\u00e1kroc\u00edch, kter\u00e9 byly provedeny za \u00fa\u010delem redukce hmotnosti. Nov\u00e1 sm\u011brnice pro rok 2016 doporu\u010dovala screening deficitu fol\u00e1t\u016f p\u0159ed t\u00edmto typem operace. D\u016fvodem bylo to, \u017ee a\u017e 54% ob\u00e9zn\u00edch pacient\u016f trp\u00ed nedostatkem fol\u00e1t\u016f. (25)<\/p>\n\n\n\n
V tomto p\u0159\u00edpad\u011b v\u011bdci nem\u011bli v \u00famyslu vy\u0161et\u0159ovat p\u0159\u00ed\u010dinu a n\u00e1sledek, ale v\u0161imli si tohoto spojen\u00ed, na kter\u00e9 reagovali doporu\u010den\u00edm p\u0159ed operac\u00ed monitorovat a dopl\u0148ovat fol\u00e1t.<\/p>\n\n\n\n
Zni\u010d\u00ed se fol\u00e1ty b\u011bhem jejich va\u0159en\u00ed?<\/strong><\/h2>\n\n\n\n<\/a>To, jestli va\u0159en\u00ed sni\u017euje obsah fol\u00e1tu v potrav\u011b, z\u00e1vis\u00ed na druhu potraviny a zp\u016fsobu a d\u00e9lce va\u0159en\u00ed.<\/p>\n\n\n\nNorm\u00e1ln\u00ed doba varu m\u016f\u017ee eliminovat mno\u017estv\u00ed fol\u00e1tu ve \u0161pen\u00e1tu a brokolici zhruba na polovinu, p\u0159i\u010dem\u017e p\u0159\u00edprava v p\u00e1\u0159e hladinu fol\u00e1tu v\u016fbec nesni\u017euje. Va\u0159en\u00ed brambor a grilov\u00e1n\u00ed masa by mno\u017estv\u00ed fol\u00e1tu sni\u017eovat tak\u00e9 nem\u011blo, a to i v p\u0159\u00edpad\u011b, \u017ee je va\u0159\u00edte d\u00e9le, ne\u017e je obvykl\u00e9. (26)<\/p>\n\n\n\n
Va\u0159en\u00ed cibule sni\u017euje fol\u00e1t o 35%, zat\u00edmco pe\u010den\u00edm se mno\u017estv\u00ed ni\u010d\u00ed pouze z 15%. Uk\u00e1zalo se tak\u00e9, \u017ee hr\u00e1\u0161ek si b\u011bhem va\u0159en\u00ed, ve srovn\u00e1n\u00ed s jin\u00fdmi metodami tepeln\u00e9 \u00fapravy, zachov\u00e1v\u00e1 nejv\u00edce fol\u00e1tu. D\u00e1le v p\u0159\u00edpad\u011b, \u017ee va\u0159\u00edte fazole po dobu dvou hodin, a pak je nav\u00edc je\u0161t\u011b pe\u010dete nebo sma\u017e\u00edte, ztr\u00e1c\u00ed a\u017e 50%. Jedna ze studi\u00ed doporu\u010duje nejprve je namo\u010dit do slan\u00e9 vody, a pot\u00e9 je va\u0159it ve sladk\u00e9 vod\u011b, aby se zachovalo co nejv\u00edce \u017eivin. (27) <\/p>\n\n\n\n
M\u011bly by t\u011bhotn\u00e9 \u017eeny a\/nebo \u017eeny, kter\u00e9 t\u011bhotenstv\u00ed pl\u00e1nuj\u00ed u\u017e\u00edvat dopl\u0148ky stravy s fol\u00e1ty?<\/strong><\/h2>\n\n\n\nMezi odbornou l\u00e9ka\u0159skou ve\u0159ejnost\u00ed je v\u0161eobecn\u011b p\u0159ij\u00edm\u00e1no, \u017ee udr\u017eov\u00e1n\u00ed hladiny fol\u00e1t\u016f na po\u017eadovan\u00e9 \u00farovni je vhodn\u00e9, jeliko\u017e je prok\u00e1z\u00e1na siln\u00e1 korelace mezi optim\u00e1ln\u00ed hladinou fol\u00e1tu a p\u0159edch\u00e1zen\u00edm vrozen\u00fdm vad\u00e1m.<\/p>\n\n\n\n
Jak ji\u017e bylo uvedeno v\u00fd\u0161e, ji\u017e od ot\u011bhotn\u011bn\u00ed je t\u0159eba m\u00edt v t\u011ble dostatek bioaktivn\u00edho fol\u00e1tu, aby byl zaji\u0161t\u011bn spr\u00e1vn\u00fd v\u00fdvoj nervov\u00e9ho syst\u00e9mu d\u00edt\u011bte. To znamen\u00e1, \u017ee je vhodn\u00e9 za\u010d\u00edt fol\u00e1t dopl\u0148ovat ji\u017e b\u011bhem samotn\u00e9 snahy o po\u010det\u00ed. <\/p>\n\n\n\n
Dopl\u0148ov\u00e1n\u00ed 5-MTHF je ten nejefektivn\u011bj\u0161\u00ed zp\u016fsob, kter\u00fd zajist\u00ed, \u017ee Va\u0161e t\u011blo skute\u010dn\u011b absorbuje dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. <\/p>\n\n\n\n
Pokud jste t\u011bhotn\u00e1, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em. Nen\u00ed vhodn\u00e9 si s dopl\u0148ky stravy pohr\u00e1vat bez odborn\u00e9ho dohledu, kter\u00fd zajist\u00ed p\u0159izp\u016fsoben\u00ed vhodn\u00e9 medikace p\u0159\u00edmo V\u00e1m na m\u00edru.<\/p>\n\n\n\n
M\u016f\u017ee m\u00edt Va\u0161e t\u011blo nadbytek fol\u00e1t\u016f?<\/strong><\/h2>\n\n\n\nToto je v l\u00e9ka\u0159sk\u00e9 v\u011bd\u011b kontroverzn\u00ed z\u00e1le\u017eitost. N\u011bkte\u0159\u00ed v\u011bdci tvrd\u00ed, \u017ee ve Va\u0161em t\u011ble m\u016f\u017ee cirkulovat p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9, co\u017e m\u016f\u017ee zp\u016fsobit zdravotn\u00ed probl\u00e9my. (28) <\/p>\n\n\n\n
Pr\u00e1v\u011b kv\u016fli t\u00e9to kontroverzi a pot\u0159eb\u011b dal\u0161\u00edch studi\u00ed m\u016f\u017eete naj\u00edt vl\u00e1dn\u00ed zdravotnick\u00e9 agentury, kter\u00e9 se odm\u00edtaj\u00ed \u00fa\u010dastnit debat na toto t\u00e9ma a rad\u00ed spot\u0159ebitel\u016fm, aby rad\u011bji byli v tomto ohledu velmi opatrn\u00ed. <\/p>\n\n\n\n
Nic z toho by v\u0161ak nem\u011bl b\u00fdt probl\u00e9m pro 5-MTHF nebo fol\u00e1t, kter\u00fd se nach\u00e1z\u00ed v p\u0159irozen\u00e9 form\u011b v potrav\u011b.<\/p>\n\n\n\n
Co m\u016f\u017ee zp\u016fsobit nadbytek kyseliny listov\u00e9?<\/p>\n\n\n\n
Mo\u017en\u00e9 skryt\u00e9 zn\u00e1mky nedostatku B12<\/strong><\/h3>\n\n\n\nP\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 v t\u011ble m\u016f\u017ee m\u016f\u017ee maskovat p\u0159\u00edznaky megaloblastick\u00e9 an\u00e9mie zp\u016fsoben\u00e9 nedostatkem vitam\u00ednu B12. Nejedn\u00e1 se v\u0161ak o konsenzus, pro v\u011bdce je toto st\u00e1le z\u00e1hadou. Ale pakli\u017ee je toto tvrzen\u00ed pravdiv\u00e9, m\u016f\u017ee se st\u00e1t, \u017ee l\u00e9ka\u0159 stanov\u00ed \u0161patnou diagn\u00f3zu. To m\u016f\u017ee zp\u016fsobit zhor\u0161en\u00ed probl\u00e9m\u016f souvisej\u00edc\u00edch krevn\u00edm ob\u011bhem a po\u0161kodit mozek a nervov\u00fd syst\u00e9m. Po\u0161kozen\u00ed mozku m\u016f\u017ee zp\u016fsobit rychl\u00fd kognitivn\u00ed pokles a zmatek. (29) <\/p>\n\n\n\n
V \u010dem se ale odborn\u00e1 ve\u0159ejnost shoduje je to, \u017ee tento probl\u00e9m se net\u00fdk\u00e1 5-MTHF, tud\u00ed\u017e aktivn\u00ed formy fol\u00e1tu, kter\u00e1 se tvo\u0159\u00ed p\u0159i spr\u00e1vn\u00e9m metabolismu fol\u00e1t\u016f. Nadm\u011brn\u00e1 konzumace fazol\u00ed, pomeran\u010d\u016f nebo zelen\u00e9 zeleniny, s p\u0159irozen\u011b vysok\u00fdm obsahem fol\u00e1t\u016f se tak\u00e9 nezd\u00e1 b\u00fdt – dle odborn\u00edk\u016f – probl\u00e9m. (39)<\/p>\n\n\n\n
Nedostatek vitam\u00ednu B12 m\u016f\u017ee b\u00fdt v\u011bt\u0161\u00ed probl\u00e9m pro vegetari\u00e1ny a star\u0161\u00ed lidi, ne\u017e pro v\u011bt\u0161inu ostatn\u00edch. Vegetari\u00e1nsk\u00e1 strava nen\u00ed na tento vitam\u00edn dostate\u010dn\u011b bohat\u00e1 a star\u0161\u00ed lid\u00e9 ho t\u011b\u017eko vst\u0159eb\u00e1vaj\u00ed. Ob\u011b skupiny mohou doplnit B12 sublingv\u00e1ln\u011b (rozpustit pod jazykem).<\/p>\n\n\n\n
<\/a>Poruchy sp\u00e1nku & n\u00e1lady<\/strong><\/h3>\n\n\n\nNadu\u017e\u00edv\u00e1n\u00ed kyseliny listov\u00e9, zejm\u00e9na pokud je pod\u00e1v\u00e1na v dopl\u0148c\u00edch stravy, m\u016f\u017ee zp\u016fsobit poruchy sp\u00e1nku a podr\u00e1\u017ed\u011bnost. (30)<\/p>\n\n\n\n
Nevolnost & nechutenstv\u00ed<\/strong><\/h3>\n\n\n\nN\u011bkte\u0159\u00ed lid\u00e9 mohou ztratit chu\u0165 k j\u00eddlu nebo trp\u011bt nevolnost\u00ed, a to zejm\u00e9na pokud u\u017eij\u00ed p\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 z dopl\u0148k\u016f nebo vitam\u00edn\u016f. (30)<\/p>\n\n\n\n
\u0158e\u0161en\u00ed<\/strong><\/h3>\n\n\n\nPakli\u017ee se rozhodnete za\u010d\u00edt dopl\u0148ovat fol\u00e1ty, ujist\u011bte se, \u017ee zvol\u00edte jejich bioaktivn\u00ed formu: 5-MTHF.<\/p>\n\n\n\n
P\u0159e\u010dt\u011bte si informace uveden\u00e9 na vitam\u00ednech, kter\u00e9 u\u017e\u00edv\u00e1te. Neobsahuj\u00ed p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9? V\u011bt\u0161ina dosp\u011bl\u00fdch by m\u011bla konzumovat asi 0,5 mg kyseliny listov\u00e9 denn\u011b. P\u0159e\u010dt\u011bte si tak\u00e9 etikety na chlebu a obilovin\u00e1ch.<\/p>\n\n\n\n
Pokud ji\u017e u\u017e\u00edv\u00e1te 5-MTHF, zkuste omezit mno\u017estv\u00ed kyseliny listov\u00e9 p\u0159ij\u00edman\u00e9 z o n\u00ed obohacen\u00fdch potravin na minimum a pokuste se tak\u00e9 vyhnout vitam\u00edn\u016fm s jej\u00edm obsahem. Kombinace t\u011bchto dvou forem fol\u00e1tu by toti\u017e mohla (ale nemusela) zp\u016fsobit probl\u00e9my.<\/p>\n\n\n\n
Americk\u00fd N\u00e1rodn\u00ed \u00fastav pro zdrav\u00ed a v\u00fd\u017eivov\u00e9 dopl\u0148ky stanovil maxim\u00e1ln\u00ed doporu\u010denou denn\u00ed d\u00e1vku kyseliny listov\u00e9, kter\u00e1 poch\u00e1z\u00ed z obohacen\u00fdch zrn a v\u00fd\u017eivov\u00fdch dopl\u0148k\u016f na 1 mg. Limit pro fol\u00e1ty, kter\u00e9 poch\u00e1zej\u00ed ze zeleniny nebo 5-MTHF nebyl stanoven. (29)<\/p>\n\n\n\n
Dle Harvardsk\u00e9ho zdravotn\u00edho dopisu se m\u016f\u017ee kyselina listov\u00e1 ze zrn rychle nahromadit (31), viz. seznam n\u00ed\u017ee.<\/p>\n\n\n\n
Common foods fortified with folic acid:<\/p>\n\n\n\n
\n- Bowl of special cereals: 0.394mg<\/li>\n\n\n\n
- 1 serving of pretzels: 0.172mg<\/li>\n\n\n\n
- 1 serving of cooked spaghetti: 0.166mg<\/li>\n\n\n\n
- 1 multivitamin: 0.4mg<\/li>\n<\/ul>\n\n\n\n
Total = 1.132mg<\/p>\n\n\n\n
Therefore, this limit can be easily exceeded during the day, so it is good to monitor the amount of cereals and vitamins, especially if you have a problem with folic acid metabolism. Surely you also want to make sure that you have a sufficient income. B12, and that your body absorbs it properly.<\/p>\n\n\n\n
<\/a><\/figure>\n\n\n\nSlovo \u201cfol\u00e1t\u201d popisuje skupinu \u017eivin, kter\u00e9 se nach\u00e1zej\u00ed v potravin\u00e1ch, zejm\u00e9na v zelen\u00e9 listov\u00e9 zelenin\u011b, fazol\u00edch a vejc\u00edch. Jedn\u00e1 se o p\u0159irozen\u011b se vyskytuj\u00edc\u00ed a ve vod\u011b rozpustn\u00e9 formy vitaminu B9. (1)<\/p>\n\n\n\n
V obecn\u00e9 mluv\u011b lze pou\u017e\u00edt jak jednotn\u00e9 \u010d\u00edslo \u201cfol\u00e1t\u201d, tak mno\u017en\u00e9 \u010d\u00edslo \u201cfol\u00e1ty\u201d .<\/p>\n\n\n\n
Mezi potraviny bohat\u00e9 na fol\u00e1ty pat\u0159\u00ed nap\u0159\u00edklad kapusta, brokolice, citrusov\u00e9 plody, ch\u0159est, ban\u00e1ny, fazole nebo t\u0159eba j\u00e1tra. (1)<\/p>\n\n\n\n
Fazole a j\u00e1tra jsou zdrojem mnohem p\u0159irozen\u011bj\u0161\u00ed formy fol\u00e1tu ne\u017e ostatn\u00ed v\u00fd\u0161e uveden\u00e9 potraviny. <\/p>\n\n\n\n
Pokud m\u00e1 n\u011bkdo vy\u0161\u0161\u00ed pot\u0159ebu fol\u00e1tu nebo jej m\u00e1 nedostatek, p\u0159esto\u017ee jej konzumuje v dostate\u010dn\u00e9m mno\u017estv\u00ed, je velmi pravd\u011bpodobn\u00e9, \u017ee pr\u00e1v\u011b j\u00eddlo nebude ten nejvhodn\u011bj\u0161\u00ed zp\u016fsob, jak fol\u00e1t t\u011blu dodat. Existuj\u00ed nemoci a genetick\u00e9 faktory, kter\u00e9 mohou n\u011bkter\u00fdm lidem znemo\u017enit metabolismus fol\u00e1t\u016f p\u0159ijat\u00fdch z potravin. Pokra\u010dujte pros\u00edm ve \u010dten\u00ed pro dal\u0161\u00ed podrobnosti.<\/p>\n\n\n\n
Co je kyselina listov\u00e1?<\/strong><\/h2>\n\n\n\nKyselina listov\u00e1 je syntetick\u00e1 a ve vod\u011b rozpustn\u00e1 forma vitam\u00ednu B9. Obvykle je synteticky vyr\u00e1b\u011bna a potraviny jsou o n\u00ed fortifikov\u00e1ny. B\u011b\u017en\u011b se vyskytuje zejm\u00e9na v pe\u010divu, chlebu a cere\u00e1li\u00edch. <\/p>\n\n\n\n
<\/a>V roce 1998 bylo v USA na\u0159\u00edzeno p\u0159id\u00e1v\u00e1n\u00ed kyseliny listov\u00e9 do konkr\u00e9tn\u00edch obiln\u00fdch zrn, aby byl zaji\u0161t\u011bn odpov\u00eddaj\u00edc\u00ed p\u0159\u00edjem B9 v masov\u00e9m m\u011b\u0159\u00edtku. <\/p>\n\n\n\nOd roku 2017 pak 86 zem\u00ed uz\u00e1konilo, \u017ee p\u0161eni\u010dn\u00e1 mouka mus\u00ed obsahovat ur\u010ditou minim\u00e1ln\u00ed hodnotu kyseliny listov\u00e9. (2)(3)<\/p>\n\n\n\n
16 z t\u011bchto 86 zem\u00ed pak ud\u011blalo tot\u00e9\u017e i pro kuku\u0159i\u010dnou mouku. \u0160est zem\u00ed do tohoto seznamu p\u0159idalo tak\u00e9 r\u00fd\u017eovou mouku.<\/p>\n\n\n\n
Co je 5-MTHF?<\/strong><\/h2>\n\n\n\n5-methyltetrahydrofol\u00e1t neboli tak\u00e9 5-MTHF je p\u0159\u00edrodn\u00ed forma vitam\u00ednu B9, kterou t\u011blo dok\u00e1\u017ee absorbovat a vyu\u017e\u00edt pro v\u00fd\u017eivov\u00e9 \u00fa\u010dely. Z tohoto d\u016fvodu je to v sou\u010dasnosti velice popul\u00e1rn\u00ed forma fol\u00e1tu, a to zejm\u00e9na mezi lidmi, u nich\u017e se vyskytl probl\u00e9m metabolizovat B9 z j\u00eddla nebo jin\u00fdch dopl\u0148k\u016f.<\/p>\n\n\n\n
Synonyma 5-MTHF:<\/p>\n\n\n\n
\n- L-5-MTHF<\/li>\n\n\n\n
- L-methylfol\u00e1t<\/li>\n\n\n\n
- L-methylfol\u00e1t v\u00e1penat\u00fd (pouze pokud je v\u00e1z\u00e1n na v\u00e1penatou s\u016fl)<\/li>\n\n\n\n
- Methylfol\u00e1t<\/li>\n\n\n\n
- Kyselina levomefolov\u00e1<\/li>\n<\/ul>\n\n\n\n
V\u0161imn\u011bte si pros\u00edm p\u00edsmene \u201cL\u201d u n\u011bkter\u00fdch z v\u00fd\u0161e uveden\u00fdch jmen. Toto p\u00edsmeno indikuje, \u017ee je vst\u0159ebateln\u00fd u drtiv\u00e9 v\u011bt\u0161iny lid\u00ed. \u201c6(S)\u201d nam\u00edsto \u201cL\u201d znamen\u00e1 tot\u00e9\u017e.<\/p>\n\n\n\n
V p\u0159\u00edpad\u011b, \u017ee \u201cL\u201d je nahrazeno \u201c6(R),\u201d tak V\u00e1m tento prepar\u00e1t asi p\u0159\u00edli\u0161 nepom\u016f\u017ee.<\/p>\n\n\n\n
Jak\u00e1 forma 5-MTHF je pro Va\u0161e t\u011blo nejl\u00e9pe vst\u0159ebateln\u00e1 & vyu\u017eiteln\u00e1?<\/strong><\/h2>\n\n\n\nStudie publikovan\u00e1 v British Journal of Pharmacology porovn\u00e1vala absorpci 6 (S) -5-MTHF v t\u011ble s kyselinou listovou. P\u0159edm\u011btem testov\u00e1n\u00ed byly zdrav\u00e9 \u017eeny, kter\u00e9 m\u011bly kv\u016fli defektn\u00edm gen\u016fm, pot\u0159ebn\u00fdm ke zpracov\u00e1n\u00ed t\u011bchto \u017eivin probl\u00e9m s absorpc\u00ed fol\u00e1tu z potravin nebo ve form\u011b kyseliny listov\u00e9. 6(S)-5-MTHF dok\u00e1zal mnohem l\u00e9pe dostat vitam\u00edn B do krevn\u00ed plazmy, odkud pak mohl za\u010d\u00edt v t\u011ble \u00fa\u010dinkovat. <\/p>\n\n\n\n
V t\u00e9to studii v\u011bdci pou\u017eili 6(S)-5-MTHF, kter\u00fd byl v\u00e1z\u00e1n na v\u00e1penatou s\u016fl a ano, co se vst\u0159eb\u00e1v\u00e1n\u00ed t\u00fd\u010de, p\u0159ekonal kyselinu listovou\u2026<\/p>\n\n\n\n
ALE\u2026<\/p>\n\n\n\n
Jin\u00e1 studie porovn\u00e1vala u potkan\u016f l\u00e1tky na b\u00e1zi v\u00e1pn\u00edku s jinou formou 6 (S) -5-MTHF v\u00e1zanou na glukosamin nam\u00edsto v\u00e1pn\u00edku. Ob\u011b tyto formy porovnali v\u011bdci tak\u00e9 s kyselinou listovou. Studie u prok\u00e1zala u glukosaminov\u00e9 soli 6 (S) -5-MTHF 1,8kr\u00e1t vy\u0161\u0161\u00ed maxim\u00e1ln\u00ed plazmatick\u00e9 hladiny v krvi ne\u017e u v\u00e1penat\u00e9 soli 5-MTHF a 3,1kr\u00e1t vy\u0161\u0161\u00ed hladiny ne\u017e u kyseliny listov\u00e9. (5)<\/p>\n\n\n
\n<\/a><\/figure>\n<\/div>\n\n\nProto v Intelligent Labs pou\u017e\u00edv\u00e1me Glukosaminovou s\u016fl 6(S)-5-methyltetrahydrofol\u00e1tu (5-MTHF), bez obsahu alergenu – sko\u0159\u00e1pek. V na\u0161ich dopl\u0148c\u00edch pou\u017e\u00edv\u00e1me patentovan\u00fd vzorec s n\u00e1zvem Quatrefolic Acid\u00ae a nab\u00edz\u00edme jej ve form\u011b 1mg 5-MTHF<\/a> a 5mg 5-MTHF.<\/a><\/p>\n\n\n\nV \u010dem jsou fol\u00e1ty & 5-MTHF p\u0159\u00ednosn\u00e9 pro zdrav\u00ed?<\/strong><\/h2>\n\n\n\nNezbytn\u00e9 pro udr\u017een\u00ed z\u00e1kladn\u00edch funkc\u00ed lidsk\u00e9ho t\u011bla<\/strong><\/h3>\n\n\n\nB9 je nutn\u00fd pro tvorbu: (6)(7)(8)<\/p>\n\n\n\n
\n- Energie ze sacharid\u016f<\/li>\n\n\n\n
- DNA & RNA<\/li>\n\n\n\n
- \u010cerven\u00fdch & b\u00edl\u00fdch krvinek<\/li>\n\n\n\n
- Melatoninu, l\u00e1tky kter\u00e1 reguluje sp\u00e1nek<\/li>\n\n\n\n
- D\u016fle\u017eit\u00fdch neurotransmiter\u016f, jak\u00fdmi jsou norepinefrin, serotonin & dopamin<\/li>\n\n\n\n
- Va\u0161eho nervov\u00e9ho syst\u00e9mu<\/li>\n<\/ul>\n\n\n\n
<\/a><\/h3>\n\n\n\nB\u011bhem t\u011bhotenstv\u00ed p\u0159edch\u00e1zej\u00ed v\u00fdskytu vrozen\u00fdch vad<\/strong><\/h3>\n\n\n\nZdravotn\u00edci \u010dasto tvrd\u00ed, \u017ee \u017eeny by b\u011bhem t\u011bhotenstv\u00ed m\u011bly u\u017e\u00edvat fol\u00e1ty, aby se zabr\u00e1nilo vrozen\u00fdm vad\u00e1m a po\u0161kozen\u00ed nervov\u00e9ho syst\u00e9mu plodu. \u00da\u010dinky nedostatku fol\u00e1t\u016f na v\u00fdvoj d\u00edt\u011bte byly dlouho studov\u00e1ny, a proto jsou tato doporu\u010den\u00ed rozhodn\u011b na m\u00edst\u011b. (9)<\/p>\n\n\n\n
Pro v\u00fdvoj nervov\u00e9ho syst\u00e9mu b\u011bhem t\u011bhotenstv\u00ed je zapot\u0159eb\u00ed dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. To je z\u00e1sadn\u00ed od za\u010d\u00e1tku t\u011bhotenstv\u00ed, a dokonce se doporu\u010duje fol\u00e1ty za\u010d\u00edt u\u017e\u00edvat ji\u017e b\u011bhem jeho pl\u00e1nov\u00e1n\u00ed. \u017deny obvykle zjist\u00ed, \u017ee jsou t\u011bhotn\u00e9 a\u017e po p\u00e1r t\u00fddnech, proto je dobr\u00e9 si ji\u017e b\u011bhem snahy o ot\u011bhotn\u011bn\u00ed, doplnit hladinu fol\u00e1t\u016f na dostate\u010dnou \u00farove\u0148. (6)<\/p>\n\n\n\n
POZOR, tat\u00ednci: tohle je i pro V\u00e1s!<\/p>\n\n\n\n
I mu\u017ei, kte\u0159\u00ed se sna\u017e\u00ed zplodit potomka by se m\u011bli, \u017ee netrp\u00ed nedostatkem fol\u00e1t\u016f. Studie z roku 2013 zjistila, \u017ee u mu\u017e\u016f, kter\u00fdm zdrav\u00e1 hladina tohoto vitam\u00ednu b\u011bhem snahy o po\u010det\u00ed sch\u00e1z\u00ed, hroz\u00ed zna\u010dn\u00e9 zv\u00fd\u0161en\u00ed pravd\u011bpodobnost\u00ed deformit. (10)<\/p>\n\n\n\n
N\u011bkter\u00fdm \u017een\u00e1m tedy m\u016f\u017ee b\u00fdt doporu\u010deno za\u010d\u00edt dopl\u0148ovat fol\u00e1ty ji\u017e n\u011bkolik m\u011bs\u00edc\u016f p\u0159ed po\u010det\u00edm, aby se zv\u00fd\u0161ila jistota zdrav\u00e9ho d\u00edt\u011bte. (11) <\/p>\n\n\n\n<\/a><\/figure>\n\n\n\nMohou sni\u017eovat riziko vzniku deprese a\/nebo podpo\u0159it \u00fa\u010dinek antidepresiv<\/strong><\/h3>\n\n\n\nVe studii z roku 2013 v\u00edce ne\u017e 500 pacient\u016f, jim\u017e byl pod\u00e1v\u00e1n l\u00e9k na depresi v automatizovan\u00e9m telefonn\u00edm pr\u016fzkumu nazna\u010dovalo, \u017ee poci\u0165ovali lep\u0161\u00ed pr\u016fm\u011brnou kvalitu \u017eivota a zv\u00fd\u0161enou spokojenost s jejich l\u00e9ky ji\u017e po t\u0159ech m\u011bs\u00edc\u00edch u\u017e\u00edv\u00e1n\u00ed. Sou\u010dasn\u011b tak\u00e9 uvedli, \u017ee m\u011bli lep\u0161\u00ed vztahy s rodinou, p\u0159\u00e1teli, kolegy, partnery, ale dokonce i s ostatn\u00edmi lidmi, s nimi\u017e nebyli v \u017e\u00e1dn\u00e9m bli\u017e\u0161\u00edm vztahu. Celkov\u00fd rozd\u00edl byl tud\u00ed\u017e po 95 dnech celkem znateln\u00fd. Testovan\u00ed jedinci u\u017e\u00edvali p\u0159edepsanou a velmi silnou formu 5-MTHF. Ka\u017ed\u00e1 d\u00e1vka obsahovala 7.5 nebo 15mg. Obvykl\u00e1 po\u010d\u00e1te\u010dn\u00ed d\u00e1vka pro b\u011b\u017en\u00e9 u\u017eivatele, kte\u0159\u00ed depres\u00ed netrp\u00ed je 1mg nebo i m\u00e9n\u011b. (12)<\/p>\n\n\n\n
Jedn\u00edm z d\u016fvod\u016f, pro\u010d je u\u017e\u00edv\u00e1n\u00ed 5-MTHF vhodn\u00e9 u pacient\u016f s depres\u00ed, je i to, \u017ee fol\u00e1ty jsou nezbytnou sou\u010d\u00e1st\u00ed produkce hlavn\u00edch neurotransmiter\u016f, jako je serotonin, dopamin a norepinefrin a m\u016f\u017ee napom\u00e1hat jejich regulaci. (13) <\/p>\n\n\n\n
5-MTHF m\u016f\u017ee tak\u00e9 p\u0159\u00edzniv\u011b m\u00edrnit n\u011bkter\u00e9 symptomy bipol\u00e1rn\u00ed poruchy.<\/p>\n\n\n\n
\u0160estit\u00fddenn\u00ed studie prov\u00e1d\u011bn\u00e1 na 10 lidech trp\u00edc\u00edch velkou depres\u00ed a bipol\u00e1rn\u00ed poruchou uk\u00e1zala slibn\u00e9 v\u00fdsledky: (14)<\/p>\n\n\n\n
“V\u00fdzkumn\u00edci zjistili, \u017ee pacienti s bipol\u00e1rn\u00ed poruchou u\u017e\u00edvaj\u00edc\u00ed L-methylfol\u00e1t vykazovali zlep\u0161en\u00ed p\u0159\u00edznak\u016f deprese, fungov\u00e1n\u00ed, kognice a sebevra\u017eedn\u00fdch my\u0161lenek.<\/em><\/p>\n\n\n\nVAROV\u00c1N\u00cd: Pakli\u017ee trp\u00edte jakoukoliv formou deprese, v\u017edy se pora\u010fte s l\u00e9ka\u0159em p\u0159edt\u00edm, ne\u017e za\u010dnete u\u017e\u00edvat fol\u00e1tov\u00e9 dopl\u0148ky, a to i v p\u0159\u00edpad\u011b u\u017e\u00edv\u00e1n\u00ed n\u00edzk\u00fdch d\u00e1vek. <\/p>\n\n\n\n
Sn\u00ed\u017eit hladinu toxick\u00e9 aminokyseliny – homocysteinu<\/strong><\/h3>\n\n\n\nHomocystein je aminokyselina vyskytuj\u00edc\u00ed se v lidsk\u00e9m t\u011ble, kter\u00e1 vyvol\u00e1v\u00e1 z\u00e1n\u011bt. Mnoho nemoc\u00ed je zp\u016fsobeno pr\u00e1v\u011b z\u00e1n\u011btem.<\/p>\n\n\n\n
Vysok\u00e1 hladina homocysteinu m\u016f\u017ee v\u00e9st ke zv\u00fd\u0161en\u00e9mu riziku vzniku: (18)<\/p>\n\n\n\n
\n- Krevn\u00edch sra\u017eenin<\/li>\n\n\n\n
- Mozkov\u00e9 p\u0159\u00edhody<\/li>\n\n\n\n
- Alzheimerovy choroby<\/li>\n\n\n\n
- Infarktu myokardu<\/li>\n\n\n\n
- Ischemick\u00e9 choroby srde\u010dn\u00ed<\/li>\n\n\n\n
- Osteopor\u00f3zy<\/li>\n\n\n\n
- Arteroskler\u00f3zy<\/li>\n<\/ul>\n\n\n\n
Vysok\u00e9 hladiny t\u00e9to l\u00e1tky jsou tak\u00e9 spojov\u00e1ny s n\u00edzk\u00fdmi hladinami vitam\u00edn\u016f B6, B9 a B12. Tato kombinace je siln\u00fdm prediktorem kognitivn\u00edho poklesu u mu\u017e\u016f a pravd\u011bpodobn\u011b i u \u017een. (15) <\/p>\n\n\n\n
Zdrav\u00e9 hladiny v\u0161ech t\u0159\u00ed t\u011bchto typ\u016f vitam\u00ednu B jsou d\u016fle\u017eit\u00e9 pro udr\u017een\u00ed hladiny homocysteinu pod kontrolou. A\u010dkoliv m\u016f\u017ee 5-MTHF do ur\u010dit\u00e9 m\u00edry kognitivn\u00edmu poklesu zabr\u00e1nit s\u00e1m o sob\u011b, ud\u011bl\u00e1te l\u00e9pe, kdy\u017e budete na zdrav\u00e9 \u00farovni udr\u017eovat i zbyl\u00e9 dva typy. (15) (16) (17)<\/p>\n\n\n\n
Mezi dal\u0161\u00ed p\u0159\u00ed\u010diny vysok\u00e9 hladiny homocysteinu pat\u0159\u00ed: probl\u00e9my se \u0161t\u00edtnou \u017el\u00e1zou, onemocn\u011bn\u00ed ledvin a psori\u00e1za. To znamen\u00e1, \u017ee ne v\u017edy je na vin\u011b nedostatek vitam\u00ednu B. (18) <\/p>\n\n\n\n
Jak jste se ji\u017e do\u010detli v\u00fd\u0161e, zm\u011bna z\u00e1kon\u016f v des\u00edtk\u00e1ch zem\u00ed sn\u00ed\u017eila hladinu homocysteinu t\u00edm, \u017ee zavedla, aby byly mouky obohaceny o kyselinou listovou. 24 t\u00fddenn\u00ed randomizovan\u00e1 studie s placebem uk\u00e1zala, \u017ee p\u0159i sni\u017eov\u00e1n\u00ed hladiny homocysteinu u zdrav\u00fdch lid\u00ed je 5-MTHF je mnohem efektivn\u011bj\u0161\u00ed ne\u017e kyselina listov\u00e1. (19)<\/p>\n\n\n\n
Mohou sn\u00ed\u017eit riziko vzniku c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody & infarktu myokardu<\/strong><\/h3>\n\n\n\n5-MTHF by mohl zlep\u0161it zdrav\u00ed srdce a krevn\u00edho ob\u011bhu jednak sn\u00ed\u017een\u00edm homocysteinu ale i jin\u00fdmi mechanismy. Je to v\u0161ak komplikovan\u011bj\u0161\u00ed, jeliko\u017e riziko infarktu myokardu (IM) nebo c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody dok\u00e1\u017ee sn\u00ed\u017eit pouze v p\u0159\u00edpad\u011b, \u017ee m\u00e1te nedostatek fol\u00e1t\u016f.<\/p>\n\n\n\n
<\/a>Here is a summary of the key facts of this mysterious story\u2026<\/p>\n\n\n\nA 2015 study found that men who supplemented with folic acid while taking enalapril, a blood pressure lowering medicine, reduced their risk of stroke for 4.5 years. The results were significant for the group that used the combination of folic acid and enalapril compared with the group that used enalapril alone. Old studies from the 1970s also seem to show a lower risk of stroke and MI with increased folate intake. (20)<\/p>\n\n\n\n
On the other hand, some placebo-based studies in the United States have not shown a reduction in the risk of stroke or heart attack. This could mean that folate has this effect only if it is used by people who suffer from its deficiency. Recall also that the United States began enriching flour in 1998, which could explain the results of the 1970s, when people had lower folate levels. (20)<\/p>\n\n\n\n
China does not enrich flour or cereal grains with folic acid, which means that its population may be deficient. Some of the old American studies looked at people who had a history of stroke and MI. In response to these events, these people were able to reduce the risk with drugs and foods other than folate. (20)<\/p>\n\n\n\n
How do you know if you have a folate deficiency?<\/strong><\/h2>\n\n\n\nSome signs that you have a folate deficiency may include anemia (lack of red blood cells), chronic weakness & fatigue: (21)<\/p>\n\n\n\n
\n- Stuffiness<\/li>\n\n\n\n
- Flammability, resentment & irritability<\/li>\n\n\n\n
- Your skin is extremely pale<\/li>\n\n\n\n
- And other signs of low oxygen levels, such as memory problems<\/li>\n<\/ul>\n\n\n\n
Other signs of folate deficiency: (22)<\/p>\n\n\n\n
\n- Premature graying of hair<\/li>\n\n\n\n
- Swollen tongue<\/li>\n\n\n\n
- Ulcers or aphthae in the mouth<\/li>\n\n\n\n
- Your baby was born with a congenital defect & deformities<\/li>\n\n\n\n
- Diarrhea<\/li>\n\n\n\n
- Growth problems<\/li>\n<\/ul>\n\n\n\n
Self-diagnosis of folate deficiency is difficult in part because the symptoms of folate and vitamin B deficiency are very similar. Your doctor will probably perform tests to find out the cause of your problems.<\/p>\n\n\n\n
What causes folate deficiency?<\/strong><\/h2>\n\n\n\nA diet that is not rich enough in folate<\/strong><\/h3>\n\n\n\nPokud nekonzumujete dostate\u010dn\u00e9 mno\u017estv\u00ed fazol\u00ed,vajec, zelen\u00e9 zeleniny a dal\u0161\u00edch potravin nebo dopl\u0148k\u016f bohat\u00fdch na fol\u00e1ty, pravd\u011bpodobn\u011b budete m\u00edt ve sv\u00e9m t\u011ble nedostatek fol\u00e1tu.<\/p>\n\n\n\n
<\/a>Probl\u00e9my, kter\u00e9 zabra\u0148uj\u00ed absorpci fol\u00e1tu z j\u00eddla & dopl\u0148k\u016f stravy<\/strong><\/h3>\n\n\n\n\u0160patn\u00e9 vst\u0159eb\u00e1v\u00e1n\u00ed kyseliny listov\u00e9 a fol\u00e1t\u016f z potravin m\u016f\u017ee b\u00fdt zap\u0159\u00ed\u010din\u011bno mnoha d\u016fvody, v\u010detn\u011b: (21)<\/p>\n\n\n\n
\n- Nemoc\u00ed, jako nap\u0159\u00edklad Crohnova choroba, celiakie, n\u011bkter\u00e9 druhy rakoviny & poruchy ledvin<\/li>\n\n\n\n
- Poruch genu MTHFR, kter\u00e9 jsou relativn\u011b b\u011b\u017en\u00e9<\/li>\n\n\n\n
- Interakc\u00ed s l\u00e9ky, kter\u00e9 reaguj\u00ed s fol\u00e1tem\u00a0<\/li>\n\n\n\n
- Nadm\u011brn\u00e9ho u\u017e\u00edv\u00e1n\u00ed alkoholu nebo antacid<\/li>\n\n\n\n
- Mutac\u00ed gen\u016f odpov\u011bdn\u00fdch za metabolizaci fol\u00e1tu<\/li>\n<\/ul>\n\n\n\n
Kyselina listov\u00e1 a p\u0159\u00edrodn\u00ed fol\u00e1ty v potravin\u00e1ch mus\u00ed proj\u00edt n\u011bkolika chemick\u00fdmi reakcemi, ne\u017e se zm\u011bn\u00ed v u\u017eite\u010dnou formu 5-MTHF.<\/p>\n\n\n\n
V\u011bt\u0161ina efektivn\u011b metabolizuje a \u00fa\u010dinn\u011b transformuje kyselinu listovou na 5-MTHF. Tento proces je \u0159\u00edzen speci\u00e1ln\u00edm genem, kter\u00fd se naz\u00fdv\u00e1 MTHFR a lid\u00e9 ho maj\u00ed ve dvou kopi\u00edch. Mnoho z n\u00e1s m\u00e1 v\u0161ak varianty jedn\u00e9 nebo obou t\u011bchto genov\u00fdch kopi\u00ed, kter\u00e9 transformaci na 5-MTHF neumo\u017e\u0148uj\u00ed. Pokud je jedna kopie tohoto genu \u0161patn\u00e1, efektivita metabolizmu m\u016f\u017ee b\u00fdt zna\u010dn\u011b naru\u0161ena. Pakli\u017ee jsou \u0161patn\u00e9 ob\u011b kopie, Va\u0161e t\u011blo p\u0159\u00edli\u0161 fol\u00e1tu ani kyseliny listov\u00e9 metabolizovat nebude. (23)<\/p>\n\n\n\n
Jak zjist\u00edte, jestli pr\u00e1v\u011b Vy nem\u00e1te jednu nebo ob\u011b dv\u011b \u0161patn\u00e9 kopie genu MTHFR? K tomu je t\u0159eba prov\u00e9st test DNA a nechat jej poslat do laborato\u0159e. Tyto laborato\u0159e lze naj\u00edt i online a m\u016f\u017eete je vyhledat sami nebo se zeptat Va\u0161eho l\u00e9ka\u0159e. <\/p>\n\n\n\n
V p\u0159\u00edpad\u011b, \u017ee se V\u00e1s tento probl\u00e9m genov\u00e9 variace t\u00fdk\u00e1, nejjednodu\u0161\u0161\u00ed zp\u016fsob, jak jej vy\u0159e\u0161it je u\u017e\u00edvat dopln\u011bk stravy 5-MTHF. Tento dopln\u011bk um\u00ed t\u011blo spr\u00e1vn\u011b vyu\u017e\u00edt bez dal\u0161\u00edch chemick\u00fdch reakc\u00ed, jeliko\u017e 5-MTHF je ji\u017e bioaktivn\u00ed.<\/p>\n\n\n\n
Obezitou<\/strong><\/h3>\n\n\n\nExistuje n\u00e1padn\u00e1 souvislost mezi obezitou a nedostate\u010dnou hladinou fol\u00e1tu, av\u0161ak zd\u00e1 se, \u017ee nikdo nep\u0159i\u0161el na to, pro\u010d.<\/p>\n\n\n\n
P\u0159ezkum studi\u00ed publikovan\u00fdch v letech 2005 a\u017e 2015 zkoumal hladiny fol\u00e1t\u016f u ob\u00e9zn\u00edch \u017een \u201ev plodn\u00e9m v\u011bku\u201c se zvl\u00e1\u0161tn\u00edm zam\u011b\u0159en\u00edm na t\u011bhotn\u00e9 \u017eeny. C\u00edlem v\u011bdc\u016f bylo u t\u011bchto \u017een zjistit mo\u017en\u00e9 p\u0159\u00ed\u010diny vysok\u00e9ho procenta deficitu fol\u00e1t\u016f. Objevena byla britsk\u00e1 studie, kter\u00e1 vylu\u010dovala faktory, jako jsou strava, vitam\u00edny a v\u011bk. Tato studie odkazovala tak\u00e9 na n\u011bkolik dal\u0161\u00edch studi\u00ed, kter\u00e9 stravu jako p\u0159\u00ed\u010dinu tak\u00e9 vylu\u010dovaly. V\u011bdci v t\u00e9to studii pouze uvedli, \u017ee je t\u0159eba prov\u00e9st v\u00edce b\u00e1d\u00e1n\u00ed na toto t\u00e9ma a uvedli rady, jak\u00fdm zp\u016fsobem je sestavit. (24)<\/p>\n\n\n\n
V\u011bc se m\u00e1 tak, \u017ee obezita sama o sob\u011b nebo i jej\u00ed konkr\u00e9tn\u00ed p\u0159\u00ed\u010diny by mohly v\u00e9st ke sn\u00ed\u017een\u00ed obsahu fol\u00e1t\u016f na nezdravou \u00farove\u0148. Korelace je siln\u00e1 a v\u0161echny ot\u00e1zky se t\u00fdkaj\u00ed toho, co k \u010demu vede.<\/p>\n\n\n\n
Dal\u0161\u00ed studie zaznamenala silnou souvislost mezi obezitou a deficitem fol\u00e1tu:<\/p>\n\n\n\n
V roce 2016 v\u011bdci p\u0159ezkoum\u00e1vali studie s c\u00edlem aktualizovat Sm\u011brnici pro bariatrickou chirurgii Americk\u00e9 spole\u010dnosti pro v\u00fd\u017eivu metabolick\u00e9 a bariatrick\u00e9 chirurgie, z roku 2008. Sm\u011brnice je zalo\u017eena na studi\u00edch zji\u0161\u0165uj\u00edc\u00edch hladinu \u017eivin p\u0159ed a po chirurgick\u00fdch z\u00e1kroc\u00edch, kter\u00e9 byly provedeny za \u00fa\u010delem redukce hmotnosti. Nov\u00e1 sm\u011brnice pro rok 2016 doporu\u010dovala screening deficitu fol\u00e1t\u016f p\u0159ed t\u00edmto typem operace. D\u016fvodem bylo to, \u017ee a\u017e 54% ob\u00e9zn\u00edch pacient\u016f trp\u00ed nedostatkem fol\u00e1t\u016f. (25)<\/p>\n\n\n\n
V tomto p\u0159\u00edpad\u011b v\u011bdci nem\u011bli v \u00famyslu vy\u0161et\u0159ovat p\u0159\u00ed\u010dinu a n\u00e1sledek, ale v\u0161imli si tohoto spojen\u00ed, na kter\u00e9 reagovali doporu\u010den\u00edm p\u0159ed operac\u00ed monitorovat a dopl\u0148ovat fol\u00e1t.<\/p>\n\n\n\n
Zni\u010d\u00ed se fol\u00e1ty b\u011bhem jejich va\u0159en\u00ed?<\/strong><\/h2>\n\n\n\n<\/a>To, jestli va\u0159en\u00ed sni\u017euje obsah fol\u00e1tu v potrav\u011b, z\u00e1vis\u00ed na druhu potraviny a zp\u016fsobu a d\u00e9lce va\u0159en\u00ed.<\/p>\n\n\n\nNorm\u00e1ln\u00ed doba varu m\u016f\u017ee eliminovat mno\u017estv\u00ed fol\u00e1tu ve \u0161pen\u00e1tu a brokolici zhruba na polovinu, p\u0159i\u010dem\u017e p\u0159\u00edprava v p\u00e1\u0159e hladinu fol\u00e1tu v\u016fbec nesni\u017euje. Va\u0159en\u00ed brambor a grilov\u00e1n\u00ed masa by mno\u017estv\u00ed fol\u00e1tu sni\u017eovat tak\u00e9 nem\u011blo, a to i v p\u0159\u00edpad\u011b, \u017ee je va\u0159\u00edte d\u00e9le, ne\u017e je obvykl\u00e9. (26)<\/p>\n\n\n\n
Va\u0159en\u00ed cibule sni\u017euje fol\u00e1t o 35%, zat\u00edmco pe\u010den\u00edm se mno\u017estv\u00ed ni\u010d\u00ed pouze z 15%. Uk\u00e1zalo se tak\u00e9, \u017ee hr\u00e1\u0161ek si b\u011bhem va\u0159en\u00ed, ve srovn\u00e1n\u00ed s jin\u00fdmi metodami tepeln\u00e9 \u00fapravy, zachov\u00e1v\u00e1 nejv\u00edce fol\u00e1tu. D\u00e1le v p\u0159\u00edpad\u011b, \u017ee va\u0159\u00edte fazole po dobu dvou hodin, a pak je nav\u00edc je\u0161t\u011b pe\u010dete nebo sma\u017e\u00edte, ztr\u00e1c\u00ed a\u017e 50%. Jedna ze studi\u00ed doporu\u010duje nejprve je namo\u010dit do slan\u00e9 vody, a pot\u00e9 je va\u0159it ve sladk\u00e9 vod\u011b, aby se zachovalo co nejv\u00edce \u017eivin. (27) <\/p>\n\n\n\n
M\u011bly by t\u011bhotn\u00e9 \u017eeny a\/nebo \u017eeny, kter\u00e9 t\u011bhotenstv\u00ed pl\u00e1nuj\u00ed u\u017e\u00edvat dopl\u0148ky stravy s fol\u00e1ty?<\/strong><\/h2>\n\n\n\nMezi odbornou l\u00e9ka\u0159skou ve\u0159ejnost\u00ed je v\u0161eobecn\u011b p\u0159ij\u00edm\u00e1no, \u017ee udr\u017eov\u00e1n\u00ed hladiny fol\u00e1t\u016f na po\u017eadovan\u00e9 \u00farovni je vhodn\u00e9, jeliko\u017e je prok\u00e1z\u00e1na siln\u00e1 korelace mezi optim\u00e1ln\u00ed hladinou fol\u00e1tu a p\u0159edch\u00e1zen\u00edm vrozen\u00fdm vad\u00e1m.<\/p>\n\n\n\n
Jak ji\u017e bylo uvedeno v\u00fd\u0161e, ji\u017e od ot\u011bhotn\u011bn\u00ed je t\u0159eba m\u00edt v t\u011ble dostatek bioaktivn\u00edho fol\u00e1tu, aby byl zaji\u0161t\u011bn spr\u00e1vn\u00fd v\u00fdvoj nervov\u00e9ho syst\u00e9mu d\u00edt\u011bte. To znamen\u00e1, \u017ee je vhodn\u00e9 za\u010d\u00edt fol\u00e1t dopl\u0148ovat ji\u017e b\u011bhem samotn\u00e9 snahy o po\u010det\u00ed. <\/p>\n\n\n\n
Dopl\u0148ov\u00e1n\u00ed 5-MTHF je ten nejefektivn\u011bj\u0161\u00ed zp\u016fsob, kter\u00fd zajist\u00ed, \u017ee Va\u0161e t\u011blo skute\u010dn\u011b absorbuje dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. <\/p>\n\n\n\n
Pokud jste t\u011bhotn\u00e1, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em. Nen\u00ed vhodn\u00e9 si s dopl\u0148ky stravy pohr\u00e1vat bez odborn\u00e9ho dohledu, kter\u00fd zajist\u00ed p\u0159izp\u016fsoben\u00ed vhodn\u00e9 medikace p\u0159\u00edmo V\u00e1m na m\u00edru.<\/p>\n\n\n\n
M\u016f\u017ee m\u00edt Va\u0161e t\u011blo nadbytek fol\u00e1t\u016f?<\/strong><\/h2>\n\n\n\nToto je v l\u00e9ka\u0159sk\u00e9 v\u011bd\u011b kontroverzn\u00ed z\u00e1le\u017eitost. N\u011bkte\u0159\u00ed v\u011bdci tvrd\u00ed, \u017ee ve Va\u0161em t\u011ble m\u016f\u017ee cirkulovat p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9, co\u017e m\u016f\u017ee zp\u016fsobit zdravotn\u00ed probl\u00e9my. (28) <\/p>\n\n\n\n
Pr\u00e1v\u011b kv\u016fli t\u00e9to kontroverzi a pot\u0159eb\u011b dal\u0161\u00edch studi\u00ed m\u016f\u017eete naj\u00edt vl\u00e1dn\u00ed zdravotnick\u00e9 agentury, kter\u00e9 se odm\u00edtaj\u00ed \u00fa\u010dastnit debat na toto t\u00e9ma a rad\u00ed spot\u0159ebitel\u016fm, aby rad\u011bji byli v tomto ohledu velmi opatrn\u00ed. <\/p>\n\n\n\n
Nic z toho by v\u0161ak nem\u011bl b\u00fdt probl\u00e9m pro 5-MTHF nebo fol\u00e1t, kter\u00fd se nach\u00e1z\u00ed v p\u0159irozen\u00e9 form\u011b v potrav\u011b.<\/p>\n\n\n\n
Co m\u016f\u017ee zp\u016fsobit nadbytek kyseliny listov\u00e9?<\/p>\n\n\n\n
Mo\u017en\u00e9 skryt\u00e9 zn\u00e1mky nedostatku B12<\/strong><\/h3>\n\n\n\nP\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 v t\u011ble m\u016f\u017ee m\u016f\u017ee maskovat p\u0159\u00edznaky megaloblastick\u00e9 an\u00e9mie zp\u016fsoben\u00e9 nedostatkem vitam\u00ednu B12. Nejedn\u00e1 se v\u0161ak o konsenzus, pro v\u011bdce je toto st\u00e1le z\u00e1hadou. Ale pakli\u017ee je toto tvrzen\u00ed pravdiv\u00e9, m\u016f\u017ee se st\u00e1t, \u017ee l\u00e9ka\u0159 stanov\u00ed \u0161patnou diagn\u00f3zu. To m\u016f\u017ee zp\u016fsobit zhor\u0161en\u00ed probl\u00e9m\u016f souvisej\u00edc\u00edch krevn\u00edm ob\u011bhem a po\u0161kodit mozek a nervov\u00fd syst\u00e9m. Po\u0161kozen\u00ed mozku m\u016f\u017ee zp\u016fsobit rychl\u00fd kognitivn\u00ed pokles a zmatek. (29) <\/p>\n\n\n\n
V \u010dem se ale odborn\u00e1 ve\u0159ejnost shoduje je to, \u017ee tento probl\u00e9m se net\u00fdk\u00e1 5-MTHF, tud\u00ed\u017e aktivn\u00ed formy fol\u00e1tu, kter\u00e1 se tvo\u0159\u00ed p\u0159i spr\u00e1vn\u00e9m metabolismu fol\u00e1t\u016f. Nadm\u011brn\u00e1 konzumace fazol\u00ed, pomeran\u010d\u016f nebo zelen\u00e9 zeleniny, s p\u0159irozen\u011b vysok\u00fdm obsahem fol\u00e1t\u016f se tak\u00e9 nezd\u00e1 b\u00fdt – dle odborn\u00edk\u016f – probl\u00e9m. (39)<\/p>\n\n\n\n
Nedostatek vitam\u00ednu B12 m\u016f\u017ee b\u00fdt v\u011bt\u0161\u00ed probl\u00e9m pro vegetari\u00e1ny a star\u0161\u00ed lidi, ne\u017e pro v\u011bt\u0161inu ostatn\u00edch. Vegetari\u00e1nsk\u00e1 strava nen\u00ed na tento vitam\u00edn dostate\u010dn\u011b bohat\u00e1 a star\u0161\u00ed lid\u00e9 ho t\u011b\u017eko vst\u0159eb\u00e1vaj\u00ed. Ob\u011b skupiny mohou doplnit B12 sublingv\u00e1ln\u011b (rozpustit pod jazykem).<\/p>\n\n\n\n
<\/a>Poruchy sp\u00e1nku & n\u00e1lady<\/strong><\/h3>\n\n\n\nNadu\u017e\u00edv\u00e1n\u00ed kyseliny listov\u00e9, zejm\u00e9na pokud je pod\u00e1v\u00e1na v dopl\u0148c\u00edch stravy, m\u016f\u017ee zp\u016fsobit poruchy sp\u00e1nku a podr\u00e1\u017ed\u011bnost. (30)<\/p>\n\n\n\n
Nevolnost & nechutenstv\u00ed<\/strong><\/h3>\n\n\n\nN\u011bkte\u0159\u00ed lid\u00e9 mohou ztratit chu\u0165 k j\u00eddlu nebo trp\u011bt nevolnost\u00ed, a to zejm\u00e9na pokud u\u017eij\u00ed p\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 z dopl\u0148k\u016f nebo vitam\u00edn\u016f. (30)<\/p>\n\n\n\n
\u0158e\u0161en\u00ed<\/strong><\/h3>\n\n\n\nPakli\u017ee se rozhodnete za\u010d\u00edt dopl\u0148ovat fol\u00e1ty, ujist\u011bte se, \u017ee zvol\u00edte jejich bioaktivn\u00ed formu: 5-MTHF.<\/p>\n\n\n\n
P\u0159e\u010dt\u011bte si informace uveden\u00e9 na vitam\u00ednech, kter\u00e9 u\u017e\u00edv\u00e1te. Neobsahuj\u00ed p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9? V\u011bt\u0161ina dosp\u011bl\u00fdch by m\u011bla konzumovat asi 0,5 mg kyseliny listov\u00e9 denn\u011b. P\u0159e\u010dt\u011bte si tak\u00e9 etikety na chlebu a obilovin\u00e1ch.<\/p>\n\n\n\n
Pokud ji\u017e u\u017e\u00edv\u00e1te 5-MTHF, zkuste omezit mno\u017estv\u00ed kyseliny listov\u00e9 p\u0159ij\u00edman\u00e9 z o n\u00ed obohacen\u00fdch potravin na minimum a pokuste se tak\u00e9 vyhnout vitam\u00edn\u016fm s jej\u00edm obsahem. Kombinace t\u011bchto dvou forem fol\u00e1tu by toti\u017e mohla (ale nemusela) zp\u016fsobit probl\u00e9my.<\/p>\n\n\n\n
Americk\u00fd N\u00e1rodn\u00ed \u00fastav pro zdrav\u00ed a v\u00fd\u017eivov\u00e9 dopl\u0148ky stanovil maxim\u00e1ln\u00ed doporu\u010denou denn\u00ed d\u00e1vku kyseliny listov\u00e9, kter\u00e1 poch\u00e1z\u00ed z obohacen\u00fdch zrn a v\u00fd\u017eivov\u00fdch dopl\u0148k\u016f na 1 mg. Limit pro fol\u00e1ty, kter\u00e9 poch\u00e1zej\u00ed ze zeleniny nebo 5-MTHF nebyl stanoven. (29)<\/p>\n\n\n\n
Dle Harvardsk\u00e9ho zdravotn\u00edho dopisu se m\u016f\u017ee kyselina listov\u00e1 ze zrn rychle nahromadit (31), viz. seznam n\u00ed\u017ee.<\/p>\n\n\n\n
Common foods fortified with folic acid:<\/p>\n\n\n\n
\n- Bowl of special cereals: 0.394mg<\/li>\n\n\n\n
- 1 serving of pretzels: 0.172mg<\/li>\n\n\n\n
- 1 serving of cooked spaghetti: 0.166mg<\/li>\n\n\n\n
- 1 multivitamin: 0.4mg<\/li>\n<\/ul>\n\n\n\n
Total = 1.132mg<\/p>\n\n\n\n
Therefore, this limit can be easily exceeded during the day, so it is good to monitor the amount of cereals and vitamins, especially if you have a problem with folic acid metabolism. Surely you also want to make sure that you have a sufficient income. B12, and that your body absorbs it properly.<\/p>\n\n\n\n
Od roku 2017 pak 86 zem\u00ed uz\u00e1konilo, \u017ee p\u0161eni\u010dn\u00e1 mouka mus\u00ed obsahovat ur\u010ditou minim\u00e1ln\u00ed hodnotu kyseliny listov\u00e9. (2)(3)<\/p>\n\n\n\n
16 z t\u011bchto 86 zem\u00ed pak ud\u011blalo tot\u00e9\u017e i pro kuku\u0159i\u010dnou mouku. \u0160est zem\u00ed do tohoto seznamu p\u0159idalo tak\u00e9 r\u00fd\u017eovou mouku.<\/p>\n\n\n\n
Co je 5-MTHF?<\/strong><\/h2>\n\n\n\n5-methyltetrahydrofol\u00e1t neboli tak\u00e9 5-MTHF je p\u0159\u00edrodn\u00ed forma vitam\u00ednu B9, kterou t\u011blo dok\u00e1\u017ee absorbovat a vyu\u017e\u00edt pro v\u00fd\u017eivov\u00e9 \u00fa\u010dely. Z tohoto d\u016fvodu je to v sou\u010dasnosti velice popul\u00e1rn\u00ed forma fol\u00e1tu, a to zejm\u00e9na mezi lidmi, u nich\u017e se vyskytl probl\u00e9m metabolizovat B9 z j\u00eddla nebo jin\u00fdch dopl\u0148k\u016f.<\/p>\n\n\n\n
Synonyma 5-MTHF:<\/p>\n\n\n\n
\n- L-5-MTHF<\/li>\n\n\n\n
- L-methylfol\u00e1t<\/li>\n\n\n\n
- L-methylfol\u00e1t v\u00e1penat\u00fd (pouze pokud je v\u00e1z\u00e1n na v\u00e1penatou s\u016fl)<\/li>\n\n\n\n
- Methylfol\u00e1t<\/li>\n\n\n\n
- Kyselina levomefolov\u00e1<\/li>\n<\/ul>\n\n\n\n
V\u0161imn\u011bte si pros\u00edm p\u00edsmene \u201cL\u201d u n\u011bkter\u00fdch z v\u00fd\u0161e uveden\u00fdch jmen. Toto p\u00edsmeno indikuje, \u017ee je vst\u0159ebateln\u00fd u drtiv\u00e9 v\u011bt\u0161iny lid\u00ed. \u201c6(S)\u201d nam\u00edsto \u201cL\u201d znamen\u00e1 tot\u00e9\u017e.<\/p>\n\n\n\n
V p\u0159\u00edpad\u011b, \u017ee \u201cL\u201d je nahrazeno \u201c6(R),\u201d tak V\u00e1m tento prepar\u00e1t asi p\u0159\u00edli\u0161 nepom\u016f\u017ee.<\/p>\n\n\n\n
Jak\u00e1 forma 5-MTHF je pro Va\u0161e t\u011blo nejl\u00e9pe vst\u0159ebateln\u00e1 & vyu\u017eiteln\u00e1?<\/strong><\/h2>\n\n\n\nStudie publikovan\u00e1 v British Journal of Pharmacology porovn\u00e1vala absorpci 6 (S) -5-MTHF v t\u011ble s kyselinou listovou. P\u0159edm\u011btem testov\u00e1n\u00ed byly zdrav\u00e9 \u017eeny, kter\u00e9 m\u011bly kv\u016fli defektn\u00edm gen\u016fm, pot\u0159ebn\u00fdm ke zpracov\u00e1n\u00ed t\u011bchto \u017eivin probl\u00e9m s absorpc\u00ed fol\u00e1tu z potravin nebo ve form\u011b kyseliny listov\u00e9. 6(S)-5-MTHF dok\u00e1zal mnohem l\u00e9pe dostat vitam\u00edn B do krevn\u00ed plazmy, odkud pak mohl za\u010d\u00edt v t\u011ble \u00fa\u010dinkovat. <\/p>\n\n\n\n
V t\u00e9to studii v\u011bdci pou\u017eili 6(S)-5-MTHF, kter\u00fd byl v\u00e1z\u00e1n na v\u00e1penatou s\u016fl a ano, co se vst\u0159eb\u00e1v\u00e1n\u00ed t\u00fd\u010de, p\u0159ekonal kyselinu listovou\u2026<\/p>\n\n\n\n
ALE\u2026<\/p>\n\n\n\n
Jin\u00e1 studie porovn\u00e1vala u potkan\u016f l\u00e1tky na b\u00e1zi v\u00e1pn\u00edku s jinou formou 6 (S) -5-MTHF v\u00e1zanou na glukosamin nam\u00edsto v\u00e1pn\u00edku. Ob\u011b tyto formy porovnali v\u011bdci tak\u00e9 s kyselinou listovou. Studie u prok\u00e1zala u glukosaminov\u00e9 soli 6 (S) -5-MTHF 1,8kr\u00e1t vy\u0161\u0161\u00ed maxim\u00e1ln\u00ed plazmatick\u00e9 hladiny v krvi ne\u017e u v\u00e1penat\u00e9 soli 5-MTHF a 3,1kr\u00e1t vy\u0161\u0161\u00ed hladiny ne\u017e u kyseliny listov\u00e9. (5)<\/p>\n\n\n
\n<\/a><\/figure>\n<\/div>\n\n\nProto v Intelligent Labs pou\u017e\u00edv\u00e1me Glukosaminovou s\u016fl 6(S)-5-methyltetrahydrofol\u00e1tu (5-MTHF), bez obsahu alergenu – sko\u0159\u00e1pek. V na\u0161ich dopl\u0148c\u00edch pou\u017e\u00edv\u00e1me patentovan\u00fd vzorec s n\u00e1zvem Quatrefolic Acid\u00ae a nab\u00edz\u00edme jej ve form\u011b 1mg 5-MTHF<\/a> a 5mg 5-MTHF.<\/a><\/p>\n\n\n\nV \u010dem jsou fol\u00e1ty & 5-MTHF p\u0159\u00ednosn\u00e9 pro zdrav\u00ed?<\/strong><\/h2>\n\n\n\nNezbytn\u00e9 pro udr\u017een\u00ed z\u00e1kladn\u00edch funkc\u00ed lidsk\u00e9ho t\u011bla<\/strong><\/h3>\n\n\n\nB9 je nutn\u00fd pro tvorbu: (6)(7)(8)<\/p>\n\n\n\n
\n- Energie ze sacharid\u016f<\/li>\n\n\n\n
- DNA & RNA<\/li>\n\n\n\n
- \u010cerven\u00fdch & b\u00edl\u00fdch krvinek<\/li>\n\n\n\n
- Melatoninu, l\u00e1tky kter\u00e1 reguluje sp\u00e1nek<\/li>\n\n\n\n
- D\u016fle\u017eit\u00fdch neurotransmiter\u016f, jak\u00fdmi jsou norepinefrin, serotonin & dopamin<\/li>\n\n\n\n
- Va\u0161eho nervov\u00e9ho syst\u00e9mu<\/li>\n<\/ul>\n\n\n\n
<\/a><\/h3>\n\n\n\nB\u011bhem t\u011bhotenstv\u00ed p\u0159edch\u00e1zej\u00ed v\u00fdskytu vrozen\u00fdch vad<\/strong><\/h3>\n\n\n\nZdravotn\u00edci \u010dasto tvrd\u00ed, \u017ee \u017eeny by b\u011bhem t\u011bhotenstv\u00ed m\u011bly u\u017e\u00edvat fol\u00e1ty, aby se zabr\u00e1nilo vrozen\u00fdm vad\u00e1m a po\u0161kozen\u00ed nervov\u00e9ho syst\u00e9mu plodu. \u00da\u010dinky nedostatku fol\u00e1t\u016f na v\u00fdvoj d\u00edt\u011bte byly dlouho studov\u00e1ny, a proto jsou tato doporu\u010den\u00ed rozhodn\u011b na m\u00edst\u011b. (9)<\/p>\n\n\n\n
Pro v\u00fdvoj nervov\u00e9ho syst\u00e9mu b\u011bhem t\u011bhotenstv\u00ed je zapot\u0159eb\u00ed dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. To je z\u00e1sadn\u00ed od za\u010d\u00e1tku t\u011bhotenstv\u00ed, a dokonce se doporu\u010duje fol\u00e1ty za\u010d\u00edt u\u017e\u00edvat ji\u017e b\u011bhem jeho pl\u00e1nov\u00e1n\u00ed. \u017deny obvykle zjist\u00ed, \u017ee jsou t\u011bhotn\u00e9 a\u017e po p\u00e1r t\u00fddnech, proto je dobr\u00e9 si ji\u017e b\u011bhem snahy o ot\u011bhotn\u011bn\u00ed, doplnit hladinu fol\u00e1t\u016f na dostate\u010dnou \u00farove\u0148. (6)<\/p>\n\n\n\n
POZOR, tat\u00ednci: tohle je i pro V\u00e1s!<\/p>\n\n\n\n
I mu\u017ei, kte\u0159\u00ed se sna\u017e\u00ed zplodit potomka by se m\u011bli, \u017ee netrp\u00ed nedostatkem fol\u00e1t\u016f. Studie z roku 2013 zjistila, \u017ee u mu\u017e\u016f, kter\u00fdm zdrav\u00e1 hladina tohoto vitam\u00ednu b\u011bhem snahy o po\u010det\u00ed sch\u00e1z\u00ed, hroz\u00ed zna\u010dn\u00e9 zv\u00fd\u0161en\u00ed pravd\u011bpodobnost\u00ed deformit. (10)<\/p>\n\n\n\n
N\u011bkter\u00fdm \u017een\u00e1m tedy m\u016f\u017ee b\u00fdt doporu\u010deno za\u010d\u00edt dopl\u0148ovat fol\u00e1ty ji\u017e n\u011bkolik m\u011bs\u00edc\u016f p\u0159ed po\u010det\u00edm, aby se zv\u00fd\u0161ila jistota zdrav\u00e9ho d\u00edt\u011bte. (11) <\/p>\n\n\n\n<\/a><\/figure>\n\n\n\nMohou sni\u017eovat riziko vzniku deprese a\/nebo podpo\u0159it \u00fa\u010dinek antidepresiv<\/strong><\/h3>\n\n\n\nVe studii z roku 2013 v\u00edce ne\u017e 500 pacient\u016f, jim\u017e byl pod\u00e1v\u00e1n l\u00e9k na depresi v automatizovan\u00e9m telefonn\u00edm pr\u016fzkumu nazna\u010dovalo, \u017ee poci\u0165ovali lep\u0161\u00ed pr\u016fm\u011brnou kvalitu \u017eivota a zv\u00fd\u0161enou spokojenost s jejich l\u00e9ky ji\u017e po t\u0159ech m\u011bs\u00edc\u00edch u\u017e\u00edv\u00e1n\u00ed. Sou\u010dasn\u011b tak\u00e9 uvedli, \u017ee m\u011bli lep\u0161\u00ed vztahy s rodinou, p\u0159\u00e1teli, kolegy, partnery, ale dokonce i s ostatn\u00edmi lidmi, s nimi\u017e nebyli v \u017e\u00e1dn\u00e9m bli\u017e\u0161\u00edm vztahu. Celkov\u00fd rozd\u00edl byl tud\u00ed\u017e po 95 dnech celkem znateln\u00fd. Testovan\u00ed jedinci u\u017e\u00edvali p\u0159edepsanou a velmi silnou formu 5-MTHF. Ka\u017ed\u00e1 d\u00e1vka obsahovala 7.5 nebo 15mg. Obvykl\u00e1 po\u010d\u00e1te\u010dn\u00ed d\u00e1vka pro b\u011b\u017en\u00e9 u\u017eivatele, kte\u0159\u00ed depres\u00ed netrp\u00ed je 1mg nebo i m\u00e9n\u011b. (12)<\/p>\n\n\n\n
Jedn\u00edm z d\u016fvod\u016f, pro\u010d je u\u017e\u00edv\u00e1n\u00ed 5-MTHF vhodn\u00e9 u pacient\u016f s depres\u00ed, je i to, \u017ee fol\u00e1ty jsou nezbytnou sou\u010d\u00e1st\u00ed produkce hlavn\u00edch neurotransmiter\u016f, jako je serotonin, dopamin a norepinefrin a m\u016f\u017ee napom\u00e1hat jejich regulaci. (13) <\/p>\n\n\n\n
5-MTHF m\u016f\u017ee tak\u00e9 p\u0159\u00edzniv\u011b m\u00edrnit n\u011bkter\u00e9 symptomy bipol\u00e1rn\u00ed poruchy.<\/p>\n\n\n\n
\u0160estit\u00fddenn\u00ed studie prov\u00e1d\u011bn\u00e1 na 10 lidech trp\u00edc\u00edch velkou depres\u00ed a bipol\u00e1rn\u00ed poruchou uk\u00e1zala slibn\u00e9 v\u00fdsledky: (14)<\/p>\n\n\n\n
“V\u00fdzkumn\u00edci zjistili, \u017ee pacienti s bipol\u00e1rn\u00ed poruchou u\u017e\u00edvaj\u00edc\u00ed L-methylfol\u00e1t vykazovali zlep\u0161en\u00ed p\u0159\u00edznak\u016f deprese, fungov\u00e1n\u00ed, kognice a sebevra\u017eedn\u00fdch my\u0161lenek.<\/em><\/p>\n\n\n\nVAROV\u00c1N\u00cd: Pakli\u017ee trp\u00edte jakoukoliv formou deprese, v\u017edy se pora\u010fte s l\u00e9ka\u0159em p\u0159edt\u00edm, ne\u017e za\u010dnete u\u017e\u00edvat fol\u00e1tov\u00e9 dopl\u0148ky, a to i v p\u0159\u00edpad\u011b u\u017e\u00edv\u00e1n\u00ed n\u00edzk\u00fdch d\u00e1vek. <\/p>\n\n\n\n
Sn\u00ed\u017eit hladinu toxick\u00e9 aminokyseliny – homocysteinu<\/strong><\/h3>\n\n\n\nHomocystein je aminokyselina vyskytuj\u00edc\u00ed se v lidsk\u00e9m t\u011ble, kter\u00e1 vyvol\u00e1v\u00e1 z\u00e1n\u011bt. Mnoho nemoc\u00ed je zp\u016fsobeno pr\u00e1v\u011b z\u00e1n\u011btem.<\/p>\n\n\n\n
Vysok\u00e1 hladina homocysteinu m\u016f\u017ee v\u00e9st ke zv\u00fd\u0161en\u00e9mu riziku vzniku: (18)<\/p>\n\n\n\n
\n- Krevn\u00edch sra\u017eenin<\/li>\n\n\n\n
- Mozkov\u00e9 p\u0159\u00edhody<\/li>\n\n\n\n
- Alzheimerovy choroby<\/li>\n\n\n\n
- Infarktu myokardu<\/li>\n\n\n\n
- Ischemick\u00e9 choroby srde\u010dn\u00ed<\/li>\n\n\n\n
- Osteopor\u00f3zy<\/li>\n\n\n\n
- Arteroskler\u00f3zy<\/li>\n<\/ul>\n\n\n\n
Vysok\u00e9 hladiny t\u00e9to l\u00e1tky jsou tak\u00e9 spojov\u00e1ny s n\u00edzk\u00fdmi hladinami vitam\u00edn\u016f B6, B9 a B12. Tato kombinace je siln\u00fdm prediktorem kognitivn\u00edho poklesu u mu\u017e\u016f a pravd\u011bpodobn\u011b i u \u017een. (15) <\/p>\n\n\n\n
Zdrav\u00e9 hladiny v\u0161ech t\u0159\u00ed t\u011bchto typ\u016f vitam\u00ednu B jsou d\u016fle\u017eit\u00e9 pro udr\u017een\u00ed hladiny homocysteinu pod kontrolou. A\u010dkoliv m\u016f\u017ee 5-MTHF do ur\u010dit\u00e9 m\u00edry kognitivn\u00edmu poklesu zabr\u00e1nit s\u00e1m o sob\u011b, ud\u011bl\u00e1te l\u00e9pe, kdy\u017e budete na zdrav\u00e9 \u00farovni udr\u017eovat i zbyl\u00e9 dva typy. (15) (16) (17)<\/p>\n\n\n\n
Mezi dal\u0161\u00ed p\u0159\u00ed\u010diny vysok\u00e9 hladiny homocysteinu pat\u0159\u00ed: probl\u00e9my se \u0161t\u00edtnou \u017el\u00e1zou, onemocn\u011bn\u00ed ledvin a psori\u00e1za. To znamen\u00e1, \u017ee ne v\u017edy je na vin\u011b nedostatek vitam\u00ednu B. (18) <\/p>\n\n\n\n
Jak jste se ji\u017e do\u010detli v\u00fd\u0161e, zm\u011bna z\u00e1kon\u016f v des\u00edtk\u00e1ch zem\u00ed sn\u00ed\u017eila hladinu homocysteinu t\u00edm, \u017ee zavedla, aby byly mouky obohaceny o kyselinou listovou. 24 t\u00fddenn\u00ed randomizovan\u00e1 studie s placebem uk\u00e1zala, \u017ee p\u0159i sni\u017eov\u00e1n\u00ed hladiny homocysteinu u zdrav\u00fdch lid\u00ed je 5-MTHF je mnohem efektivn\u011bj\u0161\u00ed ne\u017e kyselina listov\u00e1. (19)<\/p>\n\n\n\n
Mohou sn\u00ed\u017eit riziko vzniku c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody & infarktu myokardu<\/strong><\/h3>\n\n\n\n5-MTHF by mohl zlep\u0161it zdrav\u00ed srdce a krevn\u00edho ob\u011bhu jednak sn\u00ed\u017een\u00edm homocysteinu ale i jin\u00fdmi mechanismy. Je to v\u0161ak komplikovan\u011bj\u0161\u00ed, jeliko\u017e riziko infarktu myokardu (IM) nebo c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody dok\u00e1\u017ee sn\u00ed\u017eit pouze v p\u0159\u00edpad\u011b, \u017ee m\u00e1te nedostatek fol\u00e1t\u016f.<\/p>\n\n\n\n
<\/a>Here is a summary of the key facts of this mysterious story\u2026<\/p>\n\n\n\nA 2015 study found that men who supplemented with folic acid while taking enalapril, a blood pressure lowering medicine, reduced their risk of stroke for 4.5 years. The results were significant for the group that used the combination of folic acid and enalapril compared with the group that used enalapril alone. Old studies from the 1970s also seem to show a lower risk of stroke and MI with increased folate intake. (20)<\/p>\n\n\n\n
On the other hand, some placebo-based studies in the United States have not shown a reduction in the risk of stroke or heart attack. This could mean that folate has this effect only if it is used by people who suffer from its deficiency. Recall also that the United States began enriching flour in 1998, which could explain the results of the 1970s, when people had lower folate levels. (20)<\/p>\n\n\n\n
China does not enrich flour or cereal grains with folic acid, which means that its population may be deficient. Some of the old American studies looked at people who had a history of stroke and MI. In response to these events, these people were able to reduce the risk with drugs and foods other than folate. (20)<\/p>\n\n\n\n
How do you know if you have a folate deficiency?<\/strong><\/h2>\n\n\n\nSome signs that you have a folate deficiency may include anemia (lack of red blood cells), chronic weakness & fatigue: (21)<\/p>\n\n\n\n
\n- Stuffiness<\/li>\n\n\n\n
- Flammability, resentment & irritability<\/li>\n\n\n\n
- Your skin is extremely pale<\/li>\n\n\n\n
- And other signs of low oxygen levels, such as memory problems<\/li>\n<\/ul>\n\n\n\n
Other signs of folate deficiency: (22)<\/p>\n\n\n\n
\n- Premature graying of hair<\/li>\n\n\n\n
- Swollen tongue<\/li>\n\n\n\n
- Ulcers or aphthae in the mouth<\/li>\n\n\n\n
- Your baby was born with a congenital defect & deformities<\/li>\n\n\n\n
- Diarrhea<\/li>\n\n\n\n
- Growth problems<\/li>\n<\/ul>\n\n\n\n
Self-diagnosis of folate deficiency is difficult in part because the symptoms of folate and vitamin B deficiency are very similar. Your doctor will probably perform tests to find out the cause of your problems.<\/p>\n\n\n\n
What causes folate deficiency?<\/strong><\/h2>\n\n\n\nA diet that is not rich enough in folate<\/strong><\/h3>\n\n\n\nPokud nekonzumujete dostate\u010dn\u00e9 mno\u017estv\u00ed fazol\u00ed,vajec, zelen\u00e9 zeleniny a dal\u0161\u00edch potravin nebo dopl\u0148k\u016f bohat\u00fdch na fol\u00e1ty, pravd\u011bpodobn\u011b budete m\u00edt ve sv\u00e9m t\u011ble nedostatek fol\u00e1tu.<\/p>\n\n\n\n
<\/a>Probl\u00e9my, kter\u00e9 zabra\u0148uj\u00ed absorpci fol\u00e1tu z j\u00eddla & dopl\u0148k\u016f stravy<\/strong><\/h3>\n\n\n\n\u0160patn\u00e9 vst\u0159eb\u00e1v\u00e1n\u00ed kyseliny listov\u00e9 a fol\u00e1t\u016f z potravin m\u016f\u017ee b\u00fdt zap\u0159\u00ed\u010din\u011bno mnoha d\u016fvody, v\u010detn\u011b: (21)<\/p>\n\n\n\n
\n- Nemoc\u00ed, jako nap\u0159\u00edklad Crohnova choroba, celiakie, n\u011bkter\u00e9 druhy rakoviny & poruchy ledvin<\/li>\n\n\n\n
- Poruch genu MTHFR, kter\u00e9 jsou relativn\u011b b\u011b\u017en\u00e9<\/li>\n\n\n\n
- Interakc\u00ed s l\u00e9ky, kter\u00e9 reaguj\u00ed s fol\u00e1tem\u00a0<\/li>\n\n\n\n
- Nadm\u011brn\u00e9ho u\u017e\u00edv\u00e1n\u00ed alkoholu nebo antacid<\/li>\n\n\n\n
- Mutac\u00ed gen\u016f odpov\u011bdn\u00fdch za metabolizaci fol\u00e1tu<\/li>\n<\/ul>\n\n\n\n
Kyselina listov\u00e1 a p\u0159\u00edrodn\u00ed fol\u00e1ty v potravin\u00e1ch mus\u00ed proj\u00edt n\u011bkolika chemick\u00fdmi reakcemi, ne\u017e se zm\u011bn\u00ed v u\u017eite\u010dnou formu 5-MTHF.<\/p>\n\n\n\n
V\u011bt\u0161ina efektivn\u011b metabolizuje a \u00fa\u010dinn\u011b transformuje kyselinu listovou na 5-MTHF. Tento proces je \u0159\u00edzen speci\u00e1ln\u00edm genem, kter\u00fd se naz\u00fdv\u00e1 MTHFR a lid\u00e9 ho maj\u00ed ve dvou kopi\u00edch. Mnoho z n\u00e1s m\u00e1 v\u0161ak varianty jedn\u00e9 nebo obou t\u011bchto genov\u00fdch kopi\u00ed, kter\u00e9 transformaci na 5-MTHF neumo\u017e\u0148uj\u00ed. Pokud je jedna kopie tohoto genu \u0161patn\u00e1, efektivita metabolizmu m\u016f\u017ee b\u00fdt zna\u010dn\u011b naru\u0161ena. Pakli\u017ee jsou \u0161patn\u00e9 ob\u011b kopie, Va\u0161e t\u011blo p\u0159\u00edli\u0161 fol\u00e1tu ani kyseliny listov\u00e9 metabolizovat nebude. (23)<\/p>\n\n\n\n
Jak zjist\u00edte, jestli pr\u00e1v\u011b Vy nem\u00e1te jednu nebo ob\u011b dv\u011b \u0161patn\u00e9 kopie genu MTHFR? K tomu je t\u0159eba prov\u00e9st test DNA a nechat jej poslat do laborato\u0159e. Tyto laborato\u0159e lze naj\u00edt i online a m\u016f\u017eete je vyhledat sami nebo se zeptat Va\u0161eho l\u00e9ka\u0159e. <\/p>\n\n\n\n
V p\u0159\u00edpad\u011b, \u017ee se V\u00e1s tento probl\u00e9m genov\u00e9 variace t\u00fdk\u00e1, nejjednodu\u0161\u0161\u00ed zp\u016fsob, jak jej vy\u0159e\u0161it je u\u017e\u00edvat dopln\u011bk stravy 5-MTHF. Tento dopln\u011bk um\u00ed t\u011blo spr\u00e1vn\u011b vyu\u017e\u00edt bez dal\u0161\u00edch chemick\u00fdch reakc\u00ed, jeliko\u017e 5-MTHF je ji\u017e bioaktivn\u00ed.<\/p>\n\n\n\n
Obezitou<\/strong><\/h3>\n\n\n\nExistuje n\u00e1padn\u00e1 souvislost mezi obezitou a nedostate\u010dnou hladinou fol\u00e1tu, av\u0161ak zd\u00e1 se, \u017ee nikdo nep\u0159i\u0161el na to, pro\u010d.<\/p>\n\n\n\n
P\u0159ezkum studi\u00ed publikovan\u00fdch v letech 2005 a\u017e 2015 zkoumal hladiny fol\u00e1t\u016f u ob\u00e9zn\u00edch \u017een \u201ev plodn\u00e9m v\u011bku\u201c se zvl\u00e1\u0161tn\u00edm zam\u011b\u0159en\u00edm na t\u011bhotn\u00e9 \u017eeny. C\u00edlem v\u011bdc\u016f bylo u t\u011bchto \u017een zjistit mo\u017en\u00e9 p\u0159\u00ed\u010diny vysok\u00e9ho procenta deficitu fol\u00e1t\u016f. Objevena byla britsk\u00e1 studie, kter\u00e1 vylu\u010dovala faktory, jako jsou strava, vitam\u00edny a v\u011bk. Tato studie odkazovala tak\u00e9 na n\u011bkolik dal\u0161\u00edch studi\u00ed, kter\u00e9 stravu jako p\u0159\u00ed\u010dinu tak\u00e9 vylu\u010dovaly. V\u011bdci v t\u00e9to studii pouze uvedli, \u017ee je t\u0159eba prov\u00e9st v\u00edce b\u00e1d\u00e1n\u00ed na toto t\u00e9ma a uvedli rady, jak\u00fdm zp\u016fsobem je sestavit. (24)<\/p>\n\n\n\n
V\u011bc se m\u00e1 tak, \u017ee obezita sama o sob\u011b nebo i jej\u00ed konkr\u00e9tn\u00ed p\u0159\u00ed\u010diny by mohly v\u00e9st ke sn\u00ed\u017een\u00ed obsahu fol\u00e1t\u016f na nezdravou \u00farove\u0148. Korelace je siln\u00e1 a v\u0161echny ot\u00e1zky se t\u00fdkaj\u00ed toho, co k \u010demu vede.<\/p>\n\n\n\n
Dal\u0161\u00ed studie zaznamenala silnou souvislost mezi obezitou a deficitem fol\u00e1tu:<\/p>\n\n\n\n
V roce 2016 v\u011bdci p\u0159ezkoum\u00e1vali studie s c\u00edlem aktualizovat Sm\u011brnici pro bariatrickou chirurgii Americk\u00e9 spole\u010dnosti pro v\u00fd\u017eivu metabolick\u00e9 a bariatrick\u00e9 chirurgie, z roku 2008. Sm\u011brnice je zalo\u017eena na studi\u00edch zji\u0161\u0165uj\u00edc\u00edch hladinu \u017eivin p\u0159ed a po chirurgick\u00fdch z\u00e1kroc\u00edch, kter\u00e9 byly provedeny za \u00fa\u010delem redukce hmotnosti. Nov\u00e1 sm\u011brnice pro rok 2016 doporu\u010dovala screening deficitu fol\u00e1t\u016f p\u0159ed t\u00edmto typem operace. D\u016fvodem bylo to, \u017ee a\u017e 54% ob\u00e9zn\u00edch pacient\u016f trp\u00ed nedostatkem fol\u00e1t\u016f. (25)<\/p>\n\n\n\n
V tomto p\u0159\u00edpad\u011b v\u011bdci nem\u011bli v \u00famyslu vy\u0161et\u0159ovat p\u0159\u00ed\u010dinu a n\u00e1sledek, ale v\u0161imli si tohoto spojen\u00ed, na kter\u00e9 reagovali doporu\u010den\u00edm p\u0159ed operac\u00ed monitorovat a dopl\u0148ovat fol\u00e1t.<\/p>\n\n\n\n
Zni\u010d\u00ed se fol\u00e1ty b\u011bhem jejich va\u0159en\u00ed?<\/strong><\/h2>\n\n\n\n<\/a>To, jestli va\u0159en\u00ed sni\u017euje obsah fol\u00e1tu v potrav\u011b, z\u00e1vis\u00ed na druhu potraviny a zp\u016fsobu a d\u00e9lce va\u0159en\u00ed.<\/p>\n\n\n\nNorm\u00e1ln\u00ed doba varu m\u016f\u017ee eliminovat mno\u017estv\u00ed fol\u00e1tu ve \u0161pen\u00e1tu a brokolici zhruba na polovinu, p\u0159i\u010dem\u017e p\u0159\u00edprava v p\u00e1\u0159e hladinu fol\u00e1tu v\u016fbec nesni\u017euje. Va\u0159en\u00ed brambor a grilov\u00e1n\u00ed masa by mno\u017estv\u00ed fol\u00e1tu sni\u017eovat tak\u00e9 nem\u011blo, a to i v p\u0159\u00edpad\u011b, \u017ee je va\u0159\u00edte d\u00e9le, ne\u017e je obvykl\u00e9. (26)<\/p>\n\n\n\n
Va\u0159en\u00ed cibule sni\u017euje fol\u00e1t o 35%, zat\u00edmco pe\u010den\u00edm se mno\u017estv\u00ed ni\u010d\u00ed pouze z 15%. Uk\u00e1zalo se tak\u00e9, \u017ee hr\u00e1\u0161ek si b\u011bhem va\u0159en\u00ed, ve srovn\u00e1n\u00ed s jin\u00fdmi metodami tepeln\u00e9 \u00fapravy, zachov\u00e1v\u00e1 nejv\u00edce fol\u00e1tu. D\u00e1le v p\u0159\u00edpad\u011b, \u017ee va\u0159\u00edte fazole po dobu dvou hodin, a pak je nav\u00edc je\u0161t\u011b pe\u010dete nebo sma\u017e\u00edte, ztr\u00e1c\u00ed a\u017e 50%. Jedna ze studi\u00ed doporu\u010duje nejprve je namo\u010dit do slan\u00e9 vody, a pot\u00e9 je va\u0159it ve sladk\u00e9 vod\u011b, aby se zachovalo co nejv\u00edce \u017eivin. (27) <\/p>\n\n\n\n
M\u011bly by t\u011bhotn\u00e9 \u017eeny a\/nebo \u017eeny, kter\u00e9 t\u011bhotenstv\u00ed pl\u00e1nuj\u00ed u\u017e\u00edvat dopl\u0148ky stravy s fol\u00e1ty?<\/strong><\/h2>\n\n\n\nMezi odbornou l\u00e9ka\u0159skou ve\u0159ejnost\u00ed je v\u0161eobecn\u011b p\u0159ij\u00edm\u00e1no, \u017ee udr\u017eov\u00e1n\u00ed hladiny fol\u00e1t\u016f na po\u017eadovan\u00e9 \u00farovni je vhodn\u00e9, jeliko\u017e je prok\u00e1z\u00e1na siln\u00e1 korelace mezi optim\u00e1ln\u00ed hladinou fol\u00e1tu a p\u0159edch\u00e1zen\u00edm vrozen\u00fdm vad\u00e1m.<\/p>\n\n\n\n
Jak ji\u017e bylo uvedeno v\u00fd\u0161e, ji\u017e od ot\u011bhotn\u011bn\u00ed je t\u0159eba m\u00edt v t\u011ble dostatek bioaktivn\u00edho fol\u00e1tu, aby byl zaji\u0161t\u011bn spr\u00e1vn\u00fd v\u00fdvoj nervov\u00e9ho syst\u00e9mu d\u00edt\u011bte. To znamen\u00e1, \u017ee je vhodn\u00e9 za\u010d\u00edt fol\u00e1t dopl\u0148ovat ji\u017e b\u011bhem samotn\u00e9 snahy o po\u010det\u00ed. <\/p>\n\n\n\n
Dopl\u0148ov\u00e1n\u00ed 5-MTHF je ten nejefektivn\u011bj\u0161\u00ed zp\u016fsob, kter\u00fd zajist\u00ed, \u017ee Va\u0161e t\u011blo skute\u010dn\u011b absorbuje dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. <\/p>\n\n\n\n
Pokud jste t\u011bhotn\u00e1, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em. Nen\u00ed vhodn\u00e9 si s dopl\u0148ky stravy pohr\u00e1vat bez odborn\u00e9ho dohledu, kter\u00fd zajist\u00ed p\u0159izp\u016fsoben\u00ed vhodn\u00e9 medikace p\u0159\u00edmo V\u00e1m na m\u00edru.<\/p>\n\n\n\n
M\u016f\u017ee m\u00edt Va\u0161e t\u011blo nadbytek fol\u00e1t\u016f?<\/strong><\/h2>\n\n\n\nToto je v l\u00e9ka\u0159sk\u00e9 v\u011bd\u011b kontroverzn\u00ed z\u00e1le\u017eitost. N\u011bkte\u0159\u00ed v\u011bdci tvrd\u00ed, \u017ee ve Va\u0161em t\u011ble m\u016f\u017ee cirkulovat p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9, co\u017e m\u016f\u017ee zp\u016fsobit zdravotn\u00ed probl\u00e9my. (28) <\/p>\n\n\n\n
Pr\u00e1v\u011b kv\u016fli t\u00e9to kontroverzi a pot\u0159eb\u011b dal\u0161\u00edch studi\u00ed m\u016f\u017eete naj\u00edt vl\u00e1dn\u00ed zdravotnick\u00e9 agentury, kter\u00e9 se odm\u00edtaj\u00ed \u00fa\u010dastnit debat na toto t\u00e9ma a rad\u00ed spot\u0159ebitel\u016fm, aby rad\u011bji byli v tomto ohledu velmi opatrn\u00ed. <\/p>\n\n\n\n
Nic z toho by v\u0161ak nem\u011bl b\u00fdt probl\u00e9m pro 5-MTHF nebo fol\u00e1t, kter\u00fd se nach\u00e1z\u00ed v p\u0159irozen\u00e9 form\u011b v potrav\u011b.<\/p>\n\n\n\n
Co m\u016f\u017ee zp\u016fsobit nadbytek kyseliny listov\u00e9?<\/p>\n\n\n\n
Mo\u017en\u00e9 skryt\u00e9 zn\u00e1mky nedostatku B12<\/strong><\/h3>\n\n\n\nP\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 v t\u011ble m\u016f\u017ee m\u016f\u017ee maskovat p\u0159\u00edznaky megaloblastick\u00e9 an\u00e9mie zp\u016fsoben\u00e9 nedostatkem vitam\u00ednu B12. Nejedn\u00e1 se v\u0161ak o konsenzus, pro v\u011bdce je toto st\u00e1le z\u00e1hadou. Ale pakli\u017ee je toto tvrzen\u00ed pravdiv\u00e9, m\u016f\u017ee se st\u00e1t, \u017ee l\u00e9ka\u0159 stanov\u00ed \u0161patnou diagn\u00f3zu. To m\u016f\u017ee zp\u016fsobit zhor\u0161en\u00ed probl\u00e9m\u016f souvisej\u00edc\u00edch krevn\u00edm ob\u011bhem a po\u0161kodit mozek a nervov\u00fd syst\u00e9m. Po\u0161kozen\u00ed mozku m\u016f\u017ee zp\u016fsobit rychl\u00fd kognitivn\u00ed pokles a zmatek. (29) <\/p>\n\n\n\n
V \u010dem se ale odborn\u00e1 ve\u0159ejnost shoduje je to, \u017ee tento probl\u00e9m se net\u00fdk\u00e1 5-MTHF, tud\u00ed\u017e aktivn\u00ed formy fol\u00e1tu, kter\u00e1 se tvo\u0159\u00ed p\u0159i spr\u00e1vn\u00e9m metabolismu fol\u00e1t\u016f. Nadm\u011brn\u00e1 konzumace fazol\u00ed, pomeran\u010d\u016f nebo zelen\u00e9 zeleniny, s p\u0159irozen\u011b vysok\u00fdm obsahem fol\u00e1t\u016f se tak\u00e9 nezd\u00e1 b\u00fdt – dle odborn\u00edk\u016f – probl\u00e9m. (39)<\/p>\n\n\n\n
Nedostatek vitam\u00ednu B12 m\u016f\u017ee b\u00fdt v\u011bt\u0161\u00ed probl\u00e9m pro vegetari\u00e1ny a star\u0161\u00ed lidi, ne\u017e pro v\u011bt\u0161inu ostatn\u00edch. Vegetari\u00e1nsk\u00e1 strava nen\u00ed na tento vitam\u00edn dostate\u010dn\u011b bohat\u00e1 a star\u0161\u00ed lid\u00e9 ho t\u011b\u017eko vst\u0159eb\u00e1vaj\u00ed. Ob\u011b skupiny mohou doplnit B12 sublingv\u00e1ln\u011b (rozpustit pod jazykem).<\/p>\n\n\n\n
<\/a>Poruchy sp\u00e1nku & n\u00e1lady<\/strong><\/h3>\n\n\n\nNadu\u017e\u00edv\u00e1n\u00ed kyseliny listov\u00e9, zejm\u00e9na pokud je pod\u00e1v\u00e1na v dopl\u0148c\u00edch stravy, m\u016f\u017ee zp\u016fsobit poruchy sp\u00e1nku a podr\u00e1\u017ed\u011bnost. (30)<\/p>\n\n\n\n
Nevolnost & nechutenstv\u00ed<\/strong><\/h3>\n\n\n\nN\u011bkte\u0159\u00ed lid\u00e9 mohou ztratit chu\u0165 k j\u00eddlu nebo trp\u011bt nevolnost\u00ed, a to zejm\u00e9na pokud u\u017eij\u00ed p\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 z dopl\u0148k\u016f nebo vitam\u00edn\u016f. (30)<\/p>\n\n\n\n
\u0158e\u0161en\u00ed<\/strong><\/h3>\n\n\n\nPakli\u017ee se rozhodnete za\u010d\u00edt dopl\u0148ovat fol\u00e1ty, ujist\u011bte se, \u017ee zvol\u00edte jejich bioaktivn\u00ed formu: 5-MTHF.<\/p>\n\n\n\n
P\u0159e\u010dt\u011bte si informace uveden\u00e9 na vitam\u00ednech, kter\u00e9 u\u017e\u00edv\u00e1te. Neobsahuj\u00ed p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9? V\u011bt\u0161ina dosp\u011bl\u00fdch by m\u011bla konzumovat asi 0,5 mg kyseliny listov\u00e9 denn\u011b. P\u0159e\u010dt\u011bte si tak\u00e9 etikety na chlebu a obilovin\u00e1ch.<\/p>\n\n\n\n
Pokud ji\u017e u\u017e\u00edv\u00e1te 5-MTHF, zkuste omezit mno\u017estv\u00ed kyseliny listov\u00e9 p\u0159ij\u00edman\u00e9 z o n\u00ed obohacen\u00fdch potravin na minimum a pokuste se tak\u00e9 vyhnout vitam\u00edn\u016fm s jej\u00edm obsahem. Kombinace t\u011bchto dvou forem fol\u00e1tu by toti\u017e mohla (ale nemusela) zp\u016fsobit probl\u00e9my.<\/p>\n\n\n\n
Americk\u00fd N\u00e1rodn\u00ed \u00fastav pro zdrav\u00ed a v\u00fd\u017eivov\u00e9 dopl\u0148ky stanovil maxim\u00e1ln\u00ed doporu\u010denou denn\u00ed d\u00e1vku kyseliny listov\u00e9, kter\u00e1 poch\u00e1z\u00ed z obohacen\u00fdch zrn a v\u00fd\u017eivov\u00fdch dopl\u0148k\u016f na 1 mg. Limit pro fol\u00e1ty, kter\u00e9 poch\u00e1zej\u00ed ze zeleniny nebo 5-MTHF nebyl stanoven. (29)<\/p>\n\n\n\n
Dle Harvardsk\u00e9ho zdravotn\u00edho dopisu se m\u016f\u017ee kyselina listov\u00e1 ze zrn rychle nahromadit (31), viz. seznam n\u00ed\u017ee.<\/p>\n\n\n\n
Common foods fortified with folic acid:<\/p>\n\n\n\n
\n- Bowl of special cereals: 0.394mg<\/li>\n\n\n\n
- 1 serving of pretzels: 0.172mg<\/li>\n\n\n\n
- 1 serving of cooked spaghetti: 0.166mg<\/li>\n\n\n\n
- 1 multivitamin: 0.4mg<\/li>\n<\/ul>\n\n\n\n
Total = 1.132mg<\/p>\n\n\n\n
Therefore, this limit can be easily exceeded during the day, so it is good to monitor the amount of cereals and vitamins, especially if you have a problem with folic acid metabolism. Surely you also want to make sure that you have a sufficient income. B12, and that your body absorbs it properly.<\/p>\n\n\n\n
V\u0161imn\u011bte si pros\u00edm p\u00edsmene \u201cL\u201d u n\u011bkter\u00fdch z v\u00fd\u0161e uveden\u00fdch jmen. Toto p\u00edsmeno indikuje, \u017ee je vst\u0159ebateln\u00fd u drtiv\u00e9 v\u011bt\u0161iny lid\u00ed. \u201c6(S)\u201d nam\u00edsto \u201cL\u201d znamen\u00e1 tot\u00e9\u017e.<\/p>\n\n\n\n
V p\u0159\u00edpad\u011b, \u017ee \u201cL\u201d je nahrazeno \u201c6(R),\u201d tak V\u00e1m tento prepar\u00e1t asi p\u0159\u00edli\u0161 nepom\u016f\u017ee.<\/p>\n\n\n\n
Jak\u00e1 forma 5-MTHF je pro Va\u0161e t\u011blo nejl\u00e9pe vst\u0159ebateln\u00e1 & vyu\u017eiteln\u00e1?<\/strong><\/h2>\n\n\n\nStudie publikovan\u00e1 v British Journal of Pharmacology porovn\u00e1vala absorpci 6 (S) -5-MTHF v t\u011ble s kyselinou listovou. P\u0159edm\u011btem testov\u00e1n\u00ed byly zdrav\u00e9 \u017eeny, kter\u00e9 m\u011bly kv\u016fli defektn\u00edm gen\u016fm, pot\u0159ebn\u00fdm ke zpracov\u00e1n\u00ed t\u011bchto \u017eivin probl\u00e9m s absorpc\u00ed fol\u00e1tu z potravin nebo ve form\u011b kyseliny listov\u00e9. 6(S)-5-MTHF dok\u00e1zal mnohem l\u00e9pe dostat vitam\u00edn B do krevn\u00ed plazmy, odkud pak mohl za\u010d\u00edt v t\u011ble \u00fa\u010dinkovat. <\/p>\n\n\n\n
V t\u00e9to studii v\u011bdci pou\u017eili 6(S)-5-MTHF, kter\u00fd byl v\u00e1z\u00e1n na v\u00e1penatou s\u016fl a ano, co se vst\u0159eb\u00e1v\u00e1n\u00ed t\u00fd\u010de, p\u0159ekonal kyselinu listovou\u2026<\/p>\n\n\n\n
ALE\u2026<\/p>\n\n\n\n
Jin\u00e1 studie porovn\u00e1vala u potkan\u016f l\u00e1tky na b\u00e1zi v\u00e1pn\u00edku s jinou formou 6 (S) -5-MTHF v\u00e1zanou na glukosamin nam\u00edsto v\u00e1pn\u00edku. Ob\u011b tyto formy porovnali v\u011bdci tak\u00e9 s kyselinou listovou. Studie u prok\u00e1zala u glukosaminov\u00e9 soli 6 (S) -5-MTHF 1,8kr\u00e1t vy\u0161\u0161\u00ed maxim\u00e1ln\u00ed plazmatick\u00e9 hladiny v krvi ne\u017e u v\u00e1penat\u00e9 soli 5-MTHF a 3,1kr\u00e1t vy\u0161\u0161\u00ed hladiny ne\u017e u kyseliny listov\u00e9. (5)<\/p>\n\n\n
\n<\/a><\/figure>\n<\/div>\n\n\nProto v Intelligent Labs pou\u017e\u00edv\u00e1me Glukosaminovou s\u016fl 6(S)-5-methyltetrahydrofol\u00e1tu (5-MTHF), bez obsahu alergenu – sko\u0159\u00e1pek. V na\u0161ich dopl\u0148c\u00edch pou\u017e\u00edv\u00e1me patentovan\u00fd vzorec s n\u00e1zvem Quatrefolic Acid\u00ae a nab\u00edz\u00edme jej ve form\u011b 1mg 5-MTHF<\/a> a 5mg 5-MTHF.<\/a><\/p>\n\n\n\nV \u010dem jsou fol\u00e1ty & 5-MTHF p\u0159\u00ednosn\u00e9 pro zdrav\u00ed?<\/strong><\/h2>\n\n\n\nNezbytn\u00e9 pro udr\u017een\u00ed z\u00e1kladn\u00edch funkc\u00ed lidsk\u00e9ho t\u011bla<\/strong><\/h3>\n\n\n\nB9 je nutn\u00fd pro tvorbu: (6)(7)(8)<\/p>\n\n\n\n
\n- Energie ze sacharid\u016f<\/li>\n\n\n\n
- DNA & RNA<\/li>\n\n\n\n
- \u010cerven\u00fdch & b\u00edl\u00fdch krvinek<\/li>\n\n\n\n
- Melatoninu, l\u00e1tky kter\u00e1 reguluje sp\u00e1nek<\/li>\n\n\n\n
- D\u016fle\u017eit\u00fdch neurotransmiter\u016f, jak\u00fdmi jsou norepinefrin, serotonin & dopamin<\/li>\n\n\n\n
- Va\u0161eho nervov\u00e9ho syst\u00e9mu<\/li>\n<\/ul>\n\n\n\n
<\/a><\/h3>\n\n\n\nB\u011bhem t\u011bhotenstv\u00ed p\u0159edch\u00e1zej\u00ed v\u00fdskytu vrozen\u00fdch vad<\/strong><\/h3>\n\n\n\nZdravotn\u00edci \u010dasto tvrd\u00ed, \u017ee \u017eeny by b\u011bhem t\u011bhotenstv\u00ed m\u011bly u\u017e\u00edvat fol\u00e1ty, aby se zabr\u00e1nilo vrozen\u00fdm vad\u00e1m a po\u0161kozen\u00ed nervov\u00e9ho syst\u00e9mu plodu. \u00da\u010dinky nedostatku fol\u00e1t\u016f na v\u00fdvoj d\u00edt\u011bte byly dlouho studov\u00e1ny, a proto jsou tato doporu\u010den\u00ed rozhodn\u011b na m\u00edst\u011b. (9)<\/p>\n\n\n\n
Pro v\u00fdvoj nervov\u00e9ho syst\u00e9mu b\u011bhem t\u011bhotenstv\u00ed je zapot\u0159eb\u00ed dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. To je z\u00e1sadn\u00ed od za\u010d\u00e1tku t\u011bhotenstv\u00ed, a dokonce se doporu\u010duje fol\u00e1ty za\u010d\u00edt u\u017e\u00edvat ji\u017e b\u011bhem jeho pl\u00e1nov\u00e1n\u00ed. \u017deny obvykle zjist\u00ed, \u017ee jsou t\u011bhotn\u00e9 a\u017e po p\u00e1r t\u00fddnech, proto je dobr\u00e9 si ji\u017e b\u011bhem snahy o ot\u011bhotn\u011bn\u00ed, doplnit hladinu fol\u00e1t\u016f na dostate\u010dnou \u00farove\u0148. (6)<\/p>\n\n\n\n
POZOR, tat\u00ednci: tohle je i pro V\u00e1s!<\/p>\n\n\n\n
I mu\u017ei, kte\u0159\u00ed se sna\u017e\u00ed zplodit potomka by se m\u011bli, \u017ee netrp\u00ed nedostatkem fol\u00e1t\u016f. Studie z roku 2013 zjistila, \u017ee u mu\u017e\u016f, kter\u00fdm zdrav\u00e1 hladina tohoto vitam\u00ednu b\u011bhem snahy o po\u010det\u00ed sch\u00e1z\u00ed, hroz\u00ed zna\u010dn\u00e9 zv\u00fd\u0161en\u00ed pravd\u011bpodobnost\u00ed deformit. (10)<\/p>\n\n\n\n
N\u011bkter\u00fdm \u017een\u00e1m tedy m\u016f\u017ee b\u00fdt doporu\u010deno za\u010d\u00edt dopl\u0148ovat fol\u00e1ty ji\u017e n\u011bkolik m\u011bs\u00edc\u016f p\u0159ed po\u010det\u00edm, aby se zv\u00fd\u0161ila jistota zdrav\u00e9ho d\u00edt\u011bte. (11) <\/p>\n\n\n\n<\/a><\/figure>\n\n\n\nMohou sni\u017eovat riziko vzniku deprese a\/nebo podpo\u0159it \u00fa\u010dinek antidepresiv<\/strong><\/h3>\n\n\n\nVe studii z roku 2013 v\u00edce ne\u017e 500 pacient\u016f, jim\u017e byl pod\u00e1v\u00e1n l\u00e9k na depresi v automatizovan\u00e9m telefonn\u00edm pr\u016fzkumu nazna\u010dovalo, \u017ee poci\u0165ovali lep\u0161\u00ed pr\u016fm\u011brnou kvalitu \u017eivota a zv\u00fd\u0161enou spokojenost s jejich l\u00e9ky ji\u017e po t\u0159ech m\u011bs\u00edc\u00edch u\u017e\u00edv\u00e1n\u00ed. Sou\u010dasn\u011b tak\u00e9 uvedli, \u017ee m\u011bli lep\u0161\u00ed vztahy s rodinou, p\u0159\u00e1teli, kolegy, partnery, ale dokonce i s ostatn\u00edmi lidmi, s nimi\u017e nebyli v \u017e\u00e1dn\u00e9m bli\u017e\u0161\u00edm vztahu. Celkov\u00fd rozd\u00edl byl tud\u00ed\u017e po 95 dnech celkem znateln\u00fd. Testovan\u00ed jedinci u\u017e\u00edvali p\u0159edepsanou a velmi silnou formu 5-MTHF. Ka\u017ed\u00e1 d\u00e1vka obsahovala 7.5 nebo 15mg. Obvykl\u00e1 po\u010d\u00e1te\u010dn\u00ed d\u00e1vka pro b\u011b\u017en\u00e9 u\u017eivatele, kte\u0159\u00ed depres\u00ed netrp\u00ed je 1mg nebo i m\u00e9n\u011b. (12)<\/p>\n\n\n\n
Jedn\u00edm z d\u016fvod\u016f, pro\u010d je u\u017e\u00edv\u00e1n\u00ed 5-MTHF vhodn\u00e9 u pacient\u016f s depres\u00ed, je i to, \u017ee fol\u00e1ty jsou nezbytnou sou\u010d\u00e1st\u00ed produkce hlavn\u00edch neurotransmiter\u016f, jako je serotonin, dopamin a norepinefrin a m\u016f\u017ee napom\u00e1hat jejich regulaci. (13) <\/p>\n\n\n\n
5-MTHF m\u016f\u017ee tak\u00e9 p\u0159\u00edzniv\u011b m\u00edrnit n\u011bkter\u00e9 symptomy bipol\u00e1rn\u00ed poruchy.<\/p>\n\n\n\n
\u0160estit\u00fddenn\u00ed studie prov\u00e1d\u011bn\u00e1 na 10 lidech trp\u00edc\u00edch velkou depres\u00ed a bipol\u00e1rn\u00ed poruchou uk\u00e1zala slibn\u00e9 v\u00fdsledky: (14)<\/p>\n\n\n\n
“V\u00fdzkumn\u00edci zjistili, \u017ee pacienti s bipol\u00e1rn\u00ed poruchou u\u017e\u00edvaj\u00edc\u00ed L-methylfol\u00e1t vykazovali zlep\u0161en\u00ed p\u0159\u00edznak\u016f deprese, fungov\u00e1n\u00ed, kognice a sebevra\u017eedn\u00fdch my\u0161lenek.<\/em><\/p>\n\n\n\nVAROV\u00c1N\u00cd: Pakli\u017ee trp\u00edte jakoukoliv formou deprese, v\u017edy se pora\u010fte s l\u00e9ka\u0159em p\u0159edt\u00edm, ne\u017e za\u010dnete u\u017e\u00edvat fol\u00e1tov\u00e9 dopl\u0148ky, a to i v p\u0159\u00edpad\u011b u\u017e\u00edv\u00e1n\u00ed n\u00edzk\u00fdch d\u00e1vek. <\/p>\n\n\n\n
Sn\u00ed\u017eit hladinu toxick\u00e9 aminokyseliny – homocysteinu<\/strong><\/h3>\n\n\n\nHomocystein je aminokyselina vyskytuj\u00edc\u00ed se v lidsk\u00e9m t\u011ble, kter\u00e1 vyvol\u00e1v\u00e1 z\u00e1n\u011bt. Mnoho nemoc\u00ed je zp\u016fsobeno pr\u00e1v\u011b z\u00e1n\u011btem.<\/p>\n\n\n\n
Vysok\u00e1 hladina homocysteinu m\u016f\u017ee v\u00e9st ke zv\u00fd\u0161en\u00e9mu riziku vzniku: (18)<\/p>\n\n\n\n
\n- Krevn\u00edch sra\u017eenin<\/li>\n\n\n\n
- Mozkov\u00e9 p\u0159\u00edhody<\/li>\n\n\n\n
- Alzheimerovy choroby<\/li>\n\n\n\n
- Infarktu myokardu<\/li>\n\n\n\n
- Ischemick\u00e9 choroby srde\u010dn\u00ed<\/li>\n\n\n\n
- Osteopor\u00f3zy<\/li>\n\n\n\n
- Arteroskler\u00f3zy<\/li>\n<\/ul>\n\n\n\n
Vysok\u00e9 hladiny t\u00e9to l\u00e1tky jsou tak\u00e9 spojov\u00e1ny s n\u00edzk\u00fdmi hladinami vitam\u00edn\u016f B6, B9 a B12. Tato kombinace je siln\u00fdm prediktorem kognitivn\u00edho poklesu u mu\u017e\u016f a pravd\u011bpodobn\u011b i u \u017een. (15) <\/p>\n\n\n\n
Zdrav\u00e9 hladiny v\u0161ech t\u0159\u00ed t\u011bchto typ\u016f vitam\u00ednu B jsou d\u016fle\u017eit\u00e9 pro udr\u017een\u00ed hladiny homocysteinu pod kontrolou. A\u010dkoliv m\u016f\u017ee 5-MTHF do ur\u010dit\u00e9 m\u00edry kognitivn\u00edmu poklesu zabr\u00e1nit s\u00e1m o sob\u011b, ud\u011bl\u00e1te l\u00e9pe, kdy\u017e budete na zdrav\u00e9 \u00farovni udr\u017eovat i zbyl\u00e9 dva typy. (15) (16) (17)<\/p>\n\n\n\n
Mezi dal\u0161\u00ed p\u0159\u00ed\u010diny vysok\u00e9 hladiny homocysteinu pat\u0159\u00ed: probl\u00e9my se \u0161t\u00edtnou \u017el\u00e1zou, onemocn\u011bn\u00ed ledvin a psori\u00e1za. To znamen\u00e1, \u017ee ne v\u017edy je na vin\u011b nedostatek vitam\u00ednu B. (18) <\/p>\n\n\n\n
Jak jste se ji\u017e do\u010detli v\u00fd\u0161e, zm\u011bna z\u00e1kon\u016f v des\u00edtk\u00e1ch zem\u00ed sn\u00ed\u017eila hladinu homocysteinu t\u00edm, \u017ee zavedla, aby byly mouky obohaceny o kyselinou listovou. 24 t\u00fddenn\u00ed randomizovan\u00e1 studie s placebem uk\u00e1zala, \u017ee p\u0159i sni\u017eov\u00e1n\u00ed hladiny homocysteinu u zdrav\u00fdch lid\u00ed je 5-MTHF je mnohem efektivn\u011bj\u0161\u00ed ne\u017e kyselina listov\u00e1. (19)<\/p>\n\n\n\n
Mohou sn\u00ed\u017eit riziko vzniku c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody & infarktu myokardu<\/strong><\/h3>\n\n\n\n5-MTHF by mohl zlep\u0161it zdrav\u00ed srdce a krevn\u00edho ob\u011bhu jednak sn\u00ed\u017een\u00edm homocysteinu ale i jin\u00fdmi mechanismy. Je to v\u0161ak komplikovan\u011bj\u0161\u00ed, jeliko\u017e riziko infarktu myokardu (IM) nebo c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody dok\u00e1\u017ee sn\u00ed\u017eit pouze v p\u0159\u00edpad\u011b, \u017ee m\u00e1te nedostatek fol\u00e1t\u016f.<\/p>\n\n\n\n
<\/a>Here is a summary of the key facts of this mysterious story\u2026<\/p>\n\n\n\nA 2015 study found that men who supplemented with folic acid while taking enalapril, a blood pressure lowering medicine, reduced their risk of stroke for 4.5 years. The results were significant for the group that used the combination of folic acid and enalapril compared with the group that used enalapril alone. Old studies from the 1970s also seem to show a lower risk of stroke and MI with increased folate intake. (20)<\/p>\n\n\n\n
On the other hand, some placebo-based studies in the United States have not shown a reduction in the risk of stroke or heart attack. This could mean that folate has this effect only if it is used by people who suffer from its deficiency. Recall also that the United States began enriching flour in 1998, which could explain the results of the 1970s, when people had lower folate levels. (20)<\/p>\n\n\n\n
China does not enrich flour or cereal grains with folic acid, which means that its population may be deficient. Some of the old American studies looked at people who had a history of stroke and MI. In response to these events, these people were able to reduce the risk with drugs and foods other than folate. (20)<\/p>\n\n\n\n
How do you know if you have a folate deficiency?<\/strong><\/h2>\n\n\n\nSome signs that you have a folate deficiency may include anemia (lack of red blood cells), chronic weakness & fatigue: (21)<\/p>\n\n\n\n
\n- Stuffiness<\/li>\n\n\n\n
- Flammability, resentment & irritability<\/li>\n\n\n\n
- Your skin is extremely pale<\/li>\n\n\n\n
- And other signs of low oxygen levels, such as memory problems<\/li>\n<\/ul>\n\n\n\n
Other signs of folate deficiency: (22)<\/p>\n\n\n\n
\n- Premature graying of hair<\/li>\n\n\n\n
- Swollen tongue<\/li>\n\n\n\n
- Ulcers or aphthae in the mouth<\/li>\n\n\n\n
- Your baby was born with a congenital defect & deformities<\/li>\n\n\n\n
- Diarrhea<\/li>\n\n\n\n
- Growth problems<\/li>\n<\/ul>\n\n\n\n
Self-diagnosis of folate deficiency is difficult in part because the symptoms of folate and vitamin B deficiency are very similar. Your doctor will probably perform tests to find out the cause of your problems.<\/p>\n\n\n\n
What causes folate deficiency?<\/strong><\/h2>\n\n\n\nA diet that is not rich enough in folate<\/strong><\/h3>\n\n\n\nPokud nekonzumujete dostate\u010dn\u00e9 mno\u017estv\u00ed fazol\u00ed,vajec, zelen\u00e9 zeleniny a dal\u0161\u00edch potravin nebo dopl\u0148k\u016f bohat\u00fdch na fol\u00e1ty, pravd\u011bpodobn\u011b budete m\u00edt ve sv\u00e9m t\u011ble nedostatek fol\u00e1tu.<\/p>\n\n\n\n
<\/a>Probl\u00e9my, kter\u00e9 zabra\u0148uj\u00ed absorpci fol\u00e1tu z j\u00eddla & dopl\u0148k\u016f stravy<\/strong><\/h3>\n\n\n\n\u0160patn\u00e9 vst\u0159eb\u00e1v\u00e1n\u00ed kyseliny listov\u00e9 a fol\u00e1t\u016f z potravin m\u016f\u017ee b\u00fdt zap\u0159\u00ed\u010din\u011bno mnoha d\u016fvody, v\u010detn\u011b: (21)<\/p>\n\n\n\n
\n- Nemoc\u00ed, jako nap\u0159\u00edklad Crohnova choroba, celiakie, n\u011bkter\u00e9 druhy rakoviny & poruchy ledvin<\/li>\n\n\n\n
- Poruch genu MTHFR, kter\u00e9 jsou relativn\u011b b\u011b\u017en\u00e9<\/li>\n\n\n\n
- Interakc\u00ed s l\u00e9ky, kter\u00e9 reaguj\u00ed s fol\u00e1tem\u00a0<\/li>\n\n\n\n
- Nadm\u011brn\u00e9ho u\u017e\u00edv\u00e1n\u00ed alkoholu nebo antacid<\/li>\n\n\n\n
- Mutac\u00ed gen\u016f odpov\u011bdn\u00fdch za metabolizaci fol\u00e1tu<\/li>\n<\/ul>\n\n\n\n
Kyselina listov\u00e1 a p\u0159\u00edrodn\u00ed fol\u00e1ty v potravin\u00e1ch mus\u00ed proj\u00edt n\u011bkolika chemick\u00fdmi reakcemi, ne\u017e se zm\u011bn\u00ed v u\u017eite\u010dnou formu 5-MTHF.<\/p>\n\n\n\n
V\u011bt\u0161ina efektivn\u011b metabolizuje a \u00fa\u010dinn\u011b transformuje kyselinu listovou na 5-MTHF. Tento proces je \u0159\u00edzen speci\u00e1ln\u00edm genem, kter\u00fd se naz\u00fdv\u00e1 MTHFR a lid\u00e9 ho maj\u00ed ve dvou kopi\u00edch. Mnoho z n\u00e1s m\u00e1 v\u0161ak varianty jedn\u00e9 nebo obou t\u011bchto genov\u00fdch kopi\u00ed, kter\u00e9 transformaci na 5-MTHF neumo\u017e\u0148uj\u00ed. Pokud je jedna kopie tohoto genu \u0161patn\u00e1, efektivita metabolizmu m\u016f\u017ee b\u00fdt zna\u010dn\u011b naru\u0161ena. Pakli\u017ee jsou \u0161patn\u00e9 ob\u011b kopie, Va\u0161e t\u011blo p\u0159\u00edli\u0161 fol\u00e1tu ani kyseliny listov\u00e9 metabolizovat nebude. (23)<\/p>\n\n\n\n
Jak zjist\u00edte, jestli pr\u00e1v\u011b Vy nem\u00e1te jednu nebo ob\u011b dv\u011b \u0161patn\u00e9 kopie genu MTHFR? K tomu je t\u0159eba prov\u00e9st test DNA a nechat jej poslat do laborato\u0159e. Tyto laborato\u0159e lze naj\u00edt i online a m\u016f\u017eete je vyhledat sami nebo se zeptat Va\u0161eho l\u00e9ka\u0159e. <\/p>\n\n\n\n
V p\u0159\u00edpad\u011b, \u017ee se V\u00e1s tento probl\u00e9m genov\u00e9 variace t\u00fdk\u00e1, nejjednodu\u0161\u0161\u00ed zp\u016fsob, jak jej vy\u0159e\u0161it je u\u017e\u00edvat dopln\u011bk stravy 5-MTHF. Tento dopln\u011bk um\u00ed t\u011blo spr\u00e1vn\u011b vyu\u017e\u00edt bez dal\u0161\u00edch chemick\u00fdch reakc\u00ed, jeliko\u017e 5-MTHF je ji\u017e bioaktivn\u00ed.<\/p>\n\n\n\n
Obezitou<\/strong><\/h3>\n\n\n\nExistuje n\u00e1padn\u00e1 souvislost mezi obezitou a nedostate\u010dnou hladinou fol\u00e1tu, av\u0161ak zd\u00e1 se, \u017ee nikdo nep\u0159i\u0161el na to, pro\u010d.<\/p>\n\n\n\n
P\u0159ezkum studi\u00ed publikovan\u00fdch v letech 2005 a\u017e 2015 zkoumal hladiny fol\u00e1t\u016f u ob\u00e9zn\u00edch \u017een \u201ev plodn\u00e9m v\u011bku\u201c se zvl\u00e1\u0161tn\u00edm zam\u011b\u0159en\u00edm na t\u011bhotn\u00e9 \u017eeny. C\u00edlem v\u011bdc\u016f bylo u t\u011bchto \u017een zjistit mo\u017en\u00e9 p\u0159\u00ed\u010diny vysok\u00e9ho procenta deficitu fol\u00e1t\u016f. Objevena byla britsk\u00e1 studie, kter\u00e1 vylu\u010dovala faktory, jako jsou strava, vitam\u00edny a v\u011bk. Tato studie odkazovala tak\u00e9 na n\u011bkolik dal\u0161\u00edch studi\u00ed, kter\u00e9 stravu jako p\u0159\u00ed\u010dinu tak\u00e9 vylu\u010dovaly. V\u011bdci v t\u00e9to studii pouze uvedli, \u017ee je t\u0159eba prov\u00e9st v\u00edce b\u00e1d\u00e1n\u00ed na toto t\u00e9ma a uvedli rady, jak\u00fdm zp\u016fsobem je sestavit. (24)<\/p>\n\n\n\n
V\u011bc se m\u00e1 tak, \u017ee obezita sama o sob\u011b nebo i jej\u00ed konkr\u00e9tn\u00ed p\u0159\u00ed\u010diny by mohly v\u00e9st ke sn\u00ed\u017een\u00ed obsahu fol\u00e1t\u016f na nezdravou \u00farove\u0148. Korelace je siln\u00e1 a v\u0161echny ot\u00e1zky se t\u00fdkaj\u00ed toho, co k \u010demu vede.<\/p>\n\n\n\n
Dal\u0161\u00ed studie zaznamenala silnou souvislost mezi obezitou a deficitem fol\u00e1tu:<\/p>\n\n\n\n
V roce 2016 v\u011bdci p\u0159ezkoum\u00e1vali studie s c\u00edlem aktualizovat Sm\u011brnici pro bariatrickou chirurgii Americk\u00e9 spole\u010dnosti pro v\u00fd\u017eivu metabolick\u00e9 a bariatrick\u00e9 chirurgie, z roku 2008. Sm\u011brnice je zalo\u017eena na studi\u00edch zji\u0161\u0165uj\u00edc\u00edch hladinu \u017eivin p\u0159ed a po chirurgick\u00fdch z\u00e1kroc\u00edch, kter\u00e9 byly provedeny za \u00fa\u010delem redukce hmotnosti. Nov\u00e1 sm\u011brnice pro rok 2016 doporu\u010dovala screening deficitu fol\u00e1t\u016f p\u0159ed t\u00edmto typem operace. D\u016fvodem bylo to, \u017ee a\u017e 54% ob\u00e9zn\u00edch pacient\u016f trp\u00ed nedostatkem fol\u00e1t\u016f. (25)<\/p>\n\n\n\n
V tomto p\u0159\u00edpad\u011b v\u011bdci nem\u011bli v \u00famyslu vy\u0161et\u0159ovat p\u0159\u00ed\u010dinu a n\u00e1sledek, ale v\u0161imli si tohoto spojen\u00ed, na kter\u00e9 reagovali doporu\u010den\u00edm p\u0159ed operac\u00ed monitorovat a dopl\u0148ovat fol\u00e1t.<\/p>\n\n\n\n
Zni\u010d\u00ed se fol\u00e1ty b\u011bhem jejich va\u0159en\u00ed?<\/strong><\/h2>\n\n\n\n<\/a>To, jestli va\u0159en\u00ed sni\u017euje obsah fol\u00e1tu v potrav\u011b, z\u00e1vis\u00ed na druhu potraviny a zp\u016fsobu a d\u00e9lce va\u0159en\u00ed.<\/p>\n\n\n\nNorm\u00e1ln\u00ed doba varu m\u016f\u017ee eliminovat mno\u017estv\u00ed fol\u00e1tu ve \u0161pen\u00e1tu a brokolici zhruba na polovinu, p\u0159i\u010dem\u017e p\u0159\u00edprava v p\u00e1\u0159e hladinu fol\u00e1tu v\u016fbec nesni\u017euje. Va\u0159en\u00ed brambor a grilov\u00e1n\u00ed masa by mno\u017estv\u00ed fol\u00e1tu sni\u017eovat tak\u00e9 nem\u011blo, a to i v p\u0159\u00edpad\u011b, \u017ee je va\u0159\u00edte d\u00e9le, ne\u017e je obvykl\u00e9. (26)<\/p>\n\n\n\n
Va\u0159en\u00ed cibule sni\u017euje fol\u00e1t o 35%, zat\u00edmco pe\u010den\u00edm se mno\u017estv\u00ed ni\u010d\u00ed pouze z 15%. Uk\u00e1zalo se tak\u00e9, \u017ee hr\u00e1\u0161ek si b\u011bhem va\u0159en\u00ed, ve srovn\u00e1n\u00ed s jin\u00fdmi metodami tepeln\u00e9 \u00fapravy, zachov\u00e1v\u00e1 nejv\u00edce fol\u00e1tu. D\u00e1le v p\u0159\u00edpad\u011b, \u017ee va\u0159\u00edte fazole po dobu dvou hodin, a pak je nav\u00edc je\u0161t\u011b pe\u010dete nebo sma\u017e\u00edte, ztr\u00e1c\u00ed a\u017e 50%. Jedna ze studi\u00ed doporu\u010duje nejprve je namo\u010dit do slan\u00e9 vody, a pot\u00e9 je va\u0159it ve sladk\u00e9 vod\u011b, aby se zachovalo co nejv\u00edce \u017eivin. (27) <\/p>\n\n\n\n
M\u011bly by t\u011bhotn\u00e9 \u017eeny a\/nebo \u017eeny, kter\u00e9 t\u011bhotenstv\u00ed pl\u00e1nuj\u00ed u\u017e\u00edvat dopl\u0148ky stravy s fol\u00e1ty?<\/strong><\/h2>\n\n\n\nMezi odbornou l\u00e9ka\u0159skou ve\u0159ejnost\u00ed je v\u0161eobecn\u011b p\u0159ij\u00edm\u00e1no, \u017ee udr\u017eov\u00e1n\u00ed hladiny fol\u00e1t\u016f na po\u017eadovan\u00e9 \u00farovni je vhodn\u00e9, jeliko\u017e je prok\u00e1z\u00e1na siln\u00e1 korelace mezi optim\u00e1ln\u00ed hladinou fol\u00e1tu a p\u0159edch\u00e1zen\u00edm vrozen\u00fdm vad\u00e1m.<\/p>\n\n\n\n
Jak ji\u017e bylo uvedeno v\u00fd\u0161e, ji\u017e od ot\u011bhotn\u011bn\u00ed je t\u0159eba m\u00edt v t\u011ble dostatek bioaktivn\u00edho fol\u00e1tu, aby byl zaji\u0161t\u011bn spr\u00e1vn\u00fd v\u00fdvoj nervov\u00e9ho syst\u00e9mu d\u00edt\u011bte. To znamen\u00e1, \u017ee je vhodn\u00e9 za\u010d\u00edt fol\u00e1t dopl\u0148ovat ji\u017e b\u011bhem samotn\u00e9 snahy o po\u010det\u00ed. <\/p>\n\n\n\n
Dopl\u0148ov\u00e1n\u00ed 5-MTHF je ten nejefektivn\u011bj\u0161\u00ed zp\u016fsob, kter\u00fd zajist\u00ed, \u017ee Va\u0161e t\u011blo skute\u010dn\u011b absorbuje dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. <\/p>\n\n\n\n
Pokud jste t\u011bhotn\u00e1, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em. Nen\u00ed vhodn\u00e9 si s dopl\u0148ky stravy pohr\u00e1vat bez odborn\u00e9ho dohledu, kter\u00fd zajist\u00ed p\u0159izp\u016fsoben\u00ed vhodn\u00e9 medikace p\u0159\u00edmo V\u00e1m na m\u00edru.<\/p>\n\n\n\n
M\u016f\u017ee m\u00edt Va\u0161e t\u011blo nadbytek fol\u00e1t\u016f?<\/strong><\/h2>\n\n\n\nToto je v l\u00e9ka\u0159sk\u00e9 v\u011bd\u011b kontroverzn\u00ed z\u00e1le\u017eitost. N\u011bkte\u0159\u00ed v\u011bdci tvrd\u00ed, \u017ee ve Va\u0161em t\u011ble m\u016f\u017ee cirkulovat p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9, co\u017e m\u016f\u017ee zp\u016fsobit zdravotn\u00ed probl\u00e9my. (28) <\/p>\n\n\n\n
Pr\u00e1v\u011b kv\u016fli t\u00e9to kontroverzi a pot\u0159eb\u011b dal\u0161\u00edch studi\u00ed m\u016f\u017eete naj\u00edt vl\u00e1dn\u00ed zdravotnick\u00e9 agentury, kter\u00e9 se odm\u00edtaj\u00ed \u00fa\u010dastnit debat na toto t\u00e9ma a rad\u00ed spot\u0159ebitel\u016fm, aby rad\u011bji byli v tomto ohledu velmi opatrn\u00ed. <\/p>\n\n\n\n
Nic z toho by v\u0161ak nem\u011bl b\u00fdt probl\u00e9m pro 5-MTHF nebo fol\u00e1t, kter\u00fd se nach\u00e1z\u00ed v p\u0159irozen\u00e9 form\u011b v potrav\u011b.<\/p>\n\n\n\n
Co m\u016f\u017ee zp\u016fsobit nadbytek kyseliny listov\u00e9?<\/p>\n\n\n\n
Mo\u017en\u00e9 skryt\u00e9 zn\u00e1mky nedostatku B12<\/strong><\/h3>\n\n\n\nP\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 v t\u011ble m\u016f\u017ee m\u016f\u017ee maskovat p\u0159\u00edznaky megaloblastick\u00e9 an\u00e9mie zp\u016fsoben\u00e9 nedostatkem vitam\u00ednu B12. Nejedn\u00e1 se v\u0161ak o konsenzus, pro v\u011bdce je toto st\u00e1le z\u00e1hadou. Ale pakli\u017ee je toto tvrzen\u00ed pravdiv\u00e9, m\u016f\u017ee se st\u00e1t, \u017ee l\u00e9ka\u0159 stanov\u00ed \u0161patnou diagn\u00f3zu. To m\u016f\u017ee zp\u016fsobit zhor\u0161en\u00ed probl\u00e9m\u016f souvisej\u00edc\u00edch krevn\u00edm ob\u011bhem a po\u0161kodit mozek a nervov\u00fd syst\u00e9m. Po\u0161kozen\u00ed mozku m\u016f\u017ee zp\u016fsobit rychl\u00fd kognitivn\u00ed pokles a zmatek. (29) <\/p>\n\n\n\n
V \u010dem se ale odborn\u00e1 ve\u0159ejnost shoduje je to, \u017ee tento probl\u00e9m se net\u00fdk\u00e1 5-MTHF, tud\u00ed\u017e aktivn\u00ed formy fol\u00e1tu, kter\u00e1 se tvo\u0159\u00ed p\u0159i spr\u00e1vn\u00e9m metabolismu fol\u00e1t\u016f. Nadm\u011brn\u00e1 konzumace fazol\u00ed, pomeran\u010d\u016f nebo zelen\u00e9 zeleniny, s p\u0159irozen\u011b vysok\u00fdm obsahem fol\u00e1t\u016f se tak\u00e9 nezd\u00e1 b\u00fdt – dle odborn\u00edk\u016f – probl\u00e9m. (39)<\/p>\n\n\n\n
Nedostatek vitam\u00ednu B12 m\u016f\u017ee b\u00fdt v\u011bt\u0161\u00ed probl\u00e9m pro vegetari\u00e1ny a star\u0161\u00ed lidi, ne\u017e pro v\u011bt\u0161inu ostatn\u00edch. Vegetari\u00e1nsk\u00e1 strava nen\u00ed na tento vitam\u00edn dostate\u010dn\u011b bohat\u00e1 a star\u0161\u00ed lid\u00e9 ho t\u011b\u017eko vst\u0159eb\u00e1vaj\u00ed. Ob\u011b skupiny mohou doplnit B12 sublingv\u00e1ln\u011b (rozpustit pod jazykem).<\/p>\n\n\n\n
<\/a>Poruchy sp\u00e1nku & n\u00e1lady<\/strong><\/h3>\n\n\n\nNadu\u017e\u00edv\u00e1n\u00ed kyseliny listov\u00e9, zejm\u00e9na pokud je pod\u00e1v\u00e1na v dopl\u0148c\u00edch stravy, m\u016f\u017ee zp\u016fsobit poruchy sp\u00e1nku a podr\u00e1\u017ed\u011bnost. (30)<\/p>\n\n\n\n
Nevolnost & nechutenstv\u00ed<\/strong><\/h3>\n\n\n\nN\u011bkte\u0159\u00ed lid\u00e9 mohou ztratit chu\u0165 k j\u00eddlu nebo trp\u011bt nevolnost\u00ed, a to zejm\u00e9na pokud u\u017eij\u00ed p\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 z dopl\u0148k\u016f nebo vitam\u00edn\u016f. (30)<\/p>\n\n\n\n
\u0158e\u0161en\u00ed<\/strong><\/h3>\n\n\n\nPakli\u017ee se rozhodnete za\u010d\u00edt dopl\u0148ovat fol\u00e1ty, ujist\u011bte se, \u017ee zvol\u00edte jejich bioaktivn\u00ed formu: 5-MTHF.<\/p>\n\n\n\n
P\u0159e\u010dt\u011bte si informace uveden\u00e9 na vitam\u00ednech, kter\u00e9 u\u017e\u00edv\u00e1te. Neobsahuj\u00ed p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9? V\u011bt\u0161ina dosp\u011bl\u00fdch by m\u011bla konzumovat asi 0,5 mg kyseliny listov\u00e9 denn\u011b. P\u0159e\u010dt\u011bte si tak\u00e9 etikety na chlebu a obilovin\u00e1ch.<\/p>\n\n\n\n
Pokud ji\u017e u\u017e\u00edv\u00e1te 5-MTHF, zkuste omezit mno\u017estv\u00ed kyseliny listov\u00e9 p\u0159ij\u00edman\u00e9 z o n\u00ed obohacen\u00fdch potravin na minimum a pokuste se tak\u00e9 vyhnout vitam\u00edn\u016fm s jej\u00edm obsahem. Kombinace t\u011bchto dvou forem fol\u00e1tu by toti\u017e mohla (ale nemusela) zp\u016fsobit probl\u00e9my.<\/p>\n\n\n\n
Americk\u00fd N\u00e1rodn\u00ed \u00fastav pro zdrav\u00ed a v\u00fd\u017eivov\u00e9 dopl\u0148ky stanovil maxim\u00e1ln\u00ed doporu\u010denou denn\u00ed d\u00e1vku kyseliny listov\u00e9, kter\u00e1 poch\u00e1z\u00ed z obohacen\u00fdch zrn a v\u00fd\u017eivov\u00fdch dopl\u0148k\u016f na 1 mg. Limit pro fol\u00e1ty, kter\u00e9 poch\u00e1zej\u00ed ze zeleniny nebo 5-MTHF nebyl stanoven. (29)<\/p>\n\n\n\n
Dle Harvardsk\u00e9ho zdravotn\u00edho dopisu se m\u016f\u017ee kyselina listov\u00e1 ze zrn rychle nahromadit (31), viz. seznam n\u00ed\u017ee.<\/p>\n\n\n\n
Common foods fortified with folic acid:<\/p>\n\n\n\n
\n- Bowl of special cereals: 0.394mg<\/li>\n\n\n\n
- 1 serving of pretzels: 0.172mg<\/li>\n\n\n\n
- 1 serving of cooked spaghetti: 0.166mg<\/li>\n\n\n\n
- 1 multivitamin: 0.4mg<\/li>\n<\/ul>\n\n\n\n
Total = 1.132mg<\/p>\n\n\n\n
Therefore, this limit can be easily exceeded during the day, so it is good to monitor the amount of cereals and vitamins, especially if you have a problem with folic acid metabolism. Surely you also want to make sure that you have a sufficient income. B12, and that your body absorbs it properly.<\/p>\n\n\n\n
<\/a><\/figure>\n<\/div>\n\n\nProto v Intelligent Labs pou\u017e\u00edv\u00e1me Glukosaminovou s\u016fl 6(S)-5-methyltetrahydrofol\u00e1tu (5-MTHF), bez obsahu alergenu – sko\u0159\u00e1pek. V na\u0161ich dopl\u0148c\u00edch pou\u017e\u00edv\u00e1me patentovan\u00fd vzorec s n\u00e1zvem Quatrefolic Acid\u00ae a nab\u00edz\u00edme jej ve form\u011b 1mg 5-MTHF<\/a> a 5mg 5-MTHF.<\/a><\/p>\n\n\n\n B9 je nutn\u00fd pro tvorbu: (6)(7)(8)<\/p>\n\n\n\n Zdravotn\u00edci \u010dasto tvrd\u00ed, \u017ee \u017eeny by b\u011bhem t\u011bhotenstv\u00ed m\u011bly u\u017e\u00edvat fol\u00e1ty, aby se zabr\u00e1nilo vrozen\u00fdm vad\u00e1m a po\u0161kozen\u00ed nervov\u00e9ho syst\u00e9mu plodu. \u00da\u010dinky nedostatku fol\u00e1t\u016f na v\u00fdvoj d\u00edt\u011bte byly dlouho studov\u00e1ny, a proto jsou tato doporu\u010den\u00ed rozhodn\u011b na m\u00edst\u011b. (9)<\/p>\n\n\n\n Pro v\u00fdvoj nervov\u00e9ho syst\u00e9mu b\u011bhem t\u011bhotenstv\u00ed je zapot\u0159eb\u00ed dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. To je z\u00e1sadn\u00ed od za\u010d\u00e1tku t\u011bhotenstv\u00ed, a dokonce se doporu\u010duje fol\u00e1ty za\u010d\u00edt u\u017e\u00edvat ji\u017e b\u011bhem jeho pl\u00e1nov\u00e1n\u00ed. \u017deny obvykle zjist\u00ed, \u017ee jsou t\u011bhotn\u00e9 a\u017e po p\u00e1r t\u00fddnech, proto je dobr\u00e9 si ji\u017e b\u011bhem snahy o ot\u011bhotn\u011bn\u00ed, doplnit hladinu fol\u00e1t\u016f na dostate\u010dnou \u00farove\u0148. (6)<\/p>\n\n\n\n POZOR, tat\u00ednci: tohle je i pro V\u00e1s!<\/p>\n\n\n\n I mu\u017ei, kte\u0159\u00ed se sna\u017e\u00ed zplodit potomka by se m\u011bli, \u017ee netrp\u00ed nedostatkem fol\u00e1t\u016f. Studie z roku 2013 zjistila, \u017ee u mu\u017e\u016f, kter\u00fdm zdrav\u00e1 hladina tohoto vitam\u00ednu b\u011bhem snahy o po\u010det\u00ed sch\u00e1z\u00ed, hroz\u00ed zna\u010dn\u00e9 zv\u00fd\u0161en\u00ed pravd\u011bpodobnost\u00ed deformit. (10)<\/p>\n\n\n\n N\u011bkter\u00fdm \u017een\u00e1m tedy m\u016f\u017ee b\u00fdt doporu\u010deno za\u010d\u00edt dopl\u0148ovat fol\u00e1ty ji\u017e n\u011bkolik m\u011bs\u00edc\u016f p\u0159ed po\u010det\u00edm, aby se zv\u00fd\u0161ila jistota zdrav\u00e9ho d\u00edt\u011bte. (11) <\/p>\n\n\n\n Ve studii z roku 2013 v\u00edce ne\u017e 500 pacient\u016f, jim\u017e byl pod\u00e1v\u00e1n l\u00e9k na depresi v automatizovan\u00e9m telefonn\u00edm pr\u016fzkumu nazna\u010dovalo, \u017ee poci\u0165ovali lep\u0161\u00ed pr\u016fm\u011brnou kvalitu \u017eivota a zv\u00fd\u0161enou spokojenost s jejich l\u00e9ky ji\u017e po t\u0159ech m\u011bs\u00edc\u00edch u\u017e\u00edv\u00e1n\u00ed. Sou\u010dasn\u011b tak\u00e9 uvedli, \u017ee m\u011bli lep\u0161\u00ed vztahy s rodinou, p\u0159\u00e1teli, kolegy, partnery, ale dokonce i s ostatn\u00edmi lidmi, s nimi\u017e nebyli v \u017e\u00e1dn\u00e9m bli\u017e\u0161\u00edm vztahu. Celkov\u00fd rozd\u00edl byl tud\u00ed\u017e po 95 dnech celkem znateln\u00fd. Testovan\u00ed jedinci u\u017e\u00edvali p\u0159edepsanou a velmi silnou formu 5-MTHF. Ka\u017ed\u00e1 d\u00e1vka obsahovala 7.5 nebo 15mg. Obvykl\u00e1 po\u010d\u00e1te\u010dn\u00ed d\u00e1vka pro b\u011b\u017en\u00e9 u\u017eivatele, kte\u0159\u00ed depres\u00ed netrp\u00ed je 1mg nebo i m\u00e9n\u011b. (12)<\/p>\n\n\n\n Jedn\u00edm z d\u016fvod\u016f, pro\u010d je u\u017e\u00edv\u00e1n\u00ed 5-MTHF vhodn\u00e9 u pacient\u016f s depres\u00ed, je i to, \u017ee fol\u00e1ty jsou nezbytnou sou\u010d\u00e1st\u00ed produkce hlavn\u00edch neurotransmiter\u016f, jako je serotonin, dopamin a norepinefrin a m\u016f\u017ee napom\u00e1hat jejich regulaci. (13) <\/p>\n\n\n\n 5-MTHF m\u016f\u017ee tak\u00e9 p\u0159\u00edzniv\u011b m\u00edrnit n\u011bkter\u00e9 symptomy bipol\u00e1rn\u00ed poruchy.<\/p>\n\n\n\n \u0160estit\u00fddenn\u00ed studie prov\u00e1d\u011bn\u00e1 na 10 lidech trp\u00edc\u00edch velkou depres\u00ed a bipol\u00e1rn\u00ed poruchou uk\u00e1zala slibn\u00e9 v\u00fdsledky: (14)<\/p>\n\n\n\n “V\u00fdzkumn\u00edci zjistili, \u017ee pacienti s bipol\u00e1rn\u00ed poruchou u\u017e\u00edvaj\u00edc\u00ed L-methylfol\u00e1t vykazovali zlep\u0161en\u00ed p\u0159\u00edznak\u016f deprese, fungov\u00e1n\u00ed, kognice a sebevra\u017eedn\u00fdch my\u0161lenek.<\/em><\/p>\n\n\n\n VAROV\u00c1N\u00cd: Pakli\u017ee trp\u00edte jakoukoliv formou deprese, v\u017edy se pora\u010fte s l\u00e9ka\u0159em p\u0159edt\u00edm, ne\u017e za\u010dnete u\u017e\u00edvat fol\u00e1tov\u00e9 dopl\u0148ky, a to i v p\u0159\u00edpad\u011b u\u017e\u00edv\u00e1n\u00ed n\u00edzk\u00fdch d\u00e1vek. <\/p>\n\n\n\n Homocystein je aminokyselina vyskytuj\u00edc\u00ed se v lidsk\u00e9m t\u011ble, kter\u00e1 vyvol\u00e1v\u00e1 z\u00e1n\u011bt. Mnoho nemoc\u00ed je zp\u016fsobeno pr\u00e1v\u011b z\u00e1n\u011btem.<\/p>\n\n\n\n Vysok\u00e1 hladina homocysteinu m\u016f\u017ee v\u00e9st ke zv\u00fd\u0161en\u00e9mu riziku vzniku: (18)<\/p>\n\n\n\n Vysok\u00e9 hladiny t\u00e9to l\u00e1tky jsou tak\u00e9 spojov\u00e1ny s n\u00edzk\u00fdmi hladinami vitam\u00edn\u016f B6, B9 a B12. Tato kombinace je siln\u00fdm prediktorem kognitivn\u00edho poklesu u mu\u017e\u016f a pravd\u011bpodobn\u011b i u \u017een. (15) <\/p>\n\n\n\n Zdrav\u00e9 hladiny v\u0161ech t\u0159\u00ed t\u011bchto typ\u016f vitam\u00ednu B jsou d\u016fle\u017eit\u00e9 pro udr\u017een\u00ed hladiny homocysteinu pod kontrolou. A\u010dkoliv m\u016f\u017ee 5-MTHF do ur\u010dit\u00e9 m\u00edry kognitivn\u00edmu poklesu zabr\u00e1nit s\u00e1m o sob\u011b, ud\u011bl\u00e1te l\u00e9pe, kdy\u017e budete na zdrav\u00e9 \u00farovni udr\u017eovat i zbyl\u00e9 dva typy. (15) (16) (17)<\/p>\n\n\n\n Mezi dal\u0161\u00ed p\u0159\u00ed\u010diny vysok\u00e9 hladiny homocysteinu pat\u0159\u00ed: probl\u00e9my se \u0161t\u00edtnou \u017el\u00e1zou, onemocn\u011bn\u00ed ledvin a psori\u00e1za. To znamen\u00e1, \u017ee ne v\u017edy je na vin\u011b nedostatek vitam\u00ednu B. (18) <\/p>\n\n\n\n Jak jste se ji\u017e do\u010detli v\u00fd\u0161e, zm\u011bna z\u00e1kon\u016f v des\u00edtk\u00e1ch zem\u00ed sn\u00ed\u017eila hladinu homocysteinu t\u00edm, \u017ee zavedla, aby byly mouky obohaceny o kyselinou listovou. 24 t\u00fddenn\u00ed randomizovan\u00e1 studie s placebem uk\u00e1zala, \u017ee p\u0159i sni\u017eov\u00e1n\u00ed hladiny homocysteinu u zdrav\u00fdch lid\u00ed je 5-MTHF je mnohem efektivn\u011bj\u0161\u00ed ne\u017e kyselina listov\u00e1. (19)<\/p>\n\n\n\n 5-MTHF by mohl zlep\u0161it zdrav\u00ed srdce a krevn\u00edho ob\u011bhu jednak sn\u00ed\u017een\u00edm homocysteinu ale i jin\u00fdmi mechanismy. Je to v\u0161ak komplikovan\u011bj\u0161\u00ed, jeliko\u017e riziko infarktu myokardu (IM) nebo c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody dok\u00e1\u017ee sn\u00ed\u017eit pouze v p\u0159\u00edpad\u011b, \u017ee m\u00e1te nedostatek fol\u00e1t\u016f.<\/p>\n\n\n\n <\/a>Here is a summary of the key facts of this mysterious story\u2026<\/p>\n\n\n\n A 2015 study found that men who supplemented with folic acid while taking enalapril, a blood pressure lowering medicine, reduced their risk of stroke for 4.5 years. The results were significant for the group that used the combination of folic acid and enalapril compared with the group that used enalapril alone. Old studies from the 1970s also seem to show a lower risk of stroke and MI with increased folate intake. (20)<\/p>\n\n\n\n On the other hand, some placebo-based studies in the United States have not shown a reduction in the risk of stroke or heart attack. This could mean that folate has this effect only if it is used by people who suffer from its deficiency. Recall also that the United States began enriching flour in 1998, which could explain the results of the 1970s, when people had lower folate levels. (20)<\/p>\n\n\n\n China does not enrich flour or cereal grains with folic acid, which means that its population may be deficient. Some of the old American studies looked at people who had a history of stroke and MI. In response to these events, these people were able to reduce the risk with drugs and foods other than folate. (20)<\/p>\n\n\n\n Some signs that you have a folate deficiency may include anemia (lack of red blood cells), chronic weakness & fatigue: (21)<\/p>\n\n\n\n Other signs of folate deficiency: (22)<\/p>\n\n\n\n Self-diagnosis of folate deficiency is difficult in part because the symptoms of folate and vitamin B deficiency are very similar. Your doctor will probably perform tests to find out the cause of your problems.<\/p>\n\n\n\n Pokud nekonzumujete dostate\u010dn\u00e9 mno\u017estv\u00ed fazol\u00ed,vajec, zelen\u00e9 zeleniny a dal\u0161\u00edch potravin nebo dopl\u0148k\u016f bohat\u00fdch na fol\u00e1ty, pravd\u011bpodobn\u011b budete m\u00edt ve sv\u00e9m t\u011ble nedostatek fol\u00e1tu.<\/p>\n\n\n\n \u0160patn\u00e9 vst\u0159eb\u00e1v\u00e1n\u00ed kyseliny listov\u00e9 a fol\u00e1t\u016f z potravin m\u016f\u017ee b\u00fdt zap\u0159\u00ed\u010din\u011bno mnoha d\u016fvody, v\u010detn\u011b: (21)<\/p>\n\n\n\n Kyselina listov\u00e1 a p\u0159\u00edrodn\u00ed fol\u00e1ty v potravin\u00e1ch mus\u00ed proj\u00edt n\u011bkolika chemick\u00fdmi reakcemi, ne\u017e se zm\u011bn\u00ed v u\u017eite\u010dnou formu 5-MTHF.<\/p>\n\n\n\n V\u011bt\u0161ina efektivn\u011b metabolizuje a \u00fa\u010dinn\u011b transformuje kyselinu listovou na 5-MTHF. Tento proces je \u0159\u00edzen speci\u00e1ln\u00edm genem, kter\u00fd se naz\u00fdv\u00e1 MTHFR a lid\u00e9 ho maj\u00ed ve dvou kopi\u00edch. Mnoho z n\u00e1s m\u00e1 v\u0161ak varianty jedn\u00e9 nebo obou t\u011bchto genov\u00fdch kopi\u00ed, kter\u00e9 transformaci na 5-MTHF neumo\u017e\u0148uj\u00ed. Pokud je jedna kopie tohoto genu \u0161patn\u00e1, efektivita metabolizmu m\u016f\u017ee b\u00fdt zna\u010dn\u011b naru\u0161ena. Pakli\u017ee jsou \u0161patn\u00e9 ob\u011b kopie, Va\u0161e t\u011blo p\u0159\u00edli\u0161 fol\u00e1tu ani kyseliny listov\u00e9 metabolizovat nebude. (23)<\/p>\n\n\n\n Jak zjist\u00edte, jestli pr\u00e1v\u011b Vy nem\u00e1te jednu nebo ob\u011b dv\u011b \u0161patn\u00e9 kopie genu MTHFR? K tomu je t\u0159eba prov\u00e9st test DNA a nechat jej poslat do laborato\u0159e. Tyto laborato\u0159e lze naj\u00edt i online a m\u016f\u017eete je vyhledat sami nebo se zeptat Va\u0161eho l\u00e9ka\u0159e. <\/p>\n\n\n\n V p\u0159\u00edpad\u011b, \u017ee se V\u00e1s tento probl\u00e9m genov\u00e9 variace t\u00fdk\u00e1, nejjednodu\u0161\u0161\u00ed zp\u016fsob, jak jej vy\u0159e\u0161it je u\u017e\u00edvat dopln\u011bk stravy 5-MTHF. Tento dopln\u011bk um\u00ed t\u011blo spr\u00e1vn\u011b vyu\u017e\u00edt bez dal\u0161\u00edch chemick\u00fdch reakc\u00ed, jeliko\u017e 5-MTHF je ji\u017e bioaktivn\u00ed.<\/p>\n\n\n\n Existuje n\u00e1padn\u00e1 souvislost mezi obezitou a nedostate\u010dnou hladinou fol\u00e1tu, av\u0161ak zd\u00e1 se, \u017ee nikdo nep\u0159i\u0161el na to, pro\u010d.<\/p>\n\n\n\n P\u0159ezkum studi\u00ed publikovan\u00fdch v letech 2005 a\u017e 2015 zkoumal hladiny fol\u00e1t\u016f u ob\u00e9zn\u00edch \u017een \u201ev plodn\u00e9m v\u011bku\u201c se zvl\u00e1\u0161tn\u00edm zam\u011b\u0159en\u00edm na t\u011bhotn\u00e9 \u017eeny. C\u00edlem v\u011bdc\u016f bylo u t\u011bchto \u017een zjistit mo\u017en\u00e9 p\u0159\u00ed\u010diny vysok\u00e9ho procenta deficitu fol\u00e1t\u016f. Objevena byla britsk\u00e1 studie, kter\u00e1 vylu\u010dovala faktory, jako jsou strava, vitam\u00edny a v\u011bk. Tato studie odkazovala tak\u00e9 na n\u011bkolik dal\u0161\u00edch studi\u00ed, kter\u00e9 stravu jako p\u0159\u00ed\u010dinu tak\u00e9 vylu\u010dovaly. V\u011bdci v t\u00e9to studii pouze uvedli, \u017ee je t\u0159eba prov\u00e9st v\u00edce b\u00e1d\u00e1n\u00ed na toto t\u00e9ma a uvedli rady, jak\u00fdm zp\u016fsobem je sestavit. (24)<\/p>\n\n\n\n V\u011bc se m\u00e1 tak, \u017ee obezita sama o sob\u011b nebo i jej\u00ed konkr\u00e9tn\u00ed p\u0159\u00ed\u010diny by mohly v\u00e9st ke sn\u00ed\u017een\u00ed obsahu fol\u00e1t\u016f na nezdravou \u00farove\u0148. Korelace je siln\u00e1 a v\u0161echny ot\u00e1zky se t\u00fdkaj\u00ed toho, co k \u010demu vede.<\/p>\n\n\n\n Dal\u0161\u00ed studie zaznamenala silnou souvislost mezi obezitou a deficitem fol\u00e1tu:<\/p>\n\n\n\n V roce 2016 v\u011bdci p\u0159ezkoum\u00e1vali studie s c\u00edlem aktualizovat Sm\u011brnici pro bariatrickou chirurgii Americk\u00e9 spole\u010dnosti pro v\u00fd\u017eivu metabolick\u00e9 a bariatrick\u00e9 chirurgie, z roku 2008. Sm\u011brnice je zalo\u017eena na studi\u00edch zji\u0161\u0165uj\u00edc\u00edch hladinu \u017eivin p\u0159ed a po chirurgick\u00fdch z\u00e1kroc\u00edch, kter\u00e9 byly provedeny za \u00fa\u010delem redukce hmotnosti. Nov\u00e1 sm\u011brnice pro rok 2016 doporu\u010dovala screening deficitu fol\u00e1t\u016f p\u0159ed t\u00edmto typem operace. D\u016fvodem bylo to, \u017ee a\u017e 54% ob\u00e9zn\u00edch pacient\u016f trp\u00ed nedostatkem fol\u00e1t\u016f. (25)<\/p>\n\n\n\n V tomto p\u0159\u00edpad\u011b v\u011bdci nem\u011bli v \u00famyslu vy\u0161et\u0159ovat p\u0159\u00ed\u010dinu a n\u00e1sledek, ale v\u0161imli si tohoto spojen\u00ed, na kter\u00e9 reagovali doporu\u010den\u00edm p\u0159ed operac\u00ed monitorovat a dopl\u0148ovat fol\u00e1t.<\/p>\n\n\n\n <\/a>To, jestli va\u0159en\u00ed sni\u017euje obsah fol\u00e1tu v potrav\u011b, z\u00e1vis\u00ed na druhu potraviny a zp\u016fsobu a d\u00e9lce va\u0159en\u00ed.<\/p>\n\n\n\n Norm\u00e1ln\u00ed doba varu m\u016f\u017ee eliminovat mno\u017estv\u00ed fol\u00e1tu ve \u0161pen\u00e1tu a brokolici zhruba na polovinu, p\u0159i\u010dem\u017e p\u0159\u00edprava v p\u00e1\u0159e hladinu fol\u00e1tu v\u016fbec nesni\u017euje. Va\u0159en\u00ed brambor a grilov\u00e1n\u00ed masa by mno\u017estv\u00ed fol\u00e1tu sni\u017eovat tak\u00e9 nem\u011blo, a to i v p\u0159\u00edpad\u011b, \u017ee je va\u0159\u00edte d\u00e9le, ne\u017e je obvykl\u00e9. (26)<\/p>\n\n\n\n Va\u0159en\u00ed cibule sni\u017euje fol\u00e1t o 35%, zat\u00edmco pe\u010den\u00edm se mno\u017estv\u00ed ni\u010d\u00ed pouze z 15%. Uk\u00e1zalo se tak\u00e9, \u017ee hr\u00e1\u0161ek si b\u011bhem va\u0159en\u00ed, ve srovn\u00e1n\u00ed s jin\u00fdmi metodami tepeln\u00e9 \u00fapravy, zachov\u00e1v\u00e1 nejv\u00edce fol\u00e1tu. D\u00e1le v p\u0159\u00edpad\u011b, \u017ee va\u0159\u00edte fazole po dobu dvou hodin, a pak je nav\u00edc je\u0161t\u011b pe\u010dete nebo sma\u017e\u00edte, ztr\u00e1c\u00ed a\u017e 50%. Jedna ze studi\u00ed doporu\u010duje nejprve je namo\u010dit do slan\u00e9 vody, a pot\u00e9 je va\u0159it ve sladk\u00e9 vod\u011b, aby se zachovalo co nejv\u00edce \u017eivin. (27) <\/p>\n\n\n\n Mezi odbornou l\u00e9ka\u0159skou ve\u0159ejnost\u00ed je v\u0161eobecn\u011b p\u0159ij\u00edm\u00e1no, \u017ee udr\u017eov\u00e1n\u00ed hladiny fol\u00e1t\u016f na po\u017eadovan\u00e9 \u00farovni je vhodn\u00e9, jeliko\u017e je prok\u00e1z\u00e1na siln\u00e1 korelace mezi optim\u00e1ln\u00ed hladinou fol\u00e1tu a p\u0159edch\u00e1zen\u00edm vrozen\u00fdm vad\u00e1m.<\/p>\n\n\n\n Jak ji\u017e bylo uvedeno v\u00fd\u0161e, ji\u017e od ot\u011bhotn\u011bn\u00ed je t\u0159eba m\u00edt v t\u011ble dostatek bioaktivn\u00edho fol\u00e1tu, aby byl zaji\u0161t\u011bn spr\u00e1vn\u00fd v\u00fdvoj nervov\u00e9ho syst\u00e9mu d\u00edt\u011bte. To znamen\u00e1, \u017ee je vhodn\u00e9 za\u010d\u00edt fol\u00e1t dopl\u0148ovat ji\u017e b\u011bhem samotn\u00e9 snahy o po\u010det\u00ed. <\/p>\n\n\n\n Dopl\u0148ov\u00e1n\u00ed 5-MTHF je ten nejefektivn\u011bj\u0161\u00ed zp\u016fsob, kter\u00fd zajist\u00ed, \u017ee Va\u0161e t\u011blo skute\u010dn\u011b absorbuje dostate\u010dn\u00e9 mno\u017estv\u00ed fol\u00e1tu. <\/p>\n\n\n\n Pokud jste t\u011bhotn\u00e1, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em. Nen\u00ed vhodn\u00e9 si s dopl\u0148ky stravy pohr\u00e1vat bez odborn\u00e9ho dohledu, kter\u00fd zajist\u00ed p\u0159izp\u016fsoben\u00ed vhodn\u00e9 medikace p\u0159\u00edmo V\u00e1m na m\u00edru.<\/p>\n\n\n\n Toto je v l\u00e9ka\u0159sk\u00e9 v\u011bd\u011b kontroverzn\u00ed z\u00e1le\u017eitost. N\u011bkte\u0159\u00ed v\u011bdci tvrd\u00ed, \u017ee ve Va\u0161em t\u011ble m\u016f\u017ee cirkulovat p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9, co\u017e m\u016f\u017ee zp\u016fsobit zdravotn\u00ed probl\u00e9my. (28) <\/p>\n\n\n\n Pr\u00e1v\u011b kv\u016fli t\u00e9to kontroverzi a pot\u0159eb\u011b dal\u0161\u00edch studi\u00ed m\u016f\u017eete naj\u00edt vl\u00e1dn\u00ed zdravotnick\u00e9 agentury, kter\u00e9 se odm\u00edtaj\u00ed \u00fa\u010dastnit debat na toto t\u00e9ma a rad\u00ed spot\u0159ebitel\u016fm, aby rad\u011bji byli v tomto ohledu velmi opatrn\u00ed. <\/p>\n\n\n\n Nic z toho by v\u0161ak nem\u011bl b\u00fdt probl\u00e9m pro 5-MTHF nebo fol\u00e1t, kter\u00fd se nach\u00e1z\u00ed v p\u0159irozen\u00e9 form\u011b v potrav\u011b.<\/p>\n\n\n\n Co m\u016f\u017ee zp\u016fsobit nadbytek kyseliny listov\u00e9?<\/p>\n\n\n\n P\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 v t\u011ble m\u016f\u017ee m\u016f\u017ee maskovat p\u0159\u00edznaky megaloblastick\u00e9 an\u00e9mie zp\u016fsoben\u00e9 nedostatkem vitam\u00ednu B12. Nejedn\u00e1 se v\u0161ak o konsenzus, pro v\u011bdce je toto st\u00e1le z\u00e1hadou. Ale pakli\u017ee je toto tvrzen\u00ed pravdiv\u00e9, m\u016f\u017ee se st\u00e1t, \u017ee l\u00e9ka\u0159 stanov\u00ed \u0161patnou diagn\u00f3zu. To m\u016f\u017ee zp\u016fsobit zhor\u0161en\u00ed probl\u00e9m\u016f souvisej\u00edc\u00edch krevn\u00edm ob\u011bhem a po\u0161kodit mozek a nervov\u00fd syst\u00e9m. Po\u0161kozen\u00ed mozku m\u016f\u017ee zp\u016fsobit rychl\u00fd kognitivn\u00ed pokles a zmatek. (29) <\/p>\n\n\n\n V \u010dem se ale odborn\u00e1 ve\u0159ejnost shoduje je to, \u017ee tento probl\u00e9m se net\u00fdk\u00e1 5-MTHF, tud\u00ed\u017e aktivn\u00ed formy fol\u00e1tu, kter\u00e1 se tvo\u0159\u00ed p\u0159i spr\u00e1vn\u00e9m metabolismu fol\u00e1t\u016f. Nadm\u011brn\u00e1 konzumace fazol\u00ed, pomeran\u010d\u016f nebo zelen\u00e9 zeleniny, s p\u0159irozen\u011b vysok\u00fdm obsahem fol\u00e1t\u016f se tak\u00e9 nezd\u00e1 b\u00fdt – dle odborn\u00edk\u016f – probl\u00e9m. (39)<\/p>\n\n\n\n Nedostatek vitam\u00ednu B12 m\u016f\u017ee b\u00fdt v\u011bt\u0161\u00ed probl\u00e9m pro vegetari\u00e1ny a star\u0161\u00ed lidi, ne\u017e pro v\u011bt\u0161inu ostatn\u00edch. Vegetari\u00e1nsk\u00e1 strava nen\u00ed na tento vitam\u00edn dostate\u010dn\u011b bohat\u00e1 a star\u0161\u00ed lid\u00e9 ho t\u011b\u017eko vst\u0159eb\u00e1vaj\u00ed. Ob\u011b skupiny mohou doplnit B12 sublingv\u00e1ln\u011b (rozpustit pod jazykem).<\/p>\n\n\n\n Nadu\u017e\u00edv\u00e1n\u00ed kyseliny listov\u00e9, zejm\u00e9na pokud je pod\u00e1v\u00e1na v dopl\u0148c\u00edch stravy, m\u016f\u017ee zp\u016fsobit poruchy sp\u00e1nku a podr\u00e1\u017ed\u011bnost. (30)<\/p>\n\n\n\n N\u011bkte\u0159\u00ed lid\u00e9 mohou ztratit chu\u0165 k j\u00eddlu nebo trp\u011bt nevolnost\u00ed, a to zejm\u00e9na pokud u\u017eij\u00ed p\u0159\u00edli\u0161n\u00e9 mno\u017estv\u00ed kyseliny listov\u00e9 z dopl\u0148k\u016f nebo vitam\u00edn\u016f. (30)<\/p>\n\n\n\n Pakli\u017ee se rozhodnete za\u010d\u00edt dopl\u0148ovat fol\u00e1ty, ujist\u011bte se, \u017ee zvol\u00edte jejich bioaktivn\u00ed formu: 5-MTHF.<\/p>\n\n\n\n P\u0159e\u010dt\u011bte si informace uveden\u00e9 na vitam\u00ednech, kter\u00e9 u\u017e\u00edv\u00e1te. Neobsahuj\u00ed p\u0159\u00edli\u0161 mnoho kyseliny listov\u00e9? V\u011bt\u0161ina dosp\u011bl\u00fdch by m\u011bla konzumovat asi 0,5 mg kyseliny listov\u00e9 denn\u011b. P\u0159e\u010dt\u011bte si tak\u00e9 etikety na chlebu a obilovin\u00e1ch.<\/p>\n\n\n\n Pokud ji\u017e u\u017e\u00edv\u00e1te 5-MTHF, zkuste omezit mno\u017estv\u00ed kyseliny listov\u00e9 p\u0159ij\u00edman\u00e9 z o n\u00ed obohacen\u00fdch potravin na minimum a pokuste se tak\u00e9 vyhnout vitam\u00edn\u016fm s jej\u00edm obsahem. Kombinace t\u011bchto dvou forem fol\u00e1tu by toti\u017e mohla (ale nemusela) zp\u016fsobit probl\u00e9my.<\/p>\n\n\n\n Americk\u00fd N\u00e1rodn\u00ed \u00fastav pro zdrav\u00ed a v\u00fd\u017eivov\u00e9 dopl\u0148ky stanovil maxim\u00e1ln\u00ed doporu\u010denou denn\u00ed d\u00e1vku kyseliny listov\u00e9, kter\u00e1 poch\u00e1z\u00ed z obohacen\u00fdch zrn a v\u00fd\u017eivov\u00fdch dopl\u0148k\u016f na 1 mg. Limit pro fol\u00e1ty, kter\u00e9 poch\u00e1zej\u00ed ze zeleniny nebo 5-MTHF nebyl stanoven. (29)<\/p>\n\n\n\n Dle Harvardsk\u00e9ho zdravotn\u00edho dopisu se m\u016f\u017ee kyselina listov\u00e1 ze zrn rychle nahromadit (31), viz. seznam n\u00ed\u017ee.<\/p>\n\n\n\n Common foods fortified with folic acid:<\/p>\n\n\n\n Total = 1.132mg<\/p>\n\n\n\n Therefore, this limit can be easily exceeded during the day, so it is good to monitor the amount of cereals and vitamins, especially if you have a problem with folic acid metabolism. Surely you also want to make sure that you have a sufficient income. B12, and that your body absorbs it properly.<\/p>\n\n\n\nV \u010dem jsou fol\u00e1ty & 5-MTHF p\u0159\u00ednosn\u00e9 pro zdrav\u00ed?<\/strong><\/h2>\n\n\n\n
Nezbytn\u00e9 pro udr\u017een\u00ed z\u00e1kladn\u00edch funkc\u00ed lidsk\u00e9ho t\u011bla<\/strong><\/h3>\n\n\n\n
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<\/a><\/h3>\n\n\n\n
B\u011bhem t\u011bhotenstv\u00ed p\u0159edch\u00e1zej\u00ed v\u00fdskytu vrozen\u00fdch vad<\/strong><\/h3>\n\n\n\n
<\/a><\/figure>\n\n\n\nMohou sni\u017eovat riziko vzniku deprese a\/nebo podpo\u0159it \u00fa\u010dinek antidepresiv<\/strong><\/h3>\n\n\n\n
Sn\u00ed\u017eit hladinu toxick\u00e9 aminokyseliny – homocysteinu<\/strong><\/h3>\n\n\n\n
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Mohou sn\u00ed\u017eit riziko vzniku c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody & infarktu myokardu<\/strong><\/h3>\n\n\n\n
How do you know if you have a folate deficiency?<\/strong><\/h2>\n\n\n\n
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What causes folate deficiency?<\/strong><\/h2>\n\n\n\n
A diet that is not rich enough in folate<\/strong><\/h3>\n\n\n\n
<\/a>Probl\u00e9my, kter\u00e9 zabra\u0148uj\u00ed absorpci fol\u00e1tu z j\u00eddla & dopl\u0148k\u016f stravy<\/strong><\/h3>\n\n\n\n
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Obezitou<\/strong><\/h3>\n\n\n\n
Zni\u010d\u00ed se fol\u00e1ty b\u011bhem jejich va\u0159en\u00ed?<\/strong><\/h2>\n\n\n\n
M\u011bly by t\u011bhotn\u00e9 \u017eeny a\/nebo \u017eeny, kter\u00e9 t\u011bhotenstv\u00ed pl\u00e1nuj\u00ed u\u017e\u00edvat dopl\u0148ky stravy s fol\u00e1ty?<\/strong><\/h2>\n\n\n\n
M\u016f\u017ee m\u00edt Va\u0161e t\u011blo nadbytek fol\u00e1t\u016f?<\/strong><\/h2>\n\n\n\n
Mo\u017en\u00e9 skryt\u00e9 zn\u00e1mky nedostatku B12<\/strong><\/h3>\n\n\n\n
<\/a>Poruchy sp\u00e1nku & n\u00e1lady<\/strong><\/h3>\n\n\n\n
Nevolnost & nechutenstv\u00ed<\/strong><\/h3>\n\n\n\n
\u0158e\u0161en\u00ed<\/strong><\/h3>\n\n\n\n
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![\"Cereals](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-10.jpg\")
<\/a><\/figure>\n\n\n\n![\"Uchov\u00e1vejte](\"https:\/\/eu.intelligentlabs.org\/wp-content\/uploads\/2025\/07\/cos-e-il-5-mthf-la-guida-definitiva-per-folato-e-metilfolato-11.jpg\")
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